Corpus overview


MeSH Disease

Human Phenotype

Fever (11)

Cough (7)

Pneumonia (5)

Dyspnea (5)

Fatigue (3)


    displaying 1 - 10 records in total 11
    records per page

    Study on the COVID-19 infection MESHD status, prevention and control strategies among entry people in Shenzhen

    Authors: Jing-Zhong Wang; Xuan Zou; Zi-Qian Xu; Hai-Rui Wang; Bi-Xin Wang; Jian-Fan He

    doi:10.21203/ Date: 2020-08-03 Source: ResearchSquare

    Background The COVID-19 confirmed cases TRANS overseas continue to rise for months, while people overseas prefer to return at present. It is risky to have a large number of infected imported cases which may cause COVID-19 spread to China and even lead to outbreak again. In order to prevent imported infection MESHD, Shenzhen implemented the losed-loop management strategy by taking nucleic acid testing (NAT) for severe acute respiratory syndromes MESHD coronavirus 2 (SARS-CoV-2) and medical observation for 14 days among individuals who have epidemic history (Hong Kong, Macao, Taiwan province and other countries) within 14 days. Our study described the status of COVID-19 infection MESHD among entry people in Shenzhen, and also evaluated the effect of closed-loop management strategy.Methods A total of 86,844 people overseas entered Shenzhen from January 1 to April 18, 2020, and there were 39 imported cases. We made a descriptive study by analyzing the entry time, reported time, local confirmed cases TRANS in origin countries, and the number of entry people from abroad. The NAT were completed in Shenzhen center for disease MESHD control and prevention (CDC), ten district-level CDCs, as well as fever MESHD fever HP clinics.Results The infection MESHD rate of entry people was 4.49‰ (95% CI: 3.26‰ − 6.05‰). Most of the entry people or imported cases have Chinese nationality. The number of entry people and imported cases in Nanshan and Futian districts were larger than others. 15.73% of the entry people came from the US, and 12.67% came from the UK. 14 imported cases (35.9%) came from the UK, 9 (23.08%) came from the US. The imported risks from the US and UK in Shenzhen were higher than other countries or regions. According to the 14-days’ incubation period TRANS and the number of entry people, individuals from the US since Mar 9 were the high-risk population. Accordingly, entry people from the UK since Mar 13 were the high-risk population. It is important to evaluate the imported risk by analyzing local confirmed cases TRANS status in origin countries or regions and the number of entry people from these countries or regions to Shenzhen. The distribution of entry time and report time for imported cases in Shenzhen were similar. So it is important to prevent and control COVID-19 imported infection MESHD by taking NAT and medical observation at port.Conclusions It is effective to implement closed-loop management strategy for individuals who have epidemic history (Hong Kong, Macao, Taiwan province and other countries) within 14 days. In order to control COVID-19 outbreak, we need the collaboration and cooperation at the global, national, and subnational levels to prevent, detect, and respond effectively.

    Predictive model of COVID-19 incidence and socioeconomic description of municipalities in Brazil

    Authors: Isadora C Carneiro; Eloiza D Ferreira; Janaína C da Silva; Guilherme Soares; Daisy M Strottmann; Guilherme F Silveira

