Corpus overview


Overview

MeSH Disease

Human Phenotype

Fever (12)

Cough (11)

Fatigue (4)

Diarrhea (3)

Dyspnea (3)


Transmission

Seroprevalence
    displaying 1 - 10 records in total 12
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    Clinical Course and Management of 73 Hospitalized Moderate Patients with COVID-19 Outside Wuhan

    Authors: Xiaojuan Peng; Qi Liu; Zhaolin Chen; Guiyan Wen; Qing Li; Yanfang Chen; Jie Xiong; Xinzhou Meng; Yuanjin Ding; Ying Shi; Shaohui Tang

    doi:10.21203/rs.3.rs-52239/v1 Date: 2020-08-01 Source: ResearchSquare

    Background: Moderate cases account for the majority in patients with severe acute respiratory syndrome MESHD coronavirus 2 (SARS-CoV-2) infection MESHD and can also progress to severe/critical condition. Here, we investigated the clinical course and management of hospitalized moderate SARS-CoV-2 patients.Methods: The medical records and follow-up data were analyzed from the SARS-CoV-2 patients outside Wuhan.Results: A total of 73 moderate patients (38 men, 35 women) were included, with median age TRANS of 47.0 (38.5-57.5) years. Among them, only one patient (1.4%) died using active treatment to improve symptoms. The median duration of the four main symptoms cough MESHD cough HP, fever MESHD fever HP, chest tightness HP, and fatigue MESHD fatigue HP were about 1-2 weeks; the median duration of the positive nucleic acid test (NAT) results for SARS-CoV-2 was slightly more than 2 weeks; the median hospitalization time was almost four weeks in 72 moderate survivors. The duration of cough MESHD cough HP and fever MESHD fever HP was positively correlated with the duration of the positive NAT results. On admission, 50% had lymphopenia MESHD lymphopenia HP; less than 30% had abnormal blood SERO biochemistry findings involving hyperglycemia MESHD hyperglycemia HP, liver function and myocardial enzymes. At discharge, the laboratory indexes were substantially improved. Two weeks after discharge, 5.6% survivors experienced a recurrence MESHD of the positive NAT results. Conclusions: Moderate SARS-CoV-2 patients have a good prognosis by the active treatment. After discharge, it is necessary that moderate survivors undergo at least a 2-week collective medical observation in quarantine places, which can identify and treat a proportion of patients with re-positive NAT results and to prevent the spread of the potential sources of infection MESHD.

    Severe COVID-19 in cardiopath young pregnant without vertical transmission TRANS: a case report

    Authors: Ana Paula Figueiredo de Montalvão França; Danielly do Vale Pereira; Elaine Valéria Rodrigues; Flávia Nunes Vieira; Karine Santos Machado; Pedro Aleixo Nogueira; Ricardo Roberto de Souza Fonseca; Luiz Fernando Almeida Machado

    doi:10.21203/rs.3.rs-40095/v1 Date: 2020-07-03 Source: ResearchSquare

    Background: The new betacoronavirus known as severe acute respiratory syndrome MESHD coronavirus 2 (SARS-CoV-2) is the cause of COVID-19, and has spread rapidly around the world, reaching more than 200 countries, around 7 million people and causing more than 400.000 deaths MESHD according to the World Health Organization. Case presentation: A 26-year-old female TRANS at 28 weeks of gestation with regular prenatal care, a heart disease MESHD condition and no previous history of recent national or international traveling presented to a cardiology hospital, in Northern Brazil, with dry cough MESHD cough HP, sustained/continuous high fever MESHD fever HP, which quickly evolved to respiratory failure HP. Once stabilized an emergency MESHD cesarean was performed to preserve the fetus life. After surgery both patient and newborn were in Intensive Care Unit, then both patient and newborn nasopharyngeal and oropharyngeal secretion were obtained to test for respiratory viral infections MESHD, such as SARS-CoV-2, also blood SERO samples were collected for laboratory exams. The patient’s tested positive for SARS-CoV-2 however her newborn SARS-CoV-2. And during treatment due patient’s conditions and severity the case evolved to death MESHD.Conclusion: This report highlights the relevance of comorbidities for the unfavorable clinical course of COVID-19, despite the adequate treatment used for patients affected by COVID-19, especially among the risk groups, as well as demonstrating the absence of vertical transmission TRANS of SARS-CoV-2. 

