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MeSH Disease


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    First case of placental infection MESHD with SARS-CoV-2

    Authors: Hillary Hosier; Shelli Farhadian; Raffaella Morotti; Uma Deshmukh; Alice Lu-Culligan; Katherine Campbell; Yuki Yasumoto; Chantal Vogels; Arnau Casanovas-Massana; Pavithra Vijayakumar; Bertie Geng; Camila Odio; John Fournier; Anderson Brito; Joseph Fauver; Feimei Liu; Tara Alpert; Reshef Tal; Klara Szigeti-Buck; Sudhir Perincheri; Christopher Larsen; Aileen Gariepy; Gabriela Aguilar; Kristen Fardelmann; Malini Harigopal; Hugh Taylor; Christian Pettker; Anne Wyllie; Charles Dela Cruz; Aaron Ring; Nathan Grubaugh; Albert Ko; Tamas Horvath; Akiko Iwasaki; Uma Reddy; Heather Lipkind

    doi:10.1101/2020.04.30.20083907 Date: 2020-05-05 Source: medRxiv

    Background: The effects of Covid-19 MESHD in pregnancy remain relatively unknown. We present a case of second trimester pregnancy with symptomatic Covid-19 MESHD complicated by severe preeclampsia HP and placental abruption HP placental abruption MESHD. Methods: We analyzed placenta for the presence of SARS-CoV-2 through molecular and immunohistochemical assays and by and electron microscopy, and we measured the maternal antibody SERO response in blood SERO to this infection. Results: SARS-CoV-2 localized predominantly to syncytiotrophoblast cells at the maternal-fetal interface of the placenta. Histological examination of the placenta revealed a dense macrophage infiltrate, but no evidence for vasculopathy MESHD typically associated with preeclampsia HP. Conclusion: This case demonstrates, for the first time, SARS-CoV-2 invasion of the placenta, highlighting the potential for severe morbidity among pregnant women with Covid-19 MESHD.

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MeSH Disease

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