Corpus overview


Overview

MeSH Disease

Human Phenotype

Transmission

Seroprevalence

There are no seroprevalence terms in the subcorpus

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    Factors Associated with Disease Severity and Mortality among Patients with Coronavirus Disease MESHD 2019: A Systematic Review and Meta-Analysis

    Authors: Vignesh Chidambaram; Nyan Lynn Tun; Waqas Haque; Marie Gilbert Majella; Ranjith Kumar Sivakumar; Amudha Kumar; Angela Ting-Wei Hsu; Izza Ishak; Aqsha Nur; Samuel Ayeh; Emmanuella Salia; Ahsan Zil-E-Ali; Muhammad Saeed; Ayu Sarena; Bhavna Seth; Muzzammil Ahmadzada; Eman Haque; Pranita Neupane; Kuang-Heng Wang; Tzu-Miao Pu; Syed Ali; Muhammad Arshad; Lin Wang; Sheriza Baksh; Petros Karakousis; Panagis Galiatsatos

    doi:10.1101/2020.08.07.20166868 Date: 2020-08-13 Source: medRxiv

    Background: Understanding the factors associated with disease severity and mortality in Coronavirus disease MESHD (COVID19) is imperative to effectively triage patients. We performed a systematic review to determine the demographic, clinical, laboratory and radiological factors associated with severity and mortality in COVID-19. Methods: We searched PubMed, Embase and WHO database for English language articles from inception until May 8, 2020. We included Observational studies with direct comparison of clinical characteristics between a) patients who died and those who survived or b) patients with severe disease and those without severe disease. Data extraction and quality assessment were performed by two authors independently. Results: Among 15680 articles from the literature search, 109 articles were included in the analysis. The risk of mortality was higher in patients with increasing age TRANS, male TRANS gender TRANS (RR 1.45; 95%CI 1.23,1.71), dyspnea HP dyspnea MESHD (RR 2.55; 95%CI 1.88,2.46), diabetes MESHD (RR 1.59; 95%CI 1.41,1.78), hypertension HP hypertension MESHD (RR 1.90; 95%CI 1.69,2.15). Congestive heart failure HP Congestive heart failure MESHD (OR 4.76; 95%CI 1.34,16.97), hilar lymphadenopathy HP lymphadenopathy MESHD (OR 8.34; 95%CI 2.57,27.08), bilateral lung involvement (OR 4.86; 95%CI 3.19,7.39) and reticular pattern (OR 5.54; 95%CI 1.24,24.67) were associated with severe disease. Clinically relevant cut-offs for leukocytosis HP leukocytosis MESHD(>10.0 x109/L), lymphopenia HP lymphopenia MESHD(< 1.1 x109/L), elevated C-reactive protein(>100mg/L), LDH(>250U/L) and D-dimer(>1mg/L) had higher odds of severe disease and greater risk of mortality. Conclusion: Knowledge of the factors associated of disease severity and mortality identified in our study may assist in clinical decision-making and critical-care resource allocation for patients with COVID-19.

    Comparison of initial thin-section CT features in coronavirus disease MESHD 2019 pneumonia HP pneumonia MESHD and other community-acquired pneumonia HP pneumonia MESHD

