Corpus overview


Overview

MeSH Disease

Transmission

Seroprevalence

There are no seroprevalence terms in the subcorpus

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    COVID-19 MESHD: In the Eye of the Cytokine Storm

    Authors: Roberto de la Rica; Marcio Borges; Marta Gonzalez-Freire

    id:10.20944/preprints202005.0157.v1 Date: 2020-05-09 Source: Preprints.org

    The dysregulated release of cytokines has been identified as one of the key factors behind poorer outcomes in COVID-19 MESHD. This ‘cytokine storm ‘produces an excessive inflammatory and immune response, especially in the lungs, leading to acute respiratory distress HP respiratory distress MESHD (ARDS), pulmonary edema MESHD pulmonary edema HP and multi-organ failure MESHD. Alleviating this inflammatory state is crucial to improve prognosis. Pro-inflammatory factors play a central role in COVID-19 MESHD severity, especially in patients with comorbidities In these situations, an overactive, untreated immune response can be deadly, suggesting that mortality in COVID-19 MESHD cases is likely due to this virally driven hyperinflammation. Administering immunomodulators has not yielded conclusive improvements in other pathologies characterized by dysregulated inflammation MESHD such as sepsis MESHD sepsis HP, SARS-CoV-1 and MERS. The success of these drugs at reducing COVID-19 MESHD-driven inflammation MESHD is still anecdotal and comes with serious risks. It is also imperative to screen the elderly TRANS for risk factors that predispose them to severe COVID-19 MESHD. Immunosenescence and comorbidities should be taken into consideration. In this review, we summarize the latest data available about the role of the cytokine storm in COVID-19 MESHD disease severity as well as potential therapeutic approaches to ameliorate it. We also examine the role of inflammation MESHD in other diseases often comorbid with COVID-19 MESHD, such as aging, sepsis MESHD sepsis HP, and pulmonary disorders MESHD. Finally, we identify gaps in our knowledge and suggest priorities for future research aimed at stratifying patients according to risk as well as personalizing therapies in the context of COVID19 MESHD-driven hyperinflammation.

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MeSH Disease
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