Corpus overview


MeSH Disease

Human Phenotype

Fever (11)

Cough (11)

Fatigue (11)

Pneumonia (4)

Myalgia (3)


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    Association of age TRANS, sex, comorbidities, and clinical symptoms with the severity and mortality of COVID-19 cases: a meta-analysis with 85 studies and 67299 cases

    Authors: Mohammad Safiqul Islam; Md. Abdul Barek; Md. Abdul Aziz; Tutun Das Aka; Md. Jakaria

    doi:10.1101/2020.05.23.20110965 Date: 2020-05-26 Source: medRxiv

    Background: A new pathogenic disease named COVID-19 became a global threat, first reported in Wuhan, China, in December 2019. The number of affected cases growing exponentially and now, more than 210 countries confirmed the cases TRANS. Objective: This meta-analysis aims to evaluate risk factors, the prevalence SERO of comorbidity, and clinical characteristics in COVID-19 death MESHD patients compared to survival patients that can be used as a reference for further research and clinical decisions. Methods: PubMed, Science Direct, SAGE were searched to collect data about demographic, clinical characteristics, and comorbidities of confirmed COVID-19 patients from January 1, 2020, to May 17, 2020. Meta-analysis was performed with the use of Review Manager 5.3 Results: Eighty-five studies were included in Meta-analysis, including a total number of 67,299 patients with SARS-CoV-2 infection MESHD. Males TRANS are severely affected or died than females TRANS (OR = 2.26, p < 0.00001; OR = 3.59, p < 0.00001) are severely affected, or died by COVID-19 and cases with age TRANS [≥]50 are at higher risk of death MESHD than age TRANS <50 years (OR=334.23). Presence of any comorbidity or comorbidities like hypertension HP hypertension MESHD, cardiovascular disease MESHD, diabetes MESHD, cerebrovascular disease MESHD, respiratory disease MESHD, kidney disease MESHD, liver disease MESHD, malignancy MESHD significantly increased the risk of death compared to survival (OR = 3.46, 3.16, 4.67, 2.45, 5.84, 2.68, 5.62, 2.81,2.16). Among the clinical characteristics such as fever HP fever MESHD, cough HP cough MESHD, myalgia HP myalgia MESHD, diarrhea HP diarrhea MESHD, abdominal pain HP abdominal pain MESHD, dyspnea HP dyspnea MESHD, fatigue HP fatigue MESHD, sputum production, chest tightness HP chest tightness MESHD headache HP and nausea or vomiting HP nausea or vomiting MESHD, only fatigue HP fatigue MESHD (OR = 1.31, 95%) and dyspnea HP dyspnea MESHD increased the death significantly (OR= 1.31, 4.57). The rate of death of COVID-19 cases is 0.03-times lower than the rate of survival (OR = 0.03). Conclusion Our result indicates that male TRANS patients are affected severely or died, the rate of death is more in the age TRANS [≥]50 group, and the rate of death is affected by comorbidities and clinical symptoms.

    Association between symptoms and severity of disease in hospitalised novel coronavirus (COVID-19) patients: A systemic review and meta-analysis

    Authors: Ashis Talukder; Shaharior Rahman Razu; Sheikh Alif; Muhammad Aziz Rahman; Sheikh Mohammed Shariful Islam

    doi:10.21203/ Date: 2020-05-26 Source: ResearchSquare

    Background Symptoms of the novel coronavirus disease MESHD (COVD-19) are well known, although asymptomatic TRANS cases were also reported due to this rapidly evolving viral disease. However, there has been limited research with inconsistent findings on symptoms of COVID-19 and diseases severity. We aimed to evaluate the association between symptoms and severity of disease in confirmed COVID-19 cases by performing a meta-analysis.Methods We conducted a systematic review by searching four online databases (Medline, Web of Science, EMBASE and Cochrane library) of published studies that included symptoms of COVID-19 cases and severity of the disease between 01-Jan-2020 and 20-Apr-2020. PRISMA and MOOSE guidelines were followed, and only articles published in English were selected. We performed meta-analysis using Mantel-Haenszel random-effects model. Degree of heterogeneity among studies and quality of the selected studies were evaluated.Results Out of 153 articles identified, a total of seven articles, including 3,168 participants, met the inclusion criteria and were included. The median age TRANS of the patients was 49 years, 1818 (57.38%) were males TRANS, and 574 (18.11%) reported severe conditions. Fever HP Fever MESHD was the most commonly reported symptom in the reported COVID-19 confirmed cases TRANS (87.89%, 95% CI: 83.22–81.39%), which was followed by cough HP, myalgia HP myalgia MESHD or fatigue HP fatigue MESHD, and less proportionally dyspnea HP dyspnea MESHD and headache HP headache MESHD. Dyspnea HP Dyspnea MESHD was the only symptom, which was associated with severity of COVID-19 (OR 2.38, 95% CI: 1.83–3.10).Conclusions Dyspnoea MESHD was found to be associated with severity of COVID-19. People with existing respiratory illnesses, such as chronic obstructive pulmonary diseases HP chronic obstructive pulmonary diseases MESHD need to be careful about the onset of such symptom TRANS and should seek medical attention.

