Corpus overview


Overview

MeSH Disease

Human Phenotype

Fever (20)

Cough (16)

Dyspnea (7)

Pneumonia (6)

Fatigue (5)


Transmission

Seroprevalence
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    COVID-19 Infection Manifesting as a Severe Gastroparesis HP Flare: A Case Report

    Authors: Jun Song, MD; Rajiv Bhuta, MD; Kamal Baig, MD; Henry P. Parkman, MD; Zubair Malik, MD

    doi:10.21203/rs.3.rs-28584/v1 Date: 2020-05-11 Source: ResearchSquare

    Background: Coronavirus Disease MESHD 2019 (COVID-19) is a disease caused by infection with Severe HP infection with Severe MESHD Severe Acute Respiratory Syndrome Coronavirus 2 MESHD (SARS-CoV-2), which commonly presents with symptoms including fever HP fever MESHD, cough HP cough MESHD, and dyspnea HP dyspnea MESHD. More recently, however, some patients have tested positive for COVID-19 after developing gastrointestinal ( GI MESHD) symptoms either solely or in conjunction with respiratory symptoms. This may be due to SARS-CoV-2 infection MESHD of the GI MESHD tract. In patients with chronic GI illnesses MESHD, COVID-19 may initially present as a flare of their underlying GI MESHD conditions as viruses have historically been implicated in exacerbations of GI disorders MESHD, including gastroparesis HP gastroparesis MESHD. Case presentation: We report a case of a 37 year-old female TRANS with a history of diabetic gastroparesis MESHD gastroparesis HP who presented to the Emergency Department (ED) in a gastroparesis HP gastroparesis MESHD flare. Her symptoms in the ED failed to improve with fluids and anti-emetic medications. After developing a fever HP fever MESHD, she was tested and found to be positive for COVID-19.Conclusion: To our knowledge, at the present time, this is the first report of a patient with COVID-19 presenting with signs and symptoms of a gastroparesis HP gastroparesis MESHD flare. This case illustrates that patients with underlying GI disorders MESHD, such as gastroparesis HP gastroparesis MESHD, may have SARS-CoV-2 infections MESHD that present as an exacerbation of their underlying disorder. Initial presentation of these patients manifesting as a flare of their chronic GI disease MESHD, more severe than usual, should prompt an index of suspicion for COVID-19.

    Low albumin levels are associated with poorer outcomes in a case series of COVID-19 patients in Spain: a retrospective cohort study

    Authors: Roberto de la Rica; Marcio Borges; Maria Aranda; Alberto del Castillo; Antonia Socias; Antoni Payeras; Gemma Rialp; Lorenzo Socias; Lluis Masmiquel; Marta Gonzalez-Freire

    doi:10.1101/2020.05.07.20094987 Date: 2020-05-11 Source: medRxiv

    OBJECTIVE To describe the clinical characteristics and epidemiological features of severe (non-ICU) and critically patients (ICU) with COVID-19 at triage, prior hospitalization, in one of the main hospitals in The Balearic Islands health care system. DESIGN Retrospective observational study SETTING Son Llatzer University Hospital in Palma de Mallorca MESHD (Spain) PARTICIPANTS Among a cohort of 52 hospitalized patients as of 31 March 2020, 48 with complete demographic information and severe acute respiratory syndrome coronavirus 2 MESHD (SARS-CoV-2) positive test, were analyzed. Data were collected between March 15th, 2020, and March 31th 2020, inclusive of these dates. MAIN OUTCOMES Clinical, vital signs and routine laboratory outcomes at the time of hospitalization, including symptoms reported prior to hospitalization. Demographics and baseline comorbidities were also collected. Mortality was reported at the end of the study. RESULTS 48 patients (27 non-ICU and 21 ICU) resident in Mallorca, Spain (mean age TRANS, 66 years, [range, 33-88 years]; 67% males TRANS) with positive SARS-CoV-2 infection MESHD were analyzed. There were no differences in age TRANS or sex among groups (p >.05). Initial symptoms included fever HP fever MESHD (100%), coughing HP (85%), dyspnea HP dyspnea MESHD (76%), diarrhea HP diarrhea MESHD (42%) and asthenia HP asthenia MESHD (21%). The majority of patients in this case series were hospitalized because of low SpO2 (SpO2 below 90%) and presentation of bilateral pneumonia MESHD pneumonia HP (94%) at triage. ICU patients had a higher prevalence SERO of dyspnea HP dyspnea MESHD compared to non-ICU patients (95% vs 61%, p = .022). Acute respiratory syndrome MESHD ( ARDS MESHD) was presented in 100% of the ICU-patients. All the patients included in the study required oxygen therapy. ICU-patients had lymphopenia HP lymphopenia MESHD as well as hypoalbuminemia HP hypoalbuminemia MESHD. Inflammatory markers such as lactate dehydrogenase (LDH), C-reactive protein (CRP), and procalcitonin were significantly higher in ICU patients compared to non-ICU (p < .001).Lower albumin levels were associated with poor prognosis measured as longer hospital length (r= -0.472, p

