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MeSH Disease

Transmission

Seroprevalence
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    Dynamic characteristics of Influenza A epidemic in children TRANS during the early stage of COVID-19 MESHD outbreak

    Authors: Xia Wang; Pin Liu; Shuwen Feng; Junwen Zhen; Yan Wu; Zhenyu Pan; Dongchi Zhao

    doi:10.21203/rs.3.rs-60623/v1 Date: 2020-08-16 Source: ResearchSquare

    Background: At the beginning of the outbreak of coronavirus infected disease MESHD 2019 ( COVID-19 MESHD), children TRANS in Wuhan were experiencing an extremely strong influenza A epidemic. This study is aimed to explore the epidemic dynamics characteristics of children TRANS with influenza A and its correlation with the early stage spread of COVID-19 MESHD in Wuhan.Methods: This is a retrospective single-center clinical study.From November 28, 2019 to January 23, 2020, a total of 7904 outpatient children TRANS with signs of respiratory tract infection MESHD respiratory tract infection HP were admitted, and a total of 10102 throat swabs were collected. All the detection were performed to the throat swabs of patients, which include the epidemic statues, detection rate, duration of Flu A and B persistence in airway, and the positive rate of COVID-19 MESHD nucleic acid.Results: A total of 10102 throat swabs were obtained from children TRANS with respiratory symptoms, including 5450 (53.9%) male TRANS and 4652 (46.1%) female TRANS. 2899 (28.7%) cases were positive for Influenza A. There were 617 (6.1% ) cases of Influenza B . In group of Influenza A , the lowest positive rate was in the infants less than 1 year old (18.4%), and the highest in the group 12 year old (32.1%). During the period of high prevalence SERO of influenza A, there was a low level of infection of influenza B. The detection rate of each age group TRANS fluctuated from 3% to 10%. 73.7% of children TRANS's influenza A and B virus turned negative within 7 days, and very few children TRANS's respiratory influenza virus can last even more than 1 month. Among 35 throat swabs detected with qRT-PCR, 11 (31.4%) were positive for Flu A, and all children TRANS were negative for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).Conclusions: In the early stage of SARS-CoV-2 transmission, children TRANS in Wuhan were experiencing a high intensity of influenza A pandemic, and there was no the mixed infection of SARS-CoV-2 MESHD with influenza A.  COVID-19 MESHD spread caught up the tail of influenza A pandemic. 

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MeSH Disease
Transmission
Seroprevalence


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