Corpus overview


MeSH Disease

COVID-19 (1)

Fever (1)

Fatigue (1)

Diarrhea (1)

Dyspnea (1)

HGNC Genes

SARS-CoV-2 proteins

There are no SARS-CoV-2 protein terms in the subcorpus


SARS-CoV-2 Proteins
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    Prediction Model of Severe Coronavirus Disease 2019 MESHD( COVID-19 MESHD) Cases Shows the Leading Risk Factor of Hypocalcemia

    Authors: Chenchan Hu; Feifei Su; Jianyi Dai; Shushu Lu; Lianpeng Wu; Dong Chen; Qifa Song; Fan Zhou

    doi:10.21203/ Date: 2020-07-12 Source: ResearchSquare

    Background A striking characteristic of Coronavirus Disease 2019 MESHD( COVID-19 MESHD) is the coexistence of clinically mild and severe cases. A comprehensive analysis of multiple risk factors predicting progression to severity is clinically meaningful. Methods The patients were classified into moderate and severe groups. The univariate regression analysis was used to identify their epidemiological and clinical features related to severity, which were used as possible risk factors and were entered into a forward-stepwise multiple logistic regression analysis to develop a multiple factor prediction model for the severe cases.Results 255 patients (mean age, 49.1±SD 14.6) were included, consisting of 184 (72.2%) moderate cases and 71 (27.8%) severe cases. The common symptoms were dry cough (78.0%), sputum (62.7%), and fever MESHD (59.2%). The less common symptoms were fatigue MESHD (29.4%), diarrhea MESHD (25.9%), and dyspnea MESHD (20.8%). The univariate regression analysis determined 23 possible risk factors. The multiple logistic regression identified seven risk factors closely related to the severity of COVID-19 MESHD, including dyspnea MESHD, exposure history in Wuhan, CRP HGNC ( C-reactive protein HGNC), aspartate aminotransferase ( AST HGNC), calcium, lymphocytes, and age. The probability model for predicting the severe COVID-19 MESHD was P=1/1+exp (-1.78+1.02×age+1.62×high-transmission-setting-exposure +1.77× dyspnea MESHD+1.54×CRP+1.03×lymphocyte+1.03×AST+1.76×calcium). Dyspnea MESHD (OR=5.91) and hypocalcemia MESHD (OR=5.79) were the leading risk factors, followed by exposure to a high-transmission setting (OR=5.04), CRP HGNC (OR=4.67), AST HGNC (OR=2.81), decreased lymphocyte count (OR=2.80), and age (OR=2.78). Conclusions This quantitative prognosis prediction model can provide a theoretical basis for the early formulation of individualized diagnosis and treatment programs and prevention of severe diseases.

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MeSH Disease
HGNC Genes
SARS-CoV-2 Proteins

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