Corpus overview


Overview

MeSH Disease

Human Phenotype

Fever (21)

Pneumonia (12)

Cough (11)

Severe infection (8)

Fatigue (4)


Transmission

Seroprevalence
    displaying 1 - 10 records in total 96
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    Immunobiochemical Aspects in the Pathogenesis, Diagnosis, and Management of Novel Coronavirus (SARS-Cov-2) Infection

    Authors: Venkata Bharat Kumar Pinnelli; Mangala N. Sirsikar; W. Vishnu Vandana; Shrabani Mohanty; Wilma Delphine Silvia CR; Ranjan Kumar Mohapatra; Sabitha Vadakedath; Venkataramana Kandi

    id:202009.0565/v1 Date: 2020-09-24 Source: Preprints.org

    Background: A new coronavirus (SARS-CoV-2) that emerged from Wuhan, Hubei Province, China, has spread throughout the world and is declared a pandemic by the World Health Organization (WHO). A lot remains to be understood of SARS-CoV-2 and the disease (COVID-19). SARS-CoV-2 has until recently been identified as responsible for both asymptomatic TRANS and serious life-threatening infections. The unavailability of specific therapeutic agents is a major hurdle in the treatment and management of COVID-19 patients. The present review attempts to evaluate the immunobiochemical aspects of the pathogenesis, diagnosis, and management of SARS-CoV-2 infection MESHD. Main Body: This review is a comprehensive evaluation of the data collected through various sources, including Google Scholar, PubMed, and Scopus. The articles were searched and selected using key words such as “Coronavirus disease (COVID-19)”, “Diagnosis of COVID-19”, Pathogenesis of Covid-19”, “management of COVID-19”, “Immunology of COVID-19”, and “Complications of COVID-19”. The study noted that the novel Coronavirus infection MESHD could result in an exaggerated immune response, causing a cytokine storm and damaging several organs of the body. The infected MESHD patients develop several complications, including immunological, hematological, and biochemical alterations. Consequently, COVID-19 patients may develop cardiovascular, liver, renal, and neurological complications MESHD, among others. Conclusion: An increased understanding of the immunobiochemical aspects of the disease may contribute to better management of SARS-CoV-2-infected MESHD persons, as evidenced from the available literature. A holistic approach to the management of COVID-19 patients taking into consideration the effect of COVID-19 infection MESHD on various organs of the body assumes increased significance in patient management.

    Immunobiochemical Aspects in the Pathogenesis, Diagnosis, and Management of Novel Coronavirus (SARS-Cov-2) Infection

    Authors: Venkata Bharat Kumar Pinnelli; Mangala N. Sirsikar; W. Vishnu Vandana; Shrabani Mohanty; Wilma Delphine Silvia CR; Ranjan Kumar Mohapatra; Sabitha Vadakedath; Venkataramana Kandi

    id:10.20944/preprints202009.0565.v1 Date: 2020-09-24 Source: Preprints.org

    Background: A new coronavirus (SARS-CoV-2) that emerged from Wuhan, Hubei Province, China, has spread throughout the world and is declared a pandemic by the World Health Organization (WHO). A lot remains to be understood of SARS-CoV-2 and the disease (COVID-19). SARS-CoV-2 has until recently been identified as responsible for both asymptomatic TRANS and serious life-threatening infections. The unavailability of specific therapeutic agents is a major hurdle in the treatment and management of COVID-19 patients. The present review attempts to evaluate the immunobiochemical aspects of the pathogenesis, diagnosis, and management of SARS-CoV-2 infection MESHD. Main Body: This review is a comprehensive evaluation of the data collected through various sources, including Google Scholar, PubMed, and Scopus. The articles were searched and selected using key words such as “Coronavirus disease (COVID-19)”, “Diagnosis of COVID-19”, Pathogenesis of Covid-19”, “management of COVID-19”, “Immunology of COVID-19”, and “Complications of COVID-19”. The study noted that the novel Coronavirus infection MESHD could result in an exaggerated immune response, causing a cytokine storm and damaging several organs of the body. The infected MESHD patients develop several complications, including immunological, hematological, and biochemical alterations. Consequently, COVID-19 patients may develop cardiovascular, liver, renal, and neurological complications MESHD, among others. Conclusion: An increased understanding of the immunobiochemical aspects of the disease may contribute to better management of SARS-CoV-2-infected MESHD persons, as evidenced from the available literature. A holistic approach to the management of COVID-19 patients taking into consideration the effect of COVID-19 infection MESHD on various organs of the body assumes increased significance in patient management.

