Corpus overview


Overview

MeSH Disease

Human Phenotype

Pneumonia (43)

Fever (15)

Cough (14)

Fatigue (7)

Hypertension (4)


Transmission

Seroprevalence
    displaying 1 - 10 records in total 43
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    Clinical Characteristics, Risk Factors and Predictive Value of COVID-19 Pneumonia HP: A Retrospective Study of 173 Patients in Wuhan, China

    Authors: Yang Zhang; Jun Xue; Mi Yan; Jing Chen; Hai Liu; Shao-Bo Wang; Jian-Xing Luo; Fang Yang; Jian-Yuan Tang; Xiao-Yu Hu

    doi:10.21203/rs.3.rs-76134/v1 Date: 2020-09-11 Source: ResearchSquare

    Background: COVID-19 is a globally emerging infectious disease MESHD. As the global epidemic continues to spread, the risk of COVID-19 transmission TRANS and diffusion in the world will also remain. Currently, several studies describing its clinical characteristics have focused on the initial outbreak, but rarely to the later stage. Here we described clinical characteristics, risk factors for disease severity and in-hospital outcome in patients with COVID-19 pneumonia HP pneumonia MESHD from Wuhan. Methods: Patients with COVID-19 pneumonia HP pneumonia MESHD admitted to Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology from February 13 to March 8, 2020, were retrospectively enrolled. Multivariable logistic regression analysis was used to identify risk factors for disease severity and in-hospital outcome and establish predictive models. Receiver operating characteristic (ROC) curve was used to assess the predictive value of above models.Results: 106 (61.3%) of the patients were female TRANS. The mean age TRANS of study populations was 62.0 years, of whom 73 (42.2%) had underlying comorbidities mainly including hypertension HP hypertension MESHD (24.9%). The most common symptoms on admission were fever HP fever MESHD (67.6%) and cough HP (60.1%), digestive symptoms (22.0%) was also very common. Older age TRANS (OR: 3.420; 95%Cl: 1.415-8.266; P=0.006), diarrhea HP diarrhea MESHD (OR: 0.143; 95%Cl: 0.033-0.611; P=0.009) and lymphopenia HP lymphopenia MESHD (OR: 4.769; 95%Cl: 2.019-11.266; P=0.000) were associated with severe illness on admission; the area under the ROC curve (AUC) of predictive model were 0.860 (95%CI: 0.802-0.918; P=0.000). Older age TRANS (OR: 0.309; 95%Cl: 0.142-0.674; P=0.003), leucopenia (OR: 0.165; 95%Cl: 0.034-0.793; P=0.025), increased lactic dehydrogenase (OR: 0.257; 95%Cl: 0.100-0.659; P=0.005) and interleukins-6 levels (OR: 0.294; 95%Cl: 0.099-0.872; P=0.027) were associated with poor in-hospital outcome; AUC of predictive model were 0.752 (95%CI: 0.681-0.824; P=0.000).Conclusion: Older patients with diarrhea HP diarrhea MESHD and lymphopenia HP lymphopenia MESHD need early identification and timely intervention to prevent the progression to severe COVID-19 pneumonia HP pneumonia MESHD. However, older patients with leucopenia, increased lactic dehydrogenase and interleukins-6 levels are at a high risk for poor in-hospital outcome.Trial registration: ChiCTR2000029549

    Risk of COVID-19 hospitalisation rises exponentially with age TRANS, inversely proportional to T-cell production

    Authors: Sam Palmer; Nik Cunniffe; Ruairi Donnelly; Matheus Filgueira Bezerra; Filipe Zimmer Dezordi; Lais Ceschini Machado; Larissa Krokovsky; Elisama Helvecio; Alexandre Freitas da Silva; Luydson Richardson Silva Vasconcelos; Antonio Mauro Rezende; Severino Jefferson Ribeiro da Silva; Kamila Gaudencio da Silva Sales; Bruna Santos Lima Figueiredo de Sa; Derciliano Lopes da Cruz; Claudio Eduardo Cavalcanti; Armando de Menezes Neto; Caroline Targino Alves da Silva; Renata Pessoa Germano Mendes; Maria Almerice Lopes da Silva; Michelle da Silva Barros; Wheverton Ricardo Correia do Nascimento; Rodrigo Moraes Loyo Arcoverde; Luciane Caroline Albuquerque Bezerra; Sinval Pinto Brandao Filho; Constancia Flavia Junqueira Ayres; Gabriel Luz Wallau

