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MeSH Disease

COVID-19 (2)


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SARS-CoV-2 proteins

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    The Application of Lactate Dehydrogenase in Coronavirus Disease 2019 MESHD as the Best Indicator for the Progression and Clinical Status: A Case-Control Study

    Authors: Yang Li; Xian Zhou; Jing-wen Ai; Hongyu Wang; Taoping Weng; Haocheng Zhang; Yuxian Huang; Wenhong Zhang

    doi:10.21203/rs.3.rs-55590/v1 Date: 2020-08-07 Source: ResearchSquare

    Introduction Coronavirus disease 2019 MESHD ( COVID-19 MESHD) is now officially a pandemic. Current studies observed extensive abnormal indexes in COVID-19 MESHD patients and significant differences between mild and severe patients. However, which index would perform better as the indicator of disease progression merits further investigation.Methods We enrolled COVID-19 MESHD patients who were admitted to Shanghai Public Health Clinical center. We closely monitored the following candidate indictors: white blood cell, lymphocyte, platelet, CD4 T cell, CD8 T cell, alanine aminotransferase HGNC, estimated glomerular filtration rate ( eGFR HGNC), fibrin degradation products (FDP), D-dimer, creatine kinase, myoglobin HGNC, troponin T ( TnT HGNC), N-terminal pro-B-type natriuretic peptide (NT-proBNP), lactase dehydrogenase (LDH), C-reactive protein HGNC ( CRP HGNC), and procalcitonin. The correlation with illness severity were assessed by Spearman analysis and the ability of differentiating the clinical statuses was quantified as the AUC value of the ROC curve. Results A total of 326 patients were enrolled, including 299 mild-ordinary and 27 severe-critical patients. At admission, D-dimer and CRP HGNC were elevated above normal range both in mild-ordinary and severe-critical patients. LDH, NT-proBNP, myoglobin HGNC, CD4 T cell, eGFR HGNC, FDP and PCT were beyond normal range in the mild-ordinary stages of severe-critical patients, but remained normal in the persistently mild-ordinary patients. Top 5 parameters with highest spearmen coefficient were LDH, procalcitonin, NT-proBNP, myoglobin HGNC and D-dimer (Spearman coefficient: 0.488, 0.453, 0.414, 0.412, 0.407). Comparing between mild-ordinary stage and severe/critical stage, LDH showed the highest receiver operating characteristics (ROC) area under the curve (AUC) of 0.951. PCT ranked second, with the ROC AUC of 0.905. Comparing between mild-ordinary and severe stages, only LDH had the ROC AUC of over 0.90 (0.927). Conclusions This study found LDH to be a superior indicator for COVID-19 MESHD status and had the potential to optimize the clinical management strategy.

    Laboratory features in severe vs. non-severe COVID-19 MESHD patients, a systematic review and meta-analysis

    Authors: Sulmaz Ghahramani; Reza Tabrizi; Kamran B Lankarani; Seyyed mohammad amin Kashani; Shahla Rezaei; Nazanin Zeidi; Maryam Akbari; Seyed Taghi Heydari; Hamed Akbari; Peyman Nowrouzi-sohrabi; Fariba Ahmadizar

    doi:10.21203/rs.3.rs-29435/v1 Date: 2020-05-15 Source: ResearchSquare

    OBJECTIVE: Understanding the common laboratory features of COVID-19 MESHD in severe cases versus non-severe patients could be quite useful for clinicians and might help to predict the model of disease progression. MATERIALS AND METHODS: Electronic databases were systematically searched in PubMed, EMBASE, Scopus, Web of ‎Science, and Google Scholar from inception to 3rd of March 2020. Heterogeneity across included ‎studies was determined using Cochrane’s Q test and the I2 statistic. We used the fixed or random-effect models to pool ‎the weighted mean differences (WMDs) or standardized mean differences and 95% confidence ‎intervals (CIs).‎RESULTS:‎ Out of a total of 3009 citations, 17 articles (22 studies, 21 from China and one study from Singapour) with 3396 ranging from 12-1099 patients, ‎were included. Our meta-analyses showed a significant decrease in ‎lymphocyte, monocyte, and eosinophil, hemoglobin, platelet, albumin, serum sodium, lymphocyte to C-reactive protein HGNC ratio (LCR), leukocyte to C-reactive protein HGNC ratio (LeCR), leukocyte to IL-6 HGNC ratio (LeIR), and an increase in the ‎neutrophil, alanine ‎aminotransferase HGNC (ALT), aspartate aminotransferase ( AST HGNC), total bilirubin, blood urea nitrogen (BUN), creatinine (Cr), erythrocyte sedimentation rate (ESR), C-reactive protein HGNC ( CRP HGNC), procalcitonin (PCT), lactate dehydrogenase (LDH), fibrinogen HGNC, prothrombin time (PT), D-dimer, glucose ‎level, and neutrophil to lymphocyte ratio (NLR) in the severe group compared with the non-severe group. However, no significant changes were observed in white blood cells (WBC), ‎ creatine kinase (CK), troponin I, myoglobin HGNC, interleukin-6 HGNC ( IL-6 HGNC), and potassium (K) between the two groups.‎CONCLUSIONS: This meta-analysis provides evidence for the differentiation of severe cases of COVID-19 MESHD based on laboratory test results at the time of hospital admission. Future well-methodologically designed studies from other populations are strongly recommended.

The ZB MED preprint Viewer preVIEW includes all COVID-19 related preprints from medRxiv and bioRxiv, from ChemRxiv, from ResearchSquare, from arXiv and from Preprints.org and is updated on a daily basis (7am CET/CEST).
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MeSH Disease
HGNC Genes
SARS-CoV-2 Proteins


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