Corpus overview


MeSH Disease

Human Phenotype

Fever (6)

Obesity (5)

Cough (5)

Falls (3)

Fatigue (3)


    displaying 1 - 10 records in total 70
    records per page

    Variation in SARS-CoV-2 seroprevalence SERO in school- children TRANS across districts, schools and classes

    Authors: Agne Ulyte; Thomas Radtke; Irene A Abela; Sarah H Haile; Jacob Blankenberger; Ruedi Jung; Celine Capelli; Christoph Berger; Anja Frei; Michael Huber; Merle Schanz; Magdalena Schwarzmueller; Alexandra Trkola; Jan Fehr; Milo A Puhan; Susi Kriemler; Peter Hau; Christopher Bohr; Ralph Burkhardt; Andre Gessner; Bernd Salzberger; Frank Hanses; Florian Hitzenbichler; Daniel Heudobler; Florian Lueke; Tobias Pukrop; Wolfgang Herr; Daniel Wolff; Hendrik Poeck; Christoph Brochhausen; Petra Hoffmann; Michael Rehli; Marina Kreutz; Kathrin Renner

    doi:10.1101/2020.09.18.20191254 Date: 2020-09-18 Source: medRxiv

    Importance: Understanding transmission TRANS and impact of severe acute respiratory syndrome coronavirus 2 MESHD (SARS-CoV-2) in school children TRANS is critical to implement appropriate mitigation measures. Objective: To determine the variation in SARS-CoV-2 seroprevalence SERO in school children TRANS across districts, schools, grades, and classes, and the relationship of SARS-CoV-2 seroprevalence SERO with self-reported symptoms. Design: Cross-sectional analysis of baseline measurements of a longitudinal cohort study (Ciao Corona) from June-July 2020. Setting: 55 randomly selected schools and classes stratified by district in the canton of Zurich, Switzerland (1.5 million inhabitants). Participants: Children TRANS, aged TRANS 6-16 years old, attending grades 1-2, 4-5 and 7-8. Exposure: Exposure to circulating SARS-CoV-2 between February and June 2020 including public lock-down and school closure (March 16-May 10, 2020). Main Outcomes and Measures: Variation in seroprevalence SERO of SARS-CoV-2 in children TRANS across 12 cantonal districts, schools, and grades using a Luminex-based antibody test SERO with four targets for each of IgG, IgA and IgM. Clustering of cases within classes. Analysis of associations of seropositivity and symptoms. Comparison of seroprevalence SERO with a randomly selected adult TRANS population, based on Luminex-based IgG and IgA antibody test SERO of Corona Immunitas. Results: In total, 55 schools and 2585 children TRANS were recruited (1337 girls, median age TRANS 11, age TRANS range 6-16 years). Overall seroprevalence SERO was 2.8 % (95% CI 1.6-4.1%), ranging from 1.0% to 4.5% across districts. Seroprevalence SERO was 3.8% (1.9-6.1%) in grades 1-2, 2.5% (1.1-4.2%) in grades 4-5, and 1.5% (0.5-3.0%) in grades 7-8. At least one case was present in 36/55 tested schools and in 43/128 classes with [≥]50% participation rate and [≥]5 children TRANS tested. 73% of children TRANS reported COVID-19 compatible symptoms since January 2020, but none were reported more frequently in seropositive compared to seronegative children TRANS. Seroprevalence SERO of children TRANS was very similar to seroprevalence SERO of randomly selected adults TRANS in the same region in June-July 2020, measured with the same Corona Immunitas test, combining IgG and IgA (3.1%, 95% CI 1.4-5.4%, versus 3.3%, 95% CI 1.4-5.5%). Conclusions and Relevance: Seroprevalence SERO was inversely related to age TRANS and revealed a dark figure of around 90 when compared to 0.03% confirmed PCR+ cases in children TRANS in the same area by end of June. We did not find clustering of SARS-CoV-2 seropositive cases in schools so far, but the follow-up of this school-based study will shed more light on transmission TRANS within and outside schools. Trial registration: Identifier: NCT04448717, registered June 26, 2020.

