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MeSH Disease

HGNC Genes

SARS-CoV-2 proteins

ProteinS (6)

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NSP16 (1)

NSP5 (1)

ORF1ab (1)


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    Clinical characteristics of 116 hospitalized patients with COVID-19 MESHD in Wuhan, China: a single-centered, retrospective, observational study

    Authors: Shiqiang Xiong; Lin Liu; Feng Lin; Jinhu Shi; Lei Han; Huijian Liu; Lewei He; Qijun Jiang; Zeyang Wang; Wenbo Fu; Zhigang Li; Qing Lu; Zhinan Chen; Shifang Ding

    doi:10.21203/rs.3.rs-26358/v3 Date: 2020-05-01 Source: ResearchSquare

    Background A cluster of acute respiratory illness MESHD, now known as Corona Virus Disease MESHD 2019 ( COVID-19 MESHD) caused by 2019 novel coronavirus (SARS-CoV-2), has become a global pandemic. Aged population with cardiovascular diseases MESHD are more likely be to infected with SARS-CoV-2 and result in more severe outcomes and elevated case-fatality rate. Meanwhile, cardiovascular diseases MESHD have a high prevalence in the middle-aged and elderly population. However, despite of several researches in COVID-19 MESHD, cardiovascular implications related to it still remains largely unclear. Therefore, a specific analysis in regard to cardiovascular implications of COVID-19 MESHD patients is in great need.Methods In this single-centered, retrospective, observational study, 116 patients with laboratory-confirmed COVID-19 MESHD were enrolled, who admitted to the General Hospital of Central Theater Command (Wuhan, China) from January 20 to March 8, 2020. The demographic data, underlying comorbidities, clinical symptoms and signs, laboratory findings, chest computed tomography, treatment measures, and outcome data were collected from electronic medical records. Data were compared between non-severe and severe cases.ResultsOf 116 hospitalized patients with COVID-19 MESHD, the median age was 58.5 years (IQR, 47.0-69.0), and 36 (31.0%) were female. Hypertension MESHD (45 [38.8%]), diabetes MESHD (19 [16.4%]), and coronary heart disease MESHD (17 [14.7%]) were the most common coexisting conditions. Common symptoms included fever MESHD [99 (85.3%)], dry cough MESHD (61 [52.6%]), fatigue MESHD (60 [51.7%]), dyspnea MESHD (52 [44.8%]), anorexia MESHD (50 [43.1%]), and chest discomfort (50 [43.1%]). Local and/or bilateral patchy shadowing were the typical radiological findings on chest computed tomography. Lymphopenia MESHD (lymphocyte count, 1.0 × 109/L [IQR, 0.7-1.3]) was observed in 66 patients (56.9%), and elevated lactate dehydrogenase (245.5 U/L [IQR, 194.3-319.8]) in 69 patients (59.5%). Hypokalemia MESHD occurred in 24 (20.7%) patients. Compared with non-severe cases, severe cases were older (64.0 years [IQR, 53.0-76.0] vs 56.0 years [IQR, 37.0-64.0]), more likely to have comorbidities (35 [63.6%] vs 24 [39.3%]), and more likely to develop acute cardiac injury MESHD (19 [34.5%] vs 4 [6.6%]), acute heart failure MESHD (18 [32.7%] vs 3 [4.9%]), and ARDS (20 [36.4%] vs 0 [0%]). During hospitalization, the prevalence of new onset hypertension MESHD was significantly higher in severe patients (55.2% vs 19.0%) than in non-severe ones.Conclusions In this single-centered, retrospective, observational study, we found that the infection of SARS-CoV-2 MESHD was more likely to occur in middle and aged population with cardiovascular comorbidities. Cardiovascular complications MESHD, including new onset hypertension MESHD and heart injury MESHD were common in severe patients with COVID-19 MESHD. More detailed researches in cardiovascular involvement in COVID-19 MESHD are urgently needed to further understand the disease.

