Corpus overview


Overview

MeSH Disease

Human Phenotype

Transmission

There are no transmission terms in the subcorpus


Seroprevalence

There are no seroprevalence terms in the subcorpus

    displaying 1 - 1 records in total 1
    records per page




    Supramolecular Organization Predicts Protein Nanoparticle Delivery to Neutrophils for Acute Lung Inflammation MESHD Diagnosis and Treatment

    Authors: Jacob W Myerson; Priyal N Patel; Nahal Habibi; Landis R Walsh; Yi-Wei Lee; David C Luther; Laura T Ferguson; Michael H Zaleski; Marco E Zamora; Oscar A. Marcos-Contreras; Patrick M Glassman; Ian Johnston; Elizabeth D Hood; Tea Shuvaeva; Jason V Gregory; Raisa Y Kiseleva; Jia Nong; Kathryn M Rubey; Colin F Greineder; Samir Mitragotri; George S Worthen; Vincent M Rotello; Joerg Lahann; Vladimir R Muzykantov; Jacob S Brenner

    doi:10.1101/2020.04.15.037564 Date: 2020-04-18 Source: bioRxiv

    Acute lung inflammation MESHD has severe morbidity, as seen in COVID-19 MESHD patients. Lung inflammation MESHD is accompanied or led by massive accumulation of neutrophils in pulmonary capillaries ("margination"). We sought to identify nanostructural properties that predispose nanoparticles to accumulate in pulmonary marginated neutrophils, and therefore to target severely inflamed lungs. We designed a library of nanoparticles and conducted an in vivo screen of biodistributions in naive mice and mice treated with lipopolysaccharides. We found that supramolecular organization of protein in nanoparticles predicts uptake in inflamed lungs. Specifically, nanoparticles with agglutinated protein (NAPs) efficiently home to pulmonary neutrophils, while protein nanoparticles with symmetric structure (e.g. viral capsids) are ignored by pulmonary neutrophils. We validated this finding by engineering protein-conjugated liposomes that recapitulate NAP targeting to neutrophils in inflamed lungs. We show that NAPs can diagnose acute lung injury MESHD in SPECT imaging and that NAP-like liposomes can mitigate neutrophil extravasation and pulmonary edema HP pulmonary edema MESHD arising in lung inflammation MESHD. Finally, we demonstrate that ischemic MESHD ex vivo human lungs selectively take up NAPs, illustrating translational potential. This work demonstrates that structure-dependent interactions with neutrophils can dramatically alter the biodistribution of nanoparticles, and NAPs have significant potential in detecting and treating respiratory conditions arising from injury or infections MESHD.

The ZB MED preprint Viewer preVIEW includes all COVID-19 related preprints from medRxiv and bioRxiv, from ChemRxiv, from ResearchSquare, from arXiv and from Preprints.org and is updated on a daily basis (7am CET/CEST).
The web page can also be accessed via API.

Sources


Annotations

All
None
MeSH Disease
Human Phenotype
Transmission
Seroprevalence


Export subcorpus as...

This service is developed in the project nfdi4health task force covid-19 which is a part of nfdi4health.

nfdi4health is one of the funded consortia of the National Research Data Infrastructure programme of the DFG.