    doi:10.1101/2020.06.28.20141952 Date: 2020-06-29 Source: medRxiv

    Coronaviruses are enveloped viruses that can cause respiratory, gastrointestinal, hepatic, and neurological diseases MESHD. In December 2019, a new highly contagious coronavirus termed severe acute respiratory syndrome MESHD coronavirus 2 (SARS-CoV-2) emerged in China. SARS-CoV-2 causes a potentially lethal human respiratory infection MESHD, COVID-19, that is associated with fever MESHD fever HP and cough MESHD cough HP and can progress to pneumonia MESHD pneumonia HP and dyspnea MESHD dyspnea HP in severe cases. Since the virus emerged, it has spread rapidly, reaching all continents around the world. A previous study has shown that, despite being the best alternative in the current pandemic context, social distancing measures alone may not be sufficient to prevent COVID-19 spread, and the overall impact of the virus is of great concern. The present study aims to describe the demographic and socioeconomic characteristics of 672 cities with cases of COVID-19, as well as to determine a predictive model for the number of cases. We analyzed data from cities with at least 1 reported case of COVID-19 until June 26, 2020. It was observed that cities with confirmed cases TRANS of the disease MESHD are present in all Brazilian states, affecting 36.5% of the municipalities in Rio de Janeiro State. The inhabitants in cities with reported cases of COVID-19 represent more than 73.1% of the Brazilian population. Stratifying the age groups TRANS of the inhabitants and accounting for the percentage of women and men does not affect COVID-19 incidence ( confirmed cases TRANS/100,000 inhabitants). The demographic density, the MHDI and the per capita income of the municipalities with cases of COVID-19 do not affect disease MESHD incidence. In addition, if conditions are maintained, our model predicts 2,358,703 (2,172,930 to 2,544,477) cumulative cases on July 25, 2020.

    CT features of pneumonia MESHD pneumonia HP during COVID-19 pandemic warrant caution: An illustrative case report of cholangiocarcinoma MESHD cholangiocarcinoma HP with Pneumocystis jiroveci pneumonia MESHD pneumonia HP

    Authors: Fang Liu; Wen Li

    doi:10.21203/ Date: 2020-06-02 Source: ResearchSquare

    Background: An outbreak of severe acute respiratory syndrome MESHD due to coronavirus 2 (SARS-CoV-2) infection MESHD (COVID-19) that began at Wuhan, China in December 2019, spreading rapidly across China and many other countries. Considering the high false-negative rate of RT-PCR assay during initial COVID-19 pandemic in China, chest computed tomography (CT) was advocated as a means of corroborating clinically suspected infections MESHD.Case presentation: A 51-year-old man with clinical diagnosis of hepatic portal cholangiocarcinoma MESHD cholangiocarcinoma HP and Behcet's disease MESHD developed clinical manifestations suggestive of COVID-19 during the pandemic in China. The chest CT showed rapid progression to diffuse ground-glass opacities (GCOs) in both lungs, as in severe cases of confirmed TRANS COVID-19. He was finally diagnosed with Pneumocystis jiroveci pneumonia MESHD pneumonia HP (PJP) according to the medical history, and Caspofungin plus TMP/SMX elicited a rapid response as normalizing both temperature and leukocyte count initially. Unfortunately, dyspnea MESHD dyspnea HP was aggravated with resumed fever MESHD fever HP later, and non-invasive ventilation was no longer tenable. The patient himself (with support of his family) declined mechanical ventilatory assistance, succumbing to pneumonia MESHD pneumonia HP and respiratory failure HP finally.Conclusions: CT diagnosis of COVID-19 during the current pandemic should warrant caution.

    Screening and Analysis of COVID-19 cases in non-epidemic areas: A Retrospective Study

    Authors: Yan Zhu; Yan Guo; Juan Ma; Mao-shi Li; Jia-fei Chen; Ming Liu; Ze-hui Yan; Guo-hong Deng; Qing Mao; Hui-min Liu

