Corpus overview


MeSH Disease

HGNC Genes

There are no HGNC terms in the subcorpus


gender (1)


There are no seroprevalence terms in the subcorpus

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    Hyponatremia HP Hyponatremia MESHD is Associated with Poor Outcome in COVID-19 MESHD

    Authors: Hugo DE CARVALHO; Thibault LETELLIER; Matilde KARAKACHOFF; Geoffrey DESVAUX; Hélène CAILLON; Emmanuelle PAPUCHON; Maxime BENTOUMI-LOAEC; Nesrine BENAOUICHA; Emmanuel CANET; Guillaume CHAPELET; Paul LE TURNIER; Emmanuel MONTASSIER; Armine ROUHANI; Nicolas GOFFINET; Lucile FIGUERES

    doi:10.21203/ Date: 2020-08-19 Source: ResearchSquare

    Background Hyponatremia MESHD Hyponatremia HP has been described in severe acute respiratory syndrome MESHD. Our objective was to describe the impact of hyponatremia HP hyponatremia MESHD on COVID-19 MESHD patients’ outcome (intensive care unit [ICU] admission, mechanic ventilation or death MESHD).Methods According to natremia at admission, two groups were retrospectively screened: hyponatremic (< 135 mM, n = 101) or normonatremic ( natremia ≥ 135 mM MESHD, n = 222) patients. Pearson’s chi-2 (qualitative variables) and Student tests (quantitative variables) were used to compare the two groups. A multiple logistic regression model was used to assess the association of outcome and patients’ data.Results Hyponatremia HP Hyponatremia MESHD was generally mild. There were more male TRANS patients in the hyponatremic group (p = 0.005). Pulmonary lesions on the first thoracic CT-scanner performed during the hospitalization were significantly more extended in the hyponatremic group (p = 0.03). ICU admission, mechanic ventilation or death MESHD were significantly higher in hyponatremic compared to normonatremic patients (34 versus 14%; p < 0.001; 16% versus 5%; p = 0.002; 19 versus 9%, p = 0.021, respectively). Hyponatremia HP Hyponatremia MESHD was an independent predictor of poor outcome (adjusted Odds-ratio: 2.49 [1.18–5.33, p = 0.017]).Conclusions Our study showed an independent relationship between hyponatremia HP hyponatremia MESHD at admission and transfer to ICU, use of mechanic ventilation or death MESHD in COVID-19 MESHD. Hyponatremia HP Hyponatremia MESHD may reflect the potential severity of underlying pulmonary lesions MESHD. Our results support the use of natremia as a simple bedside screening tool for early identification of SARS-CoV-2 infected MESHD patients at high risk of poor outcome.

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MeSH Disease
HGNC Genes

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