    Screening and Analysis of COVID-19 cases in non-epidemic areas: A Retrospective Study

    Authors: Yan Zhu; Yan Guo; Juan Ma; Mao-shi Li; Jia-fei Chen; Ming Liu; Ze-hui Yan; Guo-hong Deng; Qing Mao; Hui-min Liu

    doi:10.21203/rs.3.rs-32811/v1 Date: 2020-06-01 Source: ResearchSquare

    Objective: To compare the epidemiological and clinical characteristics of confirmed and suspected corona virus disease MESHD 2019 (COVID-19) cases via the process of “triage-screening-isolation-transfer” in the hospitals of non-epidemic areas.Methods: The general data, epidemiological history, clinical symptoms, laboratory examination, and chest computed tomography (CT) imaging characteristics of 38 patients with suspected COVID-19, admitted between January 21 and March 5, 2020, were analyzed.Results: According to the results of the novel severe acute respiratory syndrome MESHD coronavirus (SARS-CoV-2) ribonucleic acid (RNA) testing, the patients were divided into study group (RNA positive) and control group (RNA negative). Ultimately, 8 cases were RNA-positive and diagnosed as CDVID-19, and 30 cases were negative. Approximately half of the patients in the study group returned to Chongqing from Wuhan; this number was significantly larger than that of the control group (P<0.05). The number of subjects in close contact TRANS with the confirmed cases TRANS with SARS-CoV-2 RNA-positive and the incidence of aggregation was significantly larger in the study group than in the control group (both P<0.05). The clinical symptom of the study group was mainly low fever MESHD fever HP (with or without cough MESHD cough HP). The patients with decreased white blood SERO cells (WBC) in the study group were significantly more than those in the control group (P<0.05). Both group had reduced lymphocytes (Lym) but the number of patients with increased C-reactive protein (CRP) in the study group was significantly more than that in the control group (P<0.05). There were different degrees of chest CT abnormalities in both study and control group (P > 0.05). Conclusion: The epidemiological investigations in screening for infectious diseases MESHD is crucial. The risk of infection TRANS risk of infection TRANS infection MESHD was high from the primary epidemic area and/or in close contact TRANS with the confirmed case TRANS. The most common form of clustering occurrence was family aggregation. CDVID-19 was mainly characterized by fever MESHD fever HP and respiratory symptoms, although asymptomatic infection MESHD asymptomatic TRANS may also occur. Decreased WBC, decreased Lym, and increased CRP are common characteristics but can also be combined with other respiratory tract virus infections MESHD. COVID 19 screening by chest CT alone had certain limitations in non- epidemic areas.

    Comparison of the Clinical Characteristics of Patients With COVID-19 in Suining and Wuhan

    Authors: Xiao-juan Wu; Chao-Ping Wang; Xiao-Bin Luo; Gao-Yan He; Bao-Lin Jia; Jing Wang; Li Luo; Rong Qiu; Zheng-Guang He; Min-Chao Li

