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MeSH Disease

Human Phenotype

Transmission

Seroprevalence
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    Kawasaki Disease MESHD Outbreak in Children TRANS During COVID-19 Pandemic.

    Authors: Ewelina Gowin; Jacek Wysocki; Magdalena Frydrychowicz; Danuta Januszkiewicz-Lewandowska

    doi:10.21203/rs.3.rs-70123/v1 Date: 2020-09-01 Source: ResearchSquare

    BackgroundIn response to the recent information about the outbreak of Kawasaki disease MESHD ( KD MESHD) in children TRANS connected to SARS-Cov-2 pandemic, we would like to present a group of six patients hospitalized from March to May 2020 with an inflammatory disease similar to KD MESHD. Findings There were four girls and two boys, aged TRANS from 15 months to 16 years. They all presented with fever HP fever MESHD lasting at least five days, irritability HP irritability MESHD, bilateral nonexudative conjunctivitis HP conjunctivitis MESHD, lymphadenopathy, mucus membrane changes, rash MESHD, edema HP edema MESHD.Neither the patients nor the other members of the patients' households had a positive history of COVID-19 infection MESHD. None of the six children TRANS had a positive PCR result for SARS-CoV-2 or a positive results for antibodies to SARS-CoV-2 SERO. All patients received empiric antibiotic therapy. Four patients were diagnosed with KD MESHD. Three children TRANS received standard treatment. One boy did not respond and received an additional 14-days course of methylprednisolone.In two girls, the diagnosis of KD MESHD was not made. All patients survived ConclusionFinding a correlation with the Covid-19 pandemic is difficult regarding the situation in our country. According to ECDC, in May 2020 Poland wass still before the peak of the epidemy. The intention of this article is to report that increased hospitalization of children TRANS with the inflammatory syndrome MESHD is also observed in countries with low levels of transmission TRANS of the SARS-Cov-2 virus. Our observation may broaden the knowledge of new inflammatory syndrome MESHD, which is not necessarily caused by SARS-Cov-2 but may be worsened by co-infection MESHD.

    Clinical and intestinal histopathological findings in SARS-CoV-2/COVID-19 patients with hematochezia HP hematochezia MESHD

    Authors: Margaret Cho; Weiguo Liu; Sophie Balzora; Yvelisse Suarez; Deepthi Hoskoppal; Neil D Theise; Wenqing Cao; Suparna A Sarkar

    doi:10.1101/2020.07.29.20164558 Date: 2020-08-07 Source: medRxiv

    Gastrointestinal ( GI MESHD) symptoms of SARS-CoV2/COVID-19 in the form of anorexia HP anorexia MESHD, nausea, vomiting HP nausea, vomiting MESHD vomiting MESHD, abdominal pain HP abdominal pain MESHD and diarrhea HP diarrhea MESHD are usually preceeded by respiratory manifestations and are associated with a poor prognosis. Hematochezia HP Hematochezia MESHD is an uncommon clinical presentation of COVID-19 disease and we hypothesize that older patients with significant comorbidites ( obesity HP obesity MESHD and cardiovascular) and prolonged hospitalization are suspectible to ischemic injury MESHD to the bowel. We reviewed the clinical course, key laboratory data including acute phase reactants, drug/medication history in two elderly TRANS male TRANS patients admitted for COVID-19 respiratory failure HP respiratory failure MESHD. Both patients had a complicated clinical course and suffered from hematochezia HP hematochezia MESHD and acute blood SERO blood MESHD loss anemia HP requiring blood SERO transfusion around day 40 of their hospitalization. Colonoscopic impressions were correlated with the histopathological findings in the colonic biopies and changes compatible with ischemia MESHD to nonspecific acute inflammation MESHD, edema HP edema MESHD and increased eosinophils in the lamina propria were noted.Both patients were on anticoagulants, multiple antibiotics and antifungal agents due to respiratory infections MESHD at the time of lower GI bleeding MESHD. Hematochezia HP Hematochezia MESHD resolved spontaneously with supportive care. Both patients eventually recovered and were discharged. Elderly TRANS patients with significant comorbid conditions are uniquely at risk for ischemic injury MESHD to the bowel. Hypoxic conditions MESHD due to COVID-19 pneumonia HP pneumonia MESHD and respiratory failure HP respiratory failure MESHD, compounded by preexisting cardiovascular complications, and/or cytokine storm orchestrated by the viral infection leading to alteration in coagulation profile and/or drug/medication injury can be difficult to distinguish in these critically ill patients. Presentation of hematochezia HP hematochezia MESHD may further increase the mortality and morbidity of COVID-19 patients, and prompt consultation and management by gastroenterology is therefore warranted.