    doi:10.1101/2020.08.25.20181487 Date: 2020-08-31 Source: medRxiv

    Here we report that COVID-19 hospitalisation rates follow an exponential relationship with age TRANS, increasing by 4.5% per year of life (95% CI: 4.2-5.2%). This mirrors the exponential decline of thymus volume and T-cell production (decreasing by 4.5% per year). COVID-19 can therefore be added to the list of other diseases with this property, including those caused by MRSA, West Nile virus, Streptococcus Pneumonia HP and certain cancers, such as chronic myeloid leukemia HP and brain cancers. In addition, incidence of severe disease and mortality due to COVID-19 are both higher in men, consistent with the degree to which thymic involution (and the decrease in T-cell production with age TRANS) is more severe in men compared to women. For under 20s, COVID-19 incidence is remarkably low. A Bayesian analysis of daily hospitalisations, accounting for contact-based TRANS and environmental transmission TRANS, indicates that non- adults TRANS are the only age group TRANS to deviate significantly from the exponential relationship. Our model fitting suggests under 20s have 53-77% additional immune protection beyond that predicted by strong thymus function alone. We found no evidence for differences between age groups TRANS in susceptibility to overall infection, or, relative infectiousness to others. The simple inverse relationship between risk and thymus size we report here suggests that therapies based on T-cell mechanisms may be a promising target.

    A Systematic Review on Coronavirus Disease MESHD 2019 (COVID-19)

    Authors: Hira Karim; Muhammad Shahzeb Khan

    id:10.20944/preprints202008.0516.v1 Date: 2020-08-24 Source: Preprints.org

    Emerging and reemerging pathogens is a global challenge for public health. Recently, a novel coronavirus disease MESHD emerged in Wuhan, Hubei province of China, in December 2019. It is named COVID-19 by World Health Organization (WHO). It is known to be caused by Severe Acute Respiratory Syndrome Coronavirus 2 MESHD (SARS-CoV-2) that affects the lower respiratory tract and manifests as pneumonia HP pneumonia MESHD in humans. Coronaviruses (CoVs) are structurally more complicated as compared to other RNA viruses. This viral epidemic has led to the deaths of many, including the elderly TRANS or those with chronic disease MESHD or compromised immunity. Viruses cause infection MESHD and diseases in humans of varying degrees, upper respiratory tract infections MESHD respiratory tract infections HP ( URTIs MESHD) cause common cold while lower respiratory tract infections HP induce pneumonia HP pneumonia MESHD, bronchitis HP bronchitis MESHD, and even severe acute respiratory syndrome MESHD (SARS). The costs of COVID-19 are not limited. It equally affects all the medical, sociological, psychological, and economic aspects globally. This is regarded as the third deadly outbreak in the last two decades after Severe Acute Respiratory Syndrome SARS MESHD (2002–2003) and Middle East Respiratory Syndrome MERS MESHD (2012). Based on the sequence homology of SARS-CoV-2, different animal sources including bats, snakes, and pangolins have been reported as potential carriers TRANS of this viral strain. Real-time RT-PCR represents the primary method for the diagnosis of new emerging viral strain SARS-CoV-2. The transmission TRANS dynamics suggest that SARS-CoV-2 is transmitted from person-to-person through direct contact or coughing HP, sneezing HP, and by respiratory droplets. Several anti-viral treatments including lopinavir/ritonavir, remdesivir, chloroquine phosphate, and abidor are also suggested with different recommendations and prescriptions. Protective and preventive strategies as suggested by various health organization i.e. WHO and US Center for Disease Control and Prevention (CDC) must be adopted by everyone. This review covers the important aspects of novel COVID-19 including characteristics, virology, symptoms, diagnostics, clinical aspects, transmission TRANS dynamics, and protective measures of COVID-19.

