Corpus overview


MeSH Disease

Human Phenotype

There are no HP terms in the subcorpus



There are no seroprevalence terms in the subcorpus

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    Evaluation of the Effect and Safety of HeberFERON vs Heberon Alpha in Patients Infected with Corona Virus SARS-CoV-2 MESHD (Study ESPERANZA/HOPE): Study Protocol for a Randomized Controlled Trial.

    Authors: Bello-Rivero Iraldo; Francisco Hernandez-Bernal; Hugo Nodarse-Cuni; Yaquelin Duncan-Roberts; Claudia Martínez Suarez; Ivan Campa-Legrá; Idelsis Esquivel-Moynelo; Verena Muzio-Gonzalez; Gerardo Guillen-Nieto

    doi:10.21203/ Date: 2020-05-14 Source: ResearchSquare

    Background: As the outbreak of COVID-19 has accelerated, an urgent need for finding strategies to combat the virus is growing. Results from in vitro studies suggest that a combination of IFN type I and Type II MESHD may be effective against SARS-CoV MESHD. The aim of this study is to investigate the efficacy of treatment with a recombinant IFN alpha 2b and gamma, provided with standard protocol (Kaletra (lopinavir-ritonavir 200/50 mg; 200/100 mg every 12 hour for 30 days; Chloroquine (250 mg) every 12 hours for 10 days) for COVID-19 patients, compared to standard protocol (IFN alpha 2b/Kaletra/Chloroquine) for COVID-19 hospitalized patients, positive diagnosed for SARS-Cov-2. Methods: Hospitalized adult TRANS patients with qPCR confirmed SARS-Cov-2 will be enrolled in this open-labeled, single center, prospective, randomized and controlled clinical trial. One hundred and twenty eligible patients with confirmed SARS-CoV-2 positivity by qPCR amplification in oropharyngeal/nasopharyngeal swab samples will be enrolled at “Luis Diaz Soto” Hospital, Havana, Cuba. The primary outcomes are the time to 2019-nCoV RNA negativity in patients and the time until progression to severe COVID-19. Discussion: This will be the first randomized controlled trial of a potential treatment for SARC-Cov-2 using the combinations of IFNs. Trial registration: The study is sponsored by Center for Genetic and Biotechnology and Ministry of Health of Cuba and was duly registered April 2020 at Enrolment for this study began in April 11, 2020, and has enrolled one hundred patients as of May-26-2020

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MeSH Disease
Human Phenotype

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