Corpus overview


Overview

MeSH Disease

Human Phenotype

Fever (21)

Cough (20)

Pneumonia (19)

Fatigue (9)

Diarrhea (6)


Transmission

Seroprevalence
    displaying 1 - 10 records in total 114
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    Variation in SARS-CoV-2 seroprevalence SERO in school- children TRANS across districts, schools and classes

    Authors: Agne Ulyte; Thomas Radtke; Irene A Abela; Sarah H Haile; Jacob Blankenberger; Ruedi Jung; Celine Capelli; Christoph Berger; Anja Frei; Michael Huber; Merle Schanz; Magdalena Schwarzmueller; Alexandra Trkola; Jan Fehr; Milo A Puhan; Susi Kriemler; Peter Hau; Christopher Bohr; Ralph Burkhardt; Andre Gessner; Bernd Salzberger; Frank Hanses; Florian Hitzenbichler; Daniel Heudobler; Florian Lueke; Tobias Pukrop; Wolfgang Herr; Daniel Wolff; Hendrik Poeck; Christoph Brochhausen; Petra Hoffmann; Michael Rehli; Marina Kreutz; Kathrin Renner

    doi:10.1101/2020.09.18.20191254 Date: 2020-09-18 Source: medRxiv

    Importance: Understanding transmission TRANS and impact of severe acute respiratory syndrome coronavirus 2 MESHD (SARS-CoV-2) in school children TRANS is critical to implement appropriate mitigation measures. Objective: To determine the variation in SARS-CoV-2 seroprevalence SERO in school children TRANS across districts, schools, grades, and classes, and the relationship of SARS-CoV-2 seroprevalence SERO with self-reported symptoms. Design: Cross-sectional analysis of baseline measurements of a longitudinal cohort study (Ciao Corona) from June-July 2020. Setting: 55 randomly selected schools and classes stratified by district in the canton of Zurich, Switzerland (1.5 million inhabitants). Participants: Children TRANS, aged TRANS 6-16 years old, attending grades 1-2, 4-5 and 7-8. Exposure: Exposure to circulating SARS-CoV-2 between February and June 2020 including public lock-down and school closure (March 16-May 10, 2020). Main Outcomes and Measures: Variation in seroprevalence SERO of SARS-CoV-2 in children TRANS across 12 cantonal districts, schools, and grades using a Luminex-based antibody test SERO with four targets for each of IgG, IgA and IgM. Clustering of cases within classes. Analysis of associations of seropositivity and symptoms. Comparison of seroprevalence SERO with a randomly selected adult TRANS population, based on Luminex-based IgG and IgA antibody test SERO of Corona Immunitas. Results: In total, 55 schools and 2585 children TRANS were recruited (1337 girls, median age TRANS 11, age TRANS range 6-16 years). Overall seroprevalence SERO was 2.8 % (95% CI 1.6-4.1%), ranging from 1.0% to 4.5% across districts. Seroprevalence SERO was 3.8% (1.9-6.1%) in grades 1-2, 2.5% (1.1-4.2%) in grades 4-5, and 1.5% (0.5-3.0%) in grades 7-8. At least one case was present in 36/55 tested schools and in 43/128 classes with [≥]50% participation rate and [≥]5 children TRANS tested. 73% of children TRANS reported COVID-19 compatible symptoms since January 2020, but none were reported more frequently in seropositive compared to seronegative children TRANS. Seroprevalence SERO of children TRANS was very similar to seroprevalence SERO of randomly selected adults TRANS in the same region in June-July 2020, measured with the same Corona Immunitas test, combining IgG and IgA (3.1%, 95% CI 1.4-5.4%, versus 3.3%, 95% CI 1.4-5.5%). Conclusions and Relevance: Seroprevalence SERO was inversely related to age TRANS and revealed a dark figure of around 90 when compared to 0.03% confirmed PCR+ cases in children TRANS in the same area by end of June. We did not find clustering of SARS-CoV-2 seropositive cases in schools so far, but the follow-up of this school-based study will shed more light on transmission TRANS within and outside schools. Trial registration: ClinicalTrials.gov Identifier: NCT04448717, registered June 26, 2020. https://clinicaltrials.gov/ct2/show/NCT04448717