    Clinical characteristics of 116 hospitalized patients with COVID-19 in Wuhan, China: a single-centered, retrospective, observational study

    Authors: Shiqiang Xiong; Lin Liu; Feng Lin; Jinhu Shi; Lei Han; Huijian Liu; Lewei He; Qijun Jiang; Zeyang Wang; Wenbo Fu; Zhigang Li; Qing Lu; Zhinan Chen; Shifang Ding

    doi:10.21203/rs.3.rs-26358/v2 Date: 2020-05-01 Source: ResearchSquare

    Background A cluster of acute respiratory illness MESHD, now known as Corona Virus Disease MESHD 2019 (COVID-19) caused by 2019 novel coronavirus (SARS-CoV-2), has become a global pandemic. Aged TRANS population with cardiovascular diseases MESHD are more likely be to infected with SARS-CoV-2 and result in more severe outcomes and elevated case-fatality rate. Meanwhile, cardiovascular diseases MESHD have a high prevalence SERO in the middle- aged TRANS and elderly TRANS population. However, despite of several researches in COVID-19, cardiovascular implications related to it still remains largely unclear. Therefore, a specific analysis in regard to cardiovascular implications of COVID-19 patients is in great need.Methods In this single-centered, retrospective, observational study, 116 patients with laboratory-confirmed COVID-19 were enrolled, who admitted to the General Hospital of Central Theater Command (Wuhan, China) from January 20 to March 8, 2020. The demographic data, underlying comorbidities, clinical symptoms and signs, laboratory findings, chest computed tomography, treatment measures, and outcome data were collected from electronic medical records. Data were compared between non-severe and severe cases. Results Of 116 hospitalized patients with COVID-19, the median age TRANS was 58.5 years (IQR, 47.0-69.0), and 36 (31.0%) were female TRANS. Hypertension HP Hypertension MESHD (45 [38.8%]), diabetes MESHD (19 [16.4%]), and coronary heart disease MESHD (17 [14.7%]) were the most common coexisting conditions. Common symptoms included fever HP fever MESHD [99 (85.3%)], dry cough MESHD cough HP (61 [52.6%]), fatigue HP fatigue MESHD (60 [51.7%]), dyspnea HP dyspnea MESHD (52 [44.8%]), anorexia HP anorexia MESHD (50 [43.1%]), and chest discomfort (50 [43.1%]). Local and/or bilateral patchy shadowing were the typical radiological findings on chest computed tomography. Lymphopenia HP Lymphopenia MESHD (lymphocyte count, 1.0 × 109/L [IQR, 0.7-1.3]) was observed in 66 patients (56.9%), and elevated lactate dehydrogenase (245.5 U/L [IQR, 194.3-319.8]) in 69 patients (59.5%). Hypokalemia HP Hypokalemia MESHD occurred in 24 (20.7%) patients. Compared with non-severe cases, severe cases were older (64.0 years [IQR, 53.0-76.0] vs 56.0 years [IQR, 37.0-64.0]), more likely to have comorbidities (35 [63.6%] vs 24 [39.3%]), and more likely to develop acute cardiac injury MESHD (19 [34.5%] vs 4 [6.6%]), acute heart failure MESHD (18 [32.7%] vs 3 [4.9%]), and ARDS (20 [36.4%] vs 0 [0%]). During hospitalization, the prevalence SERO of new onset hypertension HP hypertension MESHD was significantly higher in severe patients (55.2% vs 19.0%) than in non-severe ones.Conclusions In this single-centered, retrospective, observational study, we found that the infection of SARS-CoV-2 MESHD was more likely to occur in middle and aged TRANS population with cardiovascular comorbidities. Cardiovascular complications MESHD, including new onset hypertension HP hypertension MESHD and heart injury MESHD were common in severe patients with COVID-19. More detailed researches in cardiovascular involvement in COVID-19 are urgently needed to further understand the disease.

