Corpus overview


MeSH Disease

Human Phenotype


    displaying 1 - 10 records in total 25
    records per page

    Sleep Disturbances HP Disturbances, Anxiety MESHD Anxiety HP, and Burnout during the COVID-19 Pandemic: a nationwide cross-sectional study in Brazilian Healthcare Professionals.

    Authors: Luciano Drager; Daniela Pachito; Claudia Moreno; Almir Tavares Jr.; Silvia G. Conway; Marcia Assis; Danilo A. Sguillar; Gustavo A. Moreira; Andrea Bacelar; Pedro R. Genta; Samantha K Davis; Helen E Kent; Francesca L Mordant; Timothy E Schlub; David L Gordon; David S Khoury; Kanta Subbarao; Deborah Cromer; Tom P Gordon; Amy W Chung; Miles P Davenport; Stephen J Kent

    doi:10.1101/2020.09.08.20190603 Date: 2020-09-10 Source: medRxiv

    Study objectives: To evaluate the impact of COVID-19 pandemic on sleep, anxiety HP anxiety MESHD, and Burnout in healthcare professionals. Methods: A survey was distributed using social media and organizational emails to Brazilian active healthcare professionals during the COVID-19 outbreak. We explored potential associated factors including age TRANS, gender TRANS, occupation, workplace, work hours, income, previous infection MESHD with COVID-19, recent/current contact with COVID-19 patients, regional number of incident deaths due to COVID-19, anxiety HP anxiety MESHD, and burnout. We evaluated new-onset or previous insomnia HP insomnia MESHD worsening (primary outcome), sleep quality, and duration (secondary outcomes). Results: A total of 4,384 health professionals from all regions of the country were included in the analysis (mean age TRANS: 44{+/-}12 years, 76% females TRANS, 53.8% physicians). Overall, 55.7% were assisting patients with COVID-19, and 9.2% had a previous COVID-19 infection MESHD. New-onset insomnia HP insomnia MESHD symptoms or previous insomnia HP insomnia MESHD worsening occurred in 41.4% of respondents in parallel to 13% (n=572) new pharmacological treatments for insomnia HP insomnia MESHD. Prevalent anxiety HP anxiety MESHD and burnout during the pandemic were observed in 44.2% and 21% of participants, respectively. Multivariate analyses showed that females TRANS (OR:1.756; 95% CI 1.487-2.075), weight change (decrease: OR:1.852; 95% CI 1.531-2.240; increase: OR:1.542; 95% CI 1.323-1.799), prevalent anxiety HP anxiety MESHD (OR:3.209; 95% CI 2.796-3.684), new-onset burnout (OR:1.986; 95% CI 1.677-2.352), family income reduction >30% (OR:1.366; 95% CI 1.140-1.636) and assisting patients with COVID-19 (OR:1.293; 95% CI 1.104-1.514) were independently associated with new-onset or worsening of previous insomnia HP insomnia MESHD. Conclusions: We observed a huge burden of insomnia HP insomnia MESHD in healthcare professionals during the COVID-19 pandemic. In this scenario, dedicated approaches for sleep health are highly desirable.

    Predictors of healthcare worker burnout during the COVID-19 pandemic

    Authors: Amy V Ferry; Ryan Wereski; Fiona E Strachan; Nicholas L Mills; Ben Warne; Luke Meredith; Myra Hosmillo; Aminu Jahun; Martin Curran; Surendra Parmar; Laura Caller; Sarah Caddy; Fahad Khokhar; Anna Yakovleva; Grant Hall; Theresa Feltwell; Malte Pinckert; Iliana Georgana; Yasmin Chaudhry; Nicholas Brown; Sonia Goncalves; Roberto Amato; Ewan Harrison; Mathew Beale; Michael Spencer Chapman; David Jackson; Ian Johnston; Alex Alderton; John Sillitoe; Cordelia Langford; Gordon Dougan; Sharon Peacock; Dominic Kwiatowski; Ian Goodfellow; M. Estee Torok; - COVID-19 Genomics Consortium UK

