Corpus overview


MeSH Disease

Human Phenotype

Pneumonia (1395)

Fever (839)

Cough (696)

Hypertension (493)

Anxiety (492)


age categories (3968)

Transmission (3442)

gender (1815)

fomite (1401)

contact tracing (1284)

    displaying 17931 - 17940 records in total 18488
    records per page

    SOCRATES: An online tool leveraging a social contact data TRANS sharing initiative to assess mitigation strategies for COVID-19

    Authors: Lander Willem; Thang Van Hoang; Sebastian Funk; Pietro Coletti; Philippe Beutels; Niel Hens

    doi:10.1101/2020.03.03.20030627 Date: 2020-03-06 Source: medRxiv

    Objective: Establishing a social contact data TRANS sharing initiative and an interactive tool to assess mitigation strategies for COVID-19. Results: We organized data sharing of published social contact surveys via online repositories and formatting guidelines. We analyzed this social contact data TRANS in terms of weighted social contact matrices, next generation matrices, relative incidence and R0 TRANS. We incorporated location-specific isolation measures (e.g. school closure or telework) and capture their effect on transmission TRANS dynamics. All methods have been implemented in an online application based on R Shiny and applied to COVID-19 with age TRANS-specific susceptibility and infectiousness. Using our online tool with the available social contact data TRANS, we illustrate that social distancing could have a considerable impact on reducing transmission TRANS for COVID-19. The effect itself depends on assumptions made about disease-specific characteristics and the choice of intervention(s). Keywords: social contact data TRANS, user interface, transmission TRANS dynamics, infectious diseases MESHD, epidemics, social distancing, behavioral changes, data sharing initiative, open-source, COVID-19

    Space-time dependence of corona virus (COVID-19) outbreak

    Authors: Kathakali Biswas; Parongama Sen

    id:2003.03149v1 Date: 2020-03-06 Source: arXiv

    We analyse the data for the global corona virus (COVID-19) outbreak using the results of a previously studied Susceptible-Infected-Removed (SIR) model of epidemic spreading on Euclidean networks. We also directly study the correlation of the distance from the epicenter and the number of cases. An inverse square law is seen to exist approximately. The studies are made for China and the rest of the world separately.

    The impact of social distancing and epicenter lockdown on the COVID-19 epidemic in mainland China: A data-driven SEIQR model study

    Authors: Yuzhen Zhang; Bin Jiang; Jiamin Yuan; Yanyun Tao

    doi:10.1101/2020.03.04.20031187 Date: 2020-03-06 Source: medRxiv

    The outbreak of coronavirus disease MESHD 2019 (COVID-19) which originated in Wuhan, China, constitutes a public health emergency of international concern with a very high risk of spread and impact at the global level. We developed data-driven susceptible-exposed-infectious-quarantine-recovered (SEIQR) models to simulate the epidemic with the interventions of social distancing and epicenter lockdown. Population migration data combined with officially reported data were used to estimate model parameters, and then calculated the daily exported infected individuals by estimating the daily infected ratio and daily susceptible population size. As of Jan 01, 2020, the estimated initial number of latently infected individuals was 380.1 (95%-CI: 379.8~381.0). With 30 days of substantial social distancing, the reproductive number TRANS in Wuhan and Hubei was reduced from 2.2 (95%-CI: 1.4~3.9) to 1.58 (95%-CI: 1.34~2.07), and in other provinces from 2.56 (95%-CI: 2.43~2.63) to 1.65 (95%-CI: 1.56~1.76). We found that earlier intervention of social distancing could significantly limit the epidemic in mainland China. The number of infections could be reduced up to 98.9%, and the number of deaths could be reduced by up to 99.3% as of Feb 23, 2020. However, earlier epicenter lockdown would partially neutralize this favorable effect. Because it would cause in situ deteriorating, which overwhelms the improvement out of the epicenter. To minimize the epidemic size and death MESHD, stepwise implementation of social distancing in the epicenter city first, then in the province, and later the whole nation without the epicenter lockdown would be practical and cost-effective.

