Corpus overview


Overview

MeSH Disease

Human Phenotype

Cough (1)

Fever (1)

Odynophagia (1)

Arthralgia (1)


Transmission

Seroprevalence

There are no seroprevalence terms in the subcorpus

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    High number of RNA copies in asymptomatic TRANS individuals infected with SARS-CoV-2 in an area of the Colombian Caribbean

    Authors: Salim Mattar; Caty Martinez-Bravo; Ricardo Rivero; Hector Contreras; Alvaro Faccini_Martinez; Camilo Guzman; Ketty Galeano; Nelson Alvis; Veronica Contreras; German Arrieta; Marco Gonzalez; Jorge Miranda; Martha Lucia Ospina; Francisco Camargo-Assis; Marcela Mercado-Reyes; Evelyn Garay; Alejandra Garcia-Perez; Yesica Lopez; Vaneza Tique

    doi:10.21203/rs.3.rs-57254/v2 Date: 2020-08-11 Source: ResearchSquare

    Background.   Severe acute respiratory syndrome MESHD Coronavirus 2 (SARS-CoV-2) is an emerging viral pandemic disease MESHD. In the last six months, SARS-CoV-2 has caused millions of reported cases and hundreds of thousands of deaths. As other world regions, nowadays, South America has not contained the pandemic's advance since it lacks the hospital and economic capacities. Public health implications of transmission TRANS, while the asymptomatic TRANS infection is a critical concern at the current pandemic.Objective: Describe the socio-demographic, clinical, and viral kinetics features of a cohort of SARS-CoV-2 infected MESHD individuals from the Colombian Caribbean. Methods: Six hundred eighty-six clinical samples of suspected SARS-CoV-2 infection MESHD cases and contacts individuals from several hospital centers in the department of Córdoba, Colombia, were received at our laboratory between April 9th and May 16th, 2020. RNA was extracted using lysis buffers and spin columns. The samples were tested for SARS-CoV-2 by RT-qPCR (Reverse transcription real-time polymerase chain reaction) using commercially available multiplex real-time PCR assay for simultaneous detection of 3 target genes of SARS-CoV-2 (AllplexTM, 2019-nCoV assay, Korea). Viral copies quantification was done using a standard curve constructed from seriated dilutions of a SARS-CoV-2 positive control. Statics descriptive methods were used. Results: Thirty-five nasopharyngeal samples were positive for SARS-CoV-2 infection MESHD; the average age TRANS was 43 (range, 1-95 years). Seventeen of 35 (49%) of the patients showed symptoms. Most of them had a cough HP, fever HP fever MESHD, and odynophagia HP; three of the patients reported having arthralgia HP arthralgia MESHD. Only two patients required hospitalization. None of the patients had known co-morbidities. RT-qPCR results show that two of the symptomatic patients had significantly higher RNA copies than the rest. Eighteen of 35 (51%) individuals were asymptomatic TRANS, and the average age TRANS was 30 (range, 6-61 years). Four asymptomatic TRANS individuals showed a higher copy than some symptomatic patients; nonetheless, the average of RNA copies 8.26 x10+10 was lower than the symptomatic.Conclusions: the population studied was young, with an average of 43 years in symptomatic and 30 years of asymptomatic TRANS; this is important because of the high impact in the economy. Because a large proportion of infections may result from transmission TRANS from asymptomatic TRANS or pre-symptomatic persons, the usefulness of public health interventions in Colombian provinces should be based on molecular screening in a vast conglomerate population and quantify the viral load. 

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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