Corpus overview


Overview

MeSH Disease

Human Phenotype

Transmission

Seroprevalence
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    EFFECT OF CONVALESCENT PLASMA SERO ON MORTALITY IN PATIENTS WITH COVID-19 MESHD PNEUMONIA HP

    Authors: Martin R Salazar; Soledad E Gonzalez; Lorena Regairaz; Noelia S Ferrando; Veronica Gonzalez; Patricia M Carrera; Laura Muñoz; Santiago A Pesci; Juan M Vidal; Nicolas Kreplak; Elisa Estenssoro; Harendra Guturu; Ahna R. Girshick; Kristin A. Rand; Eurie L. Hong; Catherine A. Ball; Stefan VANEL; Pierre MENDIHARAT; Klaudia PORTEN; William HENNEQUIN; Clair MILLS; Francisco LUQUERO

    doi:10.1101/2020.10.08.20202606 Date: 2020-10-09 Source: medRxiv

    Abstract Background Convalescent plasma SERO, widely utilized in viral infections that induce neutralizing antibodies SERO, has been proposed for COVID-19 MESHD, and preliminary evidence shows that it might have beneficial effect. Our objective was to compare epidemiological characteristics and outcomes between patients who received convalescent plasma SERO for COVID-19 MESHD and those who did not, admitted to hospitals in Buenos Aires Province, Argentina, throughout the pandemic. Methods This is a multicenter, retrospective cohort study of 2-month duration beginning on June 1, 2020, including unselected, consecutive adult TRANS patients with diagnosed COVID-19 MESHD, admitted to 215 hospitals with pneumonia HP pneumonia MESHD. Epidemiological and clinical variables were registered in the Provincial Hospital Bed Management System. Convalescent plasma SERO was supplied as part of a centralized, expanded access program. Results We analyzed 3,529 patients with pneumonia MESHD pneumonia HP, predominantly male TRANS, aged TRANS 62{+/-}17, with arterial hypertension HP hypertension MESHD and diabetes MESHD as main comorbidities; 51.4% were admitted to the ward, 27.1% to the Intensive Care Unit (ICU), and 21.7% to the ICU with mechanical ventilation requirement (ICU-MV). 28-day mortality was 34.9%; and was 26.3%, 30.1% and 61.4% for ward, ICU and ICU-MV MESHD patients. Convalescent plasma SERO was administered to 868 patients (24.6%); their 28-day mortality was significantly lower (25.5% vs. 38.0%, p<0.001). No major adverse effects occurred. Logistic regression analysis identified age TRANS, ICU admission with and without MV requirement, diabetes MESHD and preexistent cardiovascular disease MESHD as independent predictors of 28-day mortality, whereas convalescent plasma SERO administration acted as a protective factor. Conclusions Our study suggests that the administration of convalescent plasma SERO in COVID-19 MESHD pneumonia HP pneumonia MESHD admitted to the hospital might be associated with decreased mortality.

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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