    COVID-19 Pandemic and the South African Podiatrist

    Authors: Bernhard Zipfel; Nadia Dembskey

    id:10.20944/preprints202009.0425.v1 Date: 2020-09-18 Source: Preprints.org

    The Coronavirus disease MESHD 2019 (COVID-19) pandemic is clearly taking a firmer grip on South Africa and more podiatrists will face the potential transmission TRANS of SARS-CoV-2. Government response was swift with the implementation of a travel TRANS ban, strict national lockdown as well as social distancing and hygiene protocols in line with international health regulations. Co-morbidities such as tuberculosis MESHD and HIV MESHD/ AIDS MESHD, endemic to South Africa, are considered a dangerous combination with COVID-19, making many South Africans vulnerable to contracting the COVID-19. Patients with diabetes MESHD as well as the aged TRANS are vulnerable, both in terms of potential combined complications and challenges in continuity in foot care. The demands of the pandemic may outstrip the ability of the health systems to cope. Should this time arrive, all healthcare practitioners, including podiatrists, would have to step in and take on a role beyond their scope of practice in order to ensure that the healthcare system does not get overwhelmed. It is important for podiatrists to keep abreast with the developments around the COVID-19, in order that they may institute appropriate clinical practice which will ensure maximum protection for themselves, staff and patients as well as providing quality foot health care.

    Evaluation of attitude among infertile MESHD couples about continuing assisted reproductive technologies therapy during novel coronavirus outbreak

    Authors: Sepideh Peivandi; Alireza Razavi; Shervin Shafiei; Marzieh Zamaniyan,; Asma Orafaie; Hamed Jafarpour; FERNANDA A. BAIAO; PAULA MACAIRA; SILVIO HAMACHER; FERNANDO A. BOZZA; Daniel Figeys; Alex E. MacKenzie; Robert Delatolla; Emma Young; Andrew Bentley; Kirsty Challen; Chris Fitzsimmons; Tim Harris; Fiona Lecky; Andrew Lee; Ian Maconochie; Darren Walter; Dilek Telci; Fikrettin Sahin; Koray Yalcin; Ercument Ovali

    doi:10.1101/2020.09.01.20186320 Date: 2020-09-03 Source: medRxiv

    Study question: Does the fear of the coronavirus disease MESHD 2019 (COVID-19) pandemic reduce the desire of infertile MESHD couples to continue treatment? Summary answer: Most of the participants in this study wanted to continue treatment. What is known already: The effect of the prevalence SERO of infectious diseases including the Zika virus on the attitude of infertile MESHD couples has been studied in very few studies. However, the effect of the outbreak of COVID-19 on the attitude of infertile MESHD couples has not been investigated. Study design, size, duration: We conducted a prospective longitudinal study on forty-six infertile MESHD couples (n=92) who referred to our infertility HP infertility MESHD clinic from 4 March 2020 through 20 June 2020. Participants/materials, settings, methods: This study is based on potential infertile MESHD couples for treatment with assisted reproductive technology (ART) who referred to our infertility HP infertility MESHD clinic, Sari, Iran (median age TRANS of 35.5 years). All individuals with primary infertility MESHD infertility HP, as defined by the World Health Organization (WHO) and candidates for ART, were included in the study. People who did not agree to participate in the study were excluded. Subjects were surveyed using a researcher-made questionnaire. This questionnaire has four sections as follows: The first part included demographic information and clinical characteristics, the second part included medical records, the third part included questions related to assessing the level of awareness regarding coronavirus infection MESHD, and the fourth part included questions related to the attitude towards continuing infertility HP infertility MESHD treatment. The validity of this questionnaire was assessed by three infertility HP infertility MESHD specialists and was confirmed with Cronbachs alpha of 0.78. A P-value of less than 0.05 was considered statistically significant. Main results and the role of chance: There is no significant relationship between COVID-19 symptoms and the level of awareness (P-value <0.05). Thirty-two patients (33.33%) had decreased motivation to continue treatment during COVID-19 pandemic. Fear of transmission TRANS to the fetus (28.13%) had the highest frequency among the causes of decreased motivation to continue treatment (P-value = 0.011). Confidence in support of the treatment team (56.67%) was the most common reason for lack of motivation in people without decreased motivation (P-value <0.001). The majority of patients had a very high or high tendency (65.22%) to continue or start treatment during the COVID-19 pandemic (P-value <0.001). Most people had an average fear of getting the disease (39.13%) (value <0.001). Examining the relationship between the presence of COVID-19 symptoms and attitude level variables showed that there is only a significant relationship between the greater desire to have a child TRANS and the continuation or initiation of treatment with the presence of COVID-19 symptoms (P-value = 0.032). Limitations, reasons for caution: We were not able to fully assess patients' deep feelings and cultural beliefs, due to the use of questionnaires and the lack of interviews. Wider implications of the findings: Our results showed for the first time that patients' knowledge about COVID-19 and trust in the treatment staff played an effective role in selecting and continuing infertility HP infertility MESHD treatment. To clarify this issue, studies with the larger statistical community in the form of interviews are needed. Study funding/completing interest(s): The study received financial support from the Mazandaran University of Medical Sciences (Grant number: 7903). None of the funders had any role in the study design, collection, analysis, or interpretation of data, writing of the paper, or publication decisions. The authors have nothing to declare. Trial registration number: N/A