    Clinical Characteristics of 10 Children TRANS With a Pediatric Inflammatory Multisystem Syndrome MESHD Associated with COVID-19 In Iran

    Authors: Leila Shahbaznejad; Mohammad Reza Navaifar; Ali Abbaskhanian; Fatemeh Hosseinzadeh; Golnar Rahimzadeh; Mohammad Sadegh Rezai

    doi:10.21203/rs.3.rs-51157/v3 Date: 2020-07-30 Source: ResearchSquare

    Background: Although symptoms and signs of COVID-19 (Coronavirus disease 2019) in children TRANS are milder than adults TRANS, there are reports of more severe cases which were defined as pediatric inflammatory multisystem syndrome MESHD ( PIMS MESHD). The purpose of this report was to describe the possible association between COVID-19 and PIMS in children TRANS.  Methods: From 28 March to 24 June 2020, 10 febrile children TRANS were admitted with COVID-19 infection MESHD showing characteristics of PIMS in Buali tertiary hospital of Sari, in Mazandaran province, northern Iran. Demographic and clinical characteristics, laboratory and imaging findings, and therapeutic modalities were recorded and analyzed. Results: The mean age TRANS of the patients was 5.37±3.9 years (13 months to 12 years). Six of them were boys. Kawasaki disease MESHD, myocarditis HP myocarditis MESHD, toxic shock syndrome MESHD shock HP syndrome, appendicitis MESHD, sepsis HP sepsis MESHD, urosepsis, prolonged febrile seizure HP seizure MESHD, acute hemorrhagic edema MESHD edema HP of infancy, and COVID-19-related pneumonia HP pneumonia MESHD were their first presentation. All of them had increased C-reactive protein levels, and most of them had elevated erythrocyte sedimentation rate HP, lymphopenia HP lymphopenia MESHD, anemia HP, and hypoalbuminemia HP hypoalbuminemia MESHD. Three of them had thrombocytopenia HP thrombocytopenia MESHD(PLT<106). Six of them were serologically or polymerase chain reaction positive for COVID-19, and 4 of them were diagnosed as COVID-19 just by chest computed tomography scan. Most of the patients improved without a residual sequel, except one who died with multiorgan failure MESHD and another case was discharged with a giant coronary aneurysm MESHD.Conclusion: Children TRANS with COVID-19 may present symptoms similar to Kawasaki disease MESHD and inflammatory syndromes. PIMS should be considered in children TRANS with fever HP fever MESHD, rash MESHD, seizure HP seizure MESHD, cough HP, tachypnea HP tachypnea MESHD, and gastrointestinal symptoms such as vomiting HP vomiting MESHD, diarrhea HP diarrhea MESHD, and abdominal pain HP abdominal pain MESHD.

    Clinical Characteristics of Pediatric Inflammatory Multisystem Syndrome MESHD Associated With COVID-19

