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MeSH Disease

Human Phenotype


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    Adapted Diving Mask Bench Tests as an Autonomous Respiratory Support in Healthy Volunteer

    Authors: Beatriz Arias-Arcos; Carlos Collado-Escudero; Ariela Candelario-Cáceres; Maria Jesus Buendia-García; Alfredo Abad-Gurumeta; Jose María Mendiguren-Santiago; Ricardo Larrainzar-Garijo

    doi:10.21203/ Date: 2020-09-07 Source: ResearchSquare

    PurposeThe scenario of global health crisis due to SARS-CoV-2 pandemia MESHD combined with the shortage of resources in many countries has justified numerous studies to design easily replicable and economic respiratory support devices. We have developed an adapted diving mask ( ADM MESHD) to be used as an autonomous and safe respiratory support. The objective was to prove a minimum positive end expiratory pressure (PEEP) with the ADM without any adverse events.MethodsBench tests was done in 22 healthy volunteers with our ADM prototype. Expiratory-inspiratory flow and pressure were registered apart from blood SERO and transcutaneous hypercapnia HP hypercapnia MESHD.ResultsThere were no statistically significant differences in the baseline analysis results and after therapy, except in pO2. Mean PEEP measured was 8.2 ± 4.2 cmH2O with a peak measured pressure of 20 cm H2O.ConclussionsThe ADM has shown good tolerance and a therapeutic manteining PEEP with no evidence of any deletereous effect or hypercapnia HP hypercapnia MESHD with its continuous use.

    Risk and impact of using mask on COPD MESHD patients with acute exacerbation during the COVID-19 outbreak: a retrospective study

    Authors: You Mo; DunCan Wei; Qi Mai; Chongyue Chen; Hanguang Yu; Chaowen Jiang; Xuerui Tan

    doi:10.21203/ Date: 2020-07-01 Source: ResearchSquare

    Background: Chronic Obstructive Pulmonary Disease MESHD COPD MESHD) is an inflammatory airway disease characterized by the presence of expiratory flow limitation. Exacerbations of COPD MESHD are common acute events. During epidemic of COVID-19, concerns have been raised with regard to mask- using because of increasing respiratory resistance. In this study, we aimed to evaluate the relationship between the vital signs , inflammation MESHD index, hypercapnia HP hypercapnia MESHD, hypoxia MESHD and mask-using in AECOPD patients.Methods:This retrospective study was performed at a tertiary hospital, and enrolled 23 patients with AECOPD who were hospitalized three or more times in the respiratory department. Patients in Group C were hospitalized and used masks during the epidemic period of COVID-19. Patient’s data of the previous two hospitalizations from the medical record system divided into group A and group B according to the time sequence. Vital signs, inflammation MESHD index, artery blood SERO gas from medical record system and questionnaires of three hospitalizations in the same patient were collected to perform paired test.Results: Surgical mask using increased the levels of PaCO2 (8.98mm Hg; p = 0.004), HCO3-act (4.1mmol/L; p =0.006), BE (3.01mmol/L; p =0.019) and systolic blood SERO pressure (11.39mm Hg; p = 0.01) in patients with AECOPD compared to last hospitalization. Surgical mask using for 30 to 120 minutes is associated with hypercapnia HP hypercapnia MESHD. There were no significant differences observed between group B and group A without using mask in vital signs, inflammation MESHD index, and artery blood gas MESHD blood SERO gas.Conclusions: In this study, we found that systolic blood SERO pressures and PaCO2, HCO3-act, BE were significantly elevated in AECOPD patients using masks compared to the other groups without masks. In addition,the changes in PaCO2,HCO3-act,BE is closely related to serum SERO chloride concentration. Therefore, it is need to increase awareness and understanding of the use of masks in patients with chronic cardiopulmonary diseases MESHD.

    Feasibility of non-invasive nitric oxide inhalation in acute hypoxic respiratory failure MESHD respiratory failure HP: potential role during the COVID-19 pandemic

    Authors: Kiran Shekar; Sneha Varkey; George Cornmell; Leanne Parsons; Maneesha Tol; Matthew Siuba; Mahesh Ramanan

    doi:10.1101/2020.05.17.20082123 Date: 2020-05-20 Source: medRxiv

    Acute hypoxemic respiratory failure MESHD respiratory failure HP ( ARF MESHD) is characterized by both lower arterial oxygen and carbon dioxide tensions in the blood SERO. First line treatment for ARF MESHD includes oxygen therapy,intially admininstered non invasively using nasal prongs, high flow nasal cannulae or masks. Invasive mechancial ventilation (IMV) is usually reserved for patients who are unable to maintain their airway, those with worsening hypoxemia HP hypoxemia MESHD, or those who develop respiratory muscle fatigue MESHD fatigue HP and consequent hypercapnia HP hypercapnia MESHD. Inhaled nitric oxide (iNO) gas is known to improve oxygenation in patients with ARF MESHD by manipulating ventilation-perfusion matching. Addition of iNO may potentially alleviate the need for IMV MESHD in selected patients. This article demonstrates the feasibility of this technique based on our experience of patients with hypoxemic ARF MESHD. This technique may also be considered for patients with hypoxic ARF MESHD in setting of COVID-19.

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MeSH Disease
Human Phenotype

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