Corpus overview


Overview

MeSH Disease

Human Phenotype

Edema (2)

Weight loss (1)


Transmission

Seroprevalence

There are no seroprevalence terms in the subcorpus

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    Hyaluronan is abundant in COVID-19 respiratory secretions

    Authors: Gernot Kaber; Michael J. Kratochvil; Elizabeth B Burgener; Egan L Peltan; Graham Barlow; Samuel Yang; Mark R Nicolls; Vinicio de Jesus Perez; Joelle I. Rosser; Andrew J. Wardle; Anissa Kalinowski; Michael G. Ozawa; Donald P. Regula; Nadine Nagy; Sarah C. Heilshorn; Carlos E. Milla; Angela J. Rogers; Paul L. Bollyky; Marcus VG Lacerda; Pedro M Moraes-Vieira; Helder I Nakaya; Qiao Wang; Hongbin Ji; Youhua Xie; Yihua Sun; Lu Lu; Yunjiao Zhou

    doi:10.1101/2020.09.11.20191692 Date: 2020-09-11 Source: medRxiv

    COVID-19 respiratory infections MESHD are associated with copious, adherent respiratory secretions that prolong chronic ventilation and contribute to the morbidity and mortality caused by the disease. We hypothesized that hyaluronan, an extracellular matrix glycosaminoglycan produced at sites of active inflammation MESHD that promotes edema HP edema MESHD in other settings, might be a component of these secretions. To interrogate this, we examined the respiratory secretions collected from eight intubated patients with COVID-19, six control patients with cystic fibrosis MESHD ( CF MESHD), a different respiratory disease MESHD also associated with thick adherent secretions, and eight healthy controls. In this sample set we found that hyaluronan content is increased approximately 20-fold in both CF MESHD and COVID-19 patients compared to healthy controls. The hyaluronan in COVID-19 samples was comprised of low-molecular weight fragments, the hyaluronan form most strongly linked with pro-inflammatory functions. Hyaluronan is similarly abundant in histologic sections from cadaveric lung tissue from COVID-19 patients. These findings implicate hyaluronan in the thick respiratory secretions characteristic of COVID-19 infection MESHD. Therapeutic strategies targeting hyaluronan should be investigated further for potential use in patients with COVID-19.

    Age TRANS-dependent progression of SARS-CoV-2 infection MESHD in Syrian hamsters

    Authors: Nikolaus Osterrieder; Luca D. Bertzbach; Kristina Dietert; Azza Abdelgawad; Daria Vladimirova; Dusan Kunec; Donata Hoffmann; Martin Beer; Achim D. Gruber; Jakob Trimpert

    doi:10.1101/2020.06.10.144188 Date: 2020-06-10 Source: bioRxiv

    In late 2019, an outbreak of a severe respiratory disease MESHD caused by an emerging coronavirus, SARS-CoV-2, resulted in high morbidity and mortality in infected humans1. Complete understanding of COVID-19, the multi-faceted disease caused by SARS-CoV-2, requires suitable small animal models, as does the development and evaluation of vaccines and antivirals2. Because age TRANS-dependent differences of COVID-19 were identified in humans3, we compared the course of SARS-CoV-2 infection MESHD in young and aged TRANS Syrian hamsters. We show that virus replication in the upper and lower respiratory tract was independent of the age TRANS of the animals. However, older hamsters exhibited more pronounced and consistent weight loss HP weight loss MESHD. In situ hybridization in the lungs identified viral RNA in bronchial epithelium, alveolar epithelial MESHD cells type I and II, and macrophages. Histopathology revealed clear age TRANS-dependent differences, with young hamsters launching earlier and stronger immune cell influx than aged TRANS hamsters. The latter developed conspicuous alveolar MESHD and perivascular edema HP edema MESHD, indicating vascular leakage. In contrast, we observed rapid lung recovery at day 14 after infection MESHD only in young hamsters. We propose that comparative assessment in young versus aged TRANS hamsters of SARS-CoV-2 vaccines and treatments may yield valuable information as this small-animal model appears to mirror age TRANS-dependent differences in human patients.

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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