    Epidemic Response and Transmission TRANS Dynamics of Coronavirus Disease MESHD (COVID-19) in Khartoum State- Sudan 2020: Study Protocol

    Authors: Mustafa Khidir Mustafa Elnimeiri; Mohanad Kamaleldin Mahmoud Ibrahim; Shahenaz Seifaldeen Mustafa Satti

    doi:10.21203/rs.3.rs-80602/v1 Date: 2020-09-19 Source: ResearchSquare

    Background: A novel Coronavirus was identified as severe acute respiratory syndrome Coronavirus 2 MESHD (SARS-CoV-2), and the syndrome of clinical manifestation was named (COVID-19). Consequently, on Jan 30, 2020, the World Health Organization (WHO) declared the outbreak as a pandemic and a public health emergency of international concern. The objectives of this research are to investigate the response of the health system at different levels towards the control of the COVID-19 epidemic and to explore the COVID-19 transmission TRANS dynamics among Sudanese community. Methods: A community and institutional-based cross sectional based study will be conducted in Khartoum State include all the seven localities. The sample size of participant is estimated at 920 using the population formula (n=N/1+ (n*d2)) and considering the response rate. The sample will be drawn using multistage cluster sampling. Data will be collected using interview with key informant and concerned bodies/institutes involved in the response at both the federal and Khartoum State levels. Administered pre-coded, pretested closed ended questionnaire will be developed to collect data from community participants. Data will be managed and analyzed using Statistical Package for Social Sciences version 21. Analysis is mostly univariate descriptive and bi-variate with Chi Square & Fischer Exact tests analysis to find associations between variables of interest.Discussion: This study is expected to evaluate the extent and magnitude of the epidemic response at different levels in addition to the adequacy of the epidemic response. The study participants will be screened to estimate proportion of individuals per age TRANS strata who show sero-positivity for virus infection MESHD, thus it will estimate the percentages of individuals reporting symptoms/signs of infection MESHD and asymptomatic TRANS fraction. The results of this study will strengthen the current interventional approaches of COVID-19 epidemic control and will provide set of database for better planning and implementation of COVID-19 control across the country. It will contribute to in-depth understanding of the COVID-19 transmission TRANS dynamics among Sudanese community and will improve the community awareness about COVID-19.

    A fractional order approach to modeling and simulations of the novel COVID-19

    Authors: Isaac Owusu-Mensah; Lanre Akinyemi; Bismark Oduro; Olaniyi S. Iyiola

    doi:10.21203/rs.3.rs-77269/v1 Date: 2020-09-14 Source: ResearchSquare

    The novel coronavirus (SARS-CoV-2.) has emerged and spread at fast speed globally; the disease has become an unprecedented threat to public health worldwide. It is one of the greatest public health challenges in modern times, with no proven cure or vaccine. In this paper, our focus is on a fractional order approach to modeling and simulations of the novel COVID-19. We introduce a fractional type Susceptible-Exposed-Infected-Recovered (SEIR) model to gain insight into the ongoing pandemic of COVID-19. Our proposed model incorporates transmission TRANS rate, testing rates, and transition rate (from asymptomatic TRANS to symptomatic population groups) for a holistic study of the coronavirus disease MESHD. The impacts of these parameters on the dynamics of the solution proles for the disease are simulated and discussed in detail. Furthermore, across all the different parameters, the effects of the fractional order derivative are also simulated and discussed in detail. Various simulations carried out enable us gain deep insights into the dynamics of the spread of COVID-19. The simulation results confirm that fractional calculus is an appropriate tool in modeling the spread of a complex infectious disease MESHD such as the novel COVID-19. In the absence of vaccine and treatment, our analysis strongly supports the significance reduction in the transmission TRANS rate as valuable strategy to curb the spread of the virus. Our results suggest that tracing TRANS and moving testing up has an important benefit. It reduces the number of infected individuals in the general public and thereby reduce the spread of the pandemic. Once the infected MESHD individuals are identified and isolated, the interaction between susceptible and infected individuals diminishes and transmission TRANS reduces. Furthermore, aggressive testing is also highly recommended.