    Preliminary study to identify severe from moderate cases of COVID-19 using NLR&RDW-SD combination parameter

    Authors: changzheng wang; Chengbin Li

    doi:10.1101/2020.04.09.20058594 Date: 2020-04-14 Source: medRxiv

    Objectives: Investigate the characteristics and rules of hematology changes in patients with COVID-19, and explore the possibility to identify moderate and severe patients using conventional hematology parameters or combined parameters. Methods: The clinical data of 45 moderate and severe type patients with SARS-CoV-2 infections MESHD in Jingzhou Central Hospital from January 23 to February 13, 2020 were collected. The epidemiological indexes, clinical symptoms and laboratory test results of the patients were retrospectively analyzed. Those parameters with significant differences between the two groups were analyzed, and the combination parameters with best diagnostic performance SERO were selected using the LDA method. Results: Of the 45 patients with COVID-19 (35 moderate and 10 severe cases), 23 were male TRANS and 22 female TRANS, aged TRANS 16-62 years. The most common clinical symptoms were fever HP fever MESHD (89%) and dry cough MESHD cough HP (60%). As the disease progressed, WBC, Neu#, NLR, PLR, RDW-CV and RDW-SD parameters in the severe group were significantly higher than that in the moderate group (P<0.05); meanwhile, Lym#, Eos#, HFC%, RBC, HGB and HCT parameters in the severe group were significantly lower than that in the moderate group (P<0.05). For NLR, the AUC, the best cut-off value, the sensitivity SERO and the specificity were 0.890, 13.39, 83.3% and 82.4% respectively, and for PLR , the AUC, the best cut-off, the sensitivity SERO and the specificity were 0.842, 267.03, 83.3% and 74.0% respectively. The combined parameter NLR&RDW-SD had the best diagnostic efficiency (AUC was 0.938) and when the cut-off value was 1.046, the sensitivity SERO and the specificity were 90.0% and 84.7% respectively, followed by the fitting parameter NLR&RDW-CV (AUC = 0.923). When the cut-off value was 0.62, the sensitivity SERO and the specificity for distinguishing severe type from moderate cases of COVID-19 were 90.0% and 82.4% respectively. Conclusions: The combined parameter NLR&RDW-SD is the best hematology index and can help clinicians to predict the severity of COVID-19 patients, and it can be used as a useful indicator to help prevent and control the epidemic.

    Analysis on clinical features of death MESHD patients with COVID-19: a retrospective, single-center study from Wuhan, China

    Authors: Ke Yao; Yin Zhao; Xiangtian Xiao; Gunyun Wu; Ruxin Xie; Yali Wang; Jun Hu; Hexie Cai; Rong Liu

    doi:10.21203/rs.3.rs-21065/v1 Date: 2020-04-03 Source: ResearchSquare

    Background An ongoing global pandemic of pneumonia HP pneumonia MESHD caused by severe acute respiratory syndrome coronavirus 2 MESHD (SARS-CoV-2) has caused thousands of deaths MESHD in China since December, 2019. We aimed to describe the clinical course of patients died of SARS-CoV-2 infection MESHD.Methods In this retrospective study, we reviewed 194 patients with SARS-CoV-2 infection MESHD, who died consecutively between Feb 3 to 24, 2020 in Tongji Hospital (Wuhan, China). Basic demographic and clinical information, laboratory findings, complications and treatments were extracted from electronic medical records of Hospital Information System. Unpaired t test was employed to evaluate the statistical differences of the serum SERO level of high-sensitive cardiac troponin I (hs-cTnI) among different age TRANS or sex groups. The relationship between hs-cTnI and inflammatory cytokines were estimated using Spearman correlation analysis.Results The death MESHD patients aged TRANS 69.62 ± 10.98, in which 68.6% were male TRANS. 74.7% patients had underlying chronic illnesses. The most common symptoms were fever HP fever MESHD (83%), cough HP (69.3%), and dyspnea HP dyspnea MESHD (65.6%). Decreased lymphocyte count (91.4%), elevated level of hs-cTnI (82.9%) and inflammatory parameters in serum SERO were commonly seen. The hs-cTnI level was significantly higher in the group aged TRANS 60–79 and male TRANS patients. A week positive correlation was observed between hs-cTnI values and D-dimer values (r = 0.343, p༜0.05). Acute respiratory distress HP respiratory distress MESHD syndrome was the main complication. Assisted respiration, antimicrobial drugs, glucocorticoids and immune globulin were the major treatments.Conclusion Most non-survivors with SARS-CoV-2 infection MESHD were old with chronic illnesses, complicated by multiple organ dysfunction. Prevention is better than cure in high-risk population.