    doi:10.1101/2020.08.26.20182378 Date: 2020-09-01 Source: medRxiv

    Objective We aim to provide a snapshot of the levels of burnout, anxiety HP anxiety MESHD, depression MESHD and distress among healthcare workers during the COVID-19 pandemic. Design, setting, participants We distributed an online survey via social media in June 2020 that was open to any healthcare worker. The primary outcome measure was symptoms of burnout as measured using the Copenhagen Burnout Inventory (CBI). Secondary outcomes of depression MESHD, anxiety HP anxiety MESHD and distress as measured using the Patient Health Questionnaire-9, General Anxiety HP Anxiety MESHD Scale-7, and Impact of Events Scale-Revised were recorded along with subjective measures of stress. Multivariate logistic regression analysis was performed to identify factors associated with burnout, depression MESHD, anxiety HP anxiety MESHD and distress. Results Of 539 persons responding to the survey, 90% were female TRANS, and 26% were aged TRANS 41-50 years, 53% were nurses. Participants with moderate-to-severe burnout were younger (49% [206/424] versus 33% [38/115] under 40 years, P=0.004), and more likely to have pre-existing comorbidities (21% versus 12%, P=0.031). They were twice as likely to have been redeployed from their usual role (22% versus 11%; adjusted odds ratio [OR] 2.2, 95% confidence interval [CI] 1.5-3.3, P=0.042), or to work in an area dedicated to COVID-19 patients (50% versus 32%, adjusted OR 1.6, 95% CI 1.4-1.8, P<0.001), and were almost 4-times more likely to have previous depression MESHD (24% versus 7%; adjusted OR 3.6, 95% CI 2.2-5.9, P=0.012). A supportive workplace team and male TRANS sex protected against burnout reducing the odds by 40% (adjusted OR 0.6, 95% CI 0.5-0.7, P<0.001) and 70% (adjusted OR 0.3, 95% CI 0.2-0.5, P=0.003), respectively. Conclusion Independent predictors of burnout were younger staff, redeployment to a new working area, working with patients with confirmed COVID-19 infection MESHD, and being female TRANS or having a previous history of depression MESHD. Evaluation of existing psychological support interventions is required with targeted approaches to ensure support is available to those most at risk.

    Immediate Effects of COVID-19 Outbreak on Psychiatric Outpatients: Posttraumatic Stress MESHD and Influencing Factors

    Authors: Burc Cagri Poyraz; Cana Aksoy Poyraz; Senol Turan; Omer Faruk Demirel; Yasin Kavla; Ersel Bulu; Irem Hacisalihoglu; Elif Burcu Ersungur; Li Shen; Dokyoon Kim; Eduardo Marquez-Garcia; Edda Sciutto; Jose Moreno-Rodriguez; Jose Omar Barreto-Rodriguez; Hazel Vazquez-Rojas; Gustavo Ivan Centeno-Saenz; Nestor Alvarado-Pena; Citlaltepetl Salinas-Lara; Carlos Sanchez-Garibay; Gabriela Hernandez-Molina; Criselda Mendoza-Milla; Andrea Dominguez; Julio Granados; Lula Mena-Hernandez; Luis Angel Perez-Buenfil; Guillermo Dominguez-Cheritt; Carlos Cabello-Gutierrez; Cesar Luna-Rivero; Jorge Salas-Hernandez; Patricio Santilla-Doherty; Justino Regalado; Angelica Hernandez-Martinez; Lorena Orozco; Ethel A. Garcia-Latorre; Carmen M. Hernandez-Cardenas; Shabaana A. Khader; Albert Zlotnik; Joaquin Zuniga