    Functionalized TiO2 nanotube-based Electrochemical Biosensor for Rapid Detection of SARS-CoV-2 MESHD

    Authors: Bhaskar Sravan Vadlamani; Timsy Uppal; Subhash C Verma; Manoranjan Misra; Maria Christina Creel-Bulos; Christine L Kempton; Milad Sharifpour; Manila Gaddh; Roman Sniecinski; Cheryl L Maier; Fadi Nahab; Lars Heggelund; Kaj Blennow; Henrik Zetterberg; Hanne Flinstad Harbo; Niclas Johansson; Max Bell; Karin Lore; Anna Farnert; Anna Smed-Sorensen

    doi:10.1101/2020.09.07.20190173 Date: 2020-09-09 Source: medRxiv

    The coronavirus disease (COVID-19) is a newly emerging viral disease MESHD caused by severe acute respiratory syndrome coronavirus 2 MESHD (SARS-CoV-2). Rapid increase in the number of COVID-19 cases worldwide led the WHO declare pandemic within a few month after the first case of infection MESHD. Due to the lack of a prophylactic measure to control the virus infection MESHD and spread, early diagnosis and quarantining of infected as well as the asymptomatic TRANS individuals are necessary for the containment of this pandemic. However, the current methods for SARS-CoV-2 diagnosis are expensive and time consuming although some promising and inexpensive technologies are coming out for emergency use. In this work, we report the synthesis of a cheap yet highly sensitive cobalt-functionalized TiO2 nanotubes (Co-TNTs)-based electrochemical biosensor and its efficacy for rapid detection of spike glycoprotein of SARS-CoV-2 by examining S-RBD protein as the reference material. A simple, low-cost, and one-step electrochemical anodization route was used to synthesize TNTs, followed by an incipient wetting method for cobalt functionalization of the TNTs platform, which is connected to a potentiostat for data collection. The sensor specifically detected the S-RBD protein of SARS-CoV-2 even at very low concentration (range of 14 nM to 1400 nM). Additionally, our sensor showed linear response in the detection of viral protein with concentration. In summary, our Co-TNT sensor is highly effective in detecting SARS-CoV-2 S-RBD MESHD protein in approximately 30 seconds, which can be explored for developing a point of care diagnostics for rapid detection of SARS-CoV-2 in nasal secretions or saliva samples.

    Utility of Olfactory test as screening tool for COVID-19: A pilot study

    Authors: Pragyanshu Khare; Atul Munish Chander; Kanhaiya Agrawal; Satyam Singh Jayant; Soham Mukherjee; Kamalendra Yadav; Rahul Gupta; Shakun Chaudhary; Sumit Srivastava; Sanuj Muralidharan; Rijin Mohan; Shikha Chaudhary; Rimesh Pal; Sandeep Bansal; Kanthi Kiran Kondepudi; Govardhan Dutt Puri; MAHENDRA BISHNOI; Sanjay Kumar Bhadada

    doi:10.1101/2020.09.03.20187294 Date: 2020-09-05 Source: medRxiv

    Loss of smell function ( Anosmia HP Anosmia MESHD) is reported to be associated with novel coronavirus disease MESHD 2019 (COVID-19) infection MESHD. The present study was designed to evaluate the effectiveness of an indigenously developed prototype smell test to identify/diagnose asymptomatic TRANS COVID-19 positive individuals. A panel of five different odorants belonging to Indian household with unique and mutually exclusive odor were used to develop prototype kit to test the hypothesis. The developed prototype kit was tested at 2 centers (N=49 and 34) with slight modifications. Simultaneously, the kit was also tested on 55 (N=35 and 20) healthy controls. Our results indicate that otherwise asymptomatic TRANS COVID-19 positive individuals were having quantifiable deficit in smell sensation. Interestingly, the variable sensitivity SERO of different odorants was observed in different patients. None of the healthy controls reported difficulty in sensing any of the odorant, whereas, some of healthy controls did misidentify the odorants. Overall, the present study provides a preliminary data that loss in smell sensation for various odorants can be exploited as a quick and affordable screening test to identify infected cases among at risk individuals.