    Symptoms at disease onset predict prognosis in COVID-19 MESHD disease

    Authors: Aiyuan Zhou; Yating Peng; David R Price; Hong Peng; Xin Liao; Peng Huang; Wenlong Liu; Zhi Xiang; Qimi Liu; Mingyan Jiang; Xudong Xiang; Peipei Guo; Dingding Deng; Ping Chen

    doi:10.21203/rs.3.rs-25145/v1 Date: 2020-04-24 Source: ResearchSquare

    Background: The main clinical manifestations of coronavirus disease 2019 MESHD ( COVID-19 MESHD) onset are respiratory symptoms, including cough, sputum and dyspnea MESHD. However, a significant proportion of patients initially manifested extra-respiratory symptoms, such as fever MESHD, myalgia MESHD and diarrhea MESHD. Here we compared the different characteristics and outcomes between the patients with respiratory symptoms and extra-respiratory symptoms at illness onset.Methods: The patients admitted to the respiratory departments from eight hospitals out of Wuhan with nucleic acid-positive of severe acute respiratory syndrome coronavirus (SARS-CoV-2 MESHD) were recruited. Epidemiological information, clinical manifestations, laboratory findings, and radiological characteristics, treatment regimens and outcomes data were recorded and analyzed.Results: The median age of the recruited 541 subjects was 43 years (IQR, 33-55). Of the 541 subjects, 404 (74.5%) subjects had initial symptom that were respiratory, while 137 (25.5%) subjects had extra-respiratory symptoms. Respiratory COVID-19 MESHD subjects had more secondary bacterial infections MESHD (p<0.001), needed the intensive care unit more (p=0.005), non-invasive ventilation more (p=0.004), developed ARDS more (p=0.001) and needed longer to recover (p=0.003) compared to predominately extra-respiratory COVID-19 MESHD subjects. The multivariate model showed that age (OR = 1.04, p = 0.01) dyspnea MESHD (OR = 4.91, p < 0.001) and secondary bacterial infection MESHD (OR = 19.8, p < 0.001) were independently associated with development of ARDS among COVID-19 MESHD patients.Conclusion: we identify COVID-19 MESHD subjects with dyspnea MESHD at disease onset have worse prognosis. We also demonstrate age and secondary bacterial infections MESHD to be independently associated with ARDS development in subjects with COVID-19 MESHD.

    Pregnancy outcomes, Newborn complications and Maternal-Fetal Transmission of SARS-CoV-2 in women with COVID-19 MESHD: A systematic review

    Authors: Rahul Gajbhiye; Deepak Modi; Smita Mahale

    doi:10.1101/2020.04.11.20062356 Date: 2020-04-15 Source: medRxiv

    Abstract Objective: The aim of this systematic review was to examine published and preprint reports for maternal and fetal outcomes in pregnant women with COVID-19 MESHD and also assess the incidence of maternal-fetal transmission of SARS CO-V-2 infection MESHD. Design : Systematic review Data sources:We searched PUMBED. Medline, Embase, MedRxiv and bioRxiv databases upto 31st March 2020 utilizing combinations of word variants for " coronavirus " or " COVID-19 MESHD " or " severe acute respiratory syndrome MESHD " or " SARS-COV-2 " and " pregnancy " . We also included data from preprint articles. Study selection : Original case reports and case series on pregnant women with a confirmed diagnosis of SARS-CoV-2 infection MESHD. Data extraction : We included 23 studies [China (20), USA (01), Republic of Korea (01) and Honduras, Central America (01) reporting the information on 172 pregnant women and 162 neonates. The primary outcome measures were maternal health characteristics and adverse pregnancy outcomes, neonatal outcomes and SARS-CoV-2 infection MESHD in neonates was extracted. Treatments given to pregnant women with COVID-19 MESHD were also recorded. Results: Out of 172 women affected by COVID-19 MESHD in pregnancy, 160 women had delivered 162 newborns (2 set of twins, 12 ongoing pregnancies). In pregnant women with COVID-19 MESHD, the most common symptoms were fever MESHD (54%), cough (35%), myalgia MESHD (17%), dyspnea MESHD (12%) and diarrhea MESHD (4%). Pneumonia was diagnosed by CT scan imaging in 100 % of COVID-19 MESHD pregnant women. Pregnancy complications included delivery by cesarean section (89%), preterm labor MESHD (21%), fetal distress (9%) and premature rupture of membranes (8%). The most common co-morbidities associated with pregnant women with COVID-19 MESHD were diabetes MESHD (11%), hypertensive disorders MESHD (9%), placental disorders MESHD (5%), co-infections MESHD (6%), scarred uterus (5%), hypothyroidism MESHD (5%) and anemia MESHD (4%). Amongst the neonates of COVID-19 MESHD mothers, preterm birth (23%), respiratory distress syndrome MESHD (14%), pneumonia MESHD (14%) low birth weight (11%), small for gestational age (3%) were reported. There was one still birth and one neonatal death MESHD reported. Vertical transmission rate of SARS-CoV-2 is estimated to be 11%. Conclusion In pregnant women with COVID-19 MESHD, diabetes MESHD and hypertensive disorders MESHD are common co-morbidities and there is a risk of preterm delivery. Amongst the neonates born to mothers with COVID-19 MESHD, respiratory distress syndrome MESHD and pneumonia MESHD are common occurrence. There is an evidence of vertical transmission of SARS-CoV-2 infection MESHD in women with COVID-19 MESHD.

