Corpus overview


MeSH Disease

HGNC Genes

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    Virologic and clinical characteristics for prognosis of severe COVID-19 MESHD: a retrospective observational study in Wuhan, China

    Authors: Sha Fu; Xiaoyu Fu; Yang Song; Min Li; Pin-hua Pan; Tao Tang; Chunhu Zhang; Tiejian Jiang; Deming Tan; Xuegong Fan; Xinping Sha; Jingdong Ma; Yan Huang; Shaling Li; Yixiang Zheng; Zhaoxin Qian; Zeng Xiong; Lizhi Xiao; Huibao Long; Jianghai Chen; Yi Ouyang

    doi:10.1101/2020.04.03.20051763 Date: 2020-04-06 Source: medRxiv

    Background: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has progressed to a pandemic associated with substantial morbidity and mortality. The WHO and the United States Center for Disease Control and Prevention (CDC) have issued interim clinical guidance for management of patients with confirmed coronavirus disease MESHD ( COVID-19 MESHD), but there is limited data on the virologic and clinical characteristics for prognosis of severe COVID-19 MESHD. Methods: A total of 50 patients with severe COVID-19 MESHD were divided into good and poor recovery groups. The dynamic viral shedding and serological characteristics of SARS-CoV-2 were explored. The risk factors associated with poor recovery and lung lesion MESHD resolutions were identified. In addition, the potential relationships among the viral shedding, the pro-inflammatory response, and lung lesion MESHD evolutions were characterized. Results: A total of 58% of the patients had poor recovery and were more likely to have a prolonged interval of viral shedding. The longest viral shedding was 57 days after symptom onset TRANS. Older age TRANS, hyperlipemia MESHD, hypoproteinemia MESHD hypoproteinemia HP, corticosteroid therapy, consolidation on chest computed-tomography (CT), and prolonged SARS-CoV-2 IgM positive were all associated with poor recovery. Additionally, the odds of impaired lung lesion MESHD resolutions were higher in patients with hypoproteinemia MESHD hypoproteinemia HP, hyperlipemia MESHD, and elevated levels of IL-4 and ferritin. Finally, viral shedding and proinflammatory responses were closely correlated with lung lesion MESHD evolutions on chest CT. Conclusions Patients with severe COVID-19 MESHD have prolonged SARS-CoV-2 infection MESHD and delayed intermittent viral shedding. Older age TRANS, hyperlipemia MESHD, hypoproteinemia MESHD hypoproteinemia HP, corticosteroid usage, and prolonged SARS-CoV-2 IgM positive might be utilized as predicative factors for the patients with poor recovery.

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MeSH Disease
HGNC Genes

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