    On Cancer, COVID-19 and CT Scan: A Monocentric Retrospective Study

    Authors: Francesca Martini; Andrea D'Alessio; Federico Bracchi; Daniela Di Mauro; Anna Fargnoli; Marco Motta; Cristina Giussani; Marco Meazza Prina; Giovanni Gobbin; Monica Taverna

    id:10.20944/preprints202009.0075.v1 Date: 2020-09-04 Source: Preprints.org

    Background The acknowledgment of computed tomography (CT) defined diagnosis in high prevalence SERO northern Italy may identify more patients with Coronavirus Disease MESHD-2019 (COVID 19) infection MESHD, than RT-PCR alone. Methods We retrospectively reviewed 148 chest CT scans of oncological patients who were referred to the Radiological Unit of Policlinico S. Marco from 1st of February 2020 to 30th of April 2020, during the Covid-19 outbreak in Bergamo area. Therefore, we analyzed RT-PCR tests of these 148 patients. Results Among 32 patients with diagnosis of COVID-19 infection MESHD: 17 patients were asymptomatic TRANS or had mild symptoms (53.1%), while 15 developed severe disease (46.8%). The incidence of COVID-19 infection MESHD is 22.9%, the mortality rate is 18.8%. Severe COVID-19 disease is associated with higher median age TRANS. We did not find any correlation between disease severity and sex, smoke or cardiovascular comorbidities. Remarkably, patients who were on treatment developed milder disease MESHD than cancer MESHD patients who were not on treatment. Conclusions The acceptance of CT-defined diagnosis in high prevalence SERO area like Bergamo highlighted a larger number of COVID-19 oncological population than RT-PCR alone, in particular asymptomatic TRANS and mild symptomatic patients. We observed that actively treated patients had milder disease, according to previous studies that suggested a protective role of immunosuppression.

    Defining the role of asymptomatic TRANS SARS-CoV-2 transmission TRANS: a living systematic review

    Authors: Xueting Qiu; Ali Ihsan Nergiz; Alberto Enrico Maraolo; Isaac I Bogoch; Nicola Low; Muge Cevik; Michelle L. Allen; Genevieve B. Melton; Anthony Charles; Christopher J. Tignanelli; - the Yale IMPACT Research Team; Charles S. Dela Cruz; Shelli F. Farhadian; Akiko Iwasaki; Albert I. Ko; Nathan D. Grubaugh; Anne L. Wyllie

    doi:10.1101/2020.09.01.20135194 Date: 2020-09-03 Source: medRxiv

    Background Reports suggest that asymptomatic TRANS individuals (those with no symptoms at all throughout the infection) with severe HP infection) with severe MESHD acute respiratory syndrome coronavirus 2 MESHD (SARS-CoV-2) are infectious, but the extent of asymptomatic TRANS transmission TRANS requires further understanding. Purpose This living review aims to critically appraise available data about secondary attack rates TRANS from people with asymptomatic TRANS and pre-symptomatic SARS-CoV-2 infection MESHD. Data sources Medline, EMBASE, China Academic Journals full-text database (CNKI), and pre-print servers were searched from 30 December 2019 to 3 July 2020 using relevant MESH terms. Study selection Studies that report on contact tracing TRANS of index cases with asymptomatic TRANS or pre-symptomatic SARS-CoV-2 infection MESHD, in either English or Chinese were included. Data extraction Two authors independently extracted data and assessed study quality and risk of bias. We calculated the secondary attack rate TRANS as the number of contacts with SARS-CoV-2, divided by the number of contacts tested. Data synthesis Of 928 studies identified, 19 were included. Secondary attack rates TRANS from asymptomatic TRANS index cases ranged from 0% to 2.8% (9 studies). Pre-symptomatic secondary attack rates TRANS ranged from 0.7% to 31.8% (10 studies). The highest secondary attack rates TRANS were found in contacts who lived in the same household as the index case. Other activities associated with transmission TRANS were group activities such as sharing meals TRANS or playing board games with the index case. Limitations We excluded some studies because the index case or number of contacts were unclear. Owing to the anticipated heterogeneity, we did not produce a summary estimate of the included studies. Conclusion Asymptomatic TRANS patients can transmit SARS-CoV-2 to others, but our findings indicate that such individuals are responsible for fewer secondary infections than people with symptoms in the same studies. Systematic review registration PROSPERO CRD42020188168 Funding: No funding was received