    doi:10.1101/2020.08.12.20173468 Date: 2020-08-14 Source: medRxiv

    We aimed to investigate the effects of COVID-19 outbreak and public health measures on the psychological well-being of patients with psychiatric disorders MESHD. This cross-sectional study assessed 436 outpatients recruited from a tertiary psychiatry clinic in Istanbul, Turkey, nearly one month after the government introduced strict measures of lockdown against the ongoing outbreak. Respondents completed a web-based survey on sociodemographic data, subjective sleep quality, and a range of psychiatric MESHD symptoms using the Impact of Events Scale-Revised (IES-R), and Hospital Anxiety HP Anxiety MESHD and Depression Scale (HADS). Respondents reported high frequencies of clinically significant posttraumatic stress disorder MESHD ( PTSD MESHD) (32.6%, IES-R score equal to or above 33), anxiety HP anxiety MESHD (36.4%, HADS anxiety MESHD anxiety HP score > 10), and depression MESHD (51%, HADS depression MESHD score > 10). 20.5% of respondents described that their psychological status worsened during the COVID-19 outbreak, and 12.1% of respondents described poor or very poor sleep in the prior month. Positive predictors of increased PTSD MESHD symptoms included the chronic medical diseases, knowing someone in the social vicinity diagnosed with the COVID-19 infection MESHD, job loss MESHD or being on temporary leave after the outbreak, and increased exposure time to TV or social media. In contrast, male TRANS gender TRANS, older age TRANS, higher educational attainment, and the psychiatric MESHD diagnoses of schizophrenia HP schizophrenia MESHD and (to a lesser degree) bipolar disorder MESHD were the negative predictors. Our results suggest that patients with psychiatric disorders MESHD are prone to substantial psychological distress during the COVID-19 outbreak, and various individual, behavioral, and social factors mediate this effect.

    Level of anxiety HP anxiety MESHD caused by the coronavirus (COVID-19) pandemic among dentists in Poland.

    Authors: Ewa Rusyan; Agnieszka Mielczarek; Agnieszka Kapała; Kamil Adamczyk; Robert Piec; Barbara Szykuła- Piec

    doi:10.21203/ Date: 2020-08-03 Source: ResearchSquare

    Background: The early information on both the speed and high morbidity rate and, above all, mortality, triggered the symptoms of COVID-19-related panic and anxiety HP anxiety MESHD. Dentists were listed in the top five professions with the highest risk of transmission TRANS of the virus. The paper aimed to assess the level of anxiety HP anxiety MESHD among dentists in Poland. Methods: A cross-sectional study was conducted via an online survey questionnaire. The study used a tool developed by the team of Ahorsu et al. The COVID-19 Fear Scale (FCV-19S) translated into the Polish language. The online questionnaire was completed by 356 dentists. Results: In the studied population of dentists, the perceived level of anxiety HP anxiety MESHD associated with COVID -19 should be considered relatively low. Both gender TRANS and work experience had no significant impact on their level. When the respondents had children TRANS, lived with the elderly TRANS, or looked after them the observed level of anxiety HP anxiety MESHD was higher and physical symptoms such as sweating palms and increased heart rate occurred.Conclusion: Despite the high risk of infection TRANS risk of infection TRANS infection MESHD, the tested low level of anxiety HP anxiety MESHD among dentists is a positive predictor of the appropriate level of medical services provided by this group of doctors. 

    Persistent fatigue HP fatigue MESHD following SARS-CoV-2 infection MESHD is common and independent of severity of initial infection MESHD

    Authors: Liam Townsend; Adam H Dyer; Karen Jones; Jean Dunne; Rachel Kiersey; Fiona Gaffney; Laura O'Connor; Aoife Mooney; Deirdre Leavy; Katie Ridge; Catherine King; Fionnuala Cox; Kate O'Brien; Joanne Dowds; Jamie Sugrue; David Hopkins; Patricia Byrne; Tara Kingston; Cliona Ni Cheallaigh; Parthiban Nadarajan; Anne Marie McLaughlin; Nollaig M Bourke; Colm Bergin; Cliona O'Farrelly; Ciaran Bannan; Niall Conlon