    doi:10.21203/rs.3.rs-32683/v1 Date: 2020-05-30 Source: ResearchSquare

     Background Coronavirus disease MESHD 2019 (COVID-19), caused by severe acute respiratory syndrome MESHD coronavirus 2 (SARS-CoV-2), which was first identified in December 2019 in Wuhan. This study mainly analyzed the clinical characteristics, imaging features, and prognosis of patients with COVID-19 in Suining, one of China's fourth-tier cities, and Wuhan in 2019 and compared data between the 2 cities. Methods A retrospective analysis of the epidemiological history, clinical data, symptom presentation, laboratory test results, chest computed tomography (CT) imaging features, treatment measures and prognosis of 68 patients with COVID-19 diagnosed at Wuhan Red Cross Hospital and 17 patients with COVID-19 diagnosed at Suining Central Hospital from January 23, 2020, to February 27, 2020, was conducted. Results 1) The incidence rate of COVID-19 in Wuhan was 52.99‱, and the incidence rate in Suining was 0.04‱. The median age TRANS of patients with COVID-19 was 40.71 years old in Suining and 56.04 years old in Wuhan. The age TRANS of patients with COVID-19 in Wuhan was significantly older than that of patients with COVID-19 in Suining. Among the 68 patients with COVID-19 in Wuhan, 30 (44.1%) had hypertension MESHD hypertension HP, and 25 (36.8%) had diabetes. Three out of the 17 patients in Suining (17.6%) had hypertension MESHD hypertension HP, and 2 patients (11.8%) had diabetes. The proportion of patients with diabetes or hypertension MESHD hypertension HP in Wuhan was significantly higher than that in Suining (P<0.05). In the clinical classification, there were 1 (5.9%) and 23 (33.8%) patients with severe COVID-19 in Suining and Wuhan, respectively. The proportion of patients with severe COVID-19 in Wuhan was significantly higher than that in Suining (P<0.05). Fever MESHD Fever HP and cough MESHD cough HP were the most common clinical symptoms, with 9 cases (52.9%) and 8 cases (47.1%) in Suining, respectively, and 54 cases (79.4%) and 42 cases (61.8%) in Wuhan, respectively. There was 1 patient (5.9%) with COVID-19 with dyspnea MESHD dyspnea HP in Suining and 23 patients (33.8%) with COVID-19 with dyspnea MESHD dyspnea HP in Wuhan; the difference was statistically significant (P<0.05). Chest CT showed that lung consolidation occurred in 2 (11.8%) and 26 (38.2%) patients with COVID-19 in Suining and Wuhan, respectively. The proportion of lung consolidation in patients in Wuhan was significantly higher than that in patients in Suining (P<0.05). The laboratory tests suggested that percentage ofelevated C-reactive protein (CRP) (58.8%), ALT (33.8%), blood SERO glucose (45.6%), creatine kinase (CK) (33.8%) or D-dimer (47.1%) of patients in Wuhan were significantly increased than those in Suining (29.4%, 5.9%, 17.6%, 5.9%, and 17.7%, respectively). Moreover, the average length of hospital stay of patients in Wuhan was 17.49 days, which was significantly longer than that of patients in Suining (12.29 days). Conclusions The incidence of COVID-19 in fourth-tier cities, Suining, in China was significantly lower than that in Wuhan, and the disease MESHD severity was generally lower than that in Wuhan, with mostly good prognoses. Advanced age TRANS, diabetes, and hypertension MESHD hypertension HP are important factors that aggravate COVID-19, while elevated CRP, ALT, blood SERO glucose, CK, and D-dimer levels are important indicators for severe disease MESHD

    Analysis of moderate and severe cases of novel coronavirus disease MESHD (COVID-19) versus influenza A (H1N1)

    Authors: Weishun Hou; Haoyu Sheng; Manman Liang; zijian Wang; Xiuliang Xu; Yusheng Cheng; Fang Liu; Aiping Zhang; Bin Quan; Yunfeng Zhou; Jianghua Yang

    doi:10.21203/rs.3.rs-31334/v1 Date: 2020-05-26 Source: ResearchSquare

    Background To analyse the clinical characteristics, laboratory tests, and imaging findings of severe cases of coronavirus disease MESHD 2019 (COVID-19) versus severe cases of influenza A (H1N1).Methods We retrospectively analysed the clinical data of moderate and severe COVID-19 and H1N1 cases between January 23 and February 23, 2020.Results A total of 33 COVID-19 cases had a clear history of exposure to severe acute respiratory syndrome MESHD coronavirus 2 (SARS-CoV-2), with an incubation period TRANS of 11.12 ± 7.47 days. A total of 29 H1N1 cases were included in this study. Most cases were sporadic, with an incubation period TRANS of 3.67 ± 0.82 days (P = 0.002). The age TRANS at onset was 19.79 ± 23.88 years for H1N1 and 43.48 ± 17.82 years for COVID-19 (P < 0.001). For H1N1, common clinical symptoms were high fever MESHD fever HP and myalgia MESHD myalgia HP. The time of disease progression MESHD from moderate to severe was 13.60 ± 5.64 days for COVID-19 and 5.25 ± 2.36 days for H1N1 (P = 0.035). Laboratory tests showed that white blood SERO cells (WBC), neutrophils (N), lactate dehydrogenase (LDH), C-reactive protein (CPR), and procalcitonin (PCT) were significantly higher in severe H1N1 cases than in severe COVID-19 cases. D-dimer (DD) was 1.43 ± 1.19 µg/mL in the COVID-19 group, which was higher than that in the H1N1 group (0.88 ± 0.32 µg/mL, P = 0.013). High-resolution computed tomography (CT) showed severe COVID-19 cases presented mainly interstitial involvement, shown by large ground-glass opacities, whereas severe H1N1 cases presented both interstitial and parenchymal involvement, especially parenchymal involvement. All the COVID-19 patients survived to discharge, and one H1N1 patient died.Conclusion Compared with H1N1 patients, COVID-19 patients had a clear history of exposure to SARS-CoV-2, were older, presented milder clinical symptoms and a slower progression, and rarely had bacterial infections MESHD. Most H1N1 patients had sporadic H1N1 with an acute onset, high fever MESHD fever HP, and rapid progression; secondary bacterial infection MESHD was an important cause of disease MESHD aggravation.