    Clinical features and outcomes of 221 patients with COVID-19 in Wuhan, China

    Authors: Guqin Zhang; Chang Hu; Linjie Luo; Fang Fang; Yongfeng Chen; Jianguo Li; Zhiyong Peng; Huaqin Pan

    doi:10.1101/2020.03.02.20030452 Date: 2020-03-06 Source: medRxiv

    Rationale: In late December 2019, an outbreak of acute respiratory illness MESHD, now officially named as COVID-19, or coronavirus disease MESHD 2019, emerged in Wuhan, China, now spreading across the whole country and world. More data were needed to understand the clinical characteristics of the disease. Objectives: To study the epidemiology, clinical features and outcomes of patients with COVID-19. Methods: we performed a single center, retrospective case series study in 221 patients with laboratory confirmed SARS-CoV-2 pneumonia MESHD pneumonia HP at a university hospital. Measurements and Main Results: The median age TRANS was 55.0 years and 48.9% were male TRANS and only 8 (3.6%) patients had a history of exposure to the Huanan Seafood Market. Compared to the non-severe pneumonia HP pneumonia MESHD patients, the median age TRANS of the severe patients was significantly older, and they were more likely to have chronic comorbidities. Most common symptoms in severe patients were high fever HP, anorexia HP anorexia MESHD and dyspnea HP dyspnea MESHD. On admission, 33.0% patients showed leukopenia HP leukopenia MESHD and 73.8% showed lymphopenia HP lymphopenia MESHD. In addition, the severe patients suffered a higher rate of co-infections MESHD with bacteria or fungus MESHD and they were more likely to developing complications. As of February 15, 2020, 19.0% patients had been discharged and 5.4% patients died. 80% of severe cases received ICU care, and 52.3% of them transferred to the general wards due to relieved symptoms, and the mortality rate of severe patients in ICU was 20.5%. Conclusions: The COVID-19 epidemic spreads rapidly by human-to-human transmission TRANS. Patients with elder age TRANS, chronic comorbidities, blood SERO leukocyte/lymphocyte count, procalcitonin level, co-infection MESHD infection and severe HP complications might increase the risk of poor clinical outcomes. Keywords: coronavirus disease MESHD 2019; clinical features; outcomes; severe patients

    Modelling-based evaluation of the effect of quarantine control by the Chinese government in the coronavirus disease MESHD 2019 outbreak

    Authors: Xinkai Zhou; Zhigui Wu; Ranran Yu; Shanni Cao; Wen Fang; Zhen Jiang; Fang Yuan; Chao Yan; Dijun Chen

    doi:10.1101/2020.03.03.20030445 Date: 2020-03-06 Source: medRxiv

    The novel coronavirus disease MESHD 2019 (COVID-19) epidemic, which was first identified in Wuhan, China in December 2019, has rapidly spread all over China and across the world. By the end of February 2020, the epidemic outside Hubei province in China has been well controlled, yet the next wave of transmission TRANS in other countries may have just begun. A retrospective modeling of the transmission TRANS dynamics would provide insights into the epidemiological characteristics of the disease and evaluation of the effectiveness of the strict measures that have been taken by central and local governments of China. Using a refined susceptible-exposed-infectious-removed (SEIR) transmission TRANS model and a new strategy of model fitting, we were able to estimate model parameters in a dynamic manner. The resulting parameter estimation can well reflect the prevention policy scenarios. Our simulation results with different degrees of government control suggest that the strictly enforced quarantine and travel TRANS ban have significantly decreased the otherwise uncontrollable spread of the disease TRANS. Our results suggest similar measures should be considered by other countries that are of high risk of COVID-19 outbreak.

    Exuberant elevation of IP-10, MCP-3 and IL-1ra during SARS-CoV-2 infection MESHD is associated with disease severity and fatal outcome

    Authors: Yang Yang; Chenguang Shen; Jinxiu Li; Jing Yuan; Minghui Yang; Fuxiang Wang; Guobao Li; Yanjie Li; Li Xing; Ling Peng; Jinli Wei; Mengli Cao; Haixia Zheng; Weibo Wu; Rongrong Zou; Delin Li; Zhixiang Xu; Haiyan Wang; Mingxia Zhang; Zheng Zhang; Lei Liu; Yingxia Liu

