Corpus overview


MeSH Disease

HGNC Genes

There are no HGNC terms in the subcorpus



There are no seroprevalence terms in the subcorpus

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    Risk Factors of Secondary Infections in Severe HP and Critical Patients Hospitalized with COVID-19 MESHD: A Case-Control Study

    Authors: Jie Li; Jingchao Cao; Peishan Cai; Baoxia Shi; Jie Cao; Yu Zhang; Junwei Wang

    doi:10.21203/ Date: 2020-08-08 Source: ResearchSquare

    Background: Severe patients hospitalized with COVID-19 MESHD suffered secondary infections which greatly increased the length of hospital stay and the mortality. We aimed to explore risk factors of secondary infections that can help clinicians early implement preventive measures to dispose of severe and critical inpatients with COVID-19 MESHD.Methods: A case-control study enrolled 238 severe and critical patients with COVID-19 MESHD. Characteristics of cases and controls were compared.Results: Severity of illness on admission, ICU admission, ventilator, central venous catheterization were common in the cases, however almost none of these factors was observed in the controls. Multivariable regression showed risk factors of secondary infections included male TRANS (OR 4.08; 95% CI 1.58-10.50), age TRANS 65 or older (OR 3.11; 95% CI 1.25-7.76), heart diseases MESHD (OR 3.96; 95% CI 1.40-11.27), hypoproteinemia HP hypoproteinemia MESHD on admission (OR 6.41; 95% CI 1.65-24.92) and corticosteroids (OR 19.83; 95% CI 7.3-53.55) and proton-pump inhibitors (OR 3.96; 95% CI 1.51-10.37).Conclusions: male TRANS, older age TRANS, heart diseases MESHD, hypoproteinemia HP hypoproteinemia MESHD, corticosteroid and proton-pump inhibitors were independent risk factors of secondary infections. Inpatients needing ICU admission and invasive devices still need to be given optimal cares and to be minimized the duration.

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MeSH Disease
HGNC Genes

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