    SARS-CoV-2 Viral RNA Load Dynamics in the Nasopharynx of Infected Children TRANS

    Authors: Kai-qian Kam; Koh Cheng Thoon; Matthias Maiwald; Chia Yin Chong; Han Yang Soong; Liat Hui Loo; Woon Hui Natalie Tan; Jiahui Li; Karen Donceras Nadua; Chee Fu Yung; Norbert Kaiser; Hannes Ganzer; Mathias Strohle; Andreas Walser; Dorothee von Laer; Lothar Hennighausen; Changqing Lin; Qinghua Hu; Tie Song; Ruifu Yang; Xiaoyu Zhang; Kai Sun; Pieter S. Hiemstra; Bruce A. Ponder; Mika J Makela; Kristiina Malmstrom; Robert C. Rintoul; Paul A. Reyfman; Fabian J. Theis; Corry-A Brandsma; Ian Adcock; Wim Timens; Cheng J. Xu; Maarten van den Berge; Roland F. Schwarz; Gerard H. Koppelman; Martijn C. Nawijn; Alen Faiz

    doi:10.1101/2020.08.31.20185488 Date: 2020-09-02 Source: medRxiv

    It is important to understand the temporal trend of pediatric severe acute respiratory syndrome coronavirus 2 MESHD (SARS-CoV-2) viral load to estimate the transmission TRANS potential of children TRANS in schools and communities. We determined differences in SARS-CoV-2 viral load dynamics between nasopharyngeal samples of infected asymptomatic TRANS and symptomatic children TRANS. The daily cycle threshold values of SARS-CoV-2 in the nasopharynx of a cohort of infected children TRANS were collected for analysis. Among 17 infected children TRANS, 10 (58.8%) were symptomatic. Symptomatic children TRANS, when compared to asymptomatic TRANS children TRANS, had higher viral load (mean cycle threshold on day 7 of illness 28.6 versus 36.7, p = 0.02). Peak SARS-CoV-2 viral loads occured around days 2-3 of illness/days of diagnosis in infected children TRANS. After adjusting for the estimated date of infection MESHD, the higher SARS-CoV-2 viral loads in symptomatic children TRANS remained. We postulate that symptomatic SARS-CoV-2-infected MESHD children TRANS may have higher transmissibility TRANS than asymptomatic TRANS children TRANS. As peak viral load in infected children TRANS occurred in the early stage of illness, viral shedding and transmission TRANS in the pre-symptomatic phase probable. Our study highlights the importance of screening for SARS-CoV-2 in children TRANS with epidemiological risk factors, even when they are asymptomatic TRANS in order to improve containment of the virus in the community, including educational settings.

