Corpus overview


Overview

MeSH Disease

HGNC Genes

Transmission

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Seroprevalence
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    THE PATHOGENESIS OF THROMBOEMBOLIC DISEASE IN COVID-19 MESHD PATIENTS: COULD BE A CATASTROPHIC ANTIPHOSPHOLIPID SYNDROME?

    Authors: Giulia Previtali; Michela Seghezzi; Valentina Moioli; Aurelio Sonzogni; Roberto Marozzi; Lorenzo Cerutti; Rudi Ravasio; Andrea Gianatti; Giovanni Guerra; Maria Grazia Alessio

    doi:10.1101/2020.04.30.20086397 Date: 2020-05-06 Source: medRxiv

    Background The most severely COVID-19 MESHD patients need intensive care and show increased risk of thromboembolic MESHD events. Although some patients meet the diagnostic criteria for the Disseminated Intravascular Coagulation HP, the pathogenesis of the diffuse thrombotic MESHD status remains unclear. The aim of the present study is to evaluate the presence of antiphospholipid antibodies SERO (aPL) in sera of deceased patients with autoptic proven thrombotic microangiopathy MESHD to evaluate if some patients may have developed Catastrophic Antiphospholipid Syndrome MESHD ( CAPS MESHD CAPS HGNC). Methods Thirty-five patients were enrolled. The available medical history, comorbidities, therapies, laboratory and autopsy findings were collected post-mortem from clinical records. IgA, IgG and IgM anti cardiolipin (ACA) and anti { beta}2 glycoprotein 1 HGNC ({beta}2GP1) antibodies, IgG and IgM SERO anti phosphatidylserine/prothrombin (PS/PT) antibodies were tested SERO for all the patients. Results 3/35 (8.6%) patients were slightly positive for aPL: one for ACA IgG and two for ACA IgM but values were low (< 3X the cut off). No patients tested positive for ACA IgA neither for {beta}2GP1 isotypes. 3/35 (8.6%) patients were positive for PS/PT, one for IgG and two for IgM, but values were less than 2X the cut off. No patients showed simultaneous positivity for ACA and PS/ PT. Conclusions It is difficult to categorize the vascular events into a conventional disease: we did not find significant association with anti-phospholipid antibodies SERO. It is most likely that several factors contribute to trigger the hypercoagulability HP hypercoagulability MESHD status and the thromboembolism HP thromboembolism MESHD but, on the basis our results, CAPS MESHD CAPS HGNC is probably not involved into the pathogenesis of these phenomena.

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MeSH Disease
HGNC Genes
Transmission
Seroprevalence


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