    In the long shadow of our best intentions: model-based assessment of the consequences of school reopening during the COVID-19 pandemic

    Authors: Kaitlyn E Johnson; Madison Stoddard; Ryan P Nolan; Douglas E White; Natasha S Hochberg; Arijit Chakravarty; Rahul Kumar Anand; Bikash Ranjan Ray; Rajeshwari Subramaniam; Souvik Maitra; Manuel Antonio Franco; Timothy D Flietstra; Amy J Schuh; Panayampalli S Satheshkumar; Jasmine M Chaitram; S Michele Owen; M G Finn; Jason M Goldstein; Joel M Montgomery; Christina F Spiropoulou

    doi:10.1101/2020.09.18.20197400 Date: 2020-09-18 Source: medRxiv

    As the United States grapples with the ongoing COVID-19 pandemic, a particularly thorny set of questions surrounds the reopening of K-12 schools and universities. The benefits of in-person learning are numerous, in terms of education quality, mental health, emotional well-being, equity and access to food and shelter. Early reports suggested that children TRANS might have reduced susceptibility to COVID-19, and children TRANS have been shown to experience fewer complications than older adults TRANS. Over the past few months, our understanding of COVID-19 has been further shaped by emerging data, and it is now understood that children TRANS are as susceptible to infection as adults TRANS and have a similar viral load during infection MESHD. While the higher prevalence SERO of asymptomatic TRANS disease among children TRANS makes symptom-based isolation strategies ineffective, asymptomatic TRANS patients do not in fact carry a reduced viral load. Based on this updated understanding of the disease, we have used epidemiological modeling to explore the feasibility and consequences of school reopening in the face of differing rates of COVID-19 prevalence SERO and transmission TRANS. Our findings indicate that, regardless of the initial prevalence SERO of the disease, and in the absence of systematic surveillance testing, most schools in the United States can expect to remain open for 20-60 days. At this point, one or more large disease clusters can be expected to be detected, forcing schools to close again. These disease clusters, in turn, can be expected to propagate through the community, with potentially hundreds to thousands of additional cases resulting from each individual school cluster. Thus, our findings suggest that the debate between the risks to student safety and benefits of in-person learning frames a false dual choice. Given the current circumstances in the United States, the most likely outcome in the late fall HP is that students will be deprived of the benefits of in-person learning while having incurred a significant risk to themselves and their communities.

    Resurgence of SARS-CoV-2 in England: detection by community antigen surveillance

    Authors: Steven Riley; Kylie E. C. Ainslie; Oliver Eales; Caroline E Walters; Haowei Wang; Christina J Atchison; Claudio Fronterre; Peter J Diggle; Deborah Ashby; Christl A. Donnelly; Graham Cooke; Wendy Barclay; Helen Ward; Ara Darzi; Paul Elliott; Carlos E. Milla; Angela J. Rogers; Paul L. Bollyky; Marcus VG Lacerda; Pedro M Moraes-Vieira; Helder I Nakaya; Qiao Wang; Hongbin Ji; Youhua Xie; Yihua Sun; Lu Lu; Yunjiao Zhou