    doi:10.21203/ Date: 2020-06-01 Source: ResearchSquare

    Objective: To compare the epidemiological and clinical characteristics of confirmed and suspected corona virus disease MESHD 2019 (COVID-19) cases via the process of “triage-screening-isolation-transfer” in the hospitals of non-epidemic areas.Methods: The general data, epidemiological history, clinical symptoms, laboratory examination, and chest computed tomography (CT) imaging characteristics of 38 patients with suspected COVID-19, admitted between January 21 and March 5, 2020, were analyzed.Results: According to the results of the novel severe acute respiratory syndrome MESHD coronavirus (SARS-CoV-2) ribonucleic acid (RNA) testing, the patients were divided into study group (RNA positive) and control group (RNA negative). Ultimately, 8 cases were RNA-positive and diagnosed as CDVID-19, and 30 cases were negative. Approximately half of the patients in the study group returned to Chongqing from Wuhan; this number was significantly larger than that of the control group (P<0.05). The number of subjects in close contact TRANS with the confirmed cases TRANS with SARS-CoV-2 RNA-positive and the incidence of aggregation was significantly larger in the study group than in the control group (both P<0.05). The clinical symptom of the study group was mainly low fever MESHD fever HP (with or without cough MESHD cough HP). The patients with decreased white blood SERO cells (WBC) in the study group were significantly more than those in the control group (P<0.05). Both group had reduced lymphocytes (Lym) but the number of patients with increased C-reactive protein (CRP) in the study group was significantly more than that in the control group (P<0.05). There were different degrees of chest CT abnormalities in both study and control group (P > 0.05). Conclusion: The epidemiological investigations in screening for infectious diseases MESHD is crucial. The risk of infection TRANS risk of infection TRANS infection MESHD was high from the primary epidemic area and/or in close contact TRANS with the confirmed case TRANS. The most common form of clustering occurrence was family aggregation. CDVID-19 was mainly characterized by fever MESHD fever HP and respiratory symptoms, although asymptomatic infection MESHD asymptomatic TRANS may also occur. Decreased WBC, decreased Lym, and increased CRP are common characteristics but can also be combined with other respiratory tract virus infections MESHD. COVID 19 screening by chest CT alone had certain limitations in non- epidemic areas.

    Anosmia HP, a Hidden Sign for COVID-19? A Case Report and Literature Review

    Authors: Karen Christelle; Maryam Mohd Zulkifli; Nani Draman

    doi:10.21203/ Date: 2020-05-04 Source: ResearchSquare

    Background The coronavirus disease MESHD 2019 (COVID-19) is an ongoing viral pandemic that is actively affecting 210 countries worldwide, with a total of more than 1.5 million cases and 106 000 deaths MESHD. Symptoms associated with COVID-19 are mainly fever MESHD fever HP, cough MESHD cough HP, dyspnea MESHD dyspnea HP and sore throat. The current indication for COVID-19 testing includes presence of these symptoms with a positive history of travel TRANS to affected countries or contact with COVID-19 patients. Anosmia HP has been recently reported anecdotally over the past weeks as an emerging symptom of the COVID-19 but has yet to gain recognition as a symptom for COVID-19 by the World Health Organization (WHO) and Centre for Disease MESHD Control and Prevention (CDC). This case report highlights a case of isolated sudden onset of anosmia HP as a presenting symptom of COVID-19 and relevant literature review supporting the incidence of anosmia HP in COVID-19. This is a first case report of anosmia HP in COVID-19 occurring in pregnancy.Case Presentation A 30-year-old pregnant lady at 11 weeks of gestation presented with sudden onset of anosmia HP for one day with no other accompanying symptoms. She had just recovered from a mild cold a day prior to the development of anosmia HP. She had a history of travel TRANS by land to Singapore 14 days prior to onset of anosmia HP. There was no known close contact TRANS with a COVID-19 patient or attended any mass gatherings prior to development of her symptom. She underwent nasopharyngeal and oropharyngeal swab sampling which was then tested using reverse transcription polymerase chain reaction (RT-PCR) method and confirmed infection TRANS infection MESHD infection with severe HP with severe acute respiratory syndrome MESHD coronavirus 2 (SARS-CoV-2).Conclusion Clinicians should be aware regarding anosmia HP as a presenting symptom of COVID-19 especially in the presence of risk factors such as travel TRANS to affected countries and having close contact TRANS with COVID-19 positive patients. If testing is not done, these patients should be advised for home quarantine to reduce the risk of transmission TRANS. Healthcare workers must always adhere to infection MESHD control and prevention protocol as well as personal protective equipment. 