    Asymptomatic TRANS cases and limited transmission TRANS of SARS-CoV-2 in residents and healthcare workers in three Dutch nursing homes

    Authors: Laura W van Buul; Judith Henriette van den Besselaar; Fleur M.H.P.H. Koene; Bianca M. Buurman; Cees M.P.M. Hertogh; Kamalini Lokuge; Ali H Mokdad; Peter J. Hotez; Robin B. Gasser; Parveen Bahel; Kent Owusu; Yu Yamamoto; Tanima Arora; Deepak S. Atri; Amisha Patel; Rana Gbyli; Jennifer Kwan; Christine H. Won; Charles Dela Cruz; Christina Price; Jonathan Koff; Brett A. King; Henry M. Rinder; F. Perry Wilson; John Hwa; Stephanie Halene; William Damsky; David van Dijk; Alfred Ian Lee; Hyung Chun; Akhil Vaid; Guillermo Barturen; Scott R. Tyler; Hardik Shah; Yinh-chih Wang; Shwetha Hara Sridhar; Juan Soto; Swaroop Bose; Kent Madrid; Ethan Ellis; Elyze Merzier; Konstantinos Vlachos; Nataly Fishman; Manying Tin; Melissa Smith; Hui Xie; Manishkumar Patel; Kimberly Argueta; Jocelyn Harris; Neha Karekar; Craig Batchelor; Jose Lacunza; Mahlet Yishak; Kevin Tuballes; Leisha Scott; Arvind Kumar; Suraj Jaladanki; Ryan Thompson; Evan Clark; Bojan Losic; - The Mount Sinai COVID-19 Biobank Team; Jun Zhu; Wenhui Wang; Andrew Kasarskis; Benjamin S. Glicksberg; Girish Nadkarni; Dusan Bogunovic; Cordelia Elaiho; Sandeep Gangadharan; George Ofori-Amanfo; Kasey Alesso-Carra; Kenan Onel; Karen M. Wilson; Carmen Argmann; Marta E. Alarcón-Riquelme; Thomas U. Marron; Adeeb Rahman; Seunghee Kim-Schulze; Sacha Gnjatic; Bruce D. Gelb; Miriam Merad; Robert Sebra; Eric E. Schadt; Alexander W. Charney

    doi:10.1101/2020.08.31.20185033 Date: 2020-09-02 Source: medRxiv

    Purpose Many nursing homes worldwide have been hit by outbreaks of the new severe acute respiratory syndrome coronavirus 2 MESHD (SARS-CoV-2). We aimed to assess the contribution of a- and presymptomatic residents and healthcare workers in transmission TRANS of SARS-CoV-2 in three nursing homes. Methods Two serial point- prevalence SERO surveys, 1 week apart, among residents and healthcare workers of three Dutch nursing homes with recent SARS-CoV-2 introduction MESHD. Nasopharyngeal and oropharyngeal testing for SARS-CoV-2, including reverse-transcriptase polymerase chain reaction (rRT-PCR) was conducted with reporting of cycle threshold (Ct). Participants were categorized as symptomatic, presymptomatic or asymptomatic TRANS with standardized symptom assessment. Results In total, 297 residents and 542 healthcare workers participated in the study. At the first point- prevalence SERO survey, 15 residents tested positive of which one was presymptomatic (Ct value>35) and three remained asymptomatic TRANS (Ct value of 23, 30 and 32). At the second point- prevalence SERO survey one resident and one healthcare worker tested SARS-CoV-2 positive (Ct value >35 and 24, respectively) and both remained asymptomatic TRANS. Conclusion This study confirms a- and presymptomatic occurrence of Covid-19 among residents and health care workers. Ct values below 25 suggested that these cases have the potential to contribute to viral spread. However, very limited transmission TRANS impeded the ability to answer the research question. We describe factors that may contribute to the prevention of transmission TRANS and argue that the necessity of large-scale preemptive testing in nursing homes may be dependent of the local situation regarding prevalence SERO of cases in the surrounding community and infection MESHD control opportunities.