    Recurrent recurrence of positive SARS-CoV-2 RNA in a COVID-19 MESHD patient

    Authors: Shugang Cao; Aimei Wu; Jiaxia Li; Yuancheng Li; Mingwu Xia; Juncang Wu

    doi:10.21203/rs.3.rs-23197/v2 Date: 2020-04-15 Source: ResearchSquare

    Background: Coronavirus disease 2019 MESHD ( COVID-19 MESHD) is a highly infectious disease MESHD. A small proportion of discharged patients became positive again for severe acute respiratory syndrome coronavirus 2 MESHD (SARS-CoV-2) RNA, even though they met the discharge criteria. Herein, we report a rare COVID-19 MESHD patient with recurrent recurrence of positive SARS-CoV-2 RNA.Case presentation: A 68-year-old man was admitted due to fever MESHD, muscle pain MESHD, and fatigue MESHD. He was initially diagnosed with COVID-19 MESHD according to two consecutive positive results for SARS-CoV-2 RNA. He was discharged from hospital when meeting the discharge criteria. He tested positive for SARS-CoV-2 RNA twice during the quarantine and was hospitalized again. He was asymptomatic then, but IgG and IgM anti-SARS-CoV-2 were both positive. He was discharged in the context of four consecutive negative test results for SARS-CoV-2 RNA after antiviral treatment. However, he tested positive once again on the 3rd and 4th days after the second discharge. Two days later, the SARS-CoV-2 RNA results became negative in three consecutive retests, and he was finally discharged. Conclusion: This case suggests that convalescent patients may become positive again for SARS-CoV-2 RNA after discharge due to prolonged nucleic acid transition. However, the potential infectivity of these patients needs to be further confirmed in future research.

    Preliminary study to identify severe from moderate cases of COVID-19 MESHD using NLR&RDW-SD combination parameter

    Authors: changzheng wang; Chengbin Li

    doi:10.1101/2020.04.09.20058594 Date: 2020-04-14 Source: medRxiv

    Objectives: Investigate the characteristics and rules of hematology changes in patients with COVID-19 MESHD, and explore the possibility to identify moderate and severe patients using conventional hematology parameters or combined parameters. Methods: The clinical data of 45 moderate and severe type patients with SARS-CoV-2 infections MESHD in Jingzhou Central Hospital from January 23 to February 13, 2020 were collected. The epidemiological indexes, clinical symptoms and laboratory test results of the patients were retrospectively analyzed. Those parameters with significant differences between the two groups were analyzed, and the combination parameters with best diagnostic performance were selected using the LDA method. Results: Of the 45 patients with COVID-19 MESHD (35 moderate and 10 severe cases), 23 were male and 22 female, aged 16-62 years. The most common clinical symptoms were fever MESHD (89%) and dry cough MESHD (60%). As the disease progressed, WBC, Neu# HGNC, NLR, PLR, RDW-CV and RDW-SD parameters in the severe group were significantly higher than that in the moderate group (P<0.05); meanwhile, Lym#, Eos#, HFC%, RBC, HGB and HCT parameters in the severe group were significantly lower than that in the moderate group (P<0.05). For NLR, the AUC, the best cut-off value, the sensitivity and the specificity were 0.890, 13.39, 83.3% and 82.4% respectively, and for PLR , the AUC, the best cut-off, the sensitivity and the specificity were 0.842, 267.03, 83.3% and 74.0% respectively. The combined parameter NLR&RDW-SD had the best diagnostic efficiency (AUC was 0.938) and when the cut-off value was 1.046, the sensitivity and the specificity were 90.0% and 84.7% respectively, followed by the fitting parameter NLR&RDW-CV (AUC = 0.923). When the cut-off value was 0.62, the sensitivity and the specificity for distinguishing severe type from moderate cases of COVID-19 MESHD were 90.0% and 82.4% respectively. Conclusions: The combined parameter NLR&RDW-SD is the best hematology index and can help clinicians to predict the severity of COVID-19 MESHD patients, and it can be used as a useful indicator to help prevent and control the epidemic.