    Clinical features of COVID-19 patients in one designated medical institutions in Chengdu, China

    Authors: Gui Zhou; Yun-Hui Tan; Jiang-Cuo Luo; Yi-Xiao Lu; Jing Feng; Juan Li; Yun-Mei Yang; Long Chen; Jian-Ping Zhang

    doi:10.21203/rs.3.rs-30405/v1 Date: 2020-05-19 Source: ResearchSquare

    OBJECTIVE: To study the clinical characteristics of patients infected with the 2019 severe acute respiratory syndrome MESHD coronavirus 2 (SARS-Cov-2) responsible for coronavirus disease MESHD (COVID-2019).METHODS: Data were collected from 20 patients admitted to the Pidu District People’s Hospital in Chengdu from January 26, 2020 to March 1, 2020 with laboratory-confirmed SARS-Cov-2 infection MESHD. Clinical data were collected using the World Health Organization (WHO) nCoV CASE RECORDFORM Version 1.2 28JAN2020, which includes parameters such as: temperature, epidemiological characteristics, social network, history of exposure, and incubation period TRANS. If information was unclear, the team reviewed the original data and contacted TRANS patients directly if necessary.RESULTS: The median age TRANS of the 20 COVID-19 infected patients studied was 42.5 years. In this cohort, four patients became severely ill and one deteriorated rapidly during treatment. This patient was transferred to another medical center with an intensive care unit (ICU) for treatment. This patient died after admission to the ICU. Two of the twenty patients remained positive SARS-Cov-2 more than three weeks, and they were quarantined in a medical facility without medication. According to our analysis, all of the studied cases were infected by human-to-human transmission TRANS due to the lack of protective measures; transmission TRANS through contact within families requires confirmation. The most common symptoms at onset TRANS of illness were fever MESHD fever HP in 13 (65%) patients, cough MESHD cough HP in 9 (45%), headache MESHD headache HP in 3 (15%), fatigue MESHD fatigue HP in 6 (30%), diarrhea MESHD diarrhea HP in 3 (15%), and abdominal pain MESHD abdominal pain HP in 2 (10%). Six patients (30%) developed shortness of breath upon admission. The median time from exposure to onset of illness was6.5 days (interquartile range 3.25–9 days), and from the onset of symptoms TRANS to first hospital admission was 3.5 (1.25–7) days.CONCLUSION: Compared with patients infected with SARS-Cov-2 in Wuhan (up to the end of February 2020), the symptoms of patients in one hospital in Chengdu, Sichuan Province, were relatively mild and patients were discharged from the hospital after only a short stay. However, the fasting blood SERO glucose of the infected individuals was found to be slightly elevated because of the state of emergency MESHD. The dynamic changes in lymphocyte levels can predict disease MESHD status of COVID-19. They are also suggestive of changes in mean platelet volume during disease progression MESHD. This suggests that the patients had mild cases of COVID-19. However, because there is no effective drug treatment for COVID-19, it is important to detect and identify severe cases from mild cases early.

    Clinical features of COVID-19 patients in one designated medical institutions in Chengdu, China

    Authors: Gui Zhou; Yun-Hui Tan; Jiang-Cuo Luo; Yi-Xiao Lu; Jing Feng; Juan Li; Yun-Mei Yang; Long Chen; Jian-Ping Zhang

