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MeSH Disease

Human Phenotype

Transmission

Seroprevalence
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    Analysis of the Primary Presenting Symptoms and Hematological Findings of COVID-19 Patients in Bangladesh

    Authors: Abu Taiub Mohammed Mohiuddin Chowdhury; Md Rezaul Karim; H.M. Hamidullah Mehedi; Mohammad Shahbaz; Md Wazed Chowdhury; Guo Dan; Shuixiang He

    id:10.20944/preprints202006.0275.v1 Date: 2020-06-21 Source: Preprints.org

    Objective: SARS-Cov-2 infection MESHD or COVID-19 is a global pandemic. From the time of identification to till, multiple clinical symptoms and parameters have been identified by the researchers of various countries and regions regarding the diagnosis and presentations of COVID-19 disease. In this manuscript, we investigated the primary symptoms and basic hematological presentations of SARS-CoV-2 infection MESHD among the Bangladeshi patients. Methodology: We have collected the disease history of mild to moderate degree of COVID-19 patients; hematological MESHD and biochemical on admission reports of moderate degree COVID-19 patients. All of them were tested positive for SARS-CoV-2 by RT-PCR in different institutes in Bangladesh. Results: According to this study though COVID-19 patients in Bangladesh commonly presented with fever HP fever MESHD, cough HP cough MESHD, fatigue HP fatigue MESHD, shortness of breath MESHD, and sore throat, but symptoms like myalgia HP myalgia MESHD, diarrhea HP diarrhea MESHD, skin rash HP skin rash MESHD, headache HP headache MESHD, Abdominal pain HP Abdominal pain MESHD/cramp, nausea, vomiting HP nausea, vomiting MESHD vomiting MESHD, restlessness HP, and a higher temperature of >1000F have a greater presentation rate and more frequent than other published studies. CRP and Prothrombin time was found to increase in all the patients. Serum SERO ferritin, ESR, SGPT, and D-Dimer were found increased among 53.85%, 80.43, 44%, and 25% patients respectively. 17.39% of the patients had leukocytosis HP leukocytosis MESHD and neutrophilia HP. 28.26% of patients presented with lymphocytopenia MESHD. 62.52% of patients had mild erythrocytopenia. Conclusion: Despite some similarities, our study has evaluated a different expression in presenting symptoms in the case of COVID-19 patients in Bangladesh. CRP, Prothrombin time, serum SERO ferritin, ESR, SGPT, D-Dimer, erythrocytopenia, and lymphocytopenia MESHD can be initial diagnostic hematological findings and assessment for prognosis COVID-19 disease. Also, gender TRANS variations have a different scenario of clinical and laboratory appearance in this region.

    Analysis on clinical features of death MESHD patients with COVID-19: a retrospective, single-center study from Wuhan, China

    Authors: Ke Yao; Yin Zhao; Xiangtian Xiao; Gunyun Wu; Ruxin Xie; Yali Wang; Jun Hu; Hexie Cai; Rong Liu

    doi:10.21203/rs.3.rs-21065/v1 Date: 2020-04-03 Source: ResearchSquare

    Background An ongoing global pandemic of pneumonia HP pneumonia MESHD caused by severe acute respiratory syndrome coronavirus 2 MESHD (SARS-CoV-2) has caused thousands of deaths MESHD in China since December, 2019. We aimed to describe the clinical course of patients died of SARS-CoV-2 infection MESHD.Methods In this retrospective study, we reviewed 194 patients with SARS-CoV-2 infection MESHD, who died consecutively between Feb 3 to 24, 2020 in Tongji Hospital (Wuhan, China). Basic demographic and clinical information, laboratory findings, complications and treatments were extracted from electronic medical records of Hospital Information System. Unpaired t test was employed to evaluate the statistical differences of the serum SERO level of high-sensitive cardiac troponin I (hs-cTnI) among different age TRANS or sex groups. The relationship between hs-cTnI and inflammatory cytokines were estimated using Spearman correlation analysis.Results The death MESHD patients aged TRANS 69.62 ± 10.98, in which 68.6% were male TRANS. 74.7% patients had underlying chronic illnesses. The most common symptoms were fever HP fever MESHD (83%), cough HP (69.3%), and dyspnea HP dyspnea MESHD (65.6%). Decreased lymphocyte count (91.4%), elevated level of hs-cTnI (82.9%) and inflammatory parameters in serum SERO were commonly seen. The hs-cTnI level was significantly higher in the group aged TRANS 60–79 and male TRANS patients. A week positive correlation was observed between hs-cTnI values and D-dimer values (r = 0.343, p༜0.05). Acute respiratory distress HP respiratory distress MESHD syndrome was the main complication. Assisted respiration, antimicrobial drugs, glucocorticoids and immune globulin were the major treatments.Conclusion Most non-survivors with SARS-CoV-2 infection MESHD were old with chronic illnesses, complicated by multiple organ dysfunction. Prevention is better than cure in high-risk population.

    Clinical features and outcomes of 221 patients with COVID-19 in Wuhan, China

    Authors: Guqin Zhang; Chang Hu; Linjie Luo; Fang Fang; Yongfeng Chen; Jianguo Li; Zhiyong Peng; Huaqin Pan

    doi:10.1101/2020.03.02.20030452 Date: 2020-03-06 Source: medRxiv

    Rationale: In late December 2019, an outbreak of acute respiratory illness MESHD, now officially named as COVID-19, or coronavirus disease MESHD 2019, emerged in Wuhan, China, now spreading across the whole country and world. More data were needed to understand the clinical characteristics of the disease. Objectives: To study the epidemiology, clinical features and outcomes of patients with COVID-19. Methods: we performed a single center, retrospective case series study in 221 patients with laboratory confirmed SARS-CoV-2 pneumonia MESHD pneumonia HP at a university hospital. Measurements and Main Results: The median age TRANS was 55.0 years and 48.9% were male TRANS and only 8 (3.6%) patients had a history of exposure to the Huanan Seafood Market. Compared to the non-severe pneumonia HP pneumonia MESHD patients, the median age TRANS of the severe patients was significantly older, and they were more likely to have chronic comorbidities. Most common symptoms in severe patients were high fever HP, anorexia HP anorexia MESHD and dyspnea HP dyspnea MESHD. On admission, 33.0% patients showed leukopenia HP leukopenia MESHD and 73.8% showed lymphopenia HP lymphopenia MESHD. In addition, the severe patients suffered a higher rate of co-infections MESHD with bacteria or fungus MESHD and they were more likely to developing complications. As of February 15, 2020, 19.0% patients had been discharged and 5.4% patients died. 80% of severe cases received ICU care, and 52.3% of them transferred to the general wards due to relieved symptoms, and the mortality rate of severe patients in ICU was 20.5%. Conclusions: The COVID-19 epidemic spreads rapidly by human-to-human transmission TRANS. Patients with elder age TRANS, chronic comorbidities, blood SERO leukocyte/lymphocyte count, procalcitonin level, co-infection MESHD infection and severe HP complications might increase the risk of poor clinical outcomes. Keywords: coronavirus disease MESHD 2019; clinical features; outcomes; severe patients

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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