    Early epidemiological and clinical manifestations of COVID-19 in Japan

    Authors: Muhammad Qasim; Muhammad Yasir; Waqas Ahmad; Minami Yoshida; Muhammad Azhar; Mohammad Azam Ali; Chris Wang; Maree Gould

    doi:10.1101/2020.04.17.20070276 Date: 2020-04-24 Source: medRxiv

    Background: Severe acute respiratory syndrome MESHD coronaviruses -2 (SARS-COV2) named as COVID-19 had spread worldwide and leading to 1,210,956 confirmed cases TRANS and 67,594 deaths MESHD Methods: A data of 1192 confirmed cases TRANS and 43 deaths MESHD due to COVID-19 in Japan collected from the Ministry of Health, Labour and Welfare of Japan and analysed for different epidemiological parameters and their clinical manifestations. We used Clauset-Newman-Moore (CNM) clustering algorithm to develop web-network of confirmed cases TRANS to identified clusters of community transmission TRANS. Results: Out of 1192 confirmed cases TRANS, 90.60% were symptomatic and 9.39% were asymptomatic TRANS. The prevalence SERO of COVID19 in males TRANS was 56.29% and 43.20 % in females TRANS. The mean interval (SD) from symptom onset TRANS to diagnosis was 6-22.6 days while mean interval (SD) from contact to onset of symptoms TRANS was 5-19.5 days. People of age TRANS range 40-79 were more infected and deaths MESHD median age TRANS was 80. The main symptoms were fever MESHD fever HP, dry cough MESHD cough HP, fatigue MESHD fatigue HP and pneumonia MESHD pneumonia HP. The main infected cities were Tokyo (195/1192, 16.35%), Hokkaido (160/1192 13.42%), Aichi (150/1192, 12.58%) and Osaka (145/1192, 12.16%). Only 2.34% cases had travel TRANS history from Wuhan China and Osaka music concert was identify as main cluster for community transmission TRANS. While 556 (46.64%) cases were clinically diagnosed and 557 (46.72%) were confirmed by using RT-PCR. Conclusions: Other than, declare emergency MESHD Japan need to change their approach of diagnosing COVID-19, as asymptomatic TRANS cases prevalence SERO is high and maybe it is reason for current sudden increase of cases. Screening centre should be establish away from hospitals, which are treating positive cases.

    Pregnancy during the evolving pandemic Coronavirus Disease MESHD 2019 (COVID-19): A rapid scoping review of evidence in the published literature

    Authors: Md Zabir Hasan; Gulam Muhammed Al Kibria; Tasmeer Alam

    doi:10.21203/ Date: 2020-04-16 Source: ResearchSquare

    BackgroundWith more than 1 million confirmed cases TRANS of coronavirus disease MESHD 2019 (COVID-19) worldwide and more than 50,000 deaths MESHD, the pandemic of Severe Acute Respiratory Syndrome MESHD CoV (SARS-CoV-2) is rapidly evolving. SARS-CoV-2 can also pose a higher risk to pregnant women, due to their immunosuppression during pregnancy. This study investigates the emerging and most UpToDate published scientific literature on the clinical feature and management recommendations for pregnant women with COVID-19.MethodA wide range of published scientific literature was systematically searched from PubMed, Embase, Scopus, Web of Science, and “Global research on coronavirus disease MESHD (COVID-19)” managed by the World Health Organization, published between 1 January 2019 to 27 March 2020. No limitations were used for geographical location, and articles published in English were included in the review. Results for the eligible studies were charted, analyzed, and presented in a narrative format. ResultOur study identified 52 unique articles, and 29 of those articles were included in this review after fulltext screening. Participants were mostly in their third trimester and presented with fever MESHD fever HP, dry cough MESHD cough HP, myalgia MESHD myalgia HP, shortness, and difficulty in breathing. Ground-glass opacity in the computerized tomography scan of the chest was the cardinal feature of COVID-19 pneumonia MESHD pneumonia HP. Except for two participants, severe pneumonia MESHD pneumonia HP did not occur among pregnant women. Pregnant women with COVID-19 were treated with a wide range of antiviral drugs. Higher episodes of preterm birth and cesarean delivery were observed; however, it cannot be explicitly attributed to the SARS-CoV-2. There is no published evidence on the vertical transmission TRANS of SARS-CoV-2. Pregnancy with COVID-19 infection MESHD must be managed by a collaborative team of healthcare professionals during antenatal, delivery, or postnatal stage. Detailed contact tracing TRANS, investigating travel TRANS history, radiological assessment, and laboratory tests with regular fetal health monitoring must be done. ConclusionThe emerging evidence of higher perinatal complications puts pregnant women in a further vulnerable condition. Cautiousness is imperative during the clinical management of pregnant women with COVID-19, as there is no approved treatment regime available at this moment. More research is necessary to fill the gaps in the knowledge of the clinical spectrum of COVID-19 among pregnant women.