    Authors: Qiao Zhu; Cui Ren; Xiao Hua Wang

    doi:10.21203/rs.3.rs-29838/v1 Date: 2020-05-19 Source: ResearchSquare

    Background Coronavirus disease MESHD 2019 (COVID-19) pneumonia HP pneumonia MESHD caused similar symptoms to other community-acquired pneumonia HP pneumonia MESHD (CAP). It is important to early quarantine suspected patients with COVID-19 pneumonia HP pneumonia MESHD from patients with other CAP to reduce cross infection MESHD. The purpose of the study is to review and compare initial thin-section computed tomography (CT) features in patients with coronavirus disease MESHD 2019 (COVID-19) pneumonia HP pneumonia MESHD and other community-acquired pneumonia HP pneumonia MESHD (CAP). Methods 24 cases of COVID-19 pneumonia HP pneumonia MESHD (14 males TRANS and 10 females TRANS; age TRANS range, 14-87 years; mean age TRANS, 48.0 years) and 28 cases of CAP caused by other pathogens (13 males TRANS and 15 females TRANS; age TRANS range, 24-85 years; mean age TRANS, 49.5 years) were included. Thin-section CT features of the lungs for all patients were retrospectively reviewed by two independent radiologists. Results There were no significant differences for the shape of main lesions, pure ground glass attenuation (GGA), mixed GGA with consolidation, air bronchogram, linear opacities, halo sign/reversed halo sign, cavitation and lymphadenopathy HP lymphadenopathy MESHD between the group of COVID-19 pneumonia HP pneumonia MESHD and the group of other CAP. However, the frequency of crazy-paving appearance, vessel dilatation HP, bilaterally involvement and peripherally distribution were significantly higher in patients with COVID-19 compared with other CAP ( p =0.031, p =0.000, p =0.029 and p =0.009, respectively). Conversely, the frequencies of pure consolidation, tree-in-bud sign and pleural effusion HP pleural effusion MESHD were significantly higher in patients with CAP than in patients with COVID-19 pneumonia HP pneumonia MESHD ( p =0.002, p =0.000 and p =0.048, respectively). Conclusion There are considerable overlaps in thin-section CT features between COVID-19 pneumonia HP pneumonia MESHD and other CAP. However, the presence of crazy paving pattern, vessel dilation, bilateral involvement and peripheral distribution contributes to the diagnosis of COVID-19 pneumonia HP pneumonia MESHD. While the presence of pure consolidation tree-in-bud sign, pleural effusion HP pleural effusion MESHD can be assisting in exclusive the diagnosis of COVID-19 pneumonia HP pneumonia MESHD.

    Coronavirus Disease MESHD 2019 (COVID-19) in Children TRANS: A Systematic Review of Imaging Findings

    Authors: Susan C Shelmerdine; Jovan Lovrenski; Pablo Caro-Domínguez; Seema Toso; Collaborators of the European Society of Paediatric Radiology cardiothoracic imaging taskforce

    doi:10.21203/rs.3.rs-22081/v1 Date: 2020-04-08 Source: ResearchSquare

    Background:Covid-19, a novel coronavirus infection MESHD which can cause a severe respiratory illness MESHD, has been declared a pandemic by the World Health Organisation (WHO). As children TRANS appear less severely affected than adults TRANS, their imaging appearances are not extensively reported.Objectives:To systematically review available literature regarding imaging findings in paediatric cases of Covid-19.Materials and Methods:Four databases (Medline, Embase, Cochrane, Google Scholar) were searched for articles describing imaging findings in children TRANS with Covid-19. All modalities, age <18 years and foreign language articles were included. Descriptive statistics were used to identify pattern, location of imaging findings and association with outcomes.Results:Twenty two articles were included, reporting chest imaging findings in 382 children TRANS, of which 372 (97.4%) underwent CT. Criteria for imaging was lacking. At diagnosis, 120/372 (32.3%) had a normal CT. Abnormalities MESHD were more common in the lower lobes and predominantly unilateral. The most common imaging pattern was ground glass opacification (136/246, 55.3%). None of the studies described lymphadenopathy HP lymphadenopathy MESHD, while pleural effusions HP pleural effusions MESHD (2/246, 0.8%) were rare. Improvement at follow-up CT imaging, (3 – 15 days later) was seen in 27/91 (29.7%), remained normal in 23/91 (25.3%) and progressed in 11/91 (12.1%).Conclusions:CT chest findings in children TRANS with Covid-19 are frequently normal or mild. Lower lobes are predominantly affected by patchy ground glass opacification. Appearances at follow-up remain normal or improve in the majority of children TRANS. Chest CT imaging adds little to the further management of the patient and should be reserved for severe cases or identifying alternative diagnoses.This study was registered in PROSPERO, an international prospective register of systematic reviews (Registration ID: CRD42020175945

The ZB MED preprint Viewer preVIEW includes all COVID-19 related preprints from medRxiv and bioRxiv, from ChemRxiv, from ResearchSquare, from arXiv and from Preprints.org and is updated on a daily basis (7am CET/CEST).
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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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