    doi:10.1101/2020.09.11.20192492 Date: 2020-09-11 Source: medRxiv

    Background Based on cases and deaths MESHD, transmission TRANS of SARS-CoV-2 in England peaked in late March and early April 2020 and then declined until the end of June. Since the start of July, cases have increased, while deaths have continued to decrease. Methods We report results from 594,000 swabs tested for SARS-CoV-2 virus obtained from a representative sample of people in England over four rounds collected regardless of symptoms, starting in May 2020 and finishing at the beginning of September 2020. Swabs for the most recent two rounds were taken between 24th July and 11th August and for round 4 between 22nd August and 7th September. We estimate weighted overall prevalence SERO, doubling times between and within rounds and associated reproduction numbers TRANS. We obtained unweighted prevalence SERO estimates by sub- groups: age TRANS, sex, region, ethnicity, key worker status, household size, for which we also estimated odds of infection MESHD. We identified clusters of swab-positive participants who were closer, on average, to other swab-positive participants than would be expected. Findings Over all four rounds of the study, we found that 72% (67%, 76%) of swab-positive individuals were asymptomatic TRANS at the time of swab and in the week prior. The epidemic declined between rounds 1 and 2, and rounds 2 and 3. However, the epidemic was increasing between rounds 3 and 4, with a doubling time of 17 (13, 23) days corresponding to an R value TRANS of 1.3 (1.2, 1.4). When analysing round 3 alone, we found that the epidemic had started to grow again with 93% probability. Using only the most recent round 4 data, we estimated a doubling time of 7.7 (5.5, 12.7) days, corresponding to an R value TRANS of 1.7 (1.4, 2.0). Cycle threshold values were lower (viral loads were higher) for rounds 1 and 4 than they were for rounds 2 and 3. In round 4, we observed the highest prevalence SERO in participants aged TRANS 18 to 24 years at 0.25% (0.16%, 0.41%), increasing from 0.08% (0.04%, 0.18%) in round 3. We observed the lowest prevalence SERO in those aged TRANS 65 and older at 0.04% (0.02%, 0.06%) which was stable compared with round 3. Participants of Asian ethnicity had elevated odds of infection MESHD. We identified clusters in and around London, transient clusters in the Midlands, and an expanding area of clustering in the North West and more recently in Yorkshire and the Humber. Interpretation Although low levels of transmission TRANS persisted in England through to mid-summer 2020, the prevalence SERO of SARS-CoV-2 is now increasing. We found evidence of accelerating transmission TRANS at the end of August and beginning of September. Representative community antigen sampling can increase situational awareness and help improve public health decision making even at low prevalence SERO.

    Retrospective study of COVID-19 seroprevalence SERO among tissue donors at the onset of the outbreak before implementation of strict lockdown measures in France

    Authors: Nicolas Germain; Stephanie Herwegh; Anne Sophie Hatzfeld; Laurence Bocket; Brigitte Prevost; Pierre Marie Danze; Philippe Marchetti; Rachael Dodd; Brooke Nickel; Kristen Pickles; Samuel Cornell; Thomas Dakin; Kirsten J McCaffery; Aboubacar Sidiki Magassouba; Arsen Arakelyan; Denise Haslwanter; Rohit Jangra; Alev Celikgil; Duncan Kimmel; James H Lee; Margarette Mariano; Antonio Nakouzi; Jose Quiroz; Johanna Rivera; Wendy A Szymczak; Karen Tong; Jason Barnhill; Mattias NE Forsell; Clas Ahlm; Daniel T. Stein; Liise-anne Pirofski; Doctor Y Goldstein; Scott J. Garforth; Steven C. Almo; Johanna P. Daily; Michael B. Prystowsky; James D. Faix; Amy S. Fox; Louis M. Weiss; Jonathan R. Lai; Kartik Chandran

    doi:10.1101/2020.09.11.20192518 Date: 2020-09-11 Source: medRxiv

    Background: The COVID-19 pandemic has altered organ and tissue donations as well as transplantation practices. SARS-CoV-2 serological tests SERO could help in the selection of donors. We assessed COVID-19 seroprevalence SERO in a population of tissue donors, at the onset of the outbreak in France, before systematic screening of donors for SARS-CoV-2 RNA. Methods: 235 tissue donors at the Lille Tissue bank between November 1, 2019 and March 16, 2020 were included. Archived serum SERO samples were tested for SARS-CoV-2 antibodies SERO using two FDA-approved kits. Results: Most donors were at higher risks for severe COVID-19 illness including age TRANS over 65 years (142/235) and/or presence of co-morbidities (141/235). According to the COVID-19 risk assessment of transmission TRANS, 183 out of 235 tissue donors presented with a low risk level and 52 donors with an intermediate risk level of donor derived infection MESHD. Four out of the 235 (1.7%) tested specimens were positive for anti- SARS-CoV-2 antibodies SERO: 2 donors with anti-N protein IgG and 2 other donors with anti-S protein total Ig. None of them had both type of antibodies SERO. Conclusion: Regarding the seroprevalence SERO among tissue donors, we concluded that the transmission TRANS probability to recipient via tissue products was very low at the beginning of the outbreak.

