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HGNC Genes

SARS-CoV-2 proteins

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    Clinical characteristics of COVID-19 MESHD patients in Latvia under low incidence in Spring 2020

    Authors: Ludmila Viksna; Oksana Kolesova; Aleksandrs Kolesovs; Ieva Vanaga; Seda Arutjunana; Sniedze Laivacuma; Jelena Storozenko; Ieva Tolmane; Ilze Berzina; Baiba Rozentale

    doi:10.1101/2020.12.22.20239392 Date: 2020-12-24 Source: medRxiv

    Background: COVID-19 MESHD is a new infectious disease MESHD with severe disease course and high mortality in some groups. Blood tests on admission to the hospital can be useful for stratification of patients and timely correction. Our study investigated the clinical features of COVID-19 MESHD patients in Latvia and differences in blood tests in groups with different disease severity. Methods: The retrospective study included 100 patients hospitalized in Riga East Clinical University Hospital in Spring 2020. The severity of the disease course was classified by the presence of pneumonia MESHD and its combination with respiratory failure MESHD. We have assessed blood cells' count, hemoglobin, hematocrit, erythrocyte sedimentation rate (ESR), C-reactive protein HGNC ( CRP HGNC), alanine aminotransferase HGNC, lactate dehydrogenase (LDH), troponin T, electrolytes, creatinine, glomerular filtration rate (GFR), D-dimer, prothrombin time, prothrombin index, oxygen saturation, and temperature on admission to the hospital. Results: Patients were from 18 to 99, 57% males. Comorbidities were found in 74% of patients. The mild, moderate, and severe groups included 35, 44, and 16 patients, respectively. In the severe group, the mortality rate was 50%. The progression to severe COVID-19 MESHD was associated positively with temperature, ESR, CRP HGNC, creatinine, LDH, and troponin T and negatively associated with oxygen saturation, eosinophils, and GFR on admission to the hospital. Conclusions: COVID-19 MESHD severity associates with lower renal function and a higher level of inflammation MESHD and tissue damage. Eosinophils, CRP HGNC, ESR, LDH, troponin T, creatinine, and GFR are blood indicators for monitoring patients' condition.

    Maternal and neonatal outcomes of pregnant women with COVID-19 MESHD pneumonia: a case-control study

    Authors: Na Li; Lefei Han; Min Peng; Yuxia Lv; Yin Ouyang; Kui Liu; Linli Yue; Qiannan Li; Guoqiang Sun; Lin Chen; Lin Yang

    doi:10.1101/2020.03.10.20033605 Date: 2020-03-13 Source: medRxiv

    Background The ongoing epidemics of coronavirus disease 2019 MESHD ( COVID-19 MESHD) have caused serious concerns about its potential adverse effects on pregnancy. There are limited data on maternal and neonatal outcomes of pregnant women with COVID-19 MESHD pneumonia MESHD. Methods We conducted a case-control study to compare clinical characteristics, maternal and neonatal outcomes of pregnant women with and without COVID-19 MESHD pneumonia MESHD. Results During January 24 to February 29, 2020, there were sixteen pregnant women with confirmed COVID-19 MESHD pneumonia MESHD and eighteen suspected cases who were admitted to labor in the third trimester. Two had vaginal delivery and the rest took cesarean section. Few patients presented respiratory symptoms ( fever MESHD and cough MESHD) on admission, but most had typical chest CT images of COVID-19 MESHD pneumonia MESHD. Compared to the controls, COVID-19 MESHD pneumonia MESHD patients had lower counts of white blood cells (WBC), neutrophils, C-reactive protein HGNC ( CRP HGNC), and alanine aminotransferase HGNC (ALT) on admission. Increased levels of WBC, neutrophils, eosinophils, and CRP HGNC were found in postpartum blood tests of pneumonia MESHD patients. There were three (18.8%) and two (10.5%) of the mothers with confirmed or suspected COVID-19 MESHD pneumonia MESHD had preterm delivery due to maternal complications, which were significantly higher than the control group. None experienced respiratory failure MESHD during hospital stay. COVID-19 MESHD infection was not found in the newborns and none developed severe neonatal complications. Conclusion Severe maternal and neonatal complications were not observed in pregnant women with COVID-19 MESHD pneumonia MESHD who had vaginal delivery or caesarean section. Mild respiratory symptoms of pregnant women with COVID-19 MESHD pneumonia MESHD highlight the need of effective screening on admission.

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MeSH Disease
HGNC Genes
SARS-CoV-2 Proteins


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