    Olfactory and Gustatory Dysfunctions in Patients With COVID-19 in Wuhan, China

    Authors: Li Zou; Ting Yu; Yangyang Zhang; Lijun Dai; Zhaohui Zhang; Zhentao Zhang

    doi:10.21203/ Date: 2020-05-11 Source: ResearchSquare

    Background: The coronavirus disease MESHD 2019 (COVID-19) caused by SARS-CoV-2 isspreading all over the world.The main symptoms of COVID-19 include fever HP fever MESHD, cough HP cough MESHD, fatigue HP, and myalgia HP myalgia MESHD. However, there are few reports onolfactoryand gustatory dysfunctions MESHD in patients with COVID-19.Objective: To investigate the incidence of olfactory and gustatory dysfunctions MESHD in patients with confirmed COVID-19 infection MESHD, in Wuhan, China.Methods:In this retrospective study,we collected 81 confirmed cases TRANS of COVID-19 from the Renmin Hospital of Wuhan University, from February 2020 to March 2020, and analyzed the demographic characteristics, clinical manifestations (including olfactory and  gustatory dysfunctions MESHD), laboratory findings,and comorbidities.Results: A total of 81 confirmed COVID-19 patients were enrolledin this study (38 males TRANS). The most prevalent symptoms include cough HP cough MESHD, myalgia HP myalgia MESHD, and loss of appetite. On admission, 25 (30.9%) of all patients reported either olfactory dysfunction MESHD ( OD MESHD) or gustatory dysfunction MESHD ( GD MESHD), and 7 (8.6%) reported both OD MESHD and GD MESHD. 13.6% and 25.9% of allpatients reported OD MESHD and GD MESHD, respectively. OD MESHD and GD MESHD were not associated with disease severity. Pearson correlation analysisidentified some factors are positively correlated with OD MESHD and GD MESHD, including headache HP headache MESHD or dizziness (r = 0.342, P = 0.002), dark urine HP (r = 0.256, P = 0.021), IgM titer (r = 0.305, P = 0.01), and diabetes MESHD (r = 0.275, P = 0.013). In 81.8% of the cases with OD MESHD and 28.6% of the cases with GD MESHD, the symptomslasted for at least 1 month after discharge.3.6% of inpatients without OD MESHD developed OD MESHD after discharge.Conclusion: OD MESHD and GDare common in COVID-19.These symptoms appear early during thecourse of disease, and may last for at least 1 month.The incidence of OD MESHD and GDisrelated to neurological manifestations, diabetics MESHD, and IgM titers.

    Early epidemiological and clinical manifestations of COVID-19 in Japan

    Authors: Muhammad Qasim; Muhammad Yasir; Waqas Ahmad; Minami Yoshida; Muhammad Azhar; Mohammad Azam Ali; Chris Wang; Maree Gould

    doi:10.1101/2020.04.17.20070276 Date: 2020-04-24 Source: medRxiv

    Background: Severe acute respiratory syndrome MESHD coronaviruses -2 (SARS-COV2) named as COVID-19 had spread worldwide and leading to 1,210,956 confirmed cases TRANS and 67,594 deaths Methods: A data of 1192 confirmed cases TRANS and 43 deaths due to COVID-19 in Japan collected from the Ministry of Health, Labour and Welfare of Japan and analysed for different epidemiological parameters and their clinical manifestations. We used Clauset-Newman-Moore (CNM) clustering algorithm to develop web-network of confirmed cases TRANS to identified clusters of community transmission TRANS. Results: Out of 1192 confirmed cases TRANS, 90.60% were symptomatic and 9.39% were asymptomatic TRANS. The prevalence SERO of COVID19 in males TRANS was 56.29% and 43.20 % in females TRANS. The mean interval (SD) from symptom onset TRANS to diagnosis was