Corpus overview


Overview

MeSH Disease

Human Phenotype

Anosmia (4)

Fever (3)

Cough (3)

Myalgia (1)


Transmission

Seroprevalence
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    A cross-sectional study of immune seroconversion to SARS-CoV-2 in front-line maternity health professionals

    Authors: Sohail Bampoe; Dominique Nuala Lucas; Georgina Neall; Penny Sceales; Reena Aggarwal; Dimitrios Siassakos; Peter Mark Odor

    doi:10.1101/2020.06.24.20139352 Date: 2020-06-26 Source: medRxiv

    COVID-19, the respiratory disease MESHD caused by the SARS-CoV-2, is thought to cause a milder illness in pregnancy with a greater proportion of asymptomatic TRANS carriers TRANS. This has important implications for the risk of patient-to-staff, staff-to-staff and staff-to patient transmission TRANS among health professionals in maternity. The aim of this study was to investigate the prevalence SERO of previously undiagnosed SARS-CoV-2 infection MESHD in health professionals from two tertiary-level maternity units in London, UK and to determine associations between HCW characteristics, reported symptoms and serological evidence of prior SARS-CoV-2 infection MESHD. 200 anaesthetists, midwives and obstetricians with no previously confirmed diagnosis of COVID-19 were tested for immune seroconversion using laboratory IgG assays. Comprehensive symptom and medical histories were also collected. 5/40 (12.5%; 95% CI: 4.2-26.8) anaesthetists, 7/52 (13.5%; 95% CI: 5.6-25.8%) obstetricians and 17/108 (15.7%; 95% CI: 9.5-24.0%) midwives were seropositive, with an overall total of 29/200 (14.5%; 95% CI: 9.9-20.1%) of maternity healthcare workers testing positive for IgG antibodies SERO against SARS-CoV-2. Of those who had seroconverted, 10/29 (35.5%) were completely asymptomatic TRANS. Fever HP or cough HP were only present in 6/29 (20.7%) and (10/29 (34.5%) respectively. Anosmia HP was the most common symptom occurring in 15/29 (51.7%) seropositive participants and was the only symptom that was predictive of positive seroconversion (OR 18; 95% CI 6 to 55). 58.6% of those who were seropositive had not self-isolated at any point and continued to provide patient care in the hospital setting. This study was the largest study of baseline immune seroconversion in maternity healthcare workers conducted to date and reveals that 1 in 6 were seropositive, of whom 1 in 3 were asymptomatic TRANS. This has significant implications for the risk of occupational transmission TRANS of SARS-CoV-2 for both staff and patients in maternity and regular testing of staff, including asymptomatic TRANS staff should be considered to reduce transmission risk TRANS.

    SARS-CoV-2 exposure, symptoms and seroprevalence SERO in health care workers

    Authors: Ann-Sofie Rudberg; Sebastian Havervall; Anna Manberg; August Jernbom Falk; Katherina Aguilera; Henry Ng; Lena Gabrielsson; Ann-Christin Salomonsson; Leo Hanke; Benjamin Murell; Gerald McInerney; Jennie Olofsson; Eni Andersson; Cecilia Hellstrom; Shaghayegh Bayati; Sofia Bergstrom; Elisa Pin; Ronald Sjoberg; Hanna Tegel; My Hedhammar; Mia Phillipson; Peter Nilsson; Sophia Hober; Charlotte Thalin

    doi:10.1101/2020.06.22.20137646 Date: 2020-06-23 Source: medRxiv

    Background: SARS-CoV-2 may pose an occupational health risk to health care workers, but the prevalence SERO of infections in this population is unknown. We examined the seroprevalence SERO of SARS-CoV-2 antibodies SERO among health care workers at a large acute care hospital in Stockholm, Sweden. We determined correlations between seroprevalence SERO, self-reported symptoms and occupational exposure to SARS-CoV-2. Methods and findings: All employees at Danderyd Hospital (n=4375) were invited to participate in a cross-sectional study. 2149 employees from all hospital departments were enrolled in the study between April 14th and May 8th 2020. Study participants completed a questionnaire consisting of symptoms compatible with SARS-CoV-2 infection MESHD since January 2020 and occupational exposure to patients infected with SARS-CoV-2. IgG antibodies SERO against SARS-CoV-2 were analyzed using a multiplex assay evaluated to have 99.4% sensitivity SERO and 99.1% specificity. The over-all seroprevalence SERO among 2149 participants was 19.1% (n=410). There was no difference in age TRANS or sex between seropositive and seronegative participants. The symptoms with the strongest correlation to seroprevalence SERO were anosmia HP anosmia MESHD and ageusia, with odds ratios of 28.4 (p=2.02*10^-120) and 19.2 (p=1.67*10^-99) respectively. Seroprevalence SERO was strongly associated with patient-related work (OR 2.9, p=4.24*10^-8), covid-19 patient contact (OR 1.43, p=0.003), and occupation as assisting nurse (OR 3.67, p=2.16*10^-9). Conclusion: These results demonstrate that anosmia HP anosmia MESHD and ageusia MESHD should be included in screening guidance and in the recommendations of self-isolation to reduce further spread of SARS-CoV-2. The results furthermore imply an occupational health risk for SARS-CoV-2 infection MESHD among hospital workers. Continued measures are warranted to assure healthcare worker safety and reduce transmission TRANS from health care settings to the community during the covid-19 outbreak.

