Corpus overview


Overview

MeSH Disease

Human Phenotype

Fever (4)

Cough (4)

Dyspnea (4)

Hypertension (3)

Fatigue (3)


Transmission

Seroprevalence
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    Association of age TRANS, sex, comorbidities, and clinical symptoms with the severity and mortality of COVID-19 cases: a meta-analysis with 85 studies and 67299 cases

    Authors: Mohammad Safiqul Islam; Md. Abdul Barek; Md. Abdul Aziz; Tutun Das Aka; Md. Jakaria

    doi:10.1101/2020.05.23.20110965 Date: 2020-05-26 Source: medRxiv

    Background: A new pathogenic disease named COVID-19 became a global threat, first reported in Wuhan, China, in December 2019. The number of affected cases growing exponentially and now, more than 210 countries confirmed the cases TRANS. Objective: This meta-analysis aims to evaluate risk factors, the prevalence SERO of comorbidity, and clinical characteristics in COVID-19 death MESHD patients compared to survival patients that can be used as a reference for further research and clinical decisions. Methods: PubMed, Science Direct, SAGE were searched to collect data about demographic, clinical characteristics, and comorbidities of confirmed COVID-19 patients from January 1, 2020, to May 17, 2020. Meta-analysis was performed with the use of Review Manager 5.3 Results: Eighty-five studies were included in Meta-analysis, including a total number of 67,299 patients with SARS-CoV-2 infection MESHD. Males TRANS are severely affected or died than females TRANS (OR = 2.26, p < 0.00001; OR = 3.59, p < 0.00001) are severely affected, or died by COVID-19 and cases with age TRANS [≥]50 are at higher risk of death MESHD than age TRANS <50 years (OR=334.23). Presence of any comorbidity or comorbidities like hypertension HP hypertension MESHD, cardiovascular disease MESHD, diabetes MESHD, cerebrovascular disease MESHD, respiratory disease MESHD, kidney disease MESHD, liver disease MESHD, malignancy MESHD significantly increased the risk of death compared to survival (OR = 3.46, 3.16, 4.67, 2.45, 5.84, 2.68, 5.62, 2.81,2.16). Among the clinical characteristics such as fever HP fever MESHD, cough HP cough MESHD, myalgia HP myalgia MESHD, diarrhea HP diarrhea MESHD, abdominal pain HP abdominal pain MESHD, dyspnea HP dyspnea MESHD, fatigue HP fatigue MESHD, sputum production, chest tightness HP chest tightness MESHD headache HP and nausea or vomiting HP nausea or vomiting MESHD, only fatigue HP fatigue MESHD (OR = 1.31, 95%) and dyspnea HP dyspnea MESHD increased the death significantly (OR= 1.31, 4.57). The rate of death of COVID-19 cases is 0.03-times lower than the rate of survival (OR = 0.03). Conclusion Our result indicates that male TRANS patients are affected severely or died, the rate of death is more in the age TRANS [≥]50 group, and the rate of death is affected by comorbidities and clinical symptoms.

    Low albumin levels are associated with poorer outcomes in a case series of COVID-19 patients in Spain: a retrospective cohort study

    Authors: Roberto de la Rica; Marcio Borges; Maria Aranda; Alberto del Castillo; Antonia Socias; Antoni Payeras; Gemma Rialp; Lorenzo Socias; Lluis Masmiquel; Marta Gonzalez-Freire