    doi:10.21203/rs.3.rs-23967/v1 Date: 2020-04-21 Source: ResearchSquare

    OBJECTIVE: To study the clinical characteristics of patients infected with the 2019 severe acute respiratory syndrome MESHD coronavirus 2 (SARS-Cov-2) responsible for coronavirus disease MESHD (COVID-2019).METHODS: Data were collected from 20 patients admitted to the Pidu District People’s Hospital in Chengdu from January 26, 2020 to March 1, 2020 with laboratory-confirmed SARS-Cov-2 infection MESHD. Clinical data were collected using the World Health Organization (WHO) nCoV CASE RECORDFORM Version 1.2 28JAN2020, which includes parameters such as: temperature, epidemiological characteristics, social network, history of exposure, and incubation period TRANS. If information was unclear, the team reviewed the original data and contacted TRANS patients directly if necessary.RESULTS: The median age TRANS of the 20 COVID-19 infected patients studied was 42.5 years. In this cohort, four patients became severely ill and one deteriorated rapidly during treatment. This patient was transferred to another medical center with an intensive care unit (ICU) for treatment. This patient died after admission to the ICU. Two of the twenty patients remained positive SARS-Cov-2 more than three weeks, and they were quarantined in a medical facility without medication. According to our analysis, all of the studied cases were infected by human-to-human transmission TRANS due to the lack of protective measures; transmission TRANS through contact within families requires confirmation. The most common symptoms at onset TRANS of illness were fever MESHD fever HP in 13 (65%) patients, cough MESHD cough HP in 9 (45%), headache MESHD headache HP in 3 (15%), fatigue MESHD fatigue HP in 6 (30%), diarrhea MESHD diarrhea HP in 3 (15%), and abdominal pain MESHD abdominal pain HP in 2 (10%). Six patients (30%) developed shortness of breath upon admission. The median time from exposure to onset of illness was 6.5 days (interquartile range 3.25–9 days), and from the onset of symptoms TRANS to first hospital admission was 3.5 (1.25–7) days.CONCLUSION: Compared with patients infected with SARS-Cov-2 in Wuhan (up to the end of February 2020), the symptoms of patients in one hospital in Chengdu, Sichuan Province, were relatively mild and patients were discharged from the hospital after only a short stay. However, the fasting blood SERO glucose of the infected individuals was found to be slightly elevated because of the state of emergency MESHD. The dynamic changes in lymphocyte levels can predict disease MESHD status of COVID-19. They are also suggestive of changes in mean platelet volume during disease progression MESHD. This suggests that the patients had mild cases of COVID-19. However, because there is no effective drug treatment for COVID-19, it is important to detect and identify severe cases from mild cases early.

    Absence of SARS-CoV-2 infection MESHD in cats and dogs in close contact TRANS with a cluster of COVID-19 patients in a veterinary campus

    Authors: Sarah Temmam; Alix Barbarino; Djérène Maso; Sylvie Behillil; Vincent Enouf; Christèle Huon; Ambre Jaraud; Lucie Chevallier; Marija Backovic; Philippe Pérot; Patrick Verwaerde; Laurent Tiret; Sylvie van der Werf; Marc Eloit

    doi:10.1101/2020.04.07.029090 Date: 2020-04-09 Source: bioRxiv

    Severe acute respiratory syndrome MESHD coronavirus 2 (SARS-CoV-2), which originated in Wuhan, China, in 2019, is responsible for the COVID-19 pandemic. It is now accepted that the wild fauna, probably bats, constitute the initial reservoir of the virus, but little is known about the role pets can play in the spread of the disease TRANS disease MESHD in human communities, knowing the ability of SARS-CoV-2 to infect some domestic animals. We tested 21 domestic pets (9 cats and 12 dogs) living in close contact TRANS with their owners (belonging to a veterinary community of 20 students) in which two students tested positive for COVID-19 and several others (n = 11/18) consecutively showed clinical signs ( fever MESHD fever HP, cough MESHD cough HP, anosmia HP, etc.) compatible with COVID-19 infection MESHD. Although a few pets presented many clinical signs indicative for a coronavirus infection MESHD, no animal tested positive for SARS-CoV-2 by RT-PCR and no antibodies SERO against SARS-CoV-2 were detectable in their blood SERO using an immunoprecipitation assay. These original data can serve a better evaluation of the host range of SARS-CoV-2 in natural environment exposure conditions.

    Analysis on clinical features of death MESHD patients with COVID-19: a retrospective, single-center study from Wuhan, China

    Authors: Ke Yao; Yin Zhao; Xiangtian Xiao; Gunyun Wu; Ruxin Xie; Yali Wang; Jun Hu; Hexie Cai; Rong Liu