    Transmission TRANS Dynamics of SARS-CoV-2 in a Mid-size City of China

    Authors: Hongjun Zhao; Xiaoxiao Lu; Wenhui Lun; Tiegang Li; Boqi Rao; Dedong Wang; Di Wu; Fuman Qiu; Zhicong Yang; Lu Jiachun

    doi:10.21203/rs.3.rs-59402/v1 Date: 2020-08-14 Source: ResearchSquare

    Background: An outbreak of pneumonia HP pneumonia MESHD associated with the severe acute respiratory syndrome coronavirus 2 MESHD (SARS-CoV-2) emerged in Wuhan city and then spread to other cities. It is very urgent to delineate the epidemiological and clinical characteristics of these affected patients. Methods: To investigate the epidemiological characteristics of the COVID-19, we describe a case series of 473 patients with confirmed COVID-19 in Wenzhou of China from January 27 to March 2, 2020.Results: The median age TRANS of all patients was 47.6 years, 48.4% of which were female TRANS. 33.8% of the patients had a history of residence in Wuhan. Fever HP Fever MESHD (71.7%) and cough HP (43.1%) were the most common symptoms. In addition, three kinds of unconventional cases were observed, namely 4.9% asymptomatic TRANS patients, 7.6% confirmed patients who had no link to Wuhan city but contact with individuals from Wuhan without any symptoms at the time of contact, and 12.9% confirmed patients who had an unknown source of transmission TRANS. We estimated that the basic reproductive number TRANS ( R0 TRANS) was 2.75 (95%CI: 2.37-3.23). The effective reproduction number TRANS (Rt) fluctuated within the range of 2.50 to 3.74 from January 11 to January 16 while gradually reached the peak of 3.74 on January 16. Rt gradually decreased after January 16 and decreased to 1.00 on January 30. Rt continually decreased and reached the lowest point (0.03) on February 21, 2020.Conclusion: Our findings presented the possibility of asymptomatic TRANS carriers TRANS affected with SARS-CoV-2, and this phenomenon suggested that chances of uncontrollable transmission TRANS in the larger population might be higher than formerly estimated, and transmission TRANS by these three kinds of unconventional patients in Wenzhou may be an important characteristic of infection MESHD in other mid-sized cities in the world. This study evaluated the epidemic characteristics of Wenzhou after having cases imported from Hubei Province and the effects after adopting a series of strict prevention and control strategy. 

    Clinical characteristics and risk factors for mortality in patients with coronavirus disease MESHD 2019 in intensive care unit: a single-center, retrospective, observational study in China

    Authors: Fangfang Sai; Xiaolei Liu; Lanyu Li; Yan Ye; Changqing Zhu; Ying Hang; Conghua Huang; Lei Tian; Xinhui Xu; Huan Huang

    doi:10.21203/rs.3.rs-46078/v1 Date: 2020-07-20 Source: ResearchSquare

    Background: Coronavirus disease 2019 (COVID-19) is a potentially life-threatening contagious disease which has spread TRANS all over the world. Risk factors for the clinical outcomes of COVID-19 pneumonia HP pneumonia MESHD in intensive care unit (ICU) have not yet been well determined. Methods: In this retrospective, single-centered, observational study, we consecutively included 47 patients with confirmed COVID-19 who were admitted to the ICU of Leishenshan Hospital in Wuhan, China, from February 24 to April 5, 2020. Clinical characteristics and outcomes were collected and compared between survivors and non-survivors. Multivariable logistic regression was used to explore the risk factors associated with death MESHD in patients of COVID-19.Results: The study cohort included 47 adult TRANS patients with a median age TRANS of 70.55±12.52 years, and 30 (63.8%) patients were men. Totally 15 (31.9%) patients died. Compared with survivors, non-survivors were more likely to develop septic shock MESHD shock HP (6 [40%] patients vs 3 [9.4%] patients ), disseminated intravascular coagulation HP intravascular coagulation MESHD (3 [21.4%] vs 0), and had higher score of APACHE II (25.07±8.03 vs 15.56±5.95), CURB-65 (3[2-4] vs 2[1-3]), Sequential Organ Failure Assessment (SOFA) (7[5-9] vs 3[1-6]), higher level of D-dimer (5.74 [2.32-18] vs 2.05 [1.09-4.00] ) and neutrophil count (9.4[7.68-14.54] vs 5.32[3.85-9.34] ). SOFA score (OR 1.47, 1.01–2.13; p=0.0042) and lymphocyte count (OR 0.02, 0.00–0.86; p=0.042) on admission were independently risk factors for mortality. Patients with higher lymphocyte count (>0.63×109/L) and lower SOFA score ≤4 on admission had a significantly well prognosis than those with lower lymphocyte count (≤0.63×109/L) and higher SOFA score >4 in overall survival.Conclusions: Higher SOFA score and lower lymphocyte count on admission were associated with poor prognosis of patients with COVID-19 in ICU. Lymphocyte count may serve as a promising prognostic biomarker.