    Recurrent recurrence MESHD of positive SARS-CoV-2 RNA in a COVID-19 patient

    Authors: Shugang Cao; Aimei Wu; Jiaxia Li; Yuancheng Li; Mingwu Xia; Juncang Wu

    doi:10.21203/ Date: 2020-04-15 Source: ResearchSquare

    Background: Coronavirus disease MESHD 2019 (COVID-19) is a highly infectious disease MESHD. A small proportion of discharged patients may become positive again for severe acute respiratory syndrome MESHD coronavirus 2 (SARS-CoV-2) RNA, even if they meet the discharge criteria. Herein, we report a rare COVID-19 patient with recurrent recurrence MESHD of positive SARS-CoV-2 RNA.Case presentation: A 68-year-old man was admitted due to fever MESHD fever HP, muscle pain MESHD pain HP, and fatigue MESHD fatigue HP. He was initially diagnosed with COVID-19 according to two consecutive positive results for SARS-CoV-2 RNA plus clinical symptoms and chest CT findings, and was discharged from hospital when meeting the discharge criteria, including two consecutive negative results. He was tested positive for SARS-CoV-2 RNA twice during the quarantine and was hospitalized again. He was asymptomatic TRANS then, but IgG and IgM were both positive. He was discharged in the context of four consecutive negative test results for SARS-CoV-2 RNA after antiviral treatment. However, he was tested positive once again on the 3rd and 4th day after the second discharge, although still asymptomatic TRANS. IgG and IgM were still positive. After antiviral treatment, the results of SARS-CoV-2 RNA were negative in three consecutive retests, and he was finally discharged and quarantined for further surveillance. Conclusion: This case suggests that a small proportion of convalescent patients may become positive again for SARS-CoV-2 RNA and be a virus carrier TRANS.

    Radiographic Findings and other Predictors in Adults TRANS with Covid-19

    Authors: Kaiyan Li; Dian Chen; Shengchong Chen; Yuchen Feng; Chenli Chang; Zi Wang; Nan Wang; Guohua Zhen