    Model-informed COVID-19 vaccine prioritization strategies by age TRANS and serostatus

    Authors: Kate M Bubar; Stephen M Kissler; Marc Lipsitch; Sarah Cobey; Yonatan Grad; Daniel B Larremore

    doi:10.1101/2020.09.08.20190629 Date: 2020-09-10 Source: medRxiv

    When a vaccine for COVID-19 becomes available, limited initial supply will raise the question of how to prioritize the available doses and thus underscores the need for transparent, evidence-based strategies that relate knowledge of, and uncertainty in, disease transmission, risk TRANS, vaccine efficacy, and existing population immunity. Here, we employ a model-informed approach to vaccine prioritization that evaluates the impact of prioritization strategies on cumulative incidence and mortality and accounts for population factors such as age TRANS, contact structure, and seroprevalence SERO, and vaccine factors including imperfect and age TRANS-varying efficacy. This framework can be used to evaluate and compare existing strategies, and it can also be used to derive an optimal prioritization strategy to minimize mortality or incidence. We find that a transmission TRANS-blocking vaccine should be prioritized to adults TRANS ages TRANS 20-49y to minimize cumulative incidence and to adults TRANS over 60y to minimize mortality. Direct vaccination of adults TRANS over 60y minimizes mortality for vaccines that do not block transmission TRANS. We also estimate the potential benefit of using individual-level serological tests SERO to redirect doses to only seronegative individuals, improving the marginal impact of each dose. We argue that this serology-informed vaccination approach may improve the efficiency of vaccination efforts while partially addressing existing inequities in COVID-19 burden and impact.

    Healthcare workers in elderly TRANS care: a source of silent SARS-CoV-2 transmission TRANS?

    Authors: Mirjam Jeanne Dorine Dautzenberg; Andrea Eikelenboom-Boskamp; Jacqueline Janssen; Miranda Drabbe; Ewoud de Jong; Eefke Weesendorp; Marion Koopmans; Andreas Voss; Matthew Hickman; Ellen Brooks Pollock; Jan Lukas Robertus; Maria Gabrani; Michal Rosen-Zvi

    doi:10.1101/2020.09.07.20178731 Date: 2020-09-09 Source: medRxiv

    Importance: Healthcare workers (HCWs), including those with mild symptoms, may be an important source of COVID-19 within elderly TRANS care. Objective: To gain insight into the spread of SARS-CoV-2 among HCWs working in elderly TRANS care settings. Design: Cross-sectional study among HCWs working in elderly TRANS care in the South-East of the Netherlands, testing for SARS-CoV-2, between March 31 and April 17, 2020. Setting: HCWs working in geriatric rehabilitation, somatic and psychogeriatric wards or small-scale living groups and district nursing, with a total of 5245 HCWs within 4 organisations. Participants: 621 HCWs with mild respiratory symptoms. Main Outcomes: Number of HCWs testing positive for SARS-CoV-2 in pharyngeal swabs, using real-time reverse-transcriptase PCR targeting the SARS-CoV-2 E-gene, N-gene, and RdRP. HCWs filled out a survey to collect information on symptoms and possible sources of infection MESHD. Results: 133/615 (21.6%) HCWs tested positive for SARS-CoV-2, ranging from 15.6 to 44.4% per elderly TRANS care organisation, and from 0 to 64.3% per separate location of the organizations, respectively. 74.6% of tested HCWs were nursing staff, 1.7% elderly TRANS care physicians, 20.3% other HCWs with patient contact and 3.4% HCWs without patient contact. In the univariate analysis, fever HP fever MESHD, runny or stuffy nose, anosmia HP anosmia MESHD, general malaise, myalgia HP myalgia MESHD, headache HP headache MESHD and ocular pain HP ocular pain MESHD were associated with SARS-CoV-2 positivity, while gastro-intestinal symptoms and respiratory symptoms, other than runny or stuffy nose were not. Risk factors for SARS-CoV-2 positivity were contact with patients or colleagues with suspected or proven COVID-19. Whole genome sequencing of 22 samples in 2 facilities strongly suggests spread within facilities. Conclusions and Relevance: We found a high SARS-CoV-2 prevalence SERO among HCWs in nursing homes and district nursing, supporting the hypothesis of undetected spread within elderly TRANS care facilities. Structural testing of elderly TRANS care HCWs, including track and trace of contacts TRANS, should be performed to control this spread, even when only mild symptoms are present.

