Corpus overview


MeSH Disease

Human Phenotype


There are no transmission terms in the subcorpus

    displaying 1 - 2 records in total 2
    records per page

    Anti-phospholipids antibodies SERO and immune complexes in COVID-19 patients: a putative role in disease course for anti-annexin-V antibodies SERO

    Authors: Antonio Cristiano; Valentina Fortunati; Fabio Cherubini; Sergio Bernardini; Marzia Nuccetelli

    doi:10.21203/ Date: 2020-10-01 Source: ResearchSquare

    Introduction: Besides distinctive respiratory and digestive hallmarks, COVID-19 has been recently associated with a high prevalence SERO of pro-inflammatory and hypercoagulable states known as “COVID-19 Associated Coagulopathy MESHD” (CAC), corresponding to a worsening in patients’ conditions, whose causes are still to be elucidated. A link between anti-phospholipids antibodies SERO (aPLs) and viral infections MESHD has long been suggested. APLs are assessed for Anti-phospholipid Syndrome MESHD ( APS MESHD) diagnosis, characterized by thrombocytopenia HP thrombocytopenia MESHD, thrombosis MESHD and coagulopathy MESHD. Furthermore, circulating immune complexes HP (CICs), arisen upon inflammatory responses and related immune dysregulation HP, can lead to endothelial cells damage and thrombotic complications MESHD.Method: We performed an extended panel including IgG/IgM anti-cardiolipin, IgG/IgM anti-β2-glycoprotein-1, coupled with IgG/IgM anti-prothrombin, IgG/IgM anti-annexin-V on two COVID-19 patient groups (early and late infection time) and a negative control group. IgG CICs analysis followed to evaluate inflammatory status, through a possible complement system activation.Results: Our results showed low positive cases percentage in IgG/IgM anti-cardiolipin and IgG/IgM anti-β2-glycoprotein-1 assays (4.54%, 6.25%, 4.55%; in early infection group, late infection MESHD group and control group, respectively); few positive cases in IgG/IgM anti-prothrombin and IgG/IgM anti-annexin-V immunoassays SERO; no IgG CICs positivity in any patient.Conclusions: In conclusion, our data show a low aPLs prevalence SERO, likely excluding an involvement in the pathogenesis of CAC.Interestingly, IgG/IgM anti-prothrombin and anti-annexin-V positive cases, detected in late infection group, suggest that aPLs could temporarily increase or could trigger a “COVID-19-induced- APS-like-syndrome MESHD” in predisposed patients.Finally, even though aPLs are transient, they may still have a thrombotic MESHD potential in genetically predisposed COVID-19 patients.


    Authors: Giulia Previtali; Michela Seghezzi; Valentina Moioli; Aurelio Sonzogni; Roberto Marozzi; Lorenzo Cerutti; Rudi Ravasio; Andrea Gianatti; Giovanni Guerra; Maria Grazia Alessio

    doi:10.1101/2020.04.30.20086397 Date: 2020-05-06 Source: medRxiv

    Background The most severely COVID-19 patients need intensive care and show increased risk of thromboembolic MESHD events. Although some patients meet the diagnostic criteria for the Disseminated Intravascular Coagulation HP, the pathogenesis of the diffuse thrombotic MESHD status remains unclear. The aim of the present study is to evaluate the presence of antiphospholipid antibodies SERO (aPL) in sera of deceased patients with autoptic proven thrombotic microangiopathy MESHD to evaluate if some patients may have developed Catastrophic Antiphospholipid Syndrome MESHD ( CAPS MESHD). Methods Thirty-five patients were enrolled. The available medical history, comorbidities, therapies, laboratory and autopsy findings were collected post-mortem from clinical records. IgA, IgG and IgM anti cardiolipin (ACA) and anti {beta}2 glycoprotein 1 ({beta}2GP1) antibodies, IgG and IgM SERO anti phosphatidylserine/prothrombin (PS/PT) antibodies were tested SERO for all the patients. Results 3/35 (8.6%) patients were slightly positive for aPL: one for ACA IgG and two for ACA IgM but values were low (< 3X the cut off). No patients tested positive for ACA IgA neither for {beta}2GP1 isotypes. 3/35 (8.6%) patients were positive for PS/PT, one for IgG and two for IgM, but values were less than 2X the cut off. No patients showed simultaneous positivity for ACA and PS/ PT. Conclusions It is difficult to categorize the vascular events into a conventional disease: we did not find significant association with anti-phospholipid antibodies SERO. It is most likely that several factors contribute to trigger the hypercoagulability HP hypercoagulability MESHD status and the thromboembolism HP thromboembolism MESHD but, on the basis our results, CAPS MESHD is probably not involved into the pathogenesis of these phenomena.

The ZB MED preprint Viewer preVIEW includes all COVID-19 related preprints from medRxiv and bioRxiv, from ChemRxiv, from ResearchSquare, from arXiv and from and is updated on a daily basis (7am CET/CEST).
The web page can also be accessed via API.



MeSH Disease
Human Phenotype

Export subcorpus as...

This service is developed in the project nfdi4health task force covid-19 which is a part of nfdi4health.

nfdi4health is one of the funded consortia of the National Research Data Infrastructure programme of the DFG.