Corpus overview


MeSH Disease

Human Phenotype


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    Seroprevalence SERO of immunoglobulin M and G antibodies SERO against SARS-CoV-2 in ophthalmic patients

    Authors: shengjie li Sr.; yichao qiu; li tang; zhujian wang; wenjun cao; gezhi xu; xinghuai sun; Philippa C Matthews; Jienchi Dorward; Bernhard Graf; Florian Hitzenbichler; Frank Hanses; Hendrik Poeck; Marina Kreutz; Evelyn Orso; Ralph Burkhardt; Tanja Niedermair; Christoph Brochhausen; Andre Gessner; Bernd Salzberger; Matthias Mack; Christine Goffinet; Florian Kurth; Martin Witzenrath; Maria Theresa Völker; Sarah Dorothea Müller; Uwe Gerd Liebert; Naveed Ishaque; Lars Kaderali; Leif Erik Sander; Sven Laudi; Christian Drosten; Roland Eils; Christian Conrad; Ulf Landmesser; Irina Lehmann

    doi:10.1101/2020.09.22.20198465 Date: 2020-09-23 Source: medRxiv

    Using serological test SERO to estimate the prevalence SERO and infection potential of coronavirus disease MESHD 2019 in ocular diseases MESHD patients help understand the relationship between ocular diseases MESHD and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection MESHD. We conducted a cross-sectional study assaying the IgG and IgM antibodies SERO in 1331 individuals with ocular diseases MESHD by using a magnetic chemiluminescence enzyme immunoassay SERO kit, during the period from February 2020 to May 2020. In our study, the seroposivity in total ocular disease MESHD patients was 0.83% (11/1331). The patients with different ocular diseases MESHD including xerophthalmia MESHD, keratitis HP keratitis MESHD, conjunctival cyst, cataract HP cataract MESHD, glaucoma HP glaucoma MESHD, refractive error, strabismus HP and others had seroposivity of 2.94%, 12.5%, 25%, 4.41%, 2.63%, 1.6%, 2.22% and 0%, respectively. Among that, two ocular surface disease groups ( keratitis HP keratitis MESHD and conjunctival cyst) had higher seroprevalence SERO compared with others. All the participants were reverse transcription polymerase chain reaction negative for SARS-CoV-2 from throat swabs. Our study evaluated the seroprevalence SERO in patients with different ocular diseases MESHD, which will help us understand the relationship between ocular disease MESHD and SARS-CoV-2 infection MESHD. Furthermore, the serological test SERO for the presence of IgM and/or IgG antibodies SERO against SARS-CoV-2 might provide accurate estimate of the prevalence SERO of SARS-CoV-2 infection MESHD in patients with ocular diseases MESHD.

    Cataract HP Cataract MESHD Services in the COVID-19 era: Risk, Consent and Prioritisation

    Authors: Dr Kelvin Cheng; Dr Martin Anderson; Dr Stavros Velissaris; Dr Robert Moreton; Dr Ahmed Al-Mansour; Professor Roshini Sanders; Dr Shona Sutherland; Dr Peter Wilson; Dr Andrew Blaikie

    doi:10.21203/ Date: 2020-09-05 Source: ResearchSquare

    Background:The COVID-19 pandemic halted non-emergency surgery across Scotland. Measures to mitigating the risks of transmitting COVID-19 are creating significant challenges to recommencement of all surgical services safely. We describe the development of a risk stratification tool to prioritise patients for cataract HP cataract MESHD surgery and report the demographics and comorbidities of patients on the NHS Fife waiting list. Methods:A prospective case review of electronic records was performed. A risk stratification tool was developed based on review of available literature on risk factors for poor outcome from COVID-19 infection MESHD. Scores derived from the tool were used to generate 6 risk profile groups to call in time order for surgery.Results:There were 744 patients awaiting cataract HP cataract MESHD surgery of which 66 (8.9%) patients were ‘shielding’. One hundred and thirty-two (19.5%) patients had no systemic comorbidities, 218 (32.1%) patients had 1 relevant systemic comorbidity and 316 (46.5%) patients had 2 or more comorbidities. Five hundred and ninety patients (88.7%) did not have any ocular comorbidities.Conclusions:COVID-19 has presented every department an urgent challenge to deal with the mounting cataract HP cataract MESHD surgery waiting list. We present a pragmatic method of risk stratifying patients on waiting lists, blending an evidence-based objective assessment of risk and patient need combined with an element of shared decision-making. This has facilitated recommencement of our cataract HP cataract MESHD service taking into account biohazard measures of the COVID-19 era.

    Diabetic Retinopathy MESHD Retinopathy HP Screening in Urban Primary Care Setting with a Handheld Smartphone-based Retinal Camera.