    Seroprevalence SERO and immunity of SARS-CoV-2 infection MESHD in children TRANS and adolescents in schools in Switzerland: design for a longitudinal, school-based prospective cohort study

    Authors: Agne Ulyte; Thomas Radtke; Irene Abela; Sarah H Haile; Julia Braun; Ruedi Jung; Christoph Berger; Alexandra Trkola; Jan Fehr; Milo A Puhan; Susi Kriemler; Anel Nurtay; Lucie Abeler-Dörner; David G Bonsall; Michael V McConnell; Shawn O'Banion; Christophe Fraser; Scott Roberts; Jose A. Gonzalez; Marciano Sablad; Rodrigo Yelin; Wendy Taylor; Kiyoshi Tachikawa; Suezanne Parker; Priya Karmali; Jared Davis; Sean M Sullivan; Steve G. Hughes; Pad Chivukula; Eng Eong Ooi

    doi:10.1101/2020.08.30.20184671 Date: 2020-09-02 Source: medRxiv

    Introduction Seroprevalence SERO and transmission TRANS routes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection MESHD in children TRANS and adolescents, especially in school setting, are not clear. Resulting uncertainty is reflected in very different decisions on school closures and reopenings across countries. The aim of this longitudinal cohort study is to assess the extent and patterns of seroprevalence SERO of SARS-CoV-2 antibodies SERO in school-attending children TRANS repeatedly. It will examine risk factors for infection MESHD, relationship between seropositivity and symptoms, and temporal persistence of antibodies SERO. Additionally, it will include testing of school personnel and parents TRANS. Methods and analysis The study (Ciao Corona) will enroll a regionally representative, random sample of schools in the canton of Zurich, where 18% of the Swiss population live. Children TRANS aged TRANS 5 to 16 years, attending classes in primary and secondary schools are invited. Venous blood MESHD blood SERO and saliva samples are collected for SARS-CoV-2 serological testing SERO after the first wave of infections (June/July 2020), in fall HP (October/November 2020), and after winter (March/April 2021). Venous blood MESHD blood SERO is also collected for serological testing SERO of parents TRANS and school personnel. Bi-monthly questionnaires to children TRANS, parents TRANS and school personnel cover SARS-CoV-2 symptoms MESHD and tests, health, preventive behavior, lifestyle and quality of life information. Total seroprevalence SERO and cumulative incidence will be calculated. Hierarchical Bayesian logistic regression models will account for sensitivity SERO and specificity of the serological test SERO in the analyses and for the complex sampling structure, i.e., clustering within classes and schools. Ethics and dissemination The study was approved by the Ethics Committee of the Canton of Zurich, Switzerland (2020-01336). The results of this study will be published in peer-reviewed journals and will be made available to study participants and participating schools, the Federal Office of Public Health, and the Educational Department of the canton of Zurich. Trial registration number NCT04448717.

    Risk factors for SARS-CoV-2 infection MESHD, hospitalisation, and death in Catalonia MESHD, Spain: a population-based cross-sectional study

    Authors: Judit Villar-Garcia; Rosa Maria Vivanco-Hidalgo; Montserrat Cleries; Elisenda Martinez; David Monterde; Pol Perez-Sust; Luis Garcia-Eroles; Carol Sais; Montserrat Moharra; Emili Vela; Jochen Lennerz; Hetal Desai Marble; Lauren L. Ritterhouse; Julie Batten; N. Zeke Georgantas; Rebecca Pellerin; Sylvia Signorelli; Julia Thierauf; Molly Kemball; Christian Happi; Donald S. Grant; Daouda Ndiaye; Katherine J. Siddle; Samar B Mehta; Jason B. Harris; Edward T Ryan; Virginia M. Pierce; Regina C LaRocque; Jacob Lemieux; Pardis Sabeti; Eric Rosenberg; John Branda; Sarah E Turbett; Gail Carson; Malcolm G Semple; Janet T Scott