    doi:10.1101/2020.05.07.20094987 Date: 2020-05-11 Source: medRxiv

    OBJECTIVE To describe the clinical characteristics and epidemiological features of severe (non-ICU) and critically patients (ICU) with COVID-19 at triage, prior hospitalization, in one of the main hospitals in The Balearic Islands health care system. DESIGN Retrospective observational study SETTING Son Llatzer University Hospital in Palma de Mallorca MESHD (Spain) PARTICIPANTS Among a cohort of 52 hospitalized patients as of 31 March 2020, 48 with complete demographic information and severe acute respiratory syndrome coronavirus 2 MESHD (SARS-CoV-2) positive test, were analyzed. Data were collected between March 15th, 2020, and March 31th 2020, inclusive of these dates. MAIN OUTCOMES Clinical, vital signs and routine laboratory outcomes at the time of hospitalization, including symptoms reported prior to hospitalization. Demographics and baseline comorbidities were also collected. Mortality was reported at the end of the study. RESULTS 48 patients (27 non-ICU and 21 ICU) resident in Mallorca, Spain (mean age TRANS, 66 years, [range, 33-88 years]; 67% males TRANS) with positive SARS-CoV-2 infection MESHD were analyzed. There were no differences in age TRANS or sex among groups (p >.05). Initial symptoms included fever HP fever MESHD (100%), coughing HP (85%), dyspnea HP dyspnea MESHD (76%), diarrhea HP diarrhea MESHD (42%) and asthenia HP asthenia MESHD (21%). The majority of patients in this case series were hospitalized because of low SpO2 (SpO2 below 90%) and presentation of bilateral pneumonia MESHD pneumonia HP (94%) at triage. ICU patients had a higher prevalence SERO of dyspnea HP dyspnea MESHD compared to non-ICU patients (95% vs 61%, p = .022). Acute respiratory syndrome MESHD ( ARDS MESHD) was presented in 100% of the ICU-patients. All the patients included in the study required oxygen therapy. ICU-patients had lymphopenia HP lymphopenia MESHD as well as hypoalbuminemia HP hypoalbuminemia MESHD. Inflammatory markers such as lactate dehydrogenase (LDH), C-reactive protein (CRP), and procalcitonin were significantly higher in ICU patients compared to non-ICU (p < .001).Lower albumin levels were associated with poor prognosis measured as longer hospital length (r= -0.472, p

    Clinical characteristics of 116 hospitalized patients with COVID-19 in Wuhan, China: a single-centered, retrospective, observational study

    Authors: Shiqiang Xiong; Lin Liu; Feng Lin; Jinhu Shi; Lei Han; Huijian Liu; Lewei He; Qijun Jiang; Zeyang Wang; Wenbo Fu; Zhigang Li; Qing Lu; Zhinan Chen; Shifang Ding

    doi:10.21203/rs.3.rs-26358/v2 Date: 2020-05-01 Source: ResearchSquare

    Background A cluster of acute respiratory illness MESHD, now known as Corona Virus Disease MESHD 2019 (COVID-19) caused by 2019 novel coronavirus (SARS-CoV-2), has become a global pandemic. Aged TRANS population with cardiovascular diseases MESHD are more likely be to infected with SARS-CoV-2 and result in more severe outcomes and elevated case-fatality rate. Meanwhile, cardiovascular diseases MESHD have a high prevalence SERO in the middle- aged TRANS and elderly TRANS population. However, despite of several researches in COVID-19, cardiovascular implications related to it still remains largely unclear. Therefore, a specific analysis in regard to cardiovascular implications of COVID-19 patients is in great need.Methods In this single-centered, retrospective, observational study, 116 patients with laboratory-confirmed COVID-19 were enrolled, who admitted to the General Hospital of Central Theater Command (Wuhan, China) from January 20 to March 8, 2020. The demographic data, underlying comorbidities, clinical symptoms and signs, laboratory findings, chest computed tomography, treatment measures, and outcome data were collected from electronic medical records. Data were compared between non-severe and severe cases. Results Of 116 hospitalized patients with COVID-19, the median age TRANS was 58.5 years (IQR, 47.0-69.0), and 36 (31.0%) were female TRANS. Hypertension HP Hypertension MESHD (45 [38.8%]), diabetes MESHD (19 [16.4%]), and coronary heart disease MESHD (17 [14.7%]) were the most common coexisting conditions. Common symptoms included fever HP fever MESHD [99 (85.3%)], dry cough MESHD cough HP (61 [52.6%]), fatigue HP fatigue MESHD (60 [51.7%]), dyspnea HP dyspnea MESHD (52 [44.8%]), anorexia HP anorexia MESHD (50 [43.1%]), and chest discomfort (50 [43.1%]). Local and/or bilateral patchy shadowing were the typical radiological findings on chest computed tomography. Lymphopenia HP Lymphopenia MESHD (lymphocyte count, 1.0 × 109/L [IQR, 0.7-1.3]) was observed in 66 patients (56.9%), and elevated lactate dehydrogenase (245.5 U/L [IQR, 194.3-319.8]) in 69 patients (59.5%). Hypokalemia HP Hypokalemia MESHD occurred in 24 (20.7%) patients. Compared with non-severe cases, severe cases were older (64.0 years [IQR, 53.0-76.0] vs 56.0 years [IQR, 37.0-64.0]), more likely to have comorbidities (35 [63.6%] vs 24 [39.3%]), and more likely to develop acute cardiac injury MESHD (19 [34.5%] vs 4 [6.6%]), acute heart failure MESHD (18 [32.7%] vs 3 [4.9%]), and ARDS (20 [36.4%] vs 0 [0%]). During hospitalization, the prevalence SERO of new onset hypertension HP hypertension MESHD was significantly higher in severe patients (55.2% vs 19.0%) than in non-severe ones.Conclusions In this single-centered, retrospective, observational study, we found that the infection of SARS-CoV-2 MESHD was more likely to occur in middle and aged TRANS population with cardiovascular comorbidities. Cardiovascular complications MESHD, including new onset hypertension HP hypertension MESHD and heart injury MESHD were common in severe patients with COVID-19. More detailed researches in cardiovascular involvement in COVID-19 are urgently needed to further understand the disease.