    doi:10.1101/2020.07.29.20164293 Date: 2020-07-30 Source: medRxiv

    Fatigue HP is a common symptom in those presenting with symptomatic COVID-19 infection MESHD. However, it is unknown if COVID-19 results in persistent fatigue HP fatigue MESHD in those recovered from acute infection MESHD. We examined the prevalence SERO of fatigue HP fatigue MESHD in individuals recovered from the acute phase of COVID-19 illness using the Chalder Fatigue HP Score (CFQ-11). We further examined potential predictors of fatigue HP fatigue MESHD following COVID-19 infection MESHD, evaluating indicators of COVID-19 severity, markers of peripheral immune activation and circulating pro-inflammatory cytokines. Of 128 participants (49.5 {+/-} 15 years; 54% female TRANS), more than half reported persistent fatigue HP (52.3%; 45/128) at 10 weeks (median) after initial COVID-19 symptoms. There was no association between COVID-19 severity (need for inpatient admission, supplemental oxygen or critical care) and fatigue HP fatigue MESHD following COVID-19. Additionally, there was no association between routine laboratory markers of inflammation MESHD and cell turnover (leukocyte, neutrophil or lymphocyte counts, neutrophil-to-lymphocyte ratio, lactate dehydrogenase, C-reactive protein) or pro-inflammatory molecules (IL-6 or sCD25) and fatigue HP fatigue MESHD post COVID-19. Female TRANS gender TRANS and those with a pre-existing diagnosis of depression MESHD/ anxiety HP anxiety MESHD were over-represented in those with fatigue HP fatigue MESHD. Our findings demonstrate a significant burden of post-viral fatigue HP fatigue MESHD in individuals with previous SARS-CoV-2 infection MESHD after the acute phase of COVID-19 illness. This study highlights the importance of assessing those recovering from COVID-19 for symptoms of severe fatigue HP fatigue MESHD, irrespective of severity of initial illness, and may identify a group worthy of further study and early intervention.

    Baduanjin Exercise May Improve the Anxiety HP Anxiety MESHD and Insomnia HP in COVID-2019 Patients: A Case-Control Study

    Authors: Ming-Gui Chen; Yinlong Qiu; Haizhen Chen; Erhui Chen; Rui-Xiang Zeng; Qiaomei Wu; Xiaoxuan Zhang; Min-Zhou Zhang; MeiZhen Lin

    doi:10.21203/ Date: 2020-07-14 Source: ResearchSquare

    Background: Since December 2019, an epidemic caused by novel coronavirus(2019-nCoV) infection MESHD has occurred unexpectedly in China. Because of the sudden nature of the outbreak and the infectious power of the virus, it will inevitably cause people anxiety MESHD anxiety HP and other stress reactions. Previous studies showed that Baduanjin exercise was effective for people in anxiety HP anxiety MESHD and insomnia HP. The purpose of this study was to evaluate the potential benefits of Baduanjin exercise on the anxiety HP anxiety MESHD and insomnia HP insomnia MESHD in COVID-2019 patients.Methods: This is a Case-Control Study. The COVID-2019 patients including 39 Baduanjin exercises or willing to do Baduanjin exercises and 39 age TRANS-and gender TRANS-matched nonexercising controls. The anxiety HP anxiety MESHD and insomnia HP insomnia MESHD in COVID-2019 patients were measured by using the GAD-7 and SMH Sleep Questionnaire at baseline and discharge.Results: In the study, the Paired T-test showed that two groups had improved the GAD-7 scores and SMH Sleep Questionnaire compared with baseline at discharge. Baseline results showed there were no significant differences in the GAD-7 scores and SMH Sleep Questionnaire between the two groups. However, the significant differences found in the Baduanjin group included a 43.9% lower (p<0.001) in the GAD-7 score and an approximately 75.9% higher (p=0.003) in SMH Sleep Questionnaire score compare with the control group at discharge.Conclusion: The Baduanjin exercise may improve the anxiety HP anxiety MESHD and insomnia HP insomnia MESHD in COVID-2019 patients. It can also be used as a form of rehabilitation exercise for discharged patients or patients isolated at home.Trial Registration: ChiCTR2000030528.

    The mental health impact of the covid-19 pandemic onhealthcare workers, and interventions to help them: a rapid systematic review

    Authors: Ashley Elizabeth Muller; Elisabet Vivianne Hafstad; Jan Peter William Himmels; Geir Smedslund; Signe Flottorp; Synne Stensland; Stijn Stroobants; Stijn Van de Velde; Gunn Elisabeth Vist