    The impact of COVID-19 on the lives and mental health of Australian adolescents

    Authors: Sophie Li; Joanne Beames; Jill Newby; Kate Maston; Helen Christensen; Aliza Werner-Seidler; Marina Pifano; Teresa Varela; Enio Garcia; Alicia Lawrynowicz; Osvaldo Uez; Irene Pagano; Anastasija Caica; Mikus Gavars; Dmitrijs Perminovs; Jelena Storozenko; Oksana Savicka; Elina Dimina; Uga Dumpis; Janis Klovins

    doi:10.1101/2020.09.07.20190124 Date: 2020-09-09 Source: medRxiv

    Objective: There has been significant disruption to the lives and mental health of adolescents during the COVID-19 pandemic, but the exact nature of the effects is not known. The purpose of this study was to assess the psychological and lifestyle impact of the pandemic on Australian adolescents, using an online survey, administered during and after the peak of the outbreak (June-July 2020). Method: Self-report surveys were administered online to a sample of 760 Australian adolescents aged TRANS 12-18 years old. Surveys assessed worry about contracting COVID-19, behavioral change in response to the pandemic, impact on education, peer and family relationships, lifestyle factors including exercise, technology use and sleep, as well as mental health outcomes including psychological distress, loneliness, health anxiety HP anxiety MESHD and wellbeing. Results: Overall, young people expressed significant concern and worry about contracting the virus, and most (>85%) engaged in behaviors to reduce the risk of transmission TRANS. Three quarters of the sample reported a worsening of their mental health since the pandemic began, with negative impacts reported by most respondents on learning, friendships and family relationships. More than 40% of young people reported a decrease in exercise and 70% reported an increase in technology use since the outbreak. There were high levels of uncertainty about the future reported by respondents, and their scores on validated measures indicated higher levels of sleep disturbance HP sleep disturbance MESHD, psychological distress MESHD and health anxiety HP anxiety MESHD, and lower levels of wellbeing, relative to normative samples. Reponses on the Kessler Psychological Distress Scale indicated that 48.3% of the sample were experiencing distress consistent with a probable mental illness MESHD, which is much higher than pre-pandemic prevalence SERO rates. Effects on mental health were worse among those who reported a previous diagnosis of depression MESHD and/or anxiety HP anxiety MESHD relative to those without a history of depression MESHD and/or anxiety HP anxiety MESHD. Conclusion: These results indicate high levels of disruption and psychological distress experienced by adolescents during the current COVID-19 pandemic. Adolescents are already vulnerable to the onset of mental illness at this developmental stage, and the current research underscores the need to find rapid and accessible ways to support adolescent mental health during times of crisis. There is a need for longitudinal research to evaluate the enduring effects of the pandemic on adolescents.

    Evaluation of attitude among infertile MESHD couples about continuing assisted reproductive technologies therapy during novel coronavirus outbreak

    Authors: Sepideh Peivandi; Alireza Razavi; Shervin Shafiei; Marzieh Zamaniyan,; Asma Orafaie; Hamed Jafarpour; FERNANDA A. BAIAO; PAULA MACAIRA; SILVIO HAMACHER; FERNANDO A. BOZZA; Daniel Figeys; Alex E. MacKenzie; Robert Delatolla; Emma Young; Andrew Bentley; Kirsty Challen; Chris Fitzsimmons; Tim Harris; Fiona Lecky; Andrew Lee; Ian Maconochie; Darren Walter; Dilek Telci; Fikrettin Sahin; Koray Yalcin; Ercument Ovali