    Radiographic Findings and other Predictors in Adults TRANS with Covid-19

    Authors: Kaiyan Li; Dian Chen; Shengchong Chen; Yuchen Feng; Chenli Chang; Zi Wang; Nan Wang; Guohua Zhen

    doi:10.1101/2020.03.23.20041673 Date: 2020-03-27 Source: medRxiv

    As of March 20, 2020, there were 234,073 confirmed cases TRANS of coronavirus disease MESHD 2019 (Covid-19) and 9,840 deaths worldwide. Older age TRANS and elevated d-dimer are reported risk factors for Covid-19. However, whether early radiographic change is a predictor of fatality remains unknown. We retrospectively reviewed records of all laboratory-confirmed patients admitted to a quarantine unit at Tongji Hospital, a large regional hospital in Wuhan, China, between January 31 and March 5, 2020. The Tongji Hospital ethics committee approved this study. A total of 128 patients were admitted. 102 patients were confirmed to have severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection MESHD using RNA detection. As of March 20, 82 confirmed patients were discharged, 15 died, and 5 remained hospitalized. The median age TRANS was 57 years (range, 27 - 85), 59 (58%) were male TRANS, and 44 (43%) patients had a comorbidity. The most common symptoms were fever HP fever MESHD, cough HP cough MESHD, and dyspnea HP dyspnea MESHD. When compared with survivors, non-survivors were older and more likely to have lymphopenia HP lymphopenia MESHD, elevated lactate dehydrogenase (LDH), elevated d-dimer, and increased hypersensitive troponin I. In a multivariate regression model that included these predictors, older age TRANS and elevated LDH were independent risk factors for fatality. Twenty-one survivors and 11 non-survivors had CT scans within the first week. We used severity score to quantify the extent of lung opacification as described in the Supplementary Appendix. The total severity score and number of involved lung lobes within the first week were significantly greater in non-survivors compared to survivors . Using univariate logistic regression analysis, higher total severity score ([≥]15) (odds ratio 53, 95% CI 3-369; p = 0.003), and more involved lung lobes (5 involved lobes) (9, 2-53; p = 0.016) in CT images within the first week were significantly associated with fatality. Moreover, in this subset of patients with CT data within the first week, higher total severity score was the only independent risk factor in a multivariate analysis incorporated the predictors discussed above (older age TRANS, lymphocytopenia MESHD, elevated LDH, elevated d-dimer, and increased troponin I). For survivors with serial CT scans performed over four weeks, total severity score peaked in the second week. This report suggests that the extent of lung lesions MESHD in early CT images is a potential predictor of poor outcome of Covid-19. This will help clinicians to identify the patients with poor prognosis at early stage.

    Epidemiological and clinical characteristics of COVID-19 patients in Nanjing

    Authors: Wei Chen; Chunmei Hu; Lili Huang; Min Cai; Yongchen Zhang; Hongxia Wei; Yun Chi; Zhiliang Hu; Yi Zeng; Yishan Zheng; Ying Liu; Cong Cheng; Hongmei Zhang; Weixiao Wang; Xia Zhang; Yongxiang Yi

