Corpus overview


MeSH Disease

Human Phenotype

There are no HP terms in the subcorpus


gender (1)


There are no seroprevalence terms in the subcorpus

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    COVID-19 MESHD-Related Abnormal Liver Enzymes Levels: A Retrospective Study

    Authors: Jian-dan Qian; Yan Wang; Tian-tian Yao; Hai-chao Li; gui-qiang Wang

    doi:10.21203/ Date: 2020-06-19 Source: ResearchSquare

    Background: A new disease called Coronavirus disease MESHD ( COVID-19 MESHD) related to SARS-CoV-2 has brought serious attacks to the world. It causes damage to multiple organ systems of the body include liver. Here we intend to shed light on the clinical features its mechanism related to liver damage which caused by COVID-19 MESHD.Methods: Clinical records and laboratory results were obtained from 138 patients with laboratory-confirmed COVID-19 MESHD who were admitted to Tongji hospital, Wuhan, China from February 8, 2020 to February 18, 2020. Information on clinical features of patients with abnormal liver tests were collected for analysis.Results: Fifty-four (39.1%) and eighty-three (60.1%) patients had abnormal liver enzyme levels on admission and during the course of disease. Hepatocyte type was more common than cholestatic type abnormal MESHD. 24(17.4%) patients reached the liver injury MESHD standard in the course of disease. Patients with abnormal liver enzyme levels were more likely to be male TRANS, had higher levels of inflammation MESHD indicators, lower pulse oxygen saturation and lymphocyte count. There is a significantly higher proportion of abnormal liver enzymes levels in the patients which administrated antibiotics during hospitalization, compared with that in the ones without antibiotics therapy (56.6% vs 32.7%). Patients with liver injury MESHD was an independent predictor of a poor prognosis (p<0.0001, OR 7.774, 95%CI 2.674-22.599).Conclusions: Liver injury MESHD in COVID-19 MESHD patients was an independent predictor of a poor prognosis. The COVID-19 MESHD-related abnormal liver enzymes levels may be considered as the result of secondary liver damage caused mainly by several factors. Hypoxia MESHD and disease severity account for the largest proportion.

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MeSH Disease
Human Phenotype

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