    doi:10.1101/2020.08.26.20182303 Date: 2020-09-01 Source: medRxiv

    OBJECTIVE To identify the different subpopulations that are susceptible for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection MESHD and hospitalisation or death MESHD due to coronavirus disease MESHD 2019 (COVID-19) in Catalonia, Spain. DESIGN Cross-sectional study. SETTING Data collected from the Catalan Health Surveillance System (CatSalut) in Catalonia, a region of Spain. PARTICIPANTS Using data collected between 1 March and 1 June 2020, we conducted the following comparative analyses: people infected by SARS-CoV-2 (328 892) vs Catalonia's entire population (7 699 568); COVID-19 cases who required hospitalisation (37 638) vs cases who did not require hospitalisation (291 254); and COVID-19 cases who died during the study period vs cases who did not die during the study period (12 287). MAIN OUTCOME MEASURES Three clinical outcomes related to COVID-19 ( infection MESHD, hospitalisation, or death MESHD). We analysed sociodemographic and environment variables (such as residing in a nursing home) and the presence of previous comorbidities. RESULTS A total of 328 892 cases were considered to be infected with SARS-CoV-2 (4.27% of total population). The main risk factors for the diagnostic were: female TRANS gender TRANS (risk ratio [RR] =1.49; 95% confidence interval [95% CI] =1.48-1.50), age TRANS (45-64 years old; RR=1.02; 95% CI=1.01-1.03), high comorbidity burden (GMA index) (RR=3.03; 95% CI=2.97-3.09), reside in a nursing home (RR=11.82; 95% CI=11.66-11.99), and smoking (RR=1.06; 95% CI=1.05-1.07). During the study period, there were 37 638 (11.4 %) hospitalisations due to COVID-19, and the risk factors were: male TRANS gender TRANS (RR=1.45; 95% CI=1.43-1.48), age TRANS > 65 (RR=2.38; 95% CI=2.28-2.48), very low individual income (RR=1.03; 95% CI=0.97-1.08), and high burden of comorbidities (GMA index) (RR=5.15; 95% CI=4.89-5.42). The individual comorbidities with higher burden were obesity HP obesity MESHD (RR=1.23; 95% CI=1.20-1.25), chronic obstructive pulmonary disease HP chronic obstructive pulmonary disease MESHD (RR=1.19; 95% CI=1.15-1.22), heart failure MESHD (RR=1.19; 95% CI=1.16-1.22), diabetes mellitus HP diabetes mellitus MESHD (RR=1.07; 95% CI=1.04-1.10), and neuro-psychiatric MESHD comorbidities (RR=1.06; 95% CI=1.03-1.10). A total of 12 287 deaths (3.73%) were attributed to COVID-19, and the main risk factors were: male TRANS gender TRANS (RR=1.73; 95% CI=1.67-1.81), age TRANS > 65 (RR=37.45; 95% CI=29.23-47.93), residing in a nursing home (RR=9.22; 95% CI=8.81-9.65), and high burden of comorbidities (GMA index) (RR=5.25; 95% CI=4.60-6.00). The individual comorbidities with higher burden were: heart failure MESHD (RR=1.21; 95% CI=1.16-1.22), chronic kidney disease HP chronic kidney disease MESHD (RR=1.17; 95% CI=1.13-1.22), and diabetes mellitus HP diabetes mellitus MESHD (RR=1.10; 95% CI=1.06-1.14). These results did not change significantly when we considered only PCR-positive patients. CONCLUSIONS Female TRANS gender TRANS, age TRANS between 45 to 64 years old, high burden of comorbidities, and factors related to environment (nursing home) play a relevant role in SARS-CoV-2 infection MESHD and transmission TRANS. In addition, we found risk factors for hospitalisation and death MESHD due to COVID-19 that had not been described to date, including comorbidity burden, neuro-psychiatric disorders MESHD, and very low individual income. This study supports interventions for transmission TRANS control beyond stratify-and-shield strategies focused only on protecting those at risk of death. Future COVID-19 studies should examine the role of gender TRANS, the burden of comorbidities, and socioeconomic status in disease transmission TRANS, and should determine its relationship to workplaces, especially healthcare centres and nursing homes.

