Corpus overview


Overview

MeSH Disease

There are no MeSH Disease terms in the subcorpus


HGNC Genes

SARS-CoV-2 proteins

ProteinS (1)

ORF3a (1)


Filter

Genes
Diseases
SARS-CoV-2 Proteins
    displaying 1 - 1 records in total 1
    records per page




    Molecular dynamics simulation study of effects of key mutations in SARS-CoV-2 on protein structures

    Authors: Jerome Rumdon Lon; Binbin Xi; Bingxu Zhong; Yiyuan Zheng; Pei Guo; Zixi Chen; Hongli Du

    doi:10.1101/2021.02.03.429495 Date: 2021-02-03 Source: bioRxiv

    SARS-CoV-2 has been spreading rapidly since 2019 and has produced large-scale mutations in the genomes. Differences in gene sequences may lead to changes in protein structure and traits, which would have a great impact on the epidemiological characteristics. In this study, we selected the key mutations of SARS-CoV-2, including D614G and A222V of S protein PROTEIN S protein HGNC and Q57H of ORF3a PROTEIN protein, to conduct molecular dynamics simulation and analysis on the structures of the mutant proteins. The results suggested that D614G improved the stability of S protein PROTEIN S protein HGNC, while A222V enhanced the ability of protein to react with the outside environment. Q57H enhanced the structural flexibility of ORF3a PROTEIN protein. Our findings could complete the mechanistic link between genotype--phenotype--epidemiological characteristics in the study of SARS-CoV-2. We also found no significant changes in the antigenicity of S protein HGNC S protein PROTEIN, ORF3a PROTEIN protein and their mutants, which provides reference for vaccine development and application.

The ZB MED preprint Viewer preVIEW includes all COVID-19 related preprints from medRxiv and bioRxiv, from ChemRxiv, from ResearchSquare, from arXiv and from Preprints.org and is updated on a daily basis (7am CET/CEST).
The web page can also be accessed via API.

Sources


Annotations

All
None
MeSH Disease
HGNC Genes
SARS-CoV-2 Proteins


Export subcorpus as...

This service is developed in the project nfdi4health task force covid-19 which is a part of nfdi4health.

nfdi4health is one of the funded consortia of the National Research Data Infrastructure programme of the DFG.