    Authors: Márcia S Queiroz; Jacira Xavier de Carvalho; Silvia Ferreira Bortoto; Mozania Reis de Matos; Cristiane das Graças Dias Cavalcante; Elenilda Almeida Silva Andrade; Maria Lúcia Correa-Giannella; Fernando K Malerbi

    doi:10.21203/ Date: 2020-06-15 Source: ResearchSquare

    Aims: To evaluate diabetic retinopathy MESHD retinopathy HP ( DR MESHD) screening with a portable handheld smartphone-based retinal camera and telemedicine in an urban primary health care setting; to evaluate the learning curve for image acquisition, performed by healthcare personnel without previous experience on retinal imaging. Methods: Prospective study that enrolled patients with type 2 diabetes mellitus MESHD diabetes mellitus HP ( T2DM MESHD) followed at a primary healthcare unit in São Paulo, Brazil. After a brief training in image acquisition, there was further continuous feedback during the remote image reading process. Each patient underwent two fundus and one anterior ocular segment images per eye, after mydriasis HP mydriasis MESHD. Patients were classified according need of referral. Results: A total of 627 adult TRANS individuals with T2DM MESHD underwent retinal evaluation. The population was composed by 63.2% female TRANS individuals, age TRANS median of 66 years-old, diabetes MESHD duration 10.7 ± 8.2 years and A1c 7.7 ± 1.9% (61 + 20.8 mmol/mol). The most prevalent associated comorbidities were arterial hypertension HP hypertension MESHD (80.3%) and dyslipidemia MESHD (50.2%). Referral decision was possible in 81.2% patients. Most patients had absent or non-referable DR MESHD; the main ocular media opacity detected was cataract HP cataract MESHD. After the 7th day of image acquisition, the daily rate of patients whose images allowed clinical decision was maintained above 80%. A higher A1c was associated with referable DR MESHD. Conclusion: A low-cost DR MESHD screening strategy with a handheld device and telemedicine is feasible and has the potential to increase coverage of DR MESHD screening in underserved areas; the possibility of mobile units is relevant for DR MESHD screening in the context of Covid-19 pandemic.

    Ocular manifestations and clinical characteristics of 534 cases of COVID-19 in China: A cross-sectional study

    Authors: Liwen Chen; Chaohua Deng; Xuhui Chen; Xian Zhang; Bo Chen; Huimin Yu; Yuanjun Qin; Ke Xiao; Hong Zhang; Xufang Sun

    doi:10.1101/2020.03.12.20034678 Date: 2020-03-16 Source: medRxiv

    Objective: The novel coronavirus disease MESHD (COVID-19) was first reported in Wuhan, China in December 2019 and is now pandemic all over the world. Previous study has reported several COVID-19 cases with conjunctivitis HP conjunctivitis MESHD. However, the complete profiling of COVID-19 related ocular symptoms and diseases MESHD are still missing. We aim to investigate the ocular manifestations and clinical characteristics of COVID-19 patients. Methods: A total of five hundred and thirty-four patients were recruited at Mobile Cabin Hospital and Tongji Hospital. We collected information on demographic characteristics, exposure history, ocular symptoms, systemic concomitant symptoms, eye drop medication, eye protections, radiologic findings, and SARS-CoV-2 detection in nasopharyngeal swabs by RT-PCR from questionnaires and electronic medical records. Results: The median age TRANS of patients was 40 and 50 years at Mobile Cabin Hospital and Tongji Hospital, respectively. Of 534 COVID-19 patients, 25 patients (4.68%) presented with conjunctival congestion and 3 patients had conjunctival congestion as the initial symptom. The average duration of conjunctival congestion was 4.9 {+/-} 2.6 days (mean [SD]), ranging from 2 to 10 days. Dry eye (112, 20.97%), blurred vision HP blurred vision MESHD (68, 12.73%), and foreign body sensation (63, 11.80%) ranked as the top three COVID-19 related ocular symptoms. Notably, a total of 332 COVID-19 patients (62%) had a hand-eye contact history. We also found that some COVID-19 patients had a history of eye disease MESHD, including conjunctivitis HP conjunctivitis MESHD (33, 6.18%), dry eye MESHD (24, 4.49%), keratitis HP keratitis MESHD (14, 2.62%), cataract HP cataract MESHD (9, 1.69%), and diabetic retinopathy MESHD retinopathy HP (5, 0.94%). In consistent with previous studies, the most common clinical symptoms were fever HP fever MESHD, cough HP cough MESHD, and fatigue HP fatigue MESHD. Patients, 60.5% in Mobile Cabin Hospital and 67.5% in Tongji Hospital, respectively were confirmed with positive SARS-CoV-2 detection. Conclusions: Conjunctival congestion was one of the COVID-19 related ocular symptoms, which may have clinical diagnostic significance. It is essential to provide eye-care equipment and strengthen education on eye protection, as dirty hand-eye contact might be a high risk factor of COVID-19. Further detailed and comprehensive ophthalmological guidance is needed for COVID-19 control.

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MeSH Disease
Human Phenotype

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