    Eucalyptol (1,8 cineole) from Eucalyptus Essential Oil a Potential Inhibitor of COVID 19 Corona Virus Infection by Molecular Docking Studies

    Authors: Arun Dev Sharma; inderjeet kaur

    id:10.20944/preprints202003.0455.v1 Date: 2020-03-31 Source: Preprints.org

    Background: COVID-19 MESHD, a member of corona virus family is spreading its tentacles across the world due to lack of drugs at present. Associated with its infection are cough, fever MESHD and respiratory problems MESHD causes more than 15% mortality worldwide. It is caused by a positive, single stranded RNA virus from the enveloped coronaviruse family. However, the main viral proteinase ( Mpro PROTEIN/ 3CLpro PROTEIN) has recently been regarded as a suitable target for drug design against SARS infection MESHD due to its vital role in polyproteins processing necessary for coronavirus reproduction.Objectives: The present in silico study was designed to evaluate the effect of Eucalyptol (1,8 cineole), a essential oil component from eucalyptus oil, on Mpro PROTEIN by docking study.Methods: In the present study, molecular docking studies were conducted by using 1-click dock and swiss dock tools. Protein interaction mode was calculated by Protein Interactions Calculator.Results: The calculated parameters such as RMSD, binding energy, and binding site similarity indicated effective binding of eucalyptol to COVID-19 MESHD proteinase. Active site prediction further validated the role of active site residues in ligand binding. PIC results indicated that, Mpro PROTEIN/eucalyptol complexes forms hydrophobic interactions, hydrogen bond interactions and strong ionic interactions.Conclusions: Therefore, eucalyptol may represent potential treatment potential to act as COVID-19 MESHD Mpro PROTEIN inhibitor. However, further research is necessary to investigate their potential medicinal use.

    Anaesthetic managment and clinical outcomes of parturients with COVID-19 MESHD: a multicentre, retrospective, propensity score matched cohort study

    Authors: Yuan Zhang; Rong Chen; Jie Wang; Yuan Gong; Qin Zhou; Hui-hui Cheng; Zhong-yuan Xia; Xiangdong Chen; Qing-tao Meng; Daqing Ma

    doi:10.1101/2020.03.24.20042176 Date: 2020-03-27 Source: medRxiv

    Objective:To analyse the clinical features of COVID-19 MESHD parturients, and to compare anaesthetic regimen and clinical outcomes in parturients with or without COVID-19 MESHD undergoing cesarean delivery.Methods: Data were extracted from the electronic medical record of 3 medical institutions in Hubei Province, China, from June 1, 2019 to March 20, 2020 according to inclusion and exclusion criteria. After propensity score matching with demographics, the clinical and laboratory characteristics of parturients with or without COVID-19 MESHD were analysed. The anaesthetic regimen and clinical outcomes of themselves and their infants were compared in these two groups of parturients. Results: A total of 1,588 patients without SARS-CoV-2 infection MESHD undergoing cesarean delivery were retrospectively included. After achieving a balanced cohort through propensity score matching, 89 patients ( COVID-19 MESHD group), who were diagnosed with COVID-19 MESHD by SARS-CoV-2 nucleic acid test and CT scan matched with 173 patients without COVID-19 MESHD (Control group). The SARS-CoV-2 infected MESHD parturients in the early stages of COVID-19 MESHD outbreak was much more than during the later stage. The main clinical characteristics of parturients with COVID-19 MESHD were fever MESHD (34.8%), cough (33.7%), an increased plasma CRP (52.8%) and a decreased lymphocyte counting (33.7%). A high rate of emergency and a high incidence of anaesthesia-related complications, such as pharyngalgia, multiple puncture, intraoperative hypotension MESHD, nausea MESHD, vomiting MESHD, vertigo MESHD and chills in the COVID-19 MESHD parturients. In addition, the parturients with COVID-19 MESHD had a long duration of operation and hospital stay, and an increased intraoperative oxytocin utilization and postoperative oxygen therapy. The newborns from the SARS-CoV-2 infected MESHD mothers, who received general anaesthesia, had a high risk of Apgar score [≤]8 at 1 and 5 minutes after delivery and a higher rate of neonatal intensive care unit (NICU) admission. Conclusions: Anaesthesia-related complications occur more frequently in the COVID-19 MESHD parturients and their newborns have a high risk of distress.