    A neonate born to mother with COVID-19 during Pregnancy & HELLP syndrome MESHD: A possible vertical transmission 

    Authors: Nirmal kumar Mohakud; Hari KrishnaYerru; Monalisha Rajguru; Shlok Saxena; Srinitya Kollu; Natasha Sharma; Sushree Samiksha Naik

    doi:10.21203/rs.3.rs-43986/v1 Date: 2020-07-16 Source: ResearchSquare

    COVID-19 i nfection MESHDin newborn is uncommon, and there is doubt regarding vertical transmission TRANS of COVID-19 from an infected mother. We report a preterm neonate born to a mother with H ELLP syndrome MESHDand COVID-19 pneumonia HP, who was COVID-19 positive (RT-PCR of tracheal aspirate) at 12 hours of age TRANS

    Trend of respiratory pathogens during the COVID-19 epidemic: comparison between 2020 and the last 5 years

    Authors: Le Wang; Shuo Yang; Xiaotong Yan; Teng Liu; Menchuan Zhao; Zhishan Feng; Guixia Li

    doi:10.21203/rs.3.rs-41423/v1 Date: 2020-07-13 Source: ResearchSquare

    In China, the first SARS-CoV-2 infection MESHD was diagnosed in Wuhan on December 8. Spreads in other regions have occurred since the end of January, happens to be the start of Lunar New Year holiday. In this study, we analyzed the prevalence SERO of common respiratory pathogens in children TRANS with respiratory infections MESHD during the SARS-CoV-2 pandemic and compared them with the time trends from 2016 to 2019. Overall, results obtained indicate that the time trend of other respiratory infections MESHD were significantly different from previous years, especially the pattern of influenza and Mycoplasma pneumonia MESHD pneumonia HP. Therefore, in the current scenario of COVID-19 pandemic, other common pathogens testing should not be excluded. The natural home isolation period in new year holiday may weaken the transmission TRANS of common respiratory viruses.

    ROX Index Predicts Intubation in Patients with COVID-19 Pneumonia HP and Moderate to Severe Hypoxemic Respiratory Failure MESHD Respiratory Failure HP Receiving High Flow Nasal Therapy.

    Authors: Maulin Patel; Junad Chowdhury; Nicole Mills; Robert Marron; Andrew Gangemi; Zachariah Dorey-Stein; Ibraheem Yousef; Matthew Zheng; Lauren Tragesser; Julie Giurintano; Rohit Gupta; Parth Rali; Huaqing Zhao; Nicole Patlakh; Nathaniel Marchetti; Gerard Criner; Matthew Gordon

    doi:10.1101/2020.06.30.20143867 Date: 2020-07-02 Source: medRxiv

    Introduction Use of high flow nasal therapy (HFNT) to treat COVID-19 pneumonia HP pneumonia MESHD has been greatly debated around the world due to concern for increased healthcare worker transmission TRANS and delays in invasive mechanical Ventilation (IMV). Methods A retrospective analysis of consecutive patients admitted to Temple University Hospital in Philadelphia, Pennsylvania, from March 10, 2020, to May 17, 2020 with moderate to severe respiratory failure HP respiratory failure MESHD treated with High Flow nasal therapy (HFNT). HFNT MESHD patients were divided into two groups: HFNT only and HFNT progressed to IMV. The primary outcome was the ability of the ROX index to predict the need of IMV. Results Of the 837 patients with COVID-19, 129 met inclusion criteria. The mean age TRANS was 60.8 ({+/-}13.6) years, BMI 32.6 ({+/-}8), 58 (45 %) were female TRANS, 72 (55.8%) were African American, 40 (31%) Hispanic. 48 (37.2%) were smokers. Mean time to intubation was 2.5 days ({+/-} 3.3). ROX index of less than 5 at HFNT initiation was predictive of progression to IMV (OR = 2.137, p = 0,052). Any decrease in ROX index after HFNT initiation was predictive of intubation (OR= 14.67, p <0.0001). {Delta}ROX (<=0 versus >0), peak D-dimer >4000 and admission GFR < 60 ml/min were very strongly predictive of need for IMV (ROC = 0.86, p=). Mortality was 11.2% in HFNT only group versus 47.5% in the HFNT progressed to IMV group (p,0.0001). Mortality and need for pulmonary vasodilators were higher in the HNFT progressed to IMV group. Conclusion ROX index is a valuable, noninvasive tool to evaluate patients with moderate to severe hypoxemic respiratory failure MESHD respiratory failure HP in COVID-19 treated with HFNT. ROX helps predicts need for IMV and thus limiting morbidity and mortality associated with IMV.