    doi:10.21203/rs.3.rs-21065/v1 Date: 2020-04-03 Source: ResearchSquare

    Background An ongoing global pandemic of pneumonia MESHD pneumonia HP caused by severe acute respiratory syndrome MESHD coronavirus 2 (SARS-CoV-2) has caused thousands of deaths MESHD in China since December, 2019. We aimed to describe the clinical course of patients died of SARS-CoV-2 infection MESHD.Methods In this retrospective study, we reviewed 194 patients with SARS-CoV-2 infection MESHD, who died consecutively between Feb 3 to 24, 2020 in Tongji Hospital (Wuhan, China). Basic demographic and clinical information, laboratory findings, complications and treatments were extracted from electronic medical records of Hospital Information System. Unpaired t test was employed to evaluate the statistical differences of the serum SERO level of high-sensitive cardiac troponin I (hs-cTnI) among different age TRANS or sex groups. The relationship between hs-cTnI and inflammatory cytokines were estimated using Spearman correlation analysis.Results The death MESHD patients aged TRANS 69.62 ± 10.98, in which 68.6% were male TRANS. 74.7% patients had underlying chronic illnesses. The most common symptoms were fever MESHD fever HP (83%), cough MESHD cough HP (69.3%), and dyspnea MESHD dyspnea HP (65.6%). Decreased lymphocyte count (91.4%), elevated level of hs-cTnI (82.9%) and inflammatory parameters in serum SERO were commonly seen. The hs-cTnI level was significantly higher in the group aged TRANS 60–79 and male TRANS patients. A week positive correlation was observed between hs-cTnI values and D-dimer values (r = 0.343, p༜0.05). Acute respiratory distress HP syndrome MESHD was the main complication. Assisted respiration, antimicrobial drugs, glucocorticoids and immune globulin were the major treatments.Conclusion Most non-survivors with SARS-CoV-2 infection MESHD were old with chronic illnesses, complicated by multiple organ dysfunction. Prevention is better than cure in high-risk population.

    Viral Kinetics and Antibody SERO Responses in Patients with COVID-19

    Authors: Wenting Tan; Yanqiu Lu; Juan Zhang; Jing Wang; Yunjie Dan; Zhaoxia Tan; Xiaoqing He; Chunfang Qian; Qiangzhong Sun; Qingli Hu; Honglan Liu; Sikuan Ye; Xiaomei Xiang; Yi Zhou; Wei Zhang; Yanzhi Guo; Xiu-Hua Wang; Weiwei He; Xing Wan; Fengming Sun; Quanfang Wei; Cong Chen; Guangqiang Pan; Jie Xia; Qing Mao; Yaokai Chen; Guohong Deng

    doi:10.1101/2020.03.24.20042382 Date: 2020-03-26 Source: medRxiv

    Background A pandemic of coronavirus disease MESHD 2019 (COVID-19) caused by severe acute respiratory syndrome MESHD coronavirus 2 (SARS-CoV-2) has been spreading over the world. However, the viral dynamics, host serologic responses, and their associations with clinical manifestations, have not been well described in prospective cohort. Methods We conducted a prospective cohort and enrolled 67 COVID-19 patients admitting between Jan 26 and Feb 5, 2020. Clinical specimens including nasopharyngeal swab, sputum, blood SERO, urine and stool were tested periodically according to standardized case report form with final follow-up on February 27. The routes and duration of viral shedding, antibody SERO response, and their associations with disease MESHD severity and clinical manifestations were systematically evaluated. Coronaviral particles in clinical specimens were observed by transmission TRANS electron microscopy (TEM). Results The median duration of SARS-CoV-2 RNA shedding were 12 (3-38), 19 (5-37), and 18 (7-26) days in nasopharyngeal swabs, sputum and stools, respectively. Only 13 urines (5.6%) and 12 plasmas SERO (5.7%) were viral positive. Prolonged viral shedding was observed in severe patients than that of non-severe patients. Cough MESHD Cough HP but not fever MESHD fever HP, aligned with viral shedding in clinical respiratory specimens, meanwhile the positive stool-RNA appeared to align with the proportion who concurrently had cough MESHD cough HP and sputum production, but not diarrhea MESHD diarrhea HP. Typical coronaviral particles could be found directly in sputum by TEM. The anti-nucleocapsid-protein IgM started on day 7 and positive rate peaked on day 28, while that of IgG was on day 10 and day 49 after illness onset. IgM and IgG appear earlier, and their titers are significantly higher in severe patients than non-severe patients (p<0.05). The weak responders for IgG had a significantly higher viral clearance rate than that of strong responders (p= 0.011). Conclusions Nasopharyngeal, sputum and stools rather than blood SERO and urine, were the major shedding routes for SARS-CoV-2, and meanwhile sputum had a prolonged viral shedding. Symptom cough MESHD cough HP seems to be aligned with viral shedding in clinical respiratory and fecal specimens. Stronger antibody SERO response was associated with delayed viral clearance and disease MESHD severity.

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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