    doi:10.1101/2020.09.01.20186320 Date: 2020-09-03 Source: medRxiv

    Study question: Does the fear of the coronavirus disease MESHD 2019 (COVID-19) pandemic reduce the desire of infertile MESHD couples to continue treatment? Summary answer: Most of the participants in this study wanted to continue treatment. What is known already: The effect of the prevalence SERO of infectious diseases including the Zika virus on the attitude of infertile MESHD couples has been studied in very few studies. However, the effect of the outbreak of COVID-19 on the attitude of infertile MESHD couples has not been investigated. Study design, size, duration: We conducted a prospective longitudinal study on forty-six infertile MESHD couples (n=92) who referred to our infertility HP infertility MESHD clinic from 4 March 2020 through 20 June 2020. Participants/materials, settings, methods: This study is based on potential infertile MESHD couples for treatment with assisted reproductive technology (ART) who referred to our infertility HP infertility MESHD clinic, Sari, Iran (median age TRANS of 35.5 years). All individuals with primary infertility MESHD infertility HP, as defined by the World Health Organization (WHO) and candidates for ART, were included in the study. People who did not agree to participate in the study were excluded. Subjects were surveyed using a researcher-made questionnaire. This questionnaire has four sections as follows: The first part included demographic information and clinical characteristics, the second part included medical records, the third part included questions related to assessing the level of awareness regarding coronavirus infection MESHD, and the fourth part included questions related to the attitude towards continuing infertility HP infertility MESHD treatment. The validity of this questionnaire was assessed by three infertility HP infertility MESHD specialists and was confirmed with Cronbachs alpha of 0.78. A P-value of less than 0.05 was considered statistically significant. Main results and the role of chance: There is no significant relationship between COVID-19 symptoms and the level of awareness (P-value <0.05). Thirty-two patients (33.33%) had decreased motivation to continue treatment during COVID-19 pandemic. Fear of transmission TRANS to the fetus (28.13%) had the highest frequency among the causes of decreased motivation to continue treatment (P-value = 0.011). Confidence in support of the treatment team (56.67%) was the most common reason for lack of motivation in people without decreased motivation (P-value <0.001). The majority of patients had a very high or high tendency (65.22%) to continue or start treatment during the COVID-19 pandemic (P-value <0.001). Most people had an average fear of getting the disease (39.13%) (value <0.001). Examining the relationship between the presence of COVID-19 symptoms and attitude level variables showed that there is only a significant relationship between the greater desire to have a child TRANS and the continuation or initiation of treatment with the presence of COVID-19 symptoms (P-value = 0.032). Limitations, reasons for caution: We were not able to fully assess patients' deep feelings and cultural beliefs, due to the use of questionnaires and the lack of interviews. Wider implications of the findings: Our results showed for the first time that patients' knowledge about COVID-19 and trust in the treatment staff played an effective role in selecting and continuing infertility HP infertility MESHD treatment. To clarify this issue, studies with the larger statistical community in the form of interviews are needed. Study funding/completing interest(s): The study received financial support from the Mazandaran University of Medical Sciences (Grant number: 7903). None of the funders had any role in the study design, collection, analysis, or interpretation of data, writing of the paper, or publication decisions. The authors have nothing to declare. Trial registration number: N/A

    Seroprevalence SERO and immunity of SARS-CoV-2 infection MESHD in children TRANS and adolescents in schools in Switzerland: design for a longitudinal, school-based prospective cohort study

    Authors: Agne Ulyte; Thomas Radtke; Irene Abela; Sarah H Haile; Julia Braun; Ruedi Jung; Christoph Berger; Alexandra Trkola; Jan Fehr; Milo A Puhan; Susi Kriemler; Anel Nurtay; Lucie Abeler-Dörner; David G Bonsall; Michael V McConnell; Shawn O'Banion; Christophe Fraser; Scott Roberts; Jose A. Gonzalez; Marciano Sablad; Rodrigo Yelin; Wendy Taylor; Kiyoshi Tachikawa; Suezanne Parker; Priya Karmali; Jared Davis; Sean M Sullivan; Steve G. Hughes; Pad Chivukula; Eng Eong Ooi