    doi:10.21203/rs.3.rs-18007/v1 Date: 2020-03-18 Source: ResearchSquare

    Background: Since December 2019, the outbreak of COVID-19 has spread quickly and thumped many countries and regions. The epidemic of central China was under the spotlight and attracted much more attentions. However, there are few reports describing COVID-19 patients in the regions outside of Wuhan, which are undergoing the change from sporadic imported cases to community-acquired transmission TRANS.Methods: The electronic medical records of 74 laboratory-confirmed patients of COVID-19 were retrospectively reviewed and analyzed. Their epidemiological, demographic, clinical and radiological characteristics were systematically summarized. The difference between severe patients and non-severe patients were also analyzed statistically.Results: The 74 COVID-19 patients were composed of 4 (5.4%) mild patients, 56 (75.7%) common patients, 13 (17.6%) severe patients and 1 (1.4%) critical patient. 43 were male TRANS, and 31 were female TRANS, with the average age TRANS 48.1±17.5. No significant difference of susceptibility was observed between genders TRANS, and almost people with all age TRANS were susceptible to SARS-CoV-2 infection MESHD. Before Jan 26, only imported sporadic cases were observed. However, from that day onward, family cluster infection MESHD cases increased dramatically, up to 70.3% (52/74), which were mainly from 15 family. The incubation period TRANS spanned from 0 to 19 days, with the median 5, and 81.4% had symptom onset TRANS within 7 days. At admission, 31.1% of patients had underlying diseases MESHD and the most common underlying diseases were hypertension HP hypertension MESHD (13.5%) and diabetes MESHD (5.4%). The most common symptoms were fever HP fever MESHD (90.5%), cough HP (75.7%), fatigue HP fatigue MESHD (36.5%) and chest distress (32.4%). 36.5% and 16.2% of patients had leukopenia HP leukopenia MESHD and lymphocytopenia MESHD. 43.2% of patients had increased C reactive protein (CRP), and 40.5% had higher erythrocyte sedimentation rate (ESR) and 21.6% had higher calcitonin. 74.3% of patients had obvious lesions in both lung lobes MESHD and 56.8% of lesions manifested as ground glass opacity. Compared with non-severe group, the severe/critical group were significantly older and had more underlying diseases. After treatment, all patients improved and were discharged. No medical professional infection MESHD and death case were reported.Conclusion: The epidemic of COVID-19 in Nanjing were mainly caused by family cluster infection MESHD. The entire prevalence SERO and illness were much milder than those of Wuhan. The disease of COVID-19 could be controlled and cured.  

    Epidemiological, Clinical Characteristics and Outcome of Medical Staff Infected with COVID-19 in Wuhan, China: A Retrospective Case Series Analysis

    Authors: Jie Liu; Liu Ouyang; Pi Guo; Hai sheng Wu; Peng Fu; Yu liang Chen; Dan Yang; Xiao yu Han; Yu kun Cao; Osamah Alwalid; Juan Tao; Shu yi Peng; He shui Shi; Fan Yang; Chuan sheng Zheng

    doi:10.1101/2020.03.09.20033118 Date: 2020-03-13 Source: medRxiv

    Backgrounds Since December 2019, a novel coronavirus epidemic has emerged in Wuhan city, China and then rapidly spread to other areas. As of 20 Feb 2020, a total of 2,055 medical staff confirmed with coronavirus disease MESHD 2019 (COVID-19) caused by SARS-Cov-2 in China had been reported. We sought to explore the epidemiological, clinical characteristics and prognosis of novel coronavirus-infected MESHD medical staff. Methods In this retrospective study, 64 confirmed cases TRANS of novel coronavirus-infected MESHD medical staff admitted to Union Hospital, Wuhan between 16 Jan, 2020 to 15 Feb, 2020 were included. Two groups concerned were extracted from the subjects based on duration of symptoms: group 1 (<= 10 days) and group 2 (>10 days). Epidemiological and clinical data were analyzed and compared across groups. The Kaplan-Meier plot was used to inspect the change in hospital discharge rate. The Cox regression model was utilized to identify factors associated with hospital discharge. Findings The median age TRANS of medical staff included was 35 years old. 64% were female TRANS and 67% were nurses. None had an exposure to Huanan seafood wholesale market or wildlife. A small proportion of the cohort had contact with specimens (5%) as well as patients in fever HP fever MESHD clinics (8%) and isolation wards (5%). Fever HP Fever MESHD (67%) was the most common symptom, followed by cough HP (47%) and fatigue HP fatigue MESHD (34%). The median time interval between symptoms onset TRANS and admission was 8.5 days. On admission, 80% of medical staff showed abnormal IL-6 levels and 34% had lymphocytopenia MESHD. Chest CT mainly manifested as bilateral (61%), subpleural (80%) and ground-glass (52%) opacities. During the study period, no patients was transferred to intensive care unit or died, and 34 (53%) had been discharged. Higher body mass index (BMI) (HR 0.14; 95% CI 0.03-0.73), fever HP fever MESHD (HR 0.24; 95% CI 0.09-0.60) and higher levels of IL-6 on admission (HR 0.31; 95% CI 0.11-0.87) were unfavorable factors for discharge. Interpretation In this study, medical staff infected with COVID-19 have relatively milder symptoms and favorable clinical course, which may be partly due to their medical expertise, younger age TRANS and less underlying diseases. Smaller BMI, absence of fever symptoms MESHD fever HP symptoms and normal IL-6 levels on admission are favorable for discharge for medical staff. Further studies should be devoted to identifying the exact patterns of SARS-CoV-2 infection MESHD among medical staff.