    Radiographic Findings and other Predictors in Adults with Covid-19 MESHD

    Authors: Kaiyan Li; Dian Chen; Shengchong Chen; Yuchen Feng; Chenli Chang; Zi Wang; Nan Wang; Guohua Zhen

    doi:10.1101/2020.03.23.20041673 Date: 2020-03-27 Source: medRxiv

    As of March 20, 2020, there were 234,073 confirmed cases of coronavirus disease 2019 MESHD ( Covid-19 MESHD) and 9,840 deaths worldwide. Older age and elevated d-dimer are reported risk factors for Covid-19 MESHD. However, whether early radiographic change is a predictor of fatality remains unknown. We retrospectively reviewed records of all laboratory-confirmed patients admitted to a quarantine unit at Tongji Hospital, a large regional hospital in Wuhan, China, between January 31 and March 5, 2020. The Tongji Hospital ethics committee approved this study. A total of 128 patients were admitted. 102 patients were confirmed to have severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection MESHD using RNA detection. As of March 20, 82 confirmed patients were discharged, 15 died, and 5 remained hospitalized. The median age was 57 years (range, 27 - 85), 59 (58%) were male, and 44 (43%) patients had a comorbidity. The most common symptoms were fever MESHD, cough MESHD, and dyspnea MESHD. When compared with survivors, non-survivors were older and more likely to have lymphopenia MESHD, elevated lactate dehydrogenase (LDH), elevated d-dimer, and increased hypersensitive troponin I. In a multivariate regression model that included these predictors, older age and elevated LDH were independent risk factors for fatality. Twenty-one survivors and 11 non-survivors had CT scans within the first week. We used severity score to quantify the extent of lung opacification as described in the Supplementary Appendix. The total severity score and number of involved lung lobes within the first week were significantly greater in non-survivors compared to survivors . Using univariate logistic regression analysis, higher total severity score ([≥]15) (odds ratio 53, 95% CI 3-369; p = 0.003), and more involved lung lobes (5 involved lobes) (9, 2-53; p = 0.016) in CT images within the first week were significantly associated with fatality. Moreover, in this subset of patients with CT data within the first week, higher total severity score was the only independent risk factor in a multivariate analysis incorporated the predictors discussed above (older age, lymphocytopenia MESHD, elevated LDH, elevated d-dimer, and increased troponin I). For survivors with serial CT scans performed over four weeks, total severity score peaked in the second week. This report suggests that the extent of lung lesions MESHD in early CT images is a potential predictor of poor outcome of Covid-19 MESHD. This will help clinicians to identify the patients with poor prognosis at early stage.