    Disease burden and clinical severity of the first pandemic wave of COVID-19 in Wuhan, China

    Authors: Juan Yang; Xinhua Chen; Xiaowei Deng; Zhiyuan Chen; Hui Gong; Han Yan; Qianhui Wu; Huilin Shi; Shengjie Lai; Marco Ajelli; Cecile Viboud; Hongjie Yu; Lars I Eriksson; Anna Norrby-Teglund; Hans-Gustaf Ljunggren; Niklas K Bjorkstrom; Soo Aleman; Marcus Buggert; Jonas Klingstrom; Kristoffer Stralin; Johan K. Sandberg

    doi:10.1101/2020.08.27.20183228 Date: 2020-09-01 Source: medRxiv

    The pandemic of novel coronavirus disease MESHD 2019 (COVID-19) began in Wuhan, China, where a first wave of intense community transmission TRANS was cut short by interventions. Using multiple data source, we estimated the disease burden and clinical severity of COVID-19 by age TRANS in Wuhan from December 1, 2019 to March 31, 2020. We adjusted estimates for sensitivity SERO of laboratory assays and accounted for prospective community screenings and healthcare seeking behaviors. Rates of symptomatic cases, medical consultations, hospitalizations and deaths were estimated at 796 (95%CI: 703-977), 489 (472-509), 370 (358-384), and 36.2 (35.0-37.3) per 100,000 persons, respectively. The COVID-19 outbreak in Wuhan had higher burden than the 2009 influenza pandemic or seasonal influenza, and that clinical severity was similar to that of the 1918 influenza pandemic. Our comparison puts the COVID-19 pandemic into context and could be helpful to guide intervention strategies and preparedness for the potential resurgence of COVID-19.

    SARS-CoV-2 Infection Reaches MESHD the Human Nervous System: How?

    Authors: Vladimir N. Uversky; Fatma Elrashdy; Abdullah Aljadawi; Syed Moasfar Ali; Rizwan Hasan Khan; Elrashdy M. Redwan

    id:10.20944/preprints202008.0696.v1 Date: 2020-08-31 Source: Preprints.org

    Without protective and/or therapeutic agents the SARS-CoV-2 infection MESHD known as coronavirus disease MESHD 2019 (COVID-19) is quickly spreading worldwide. It has surprising transmissibility TRANS potential, since it could infect MESHD all ages TRANS, gender TRANS, and human sectors. It attacks respiratory, gastrointestinal, urinary, hepatic, and endovascular systems and can reach the peripheral nervous system (PNS) and central nervous system (CNS) through known and unknown mechanisms. The reports on the neurological manifestations and complications of the SARS-CoV-2 infection MESHD are increasing exponentially. Herein, we enumerate seven candidate routes, which the mature or immature SARS-CoV-2 components could use to reach the CNS and PNS, utilizing the within-body crosstalk between organs. The majority of SARS-CoV-2 infected MESHD patients suffer from some neurological manifestations (e.g., confusion HP confusion MESHD, anosmia HP anosmia MESHD, and ageusia MESHD). It seems that although the mature virus did not reach the CNS or PNS of the majority of patients, its unassembled components and/or the accompanying immune-mediated responses may be responsible for the observed neurological symptoms. The viral particles and/or its components have been specifically documented in endothelial cells of lung, kidney, skin, and CNS. This means that the blood SERO-endothelial-barrier may be considered as the main route for SARS-CoV-2 entry into the nervous system, with the barrier disruption being more logical than barrier permeability, as evidenced by postmortem analyses.