    doi:10.1101/2020.03.02.20029975 Date: 2020-03-06 Source: medRxiv

    The outbreak of Coronavirus Disease MESHD 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 MESHD (SARS-CoV-2) emerged in Wuhan, December 2019, and continuously poses a serious threat to public health. Our previous study has shown that cytokine storm occurred during SARS-CoV-2 infection MESHD, while the detailed role of cytokines in the disease severity and progression remained unclear due to the limited case number. In this study, we examined 48 cytokines in the plasma SERO samples from 53 COVID-19 cases, among whom 34 were severe cases, and the others moderate. Results showed that 14 cytokines were significantly elevated upon admission in COVID-19 cases. Moreover, IP-10, MCP-3, and IL-1ra were significantly higher in severe cases, and highly associated with the PaO2/FaO2 and Murray score. Furthermore, the three cytokines were independent predictors for the progression of COVID-19, and the combination of IP-10, MCP-3 and IL-1ra showed the biggest area under the curve (AUC) of the receiver-operating characteristics (ROC) calculations. Serial detection of IP-10, MCP-3 and IL-1ra in 14 severe cases showed that the continuous high levels of these cytokines were associated with disease deterioration and fatal outcome. In conclusion, we report three cytokines that closely associated with disease severity and outcome of COVID-19. These findings add to our understanding of the immunopathologic mechanisms of SARS-CoV-2 infection MESHD, which suggested novel therapeutic targets and strategy.

    Modeling the Control of COVID-19: Impact of Policy Interventions and Meteorological Factors

    Authors: Jiwei Jia; Jian Ding; Siyu Liu; Guidong Liao; Jingzhi Li; Ben Duan; Guoqing Wang; Ran Zhang

    id:2003.02985v1 Date: 2020-03-06 Source: arXiv

    In this paper, we propose a dynamical model to describe the transmission TRANS of COVID-19, which is spreading in China and many other countries. To avoid a larger outbreak in the worldwide, Chinese government carried out a series of strong strategies to prevent the situation from deteriorating. Home quarantine is the most important one to prevent the spread of COVID-19. In order to estimate the effect of population quarantine, we divide the population into seven categories for simulation. Based on a Least-Squares procedure and officially published data, the estimation of parameters for the proposed model is given. Numerical simulations show that the proposed model can describe the transmission TRANS of COVID-19 accurately, the corresponding prediction of the trend of the disease is given. The home quarantine strategy plays an important role in controlling the disease spread TRANS and speeding up the decline of COVID-19. The control reproduction number TRANS of most provinces in China are analyzed and discussed adequately. We should pay attention to that, though the epidemic is in decline in China, the disease still has high risk of human-to-human transmission TRANS continuously. Once the control strategy is removed, COVID-19 may become a normal epidemic disease MESHD just like flu. Further control for the disease is still necessary, we focus on the relationship between the spread rate of the virus and the meteorological conditions. A comprehensive meteorological index is introduced to represent the impact of meteorological factors on both high and low migration groups. As the progress on the new vaccine, we design detail vaccination strategies for COVID-19 in different control phases and show the effectiveness of efficient vaccination. Once the vaccine comes into use, the numerical simulation provide a promptly prospective research.

    Simple Strategy for Rapid and Sensitive Detection of 2019 novel coronavirus Based on Antibody SERO

    Authors: Xinjun Hu; Huiyang Deng; Yibing Shang; Mengnan Fan; Feng Yue

    doi:10.21203/ Date: 2020-03-06 Source: ResearchSquare

    Objectives: Since December 2019, acute respiratory disease MESHD due to 2019 novel coronavirus emerged in Wuhan city and rapidly spread throughout China. Real-time RT-PCR is widely deployed in diagnostic virology. However, the positive detection rates of RT-PCR are only 30% to 50%. Therefore, we propose a simple strategy for rapidly and sensitively detecting the IgM/IgG antibody SERO against 2019-nCoV using a colloidal gold-based immunochromatographic strip test.Methods A total of 41 clinically 2019-nCoV suspected cases (23 males TRANS and 18 females TRANS) were enrolled. The sensitivity SERO of colloidal gold-based immunochromatographic strip test and of RT-PCR were compared and evaluated. McNemar’s test was used to compare the detection rate of both assays (P<0.05).Results: The Antibody SERO was detected in 63.4% (26/41) of blood SERO specimens using the assay. In contrast, the 2019-nCoV was detected in 46.3% (19/41) of nasal and pharyngeal swab specimens using the RT-PCR assays. The detection rate obtained by this assay was markedly higher than that obtained by the RT-PCR assays (P=0.039)Conclusion: This detection assay exhibits a higher detection sensitivity SERO than RT-PCR. More important, the assay shows the benefits of easy operation and setup. We believe that the sensitive and time-saving approach may be used as an auxiliary diagnostic tool for 2019-nCoV detection and virus screening and confirmation.

