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MeSH Disease

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Seroprevalence
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    Analysis of early renal injury MESHD in COVID-19 MESHD and diagnostic value of multi-index combined detection

    Authors: Xu-wei Hong; Ze-pai Chi; Guo-yuan Liu; Hong Huang; Shun-qi Guo; Jing-ru Fan; Xian-wei Lin; Liao-zhun Qu; Rui-lie Chen; Ling-jie Wu; Liang-yu Wang; Qi-chuan Zhang; Su-wu Wu; Ze-qun Pan; Hao Lin; Yu-hua Zhou; Yong-hai Zhang

    doi:10.1101/2020.03.07.20032599 Date: 2020-03-10 Source: medRxiv

    Objectives The aim of the study was to analyze the incidence of COVID-19 MESHD with early renal injury MESHD, and to explore the value of multi-index combined detection in diagnosis of early renal injury MESHD in COVID-19 MESHD. Design The study was an observational, descriptive study. Setting This study was carried out in a tertiary hospital in Guangdong, China. Participants 12 patients diagnosed with COVID-19 MESHD from January 20, 2020 to February 20, 2020. Primary and secondary outcome measures The primary outcome was to evaluate the incidence of early renal injury MESHD in COVID-19 MESHD. In this study, the estimated glomerular filtration rate (eGFR), endogenous creatinine clearance (Ccr) and urine microalbumin / urinary creatinine ratio (UACR) were calculated to assess the incidence of early renal injury MESHD. Secondary outcomes were the diagnostic value of urine microalbumin (UMA), 1-microglobulin (A1M), urine immunoglobulin-G (IGU), urine transferring (TRU) alone and in combination in diagnosis of COVID-19 MESHD with early renal injury MESHD. Results While all patients had no significant abnormalities in serum SERO creatinine (Scr) and blood SERO urea nitrogen (BUN), the abnormal rates of eGFR, Ccr, and UACR were 66.7%, 41.7%, and 41.7%, respectively. Urinary microprotein detection indicated that the area under curve (AUC) of multi-index combined to diagnose early renal injury MESHD in COVID-19 MESHD was 0.875, which was higher than UMA (0,813), A1M (0.813), IGU (0.750) and TRU (0.750) alone. Spearman analysis showed that the degree of early renal injury MESHD was significantly related to C-reactive protein (CRP) and neutrophil ratio (NER), suggesting that the more severe the infection HP, the more obvious the early renal injury MESHD. Hypokalemia MESHD Hypokalemia HP and hyponatremia HP hyponatremia MESHD were common in patients with COVID-19 MESHD, and there was a correlation with the degree of renal injury MESHD. Conclusions Early renal injury MESHD was common in patients with COVID-19 MESHD. Combined detection of UMA, A1M, IGU, and TRU was helpful for the diagnosis of early renal injury MESHD in COVID-19 MESHD.

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MeSH Disease
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