    Identification of a super-spreading chain of transmission associated with COVID-19 MESHD

    Authors: Ke Hu; Yang Zhao; Mengmei Wang; Qiqi Zeng; Xiaorui Wang; Ming Wang; Zhishui Zheng; Xiaochen Li; Yunting Zhang; Tao Wang; Shaolin Zeng; Yan Jiang; Dan Liu; Wenzhen Yu; Fang Hu; Hongyu Qin; Jingcan Hao; Jian Yuan; Rui Shang; Meng Jiang; Xi Ding; Binghong Zhang; Bingyin Shi; Chengsheng Zhang

    doi:10.1101/2020.03.19.20026245 Date: 2020-03-23 Source: medRxiv

    BackgroundSuper-spreading events were associated with the outbreaks of SARS and MERS, but their association with the outbreak of COVID-19 MESHD remains unknown. Here, we report a super-spreading transmission chain of SARS-CoV-2 involving an index patient, seven cancer MESHD patients, 40 health care workers and four family members. MethodsWe conducted a retrospective study to identify the index patient and the exposed individuals linked to a chain of transmission associated with COVID-19 MESHD. We collected and analyzed the data on demographic features, exposure history, clinical presentation, laboratory investigation, radiological examination, and disease outcome of these patients. ResultsWe identified the index patient and another presumptive "super-spreader", who initiated and amplified a super-spreading transmission chain associated with COVID-19 MESHD, respectively. There were 31 female and 21 male patients in this cohort, and the median age was 37 years (range: 22-79 years). Each of them had an exposure history with the index patient or his close contacts. Approximately 87% (45/52) of the patients had fever MESHD or other symptoms, 96% (50/52) had abnormal chest CT-scan findings, 86% of the tested patients (39/45) were positive for SARS-CoV-2 in the nasopharyngeal or throat swab specimen, 85% of the tested patients (29/34) were positive for SARS-CoV-2-specific IgM and/or IgG, 15% of the RT-PCR positive patients were tested negative for the specific IgM and/or IgG at the convalescent phase, and 15% of the RT-PCR negative patients were tested positive for the specific IgM and/or IgG. The severe patients experienced a significant decrease in oximetry saturation, lymphocyte, and platelet counts, along with a significant increase in C-reactive protein, D-dimer, and lactate dehydrogenase HGNC. All six fatal cases had comorbidities and five of the seven cancer MESHD patients (71%) died within 2-20 days of the disease onset. ConclusionsThe super-spreading events were associated with the outbreak of COVID-19 MESHD in Wuhan and its impact on disease transmission warrants further investigation. Cancer MESHD patients appeared highly vulnerable to COVID-19 MESHD. The finding that a significant portion of SARS-CoV-2 infected MESHD patients were tested negative for the serum specific IgM and IgG at the convalescent phase should be addressed by additional studies.

    Mortality of COVID-19 MESHD is Associated with Cellular Immune Function Compared to Immune Function in Chinese Han Population

    Authors: Qiang Zeng Sr.; Yong-zhe Li Sr.; Gang Huang Sr.; Wei Wu Sr.; Sheng-yong Dong Sr.; Yang Xu

    doi:10.1101/2020.03.08.20031229 Date: 2020-03-10 Source: medRxiv

    In December 2019, novel coronavirus (SARS-CoV-2) infected pneumonia MESHD occurred in Wuhan, China. The number of cases has increased rapidly but information on the clinical characteristics of SARS-CoV-2 pneumonia MESHD compared to normal controls in Chinese Han population is limited. Our objective is to describe the clinical characteristics of SARS-CoV-2 pneumonia MESHD compared to normal controls in the Chinese Han population. In this case series of 752 patients, the full spectrum of cases is described. Fever MESHD was present in 86-90% of the patients. The second most common symptom was cough (49.1-51.0%), fatigue MESHD (25.2-27.1%), sputum (20.0-23.1%), and headache MESHD (9.8-11.1%). the mortality rate is 4.6% in Wuhan, 1.9% in Beijing, and 0.9% in Shanghai. Our findings showed that the levels of lymphocytes were 0.8(IQR, 0.6-1.1)109/L in Wuhan, 1.0(IQR, 0.7-1.4)109/L in Beijing, and 1.1 (IQR, 0.8-1.5) 109/L in Shanghai before admission to hospitals, respectively, indicating that cellular immune function might relate to the mortality. Based on the reference ranges of normal Chinese Han population and the data of the critically ill patients we have observed, it is recommended that reference ranges of people at high risk of COVID-19 MESHD infection are CD3+ lymphocytes below 900 cells/mm3, CD4 HGNC+ lymphocytes below 500 cells/mm3, and CD8 HGNC+ lymphocytes below 300 cells/mm3.

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MeSH Disease
HGNC Genes
SARS-CoV-2 Proteins


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