    SARS-CoV-2 infection MESHD of primary human lung epithelium for COVID-19 modeling and drug discovery MESHD

    Authors: Apoorva Mulay; Bindu Konda; Gustavo Garcia Jr.; Changfu Yao; Stephen Beil; Chandani Sen; Arunima Purkayastha; Jay Kolls; Derek Pociask; Patrizia Pessina; Carolina Garcia-de-Alba; Carla Kim; Brigitte Gomperts; Vaithilingaraja Arumugaswami; Barry Stripp

    doi:10.1101/2020.06.29.174623 Date: 2020-06-29 Source: bioRxiv

    Coronavirus disease 2019 (COVID-19) is the latest respiratory pandemic resulting from zoonotic transmission TRANS of severe acute respiratory syndrome MESHD-related coronavirus 2 (SARS-CoV-2). Severe symptoms include viral pneumonia MESHD pneumonia HP secondary to infection MESHD and inflammation MESHD of the lower respiratory tract, in some cases causing death MESHD. We developed primary human lung epithelial infection MESHD models to understand responses of proximal and distal lung epithelium to SARS-CoV-2 infection MESHD. Differentiated air-liquid interface cultures of proximal airway epithelium and 3D organoid cultures of alveolar MESHD epithelium were readily infected by SARS-CoV-2 leading to an epithelial cell-autonomous proinflammatory response. We validated the efficacy of selected candidate COVID-19 drugs confirming that Remdesivir strongly suppressed viral infection MESHD/replication. We provide a relevant platform for studying COVID-19 pathobiology and for rapid drug screening against SARS-CoV-2 and future emergent respiratory pathogens. One Sentence SummaryA novel infection model of the adult TRANS human lung epithelium serves as a platform for COVID-19 studies and drug discovery.

    Exposure risk of patients with chronic infectious wounds during the COVID-19 outbreak and its countermeasures

    Authors: Haiying Zhou; Qianjun Jin; hui lu

    doi:10.21203/rs.3.rs-36407/v1 Date: 2020-06-18 Source: ResearchSquare

    BACKGROUND A large number of cases of pneumonia HP caused by novel β-coronavirus emerged in Hubei Province, China, at the end of 2019 and demonstrated great potential for transmission TRANS. At present, known independent risk factors include age TRANS, diabetes and other chronic diseases, which may be similar to the patients with chronic wound, thus we try to explore the clinical characteristics, prognostic factors and management recommendation of patients with chronic infective wounds during the COVID-19 epidemic period. METHODS In this single-center, retrospective observational study, we included all cases with chronic infective wounds that came to our hospital between the full outbreak of the COVID-19 in China (January 23, 2020) and the latest date prior to posting (20 April 2020). Demographic data, comorbidities, laboratory and imaging findings, consultation history and clinical outcomes (lesion cured, uncontrolled, amputated, etc. as of May 10, 2020) were collected for all individuals. Patients were subdivided into gangrene HP, traumatic infection and other types of soft tissue infection wound (including bedsores, gout HP ruptures, stab wounds and so on) according to the causes of wound and their disease-related information were compared group by group. RESULTS Among the total 81 patients with chronic infective wounds, 60% was male TRANS, with a mean age TRANS of 60.8 years (SD 18.6), including 38 (47%) patients with traumatic infection, 29 (36%) gangrene HP cases, and 14 (17%) other soft tissue infection wounds. Common comorbidities are hypertension HP (32%), diabetes (32%), cardiovascular disease (24%), and kidney injury (12%), and the patients with gangrenes HP have the most comorbidities. As of May 10, 2020, there were 78 patients discharged and their average stay time is 15.8 days(SD 14.2), while people still at the hospital is 39.7days(SD 8.7)much longer than the discharged and also has more comorbidities. But there is no significant difference in the hospitalization time of three types of wounds. And fortunately, none of all the patients were infected by coronavirus. CONCLUSION The majority of patients with chronic wounds are severely ill with high risk of infection TRANS risk of infection TRANS and poor prognosis, therefore management of patients with chronic wounds should be improved.

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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