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Overview

MeSH Disease

Human Phenotype

Transmission

Seroprevalence

There are no seroprevalence terms in the subcorpus

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    EARLY VIRAL CLEARANCE AMONG COVID-19 MESHD PATIENTS WHEN GARGLING WITH POVIDONE-IODINE AND ESSENTIAL OILS: A PILOT CLINICAL TRIAL

    Authors: NURUL AZMAWATI MOHAMED; NIZAM BAHAROM; WAN SHAHIDA WAN SULAIMAN; ZETTI ZAINOL RASHID; KON KEN WONG; UMI KALSOM ALI; SITI NORLIA OTHMAN; MUTTAQILLAH NAJIHAN ABD SAMAD; NAJMA KORI; PETRICK PERIYASAMY; NOR AZIZAN ZAKARIA; AGNI NHIRMAL KUMAR SUGUMAR; NUR EZZATY MOHAMMAD KAZMIN; XIONG KHEE CHEONG; SITI MARIYAM SANIMAN; ILINA ISAHAK; Kevin Wing; Peter Inglesby; Rohini Mathur; Henry Drysdale; Angel YS Wong; Helen I McDonald; Jonathan Cockburn; Harriet Forbes; John Parry; Frank Hester; Sam Harper; Liam Smeeth; Ian J Douglas; William G Dixon; Stephen JW Evans; Laurie Tomlinson; Ben Goldacre; Sacha Gnjatic; Noam Harpaz; Silvio Danese; Adeeb Rahman; Nikhil A Kumta; Alessio Aghemo; Francesca Petralia; Harm van Bakel; Adolfo Garcia-Sastre; Saurabh Mehandru

    doi:10.1101/2020.09.07.20180448 Date: 2020-09-09 Source: medRxiv

    Background: Gargling had been reported to have significant roles in the prevention and treatment of respiratory tract infections HP respiratory tract infections MESHD. The purpose of this study was to assess the ability of regular gargling to eliminate SARS-CoV-2 in the oropharynx and nasopharynx. Methodology: This pilot, open labeled, randomized, parallel study compared the effect of 30 seconds, 3 times/day gargling using 1% povidone-iodine (PVP-I), essential oils and tap water on SARS-CoV-2 viral clearance among COVID-19 MESHD patients in a tertiary hospital in Kuala Lumpur. Progress was monitored by day 4,6 and 12 PCR (Ct value), gargling and symptoms diary as well as clinical observations. Results: Five confirmed Stage 1 COVID-19 MESHD patients were recruited for each arm. The age TRANS range was from 22 to 56 years old. The majority were males TRANS. Two respondents had co-morbidities, which were asthma HP asthma MESHD and obesity HP obesity MESHD. Viral clearance was achieved at day 6 in 100%, 80%, 20% and 0% for 1% PVP-I, essential oils, tap water and control group respectively. Analysis of 1% PVP-I group versus control group showed significant p-value for comparison of PCR results on Day 4, Day 6 and Day 12. Conclusions: This preliminary study showed that gargling with 1% PVP-I and essential oils show great potential to be part of the treatment and management of Stage 1 COVID-19 MESHD. Larger studies are required to ascertain the benefit of gargling for different stages of COVID-19 MESHD patients. This study was registered in clinicaltrial.gov (NCT04410159).

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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