    Clinical characteristics of 116 hospitalized patients with COVID-19 in Wuhan, China: a single-centered, retrospective, observational study

    Authors: Shiqiang Xiong; Lin Liu; Feng Lin; Jinhu Shi; Lei Han; Huijian Liu; Lewei He; Qijun Jiang; Zeyang Wang; Wenbo Fu; Zhigang Li; Qing Lu; Zhinan Chen; Shifang Ding

    doi:10.21203/rs.3.rs-26358/v3 Date: 2020-05-01 Source: ResearchSquare

    Background A cluster of acute respiratory illness MESHD, now known as Corona Virus Disease MESHD 2019 (COVID-19) caused by 2019 novel coronavirus (SARS-CoV-2), has become a global pandemic. Aged TRANS population with cardiovascular diseases MESHD are more likely be to infected with SARS-CoV-2 and result in more severe outcomes and elevated case-fatality rate. Meanwhile, cardiovascular diseases MESHD have a high prevalence SERO in the middle- aged TRANS and elderly TRANS population. However, despite of several researches in COVID-19, cardiovascular implications related to it still remains largely unclear. Therefore, a specific analysis in regard to cardiovascular implications of COVID-19 patients is in great need.Methods In this single-centered, retrospective, observational study, 116 patients with laboratory-confirmed COVID-19 were enrolled, who admitted to the General Hospital of Central Theater Command (Wuhan, China) from January 20 to March 8, 2020. The demographic data, underlying comorbidities, clinical symptoms and signs, laboratory findings, chest computed tomography, treatment measures, and outcome data were collected from electronic medical records. Data were compared between non-severe and severe cases.ResultsOf 116 hospitalized patients with COVID-19, the median age TRANS was 58.5 years (IQR, 47.0-69.0), and 36 (31.0%) were female TRANS. Hypertension HP Hypertension MESHD (45 [38.8%]), diabetes MESHD (19 [16.4%]), and coronary heart disease MESHD (17 [14.7%]) were the most common coexisting conditions. Common symptoms included fever HP fever MESHD [99 (85.3%)], dry cough MESHD cough HP (61 [52.6%]), fatigue HP fatigue MESHD (60 [51.7%]), dyspnea HP dyspnea MESHD (52 [44.8%]), anorexia HP anorexia MESHD (50 [43.1%]), and chest discomfort (50 [43.1%]). Local and/or bilateral patchy shadowing were the typical radiological findings on chest computed tomography. Lymphopenia HP Lymphopenia MESHD (lymphocyte count, 1.0 × 109/L [IQR, 0.7-1.3]) was observed in 66 patients (56.9%), and elevated lactate dehydrogenase (245.5 U/L [IQR, 194.3-319.8]) in 69 patients (59.5%). Hypokalemia HP Hypokalemia MESHD occurred in 24 (20.7%) patients. Compared with non-severe cases, severe cases were older (64.0 years [IQR, 53.0-76.0] vs 56.0 years [IQR, 37.0-64.0]), more likely to have comorbidities (35 [63.6%] vs 24 [39.3%]), and more likely to develop acute cardiac injury MESHD (19 [34.5%] vs 4 [6.6%]), acute heart failure MESHD (18 [32.7%] vs 3 [4.9%]), and ARDS (20 [36.4%] vs 0 [0%]). During hospitalization, the prevalence SERO of new onset hypertension HP hypertension MESHD was significantly higher in severe patients (55.2% vs 19.0%) than in non-severe ones.Conclusions In this single-centered, retrospective, observational study, we found that the infection of SARS-CoV-2 MESHD was more likely to occur in middle and aged TRANS population with cardiovascular comorbidities. Cardiovascular complications MESHD, including new onset hypertension HP hypertension MESHD and heart injury MESHD were common in severe patients with COVID-19. More detailed researches in cardiovascular involvement in COVID-19 are urgently needed to further understand the disease.

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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