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MeSH Disease

Human Phenotype

Transmission

Seroprevalence

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    Pulmonary Imaging Findings in Coronavirus Disease MESHD 2019 (COVID-19): A Series of 140 Latin American Children TRANS

    Authors: Carlos Ugas-Charcape; María Elena Ucar; Judith Almanza-Aranda; Emiliana Rizo-Patrón; Claudia Lazarte Rantes; Pablo Caro-Domínguez; Lina Cadavid; Lizbet Pérez-Marrero; Tatiana Fazecas; Lucía Gómez; Mariana Sánchez Curiel; Walter Pacheco; Ana Rizzi; Andrés García-Bayce; Efigenia Bendeck; Walter Montaño; Pedro Daltro; José D. Arce V

    doi:10.21203/rs.3.rs-94820/v1 Date: 2020-10-19 Source: ResearchSquare

    Background:The severe acute respiratory syndrome coronavirus 2 MESHD (SARS-CoV-2 virus), which resulted in the worldwide COVID-19 pandemic of 2020, has particularly affected Latin America. Objective:The purpose of the study was to analyze the imaging findings of pulmonary COVID-19 in a large pediatric series.Materials and methods: Children TRANS with confirmed SARS-CoV-2 infection MESHD infection confirmed TRANS by either quantitative reverse transcription-polymerase chain reaction from nasopharyngeal swabs or presence of circulating IgM and/or IgG antibodies SERO and who underwent chest radiograph (CXR) and/or computed tomography (CT) were included in this retrospective multicenter study. Three pediatric radiologists independently reviewed CXRs and CTs to identify the presence, localization, distribution and extension of pulmonary lesions MESHD. Results:One hundred and forty children TRANS (71 female TRANS; median age TRANS 6.2 years; interquartile range 1.6-12.1 years) were included in the study. Peribronchial thickening (93%), ground glass opacities (79%) and vascular engorgement (63%) were the most frequent findings on 131 CXRs. Ground glass opacities (91%), vascular engorgement (84%) and peribronchial thickening (72%) were the most frequent findings on 32 CTs. Peribronchial thickening (100%), ground-glass opacities (90%) and pulmonary vascular engorgement MESHD (74%) were common CXR findings in asymptomatic TRANS patients (n=20). Consolidation and ground-glass opacity were significantly higher in patients who needed ICU admission or expired, in contrast with patients with a good outcome (48% and 91%, vs 24% and 70% p<0.05, respectively).Conclusion: Asymptomatic TRANS children TRANS and those with mild symptoms of COVID-19 showed mainly peribronchial thickening, ground-glass opacities and pulmonary HP vascular engorgement on CXRs. Ground glass opacity and consolidation, were more common in patients who required ICU admission or died. 

    Age TRANS differences in clinical features and outcomes in patients with COVID-19, Jiangsu, China: a retrospective, multi-center cohort study

    Authors: Huanyuan Luo; Songqiao Liu; Yuancheng Wang; Penelope A. Phillips-Howard; Yi Yang; Shenghong Ju; Duolao Wang

    doi:10.1101/2020.06.01.20086025 Date: 2020-06-02 Source: medRxiv

    Objectives To determine the age TRANS-specific clinical presentations and incidence of adverse outcomes among patients with COVID-19 in Jiangsu, China. Design and setting This is a retrospective, multi-center cohort study performed at twenty-four hospitals in Jiangsu, China. Participants From January 10 to March 15, 2020, 625 patients with COVID-19 were involved. Results Of the 625 patients (median age TRANS, 46 years; 329 [52.6%] males TRANS), 37 (5.9%) were children TRANS (18 years or less), 261 (40%) young adults TRANS (19-44 years), 248 (39.7%) middle- aged TRANS adults TRANS (45-64 years), and 79 (12.6%) elderly TRANS (65 years or more). The incidence of hypertension HP hypertension MESHD, coronary heart disease MESHD disease, chronic obstructive pulmonary HP chronic obstructive pulmonary disease MESHD, and diabetes MESHD comorbidities increased with age TRANS (trend test, P < .0001, P = 0.0003, P < .0001, and P < .0001 respectively). Fever HP Fever MESHD, cough HP cough MESHD, and shortness of breath MESHD occurred more commonly among older patients, especially the elderly TRANS, compared to children TRANS (Chi-square test, P = 0.0008, 0.0146, and 0.0282, respectively). The quadrant score and pulmonary opacity HP score increased with age TRANS (trend test, both P < .0001). Older patients had significantly more abnormal values in many laboratory parameters than younger patients. Elderly TRANS patients contributed the highest proportion of severe or critically-ill MESHD cases (33.0%, Chi-square test P < 0.001), intensive care unit (ICU) (35.4%, Chi-square test P < 0.001), and respiratory failure HP respiratory failure MESHD (31.6%, Chi-square test P = 0.0266), and longest hospital stay (21 days, ANOVA-test P < 0.001). Conclusions Elderly TRANS ([≥]65) patients with COVID-19 had the highest risk of severe or critical illness MESHD, intensive care use, respiratory failure HP respiratory failure MESHD, and the longest hospital stay, which may be due partly to that they had higher incidence of comorbidities and poor immune responses to COVID-19.

    Clinical and CT Characteristics of Medical Personnel with the Coronavirus Disease-2019 (COVID-19) in Wuhan

    Authors: Ying Xiong; Qiang Zhang; Dong Sun; Xiaoming Li; Wenzhen Zhu

    doi:10.21203/rs.3.rs-16704/v1 Date: 2020-03-06 Source: ResearchSquare

    Objectives: To investigate the clinical and chest CT characteristics of medical personnel infected with the Coronavirus Disease-2019 (COVID-19).Methods: The clinical, laboratory test and computed tomography (CT) features of 30 medical personnel (MP group, 26-65 years, 16 males TRANS) with COVID-19 were retrospectively analyzed, and compared to 33 non-medical related patients (non-MP group, 26-74 years, 19 males TRANS). Follow-up CT characteristics were analyzed to assess the changes of the COVID-19 infection MESHD in the period of hospitalization.Results: At admission, the main complaints of MP group, including fever HP fever MESHD (86.7%), fatigue HP fatigue MESHD (53.3%) and cough HP (43.3%), were similar to the non-MP group; the C-reactive protein, erythrocyte sedimentation rate and lactate dehydrogenase levels of the non-MP group (55.6±45.9mg/L, 34.7±26.3mm/H and 321±117U/L) were higher than that of the MP group (17.8±19.9mg/L, 18.6±21.3mm/H and 219±54.2U/L, respectively, all p<0.05). Ground-grass opacities, consolidation, interstitial thickening were common CT features of both groups. The days from illness onset to the first CT exam, and the severity of opacities on initial CT were less in the MP group than that of the non-MP group (p<0.05). However, the days from onset to observation of the most obvious pulmonary opacities MESHD pulmonary opacities HP, according to CT findings, were similar in the MP group (11.5±5.9 days) and the non-MP group (12.2±3.1 days, p=0.55).Conclusions: Like the general population, medical personnel are also susceptible to the COVID-19, although with more professional knowledge and protective equipment. Occupational exposure is a very important factor. Medical personnel have a higher vigilance about the infection MESHD in the early stage of the disease.

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