    Prevalence SERO of SARS-CoV-2 Infections MESHD in a Pediatric Orthopedic Hospital

    Authors: Ghalib Bardai; Jean A Ouellet; Thomas Engelhardt; Gianluca Bertolizio; Zenghui Wu; Frank Rauch; Reinaldo E Fernandez; Owen R Baker; Morgan Keruly; Charles S Kirby; Ethan Klock; Kirsten Littlefield; Jernelle Miller; Haley A Schmidt; Philip Sullivan; Estelle Piwowar-Manning; Ruchee Shrestha; Andrew D Redd; Richard Eric Rothman; David J Sullivan; Shmuel Shoham; Arturo Casadevall; Thomas C. Quinn; Andrew Pekosz; Aaron AR Tobian; Oliver Laeyendecker; William Damsky; David van Dijk; Alfred Ian Lee; Hyung Chun; Akhil Vaid; Guillermo Barturen; Scott R. Tyler; Hardik Shah; Yinh-chih Wang; Shwetha Hara Sridhar; Juan Soto; Swaroop Bose; Kent Madrid; Ethan Ellis; Elyze Merzier; Konstantinos Vlachos; Nataly Fishman; Manying Tin; Melissa Smith; Hui Xie; Manishkumar Patel; Kimberly Argueta; Jocelyn Harris; Neha Karekar; Craig Batchelor; Jose Lacunza; Mahlet Yishak; Kevin Tuballes; Leisha Scott; Arvind Kumar; Suraj Jaladanki; Ryan Thompson; Evan Clark; Bojan Losic; - The Mount Sinai COVID-19 Biobank Team; Jun Zhu; Wenhui Wang; Andrew Kasarskis; Benjamin S. Glicksberg; Girish Nadkarni; Dusan Bogunovic; Cordelia Elaiho; Sandeep Gangadharan; George Ofori-Amanfo; Kasey Alesso-Carra; Kenan Onel; Karen M. Wilson; Carmen Argmann; Marta E. Alarcón-Riquelme; Thomas U. Marron; Adeeb Rahman; Seunghee Kim-Schulze; Sacha Gnjatic; Bruce D. Gelb; Miriam Merad; Robert Sebra; Eric E. Schadt; Alexander W. Charney

    doi:10.1101/2020.08.31.20183533 Date: 2020-09-02 Source: medRxiv

    This project assessed the prevalence SERO of active and past infection with severe HP infection with severe MESHD acute respiratory syndrome coronavirus 2 MESHD (SARS-CoV-2) in a specialized pediatric institution that did not provide care for coronavirus disease MESHD 2019 (Covid-19). The study was performed in Montreal, the city with the highest number of Covid-19 cases in Canada during the early phase of the pandemic. Testing for SARS-CoV-2 RNA in 199 individuals (39 children TRANS, 61 accompanying persons, 99 hospital employees) did not reveal active infection in any of the study participants. However, 22 (11%) of study participants had SARS-CoV-2 IgG antibodies SERO, indicating prior infection MESHD. Ten of these participants did not report symptoms compatible with Covid-19 in the 6 months prior to the study. Thus, although no evidence for active infection MESHD was found within the institution, consideration should be given to regular staff testing to detect asymptomatic TRANS spreading of SARS-CoV-2. In addition, it could be useful to test accompanying persons in children TRANS presenting for surgical procedures.

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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