    Authors: Leila Shahbaznejad; Mohammad Reza Navaifar; Ali Abbaskhanian; Fatemeh Hosseinzadeh; Mohammad Sadegh Rezai

    doi:10.21203/rs.3.rs-51157/v1 Date: 2020-07-30 Source: ResearchSquare

    Background: Although symptoms and signs of COVID-19 (Coronavirus disease 2019) in children TRANS are milder than adults TRANS, there are reports of more severe cases which was defined as pediatric inflammatory multisystem syndrome MESHD ( PIMS MESHD). The purpose of this report is to describe possible association between COVID-19 and PIMS in children TRANS.  Methods: From 28 March to 24 June 2020, 10 febrile children TRANS were admitted with COVID-19 infection MESHD showing characteristics of PIMS in a tertiary hospital in the north of Iran. Demographic and clinical characteristics, laboratory and imaging findings and therapeutic modalities were recorded and analysed. Results: The mean age TRANS of patients was 5.37±3.9 years (13 months to 12 years). Six of them were boy. Kawasaki disease MESHD, myocarditis HP myocarditis MESHD, toxic shock syndrome MESHD shock HP syndrome, appendicitis MESHD, sepsis HP sepsis MESHD, urosepsis, prolonged febrile seizure HP seizure MESHD, acute hemorrhagic edema MESHD edema HP of infancy, and COVID-19-related pneumonia HP pneumonia MESHD were their first impression. All of them had increased C-reactive protein level and most of them had an elevated erythrocyte sedimentation rate HP, lymphopenia HP lymphopenia MESHD, anemia HP, and hypoalbuminemia HP hypoalbuminemia MESHD. Some of them had thrombocytopenia HP thrombocytopenia MESHD. Six of them were serologically or polymerase chain reaction positive for COVID-19, and 4 of them were diagnosed as COVID-19 just by chest computed tomography scan. Most of the patients improved without a residual sequel, except one who died with multiorgan failure MESHD and another case discharged with a giant coronary aneurysm MESHD.Conclusion: Children TRANS with COVID-19 may present symptoms similar to Kawasaki disease MESHD and inflammatory syndromes. PIMS should be considered in children TRANS with fever HP fever MESHD and rash MESHD, seizure HP seizure MESHD, cough HP, tachypnea HP tachypnea MESHD, and gastrointestinal symptoms such as vomiting HP vomiting MESHD, diarrhea HP diarrhea MESHD, and abdominal pain HP abdominal pain MESHD.

    Clinical Characteristics of Pediatric Inflammatory Multisystem Syndrome MESHD Associated with COVID-19

    Authors: Leila Shahbaznejad; Mohammad Reza Navaifar; Ali Abbaskhanian; Fatemeh Hosseinzadeh; Golnar Rahimzadeh; Mohammad Sadegh Rezai

    doi:10.21203/rs.3.rs-51157/v2 Date: 2020-07-30 Source: ResearchSquare

    Background: Although symptoms and signs of COVID-19 (Coronavirus disease 2019) in children TRANS are milder than adults TRANS, there are reports of more severe cases which were defined as pediatric inflammatory multisystem syndrome MESHD ( PIMS MESHD). The purpose of this report was to describe the possible association between COVID-19 and PIMS in children TRANS.  Methods: From 28 March to 24 June 2020, 10 febrile children TRANS were admitted with COVID-19 infection MESHD showing characteristics of PIMS in Buali tertiary hospital of Sari, in Mazandaran province, northern Iran. Demographic and clinical characteristics, laboratory and imaging findings, and therapeutic modalities were recorded and analyzed. Results: The mean age TRANS of the patients was 5.37±3.9 years (13 months to 12 years). Six of them were boys. Kawasaki disease MESHD, myocarditis HP myocarditis MESHD, toxic shock syndrome MESHD shock HP syndrome, appendicitis MESHD, sepsis HP sepsis MESHD, urosepsis, prolonged febrile seizure HP seizure MESHD, acute hemorrhagic edema MESHD edema HP of infancy, and COVID-19-related pneumonia HP pneumonia MESHD were their first presentation. All of them had increased C-reactive protein levels, and most of them had elevated erythrocyte sedimentation rate HP, lymphopenia HP lymphopenia MESHD, anemia HP, and hypoalbuminemia HP hypoalbuminemia MESHD. Some of them had thrombocytopenia HP thrombocytopenia MESHD. Six of them were serologically or polymerase chain reaction positive for COVID-19, and 4 of them were diagnosed as COVID-19 just by chest computed tomography scan. Most of the patients improved without a residual sequel, except one who died with multiorgan failure MESHD and another case was discharged with a giant coronary aneurysm MESHD. Conclusion: Children TRANS with COVID-19 may present symptoms similar to Kawasaki disease MESHD and inflammatory syndromes. PIMS should be considered in children TRANS with fever HP fever MESHD, rash MESHD, seizure HP seizure MESHD, cough HP, tachypnea HP tachypnea MESHD, and gastrointestinal symptoms such as vomiting HP vomiting MESHD, diarrhea HP diarrhea MESHD, and abdominal pain HP abdominal pain MESHD.