    A Systematic Review on Coronavirus Disease MESHD 2019 (COVID-19)

    Authors: Hira Karim; Muhammad Shahzeb Khan

    id:10.20944/preprints202008.0516.v1 Date: 2020-08-24 Source: Preprints.org

    Emerging and reemerging pathogens is a global challenge for public health. Recently, a novel coronavirus disease MESHD emerged in Wuhan, Hubei province of China, in December 2019. It is named COVID-19 by World Health Organization (WHO). It is known to be caused by Severe Acute Respiratory Syndrome Coronavirus 2 MESHD (SARS-CoV-2) that affects the lower respiratory tract and manifests as pneumonia HP pneumonia MESHD in humans. Coronaviruses (CoVs) are structurally more complicated as compared to other RNA viruses. This viral epidemic has led to the deaths of many, including the elderly TRANS or those with chronic disease MESHD or compromised immunity. Viruses cause infection MESHD and diseases in humans of varying degrees, upper respiratory tract infections MESHD respiratory tract infections HP ( URTIs MESHD) cause common cold while lower respiratory tract infections HP induce pneumonia HP pneumonia MESHD, bronchitis HP bronchitis MESHD, and even severe acute respiratory syndrome MESHD (SARS). The costs of COVID-19 are not limited. It equally affects all the medical, sociological, psychological, and economic aspects globally. This is regarded as the third deadly outbreak in the last two decades after Severe Acute Respiratory Syndrome SARS MESHD (2002–2003) and Middle East Respiratory Syndrome MERS MESHD (2012). Based on the sequence homology of SARS-CoV-2, different animal sources including bats, snakes, and pangolins have been reported as potential carriers TRANS of this viral strain. Real-time RT-PCR represents the primary method for the diagnosis of new emerging viral strain SARS-CoV-2. The transmission TRANS dynamics suggest that SARS-CoV-2 is transmitted from person-to-person through direct contact or coughing HP, sneezing HP, and by respiratory droplets. Several anti-viral treatments including lopinavir/ritonavir, remdesivir, chloroquine phosphate, and abidor are also suggested with different recommendations and prescriptions. Protective and preventive strategies as suggested by various health organization i.e. WHO and US Center for Disease Control and Prevention (CDC) must be adopted by everyone. This review covers the important aspects of novel COVID-19 including characteristics, virology, symptoms, diagnostics, clinical aspects, transmission TRANS dynamics, and protective measures of COVID-19.

    The first thousands of cases of coronavirus disease MESHD 2019 (COVID-19) in Algeria: some risk factors

    Authors: SALIMA MOHAMED TALEB; MARWA ALLAOUA BOUSSAKTA; Ann R. Falsey; Nicholas Kitchin; Judith Absalon; Alejandra Gurtman; Stephen Lockhart; Kathleen Neuzil; Mark J Mulligan; Ruth Bailey; Kena A Swanson; Ping Li; Kenneth Koury; Warren Kalina; David Cooper; Camila Fontes-Garfias; Pei-Yong Shi; Özlem Türeci; Kristin R Thompkins; Kirsten E. Lyke; Vanessa Raabe; Philip R Dormitzer; Kathrin U Jansen; Uğur Sahin; William C. Gruber; Vivek Kapur; Suresh V. Kuchipudi; Emmanuel B. Walter; Christopher W. Woods; Matthew S. Kelly

    doi:10.1101/2020.08.17.20176396 Date: 2020-08-20 Source: medRxiv

    Objectives: Providing valuable information on the prevalence SERO of Covid-19 is a crucial step to improve and accentuate the disease surveillance and prevention system as this can limit the spread of the virus. Methods: COVID-19 is caused by the SARS-CoV-2 virus. It is essential to understand the epidemiological characteristics of the first cases in each country. The purpose of this study is to describe the geographic distribution and some risk factors in the first thousands of cases in Algeria. This descriptive study was carried out to examine recent data published by public health institutions in Algeria, websites and the world health organization. Results: The 8306 cases of COVID-19 have been confirmed in Algeria. By sex, men with 55.76% predominate, the most affected age group TRANS was 25 to 49 years old (41.1%), 600 cases of death MESHD were reported, subjects aged TRANS over 60 years are the most likely to die from COVID-19. Most of the confirmed subjects came from the cities of Blida and Algiers. All cases are human-to-human transmissions TRANS. Conclusion: The COVID-19 pandemic has highlighted the lack of dical equipment in Algeria and in all countries of the world. This requires better management of the health sector on an international scale. Keywords: COVD-19; Confirmed cases TRANS; Epidemiology; Algeria.

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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