    A population-based study of the prevalence SERO of COVID-19 infection MESHD in Espirito Santo, Brazil: methodology and results of the first stage

    Authors: Cristiana Costa Gomes; Crispim Cerutti Jr.; Eliana Zandonade; Ethel Leonor Noia Maciel; Filomena Euridice Carvalho de Alencar; Gilton Luiz Almada; Orlei Amaral Cardoso; Pablo Medeiros Jabor; Raphael Lubiana Zanotti; Tania Queiroz Reuter; Vera Lucia Gomes de Andrade; Whisllay Maciel Bastos; Nesio Fernandes de Medeiros Jr.

    doi:10.1101/2020.06.13.20130559 Date: 2020-06-16 Source: medRxiv

    BACKGROUND: COVID-19 is affecting almost the entire world, causing more than four hundred thousand deaths and undermining the health care systems, as much as the economy, of the afflicted countries. The strategies for prevention depend on largely lacking information, as infection MESHD prevalence SERO and virus pathogenicity. This study aimed to determine the prevalence SERO, the pathogenicity, and the speed of infection MESHD spreading in a large population in Brazil. MATERIALS AND METHODS: This is a serial cross-sectional study designed on a population basis and structured over houses as the sampling units. The sampling consisted of four visits at 15 days intervals in randomly selected census-designated sectors of the State major municipalities (reference municipalities) and two visits at 30 days intervals in smaller municipalities of the same regions of those of reference. At each visit, the investigators sampled houses and sampled one individual in each house for data collection. After the informed consent, the investigators performed a rapid antibody SERO detection test (Celer Technology, Inc) and applied a questionnaire containing clinical and demographic questions. RESULTS: From May 13th to 15th, the investigators performed 6,393 rapid tests SERO in 4,612 individuals of the reference municipalities, 1,163 individuals of the smaller municipalities, and 166 contacts of the positive individuals. Ninety-seven dwellers were positive in the reference municipalities, giving a prevalence SERO of 2.1% (CI 95%: 1.67-2.52%). In the smaller municipalities, the figure was 0.26% (CI 95%: 0.05%-0.75%) (three positives). There was an association of the positive result with female TRANS sex (p = 0.013) and houses with five dwellers or more (p = 0.003). Seventy-eight positive individuals reported symptoms in the previous 15 days (80.4%), being anosmia HP anosmia MESHD (45.4%), cough HP (40.2%), and myalgia HP myalgia MESHD (38.1%) the more frequent. About one-third of them reported fever HP fever MESHD (28.9%). CONCLUSIONS: The results reveal a still small prevalence SERO of infection MESHD in the study area, despite the significant number of sick people overloading the health system. The figures indicate an important underreporting in the area and a frequency that still can grow, making necessary public health actions for the containment of the transmission TRANS.

    Absence of SARS-CoV-2 infection MESHD in cats and dogs in close contact TRANS with a cluster of COVID-19 patients in a veterinary campus

    Authors: Sarah Temmam; Alix Barbarino; Djérène Maso; Sylvie Behillil; Vincent Enouf; Christèle Huon; Ambre Jaraud; Lucie Chevallier; Marija Backovic; Philippe Pérot; Patrick Verwaerde; Laurent Tiret; Sylvie van der Werf; Marc Eloit

    doi:10.1101/2020.04.07.029090 Date: 2020-04-09 Source: bioRxiv

    Severe acute respiratory syndrome coronavirus 2 MESHD (SARS-CoV-2), which originated in Wuhan, China, in 2019, is responsible for the COVID-19 pandemic. It is now accepted that the wild fauna, probably bats, constitute the initial reservoir of the virus, but little is known about the role pets can play in the spread of the disease TRANS in human communities, knowing the ability of SARS-CoV-2 to infect some domestic animals. We tested 21 domestic pets (9 cats and 12 dogs) living in close contact TRANS with their owners (belonging to a veterinary community of 20 students) in which two students tested positive for COVID-19 and several others (n = 11/18) consecutively showed clinical signs ( fever HP fever MESHD, cough HP cough MESHD, anosmia HP anosmia MESHD, etc.) compatible with COVID-19 infection MESHD. Although a few pets presented many clinical signs indicative for a coronavirus infection MESHD, no animal tested positive for SARS-CoV-2 by RT-PCR and no antibodies SERO against SARS-CoV-2 were detectable in their blood SERO using an immunoprecipitation assay. These original data can serve a better evaluation of the host range of SARS-CoV-2 in natural environment exposure conditions.

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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