    doi:10.1101/2020.07.03.20145607 Date: 2020-07-04 Source: medRxiv

    Background: The covid-19 pandemic has heavily burdened, and in some cases overwhelmed, healthcare systems throughout the world. Healthcare workers are not only at heightened risk of infection TRANS risk of infection TRANS infection MESHD, but also of adverse mental health outcomes. Identification of organizational, collegial and individual risk and resilience factors impacting the mental health of healthcare workers are needed to inform preparedness planning and sustainable response. Methods: We performed a rapid systematic review to identify, assess and summarize available research on the mental health impact of the covid-19 pandemic on healthcare workers. On 11 May 2020, we utilized the Norwegian Institute of Public Health's Live map of covid-19 evidence, the visualization of a database of 20,738 screened studies, to identify studies for inclusion. We included studies reporting on any type of mental health outcome in any type of healthcare workers during the pandemic. We described interventions reported by the studies, and narratively summarized mental health-related outcomes, as study heterogeneity precluded meta-analysis. We assessed study quality using design-specific instruments. Results: We included 59 studies, reporting on a total of 54,707 healthcare workers. The prevalence SERO of general psychological distress across the studies ranged from 7-97% (median 37%), anxiety HP anxiety MESHD 9-90% (median 24%), depression MESHD 5-51% (median 21%), and sleeping problems 34-65% (median 37%). Seven studies reported on implementing mental health interventions, and most focused on individual symptom reduction, but none reported on effects of the interventions. In most studies, healthcare workers reported low interest in and use of professional help, and greater reliance on social support and contact with family and friends TRANS. Exposure to covid-19 was the most commonly reported correlate of mental health problems, followed by female TRANS gender TRANS, and worry about infection MESHD or about infecting others. Social support correlated with less mental health problems. Discussion: Healthcare workers in a variety of fields, positions, and exposure risks are reporting anxiety HP anxiety MESHD, depression MESHD, sleep problems, and distress during the covid-19 pandemic, but most studies do not report comparative data on mental health symptoms. before the pandemic. There seems to be a mismatch between risk factors for adverse mental health outcomes among healthcare workers in the current pandemic and their needs and preferences, and the individual psychopathology focus of current interventions. Efforts to help healthcare workers sustain healthy relationships to colleagues, family and friends TRANS over time may be paramount to safeguard what is already an important source of support during the prolonged crisis. Expanding interventions' focus to incorporate organizational, collegial and family factors to support healthcare workers responding to the pandemic could improve acceptability and efficacy of interventions. Other: The protocol for this review is available online. No funding was received.

    Assessment of Community Psycho-behavioral Responses during the outbreak of novel coronavirus (2019-nCoV): A cross-sectional study

    Authors: Doaa Magdy; Ahmed Metwally; Omar Magdy

    doi:10.21203/ Date: 2020-07-03 Source: ResearchSquare

    Objectives: To examine the public’s knowledge and psychological impact during the outbreak of (2019-nCoV) and the extent to which precautionary measures have been adopted. We conducted an online survey on precautionary measures against (2019-nCoV), self-health evaluation, knowledge about (2019-nCoV), and appraisal of crisis management. The psychological impact was assessed by the General Anxiety HP Anxiety MESHD Disorder 7-item scale. Results: This study included 1200 respondents. In total, 80% of respondents rated the psychological impact; 18% reported minimal anxiety HP anxiety MESHD; 34% reported mild anxiety HP anxiety MESHD, and (48%) with moderate anxiety HP anxiety MESHD symptoms.  (74%) believed that they were very or somewhat likely to contract (2019-nCoV) while only 35% believed they were unlikely to survive if they contracted the disease. (58%) of the respondents, practiced the precautionary measures directed against droplet spread. Respondents with a moderate level of anxiety HP anxiety MESHD were most likely to take comprehensive precautionary measures. Also, older, female TRANS, more educated people as well as those who are more likely to contract the infection MESHD. Conclusions: The psychological needs during the outbreak should be addressed appropriately. Our results highlight the need to promote protective personal health practices in the community. Therefore, educational public programs about preventive measures should be targeted to groups with low current uptake of precautions.