    Age TRANS-dependent progression of SARS-CoV-2 infection MESHD in Syrian hamsters

    Authors: Nikolaus Osterrieder; Luca D. Bertzbach; Kristina Dietert; Azza Abdelgawad; Daria Vladimirova; Dusan Kunec; Donata Hoffmann; Martin Beer; Achim D. Gruber; Jakob Trimpert

    doi:10.1101/2020.06.10.144188 Date: 2020-06-10 Source: bioRxiv

    In late 2019, an outbreak of a severe respiratory disease MESHD caused by an emerging coronavirus, SARS-CoV-2, resulted in high morbidity and mortality in infected humans1. Complete understanding of COVID-19, the multi-faceted disease caused by SARS-CoV-2, requires suitable small animal models, as does the development and evaluation of vaccines and antivirals2. Because age TRANS-dependent differences of COVID-19 were identified in humans3, we compared the course of SARS-CoV-2 infection MESHD in young and aged TRANS Syrian hamsters. We show that virus replication in the upper and lower respiratory tract was independent of the age TRANS of the animals. However, older hamsters exhibited more pronounced and consistent weight loss HP weight loss MESHD. In situ hybridization in the lungs identified viral RNA in bronchial epithelium, alveolar epithelial MESHD cells type I and II, and macrophages. Histopathology revealed clear age TRANS-dependent differences, with young hamsters launching earlier and stronger immune cell influx than aged TRANS hamsters. The latter developed conspicuous alveolar MESHD and perivascular edema HP edema MESHD, indicating vascular leakage. In contrast, we observed rapid lung recovery at day 14 after infection MESHD only in young hamsters. We propose that comparative assessment in young versus aged TRANS hamsters of SARS-CoV-2 vaccines and treatments may yield valuable information as this small-animal model appears to mirror age TRANS-dependent differences in human patients.

    Multisystem inflammatory syndrome MESHD with features of Atypical Kawasaki disease MESHD during COVID-19 pandemic: Report of a case from India

    Authors: Abdul Rauf; Ajay Vijayan; Shaji Thomas John; Raghuram A Krishnan; Abdul Latheef

    doi:10.21203/rs.3.rs-29369/v1 Date: 2020-05-15 Source: ResearchSquare

    There is a global concern of increasing number of children TRANS presenting with inflammatory syndrome MESHD with clinical features simulating Kawasaki disease, during ongoing COVID-19 pandemic. We report a very similar case of 5-year-old boy from a COVID-19 hotspot area in Kerala state of India who presented in late April 2020 with acute febrile illness MESHD with abdominal pain HP abdominal pain MESHD and loose stools followed by shock HP. On examination, child TRANS had bulbar conjunctivitis HP conjunctivitis MESHD and extremity edema HP edema MESHD. Initial investigations showed high inflammatory parameters, elevated serum creatinine HP serum SERO creatinine and liver enzymes. Echocardiography showed moderate LV dysfunction MESHD and normal coronaries. Cardiac enzymes were also elevated, suggesting myocarditis HP myocarditis MESHD. He was treated with inotropic support, respiratory support with High Flow Nasal Cannula, IV Immunoglobulins, aspirin, steroids and diuretics. RT PCR for SARS-CoV-2 was negative twice. His clinical condition improved rapidly, was afebrile from day 2, inflammatory parameters decreased, left ventricular function improved and was discharged after 6 days of hospital stay.

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MeSH Disease
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