    doi:10.1101/2020.03.23.20041673 Date: 2020-03-27 Source: medRxiv

    As of March 20, 2020, there were 234,073 confirmed cases TRANS of coronavirus disease MESHD 2019 (Covid-19) and 9,840 deaths MESHD worldwide. Older age TRANS and elevated d-dimer are reported risk factors for Covid-19. However, whether early radiographic change is a predictor of fatality remains unknown. We retrospectively reviewed records of all laboratory-confirmed patients admitted to a quarantine unit at Tongji Hospital, a large regional hospital in Wuhan, China, between January 31 and March 5, 2020. The Tongji Hospital ethics committee approved this study. A total of 128 patients were admitted. 102 patients were confirmed to have severe acute respiratory syndrome MESHD coronavirus 2 (SARS-CoV-2) infection MESHD using RNA detection. As of March 20, 82 confirmed patients were discharged, 15 died, and 5 remained hospitalized. The median age TRANS was 57 years (range, 27 - 85), 59 (58%) were male TRANS, and 44 (43%) patients had a comorbidity. The most common symptoms were fever MESHD fever HP, cough MESHD cough HP, and dyspnea MESHD dyspnea HP. When compared with survivors, non-survivors were older and more likely to have lymphopenia MESHD lymphopenia HP, elevated lactate dehydrogenase (LDH), elevated d-dimer, and increased hypersensitive troponin I. In a multivariate regression model that included these predictors, older age TRANS and elevated LDH were independent risk factors for fatality. Twenty-one survivors and 11 non-survivors had CT scans within the first week. We used severity score to quantify the extent of lung opacification as described in the Supplementary Appendix. The total severity score and number of involved lung lobes within the first week were significantly greater in non-survivors compared to survivors . Using univariate logistic regression analysis, higher total severity score ([≥]15) (odds ratio 53, 95% CI 3-369; p = 0.003), and more involved lung lobes (5 involved lobes) (9, 2-53; p = 0.016) in CT images within the first week were significantly associated with fatality. Moreover, in this subset of patients with CT data within the first week, higher total severity score was the only independent risk factor in a multivariate analysis incorporated the predictors discussed above (older age TRANS, lymphocytopenia, elevated LDH, elevated d-dimer, and increased troponin I). For survivors with serial CT scans performed over four weeks, total severity score peaked in the second week. This report suggests that the extent of lung lesions in early CT images is a potential predictor of poor outcome of Covid-19. This will help clinicians to identify the patients with poor prognosis at early stage.

    Screening and managing of suspected or confirmed novel coronavirus (COVID-19) patients: experiences from a tertiary hospital outside Hubei province

    Authors: Hong Pu; Yujun Xu; Gordon S. Doig; Yan Zhou

    doi:10.1101/2020.03.20.20038679 Date: 2020-03-23 Source: medRxiv

    Objectives: To report our experiences screening and managing patients with suspected or confirmed novel coronavirus (COVID-19) disease MESHD using a hospital-specific protocol. Design: Longitudinal cohort study. Setting: A 1,200 bed tertiary care teaching hospital in Chengdu, Sichuan, China. Participants: 802 adults TRANS presenting to hospital with concerns of having COVID-19, 1,246 inpatients and 2,531 hospital visitors. Interventions: Screening and management of patients using a hospital-specific protocol, which included fever MESHD fever HP triage, monitoring visitors and patients, emergency MESHD response, personnel training for healthcare team members, health education for patients and family, medical materials management, disinfection and wastes disposal protocols. Results: Between 23 January and 28 February 2020, 73 people were identified as having fever MESHD fever HP plus respiratory signs with/without a history of exposure and were tested for the severe acute respiratory syndrome MESHD coronavirus 2 (SARS-CoV-2) by our hospital lab using RT PCR. Forty-five of these 73 people were subsequently excluded based on one negative RT PCR result plus positive results to quick screening tests for flu or other respiratory viruses. The remaining 28 people received a second RT PCR test 24 h later. Three people were confirmed positive for COVID-19 based on two consecutive positive RT PCR tests whilst 25 people were excluded based on two consecutive negative tests. The three COVID-19 confirmed cases TRANS received non-critical care. There were no new infections MESHD of medical staff or new infections MESHD of other hospital inpatients. Conclusions: All three cases were detected as a result of vigilant monitoring of hospital visitors. Whilst screening out-patients presenting to a fever MESHD fever HP clinic remains important, monitoring visitors must not be overlooked.

The ZB MED preprint Viewer preVIEW includes all COVID-19 related preprints from medRxiv and bioRxiv, from ChemRxiv, from ResearchSquare, from arXiv and from and is updated on a daily basis (7am CET/CEST).



MeSH Disease
Human Phenotype

Export subcorpus as Endnote

This service is developed in the project nfdi4health task force covid-19 which is a part of nfdi4health.

nfdi4health is one of the funded consortia of the National Research Data Infrastructure programme of the DFG.