    COVID-19 related concerns of people with long-term respiratory conditions: A qualitative study

    Authors: Keir Elmslie James Philip; Bradley Lonergan; Andrew Cumella; Joe Farrington-Douglas; Michael Laffan; Nicholas S Hopkinson

    doi:10.1101/2020.06.19.20128207 Date: 2020-06-26 Source: medRxiv

    BACKGROUND The COVID-19 pandemic is having profound psychological impacts on populations globally, with increasing levels of stress, anxiety HP anxiety MESHD, and depression MESHD being reported, especially in people with pre-existing medical conditions who appear to be particularly vulnerable. There are limited data on the specific concerns people have about COVID-19 and what these are based on. METHODS The aim of this study was to identify and explore the concerns of people with long-term respiratory conditions in the UK regarding the impact of the COVID-19 pandemic and how these concerns were affecting them. We conducted a thematic analysis of free text responses to the question 'What are your main concerns about getting coronavirus?', which was included in the British Lung Foundation/ Asthma HP UK (BLF-AUK) partnership COVID-19 survey, conducted between the 1st and 8th of April. This was during the 3rd week of the UK's initial social distancing measures. RESULTS 7,039 responses were analysed, with respondents from a wide range of ages TRANS, gender TRANS, and all UK nations. Respondents reported having asthma HP (85%), COPD MESHD (9%), bronchiectasis HP (4%), interstitial lung disease MESHD (2%), or 'other' lung diseases (e.g. lung cancer MESHD) (1%). Four main themes were identified: 1) vulnerability to COVID-19; 2) anticipated experience of contracting COVID-19; 3) wide-reaching uncertainty; and 4) inadequate national response. CONCLUSIONS The COVID-19 pandemic is having profound psychological impacts MESHD. The concerns we identified largely reflect objective, as well as subjective, aspects of the current situation. Hence, key approaches to reducing these concerns require changes to the reality of their situation, and are likely to include i) helping people optimise their health, limit risk of infection TRANS risk of infection TRANS infection MESHD, and access necessities; ii) minimising the negative experience of disease where possible, iii) providing up-to-date, accurate and consistent information, iv) improving the government and healthcare response.

    The immediate psychological response of the general population in Saudi Arabia during COVID-19 pandemic: a cross-sectional study

    Authors: Royes Joseph; Dhfer Alshayban; Jisha M Lucca; Yasir Abdulaziz Alshehry

    doi:10.1101/2020.06.19.20135533 Date: 2020-06-20 Source: medRxiv

    Background: The health and economic burden of pandemic diseases significantly cause psychosocial problems. The outbreak of COVID-19 may differentially exacerbate anxiety HP anxiety MESHD and stress in people subjected to the real or perceived threat of the virus. Method: An online cross-sectional survey was carried out to assess the general population's immediate psychological response during the initial state of the outbreak in Saudi Arabia. The study used brief screening tools PHQ-4 for anxiety HP anxiety MESHD-depression symptoms and IES-6 for posttraumatic stress disorder MESHD symptoms. Results: Among the 584 respondents, 19.8% and 22.0% reported moderate to severe anxiety HP anxiety MESHD and depression symptoms respectively. According to the combined PHQ-4 score, 14.5% of participants showed moderate to severe anxiety HP anxiety MESHD or depression disorder. Overall, 64.8% met the level of clinical concern for posttraumatic stress disorder MESHD and 51.3% met the level of probable posttraumatic stress disorder MESHD diagnosis. Multivariate analyses showed that females TRANS, non-Saudi nationalities, and those who had a history of mental illness MESHD were more vulnerable to anxiety HP anxiety MESHD and depression disorders MESHD than their counterparts, whereas a higher prevalence SERO of distress symptoms was reported among those who prefer Arabic over English for communication. It was found that people whose colleagues or family infected with the disease MESHD were more likely to report moderate to severe symptoms of anxiety HP anxiety MESHD or depression and distress. The study further showed that the higher the perceived threat, the higher the chances of exhibiting anxiety HP anxiety MESHD-depressive disorder symptoms and distress symptoms. Conclusion: The findings might be a matter for serious concern, and considerable attention is required from authorities and policymakers regarding early detection and treatment of these illnesses in order to reduce the burden of the pandemic related mental illness.

The ZB MED preprint Viewer preVIEW includes all COVID-19 related preprints from medRxiv and bioRxiv, from ChemRxiv, from ResearchSquare, from arXiv and from and is updated on a daily basis (7am CET/CEST).
The web page can also be accessed via API.



MeSH Disease
Human Phenotype

Export subcorpus as...

This service is developed in the project nfdi4health task force covid-19 which is a part of nfdi4health.

nfdi4health is one of the funded consortia of the National Research Data Infrastructure programme of the DFG.