    Face mask use among individuals who are not medically diagnosed with COVID-19: A lack of evidence for and against and implications around public health recommendations.

    Authors: Keshini Madara Marasinghe

    doi:10.21203/ Date: 2020-03-06 Source: ResearchSquare

    IntroductionSince the beginning of the COVID-19 outbreak, public health professionals have been constantly making decisions on face mask use among individuals who are not medically diagnosed with COVID-19 or “healthy individuals” to limit the spread of COVID-19. While some countries have strongly recommended face masks for “healthy individuals”, other countries have recommended against it. Public health recommendations that have been provided to this population since the beginning of the outbreak have been controversial, contradicting, and inconsistent around the world. The purpose of this paper is to understand available evidence around the effectiveness or ineffectiveness of face mask use in limiting the spread of COVID-19 among individuals who have not yet been diagnosed with COVID-19 and most importantly, to understand the state of knowledge that the public health recommendations that have been provided since the beginning of the COVID-19 outbreak are based on.MethodsA systematic review was conducted to identify studies that investigated the use of face masks to limit the spread of COVID-19 among “healthy individuals”.ResultsNo studies were found, demonstrating a lack of evidence for and against face mask use suggesting implications around public health recommendations provided to “healthy individuals” since the beginning of the COVID-19 outbreak.ConclusionsThree and a half months into the COVID-19 outbreak (December 2019 – 2nd week of April 2020), there are no peer-reviewed scientific studies that have investigated the effectiveness or ineffectiveness of face mask use among “healthy individuals”. Yet, very strong public health recommendations have been provided on whether they should or should not wear face masks to limit the spread of COVID-19. A lack of scientific evidence heavily questions the basis of these public health recommendations provided at a very early, yet a crucial stage of an outbreak. This finding and a further look at public health recommendations conclude that there is a clear need for more concentrated research around face mask use among healthy individuals as well as public health recommendations that are evidence-based; precautionary in the absence of evidence; based on benefit-risk assessment; transparent; and globally aligned in order to provide the most successful guidelines during an infectious disease outbreak.

    Caution: The clinical characteristics of COVID-19 patients at admission are changing

    Authors: Zhaowei Chen; Jijia Hu; Zongwei Zhang; Shan Jiang; Tao Wang; Zhengli Shi; Zhan Zhang

    doi:10.1101/2020.03.03.20030833 Date: 2020-03-06 Source: medRxiv

    Background With the emergence of 4rd generation transmission TRANS, the prevention and treatment of the novel coronavirus disease MESHD 2019 (COVID-19) has entered a new period. We aimed to report several changes in the clinical characteristics at admission of patients with COVID-19. Methods Clinical records and laboratory results of patients suffering from COVID-19 were retrospectively reviewed and matched with the admission dates to analyze the changes in characteristics at the onset of illness. Results Of the 89 affected patients, 31 [34.8%] patients were admitted from January 16 to 22, and 58 [65.2%] were admitted from January 23 to 29. Patients were admitted with more systemic symptoms, such as fever HP fever MESHD (21 [67.7%] of 31), fatigue HP fatigue MESHD (13 [41.9%] of 31), and myalgia HP myalgia MESHD (7 [22.6%] of 31), before January 23. More patients (10 [32.3%] of 31) admitted before January 23 had a small amount of sputum production compared with a smaller proportion (4 [6.9%] of 58) of the patients admitted after January 23. Other symptoms, such as cough HP cough MESHD, nausea HP nausea MESHD, diarrhea HP diarrhea MESHD, and chest tightness HP chest tightness MESHD, were not significantly different between the two groups. In addition, the group admitted before January 23 had a larger proportion of patients with reduced lymphocyte (13 [54.2%] of 24), CD3 (11 [54.4%] of 21), and CD8 (9 [42.9%] of 21) counts and elevated serum SERO amyloid A (SAA, 18 [75%] of 24). Conclusions The initial symptoms of recently infected MESHD patients seem more insidious, indicating that the new coronavirus may gradually evolve into a virus similar to influenza and latent in asymptomatic TRANS carriers TRANS for a long time.

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MeSH Disease
Human Phenotype

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