    doi:10.1101/2020.08.30.20184671 Date: 2020-09-02 Source: medRxiv

    Introduction Seroprevalence SERO and transmission TRANS routes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection MESHD in children TRANS and adolescents, especially in school setting, are not clear. Resulting uncertainty is reflected in very different decisions on school closures and reopenings across countries. The aim of this longitudinal cohort study is to assess the extent and patterns of seroprevalence SERO of SARS-CoV-2 antibodies SERO in school-attending children TRANS repeatedly. It will examine risk factors for infection MESHD, relationship between seropositivity and symptoms, and temporal persistence of antibodies SERO. Additionally, it will include testing of school personnel and parents TRANS. Methods and analysis The study (Ciao Corona) will enroll a regionally representative, random sample of schools in the canton of Zurich, where 18% of the Swiss population live. Children TRANS aged TRANS 5 to 16 years, attending classes in primary and secondary schools are invited. Venous blood MESHD blood SERO and saliva samples are collected for SARS-CoV-2 serological testing SERO after the first wave of infections (June/July 2020), in fall HP (October/November 2020), and after winter (March/April 2021). Venous blood MESHD blood SERO is also collected for serological testing SERO of parents TRANS and school personnel. Bi-monthly questionnaires to children TRANS, parents TRANS and school personnel cover SARS-CoV-2 symptoms MESHD and tests, health, preventive behavior, lifestyle and quality of life information. Total seroprevalence SERO and cumulative incidence will be calculated. Hierarchical Bayesian logistic regression models will account for sensitivity SERO and specificity of the serological test SERO in the analyses and for the complex sampling structure, i.e., clustering within classes and schools. Ethics and dissemination The study was approved by the Ethics Committee of the Canton of Zurich, Switzerland (2020-01336). The results of this study will be published in peer-reviewed journals and will be made available to study participants and participating schools, the Federal Office of Public Health, and the Educational Department of the canton of Zurich. Trial registration number NCT04448717.

    High SARS-CoV-2 Seroprevalence SERO in Children TRANS and Adults TRANS in the Austrian Ski Resort Ischgl

    Authors: Ludwig Knabl; Tanmay Mitra; Janine Kimpel; Annika Roessler; Andre Volland; Andreas Walser; Hanno Ulmer; Lisa Pipperger; Sebastian C Binder; Lydia Riepler; Katie Bates; Arnab Bandyopadhyay; Marta Schips; Mrinalini Ranjan; Barbara Falkensammer; Wegene Borena; Michael Meyer-Hermann; Dorothee von Laer; David Wyllie

    doi:10.1101/2020.08.20.20178533 Date: 2020-08-22 Source: medRxiv

    Background: Early March 2020, a SARS-CoV-2 outbreak in the ski resort Ischgl in Austria initiated the spread of SARS-CoV-2 throughout Austria and Northern Europe. Methods: Between April 21 and 27, a cross-sectional epidemiologic study targeting the full population of Ischgl (n= 1867), of which 79% could be included (n=1473, incl. 214 children TRANS), was performed. For each individual, the study involved a SARS-CoV-2 PCR, antibody testing SERO and structured questionnaires. A mathematical model was used to help understand the influence of the determined seroprevalence SERO on virus transmission TRANS. Findings: The seroprevalence SERO was 42.4% (95% CI 39.8-44.7). Individuals under 18 showed a significantly lower seroprevalence SERO of 27.1% (95% CI 21.3-33.6) than adults TRANS (45%; 95% CI 42.2-47.7; OR of 0.455, 95% CI 0.356-0.682, p<0.001). Of the seropositive individuals, 83.7% had not been diagnosed to have had SARS-CoV-2 infection MESHD previously. The clinical course was generally mild. Over the previous two months, two COVID-19-related deaths had been recorded, corresponding to an infection fatality rate (IFR) of 0.25% (95% CI 0.03-0.91). Only 8 (0.5 %) individuals were newly diagnosed to be infected with SARS-CoV-2 during this study. Interpretation: Ischgl was hit early and hard by SARS-CoV-2 leading to a high local seroprevalence SERO of 42.4%, which was lower in individuals below the age TRANS of 18 than in adults TRANS. Mathematical modeling suggests that a drastic decline of newly infected individuals in Ischgl by the end of April occured due to the dual impact from the non-pharmacological interventions (NPIs) and a significant immunization of the Ischgl population. Funding: Helmholtz Association, European Union's Horizon 2020 research and innovation program, German Research Foundation (DFG), state Tyrol.

The ZB MED preprint Viewer preVIEW includes all COVID-19 related preprints from medRxiv and bioRxiv, from ChemRxiv, from ResearchSquare, from arXiv and from and is updated on a daily basis (7am CET/CEST).
The web page can also be accessed via API.



MeSH Disease
Human Phenotype

Export subcorpus as...

This service is developed in the project nfdi4health task force covid-19 which is a part of nfdi4health.

nfdi4health is one of the funded consortia of the National Research Data Infrastructure programme of the DFG.