    Clinical features and outcomes of 221 patients with COVID-19 in Wuhan, China

    Authors: Guqin Zhang; Chang Hu; Linjie Luo; Fang Fang; Yongfeng Chen; Jianguo Li; Zhiyong Peng; Huaqin Pan

    doi:10.1101/2020.03.02.20030452 Date: 2020-03-06 Source: medRxiv

    Rationale: In late December 2019, an outbreak of acute respiratory illness MESHD, now officially named as COVID-19, or coronavirus disease MESHD 2019, emerged in Wuhan, China, now spreading across the whole country and world. More data were needed to understand the clinical characteristics of the disease. Objectives: To study the epidemiology, clinical features and outcomes of patients with COVID-19. Methods: we performed a single center, retrospective case series study in 221 patients with laboratory confirmed SARS-CoV-2 pneumonia MESHD pneumonia HP at a university hospital. Measurements and Main Results: The median age TRANS was 55.0 years and 48.9% were male TRANS and only 8 (3.6%) patients had a history of exposure to the Huanan Seafood Market. Compared to the non-severe pneumonia HP pneumonia MESHD patients, the median age TRANS of the severe patients was significantly older, and they were more likely to have chronic comorbidities. Most common symptoms in severe patients were high fever HP, anorexia HP anorexia MESHD and dyspnea HP dyspnea MESHD. On admission, 33.0% patients showed leukopenia HP leukopenia MESHD and 73.8% showed lymphopenia HP lymphopenia MESHD. In addition, the severe patients suffered a higher rate of co-infections MESHD with bacteria or fungus MESHD and they were more likely to developing complications. As of February 15, 2020, 19.0% patients had been discharged and 5.4% patients died. 80% of severe cases received ICU care, and 52.3% of them transferred to the general wards due to relieved symptoms, and the mortality rate of severe patients in ICU was 20.5%. Conclusions: The COVID-19 epidemic spreads rapidly by human-to-human transmission TRANS. Patients with elder age TRANS, chronic comorbidities, blood SERO leukocyte/lymphocyte count, procalcitonin level, co-infection MESHD infection and severe HP complications might increase the risk of poor clinical outcomes. Keywords: coronavirus disease MESHD 2019; clinical features; outcomes; severe patients

    Clinical Features of COVID-19 Related Liver Damage

    Authors: Zhenyu Fan; Liping Chen; Jun Li; Cheng Tian; Yajun Zhang; Shaoping Huang; Zhanju Liu; Jilin Cheng

    doi:10.1101/2020.02.26.20026971 Date: 2020-02-27 Source: medRxiv

    BACKGROUND: A recent outbreak of SARS-CoV-2 infection MESHD occurs mainly in China, with rapidly increasing the number of cases (namely COVID-19). Abnormal liver functions MESHD are frequently present in these patients, here we aimed to clarify the clinical features of COVID-19-related liver damage to provide some references for the clinical treatment. METHODS: In this retrospective, single-center study, we included all confirmed COVID-19 cases in Shanghai Public Health Clinical Center from January 20 to January 31, 2020. The outcomes were followed up until February 19, 2020. A total of 148 cases were analyzed for clinical features, laboratory parameters (including liver function tests), medications and the length of stay. FINDINGS: Of 148 confirmed SARS-CoV-2-infected MESHD patients, 49.3% were females TRANS and 50.7% were males TRANS. The median age TRANS was 50.5 years (interquartile range, 36-64). Patients had clinical manifestations of fever HP fever MESHD (70.1%), cough HP (45.3%), expectoration (26.7%) at admission. 75 patients (50.7%) showed abnormal liver functions at admission. Patients (n = 75) who had elevated liver function index were more likely to have a moderate-high degree fever HP fever MESHD (44% vs 27.4%; p = 0.035) and significantly present in male TRANS patients (62.67% vs 38.36%; p = 0.005). The numbers of CD4+ and CD8+ T cells were significantly lower in abnormal liver function group than those in normal liver function group. There was no statistical difference in prehospital medications between normal and abnormal liver function groups, while the utilization rate of lopinavir/ritonavir after admission was significantly higher in patients with emerging liver injury MESHD than that in patients with normal liver functions. Importantly, the emerging abnormal liver functions MESHD after admission caused a prolonged length of stay. INTERPRETATION: SARS-CoV-2 may cause the liver function damage MESHD and the Lopinavir/ritonavir should be applied carefully for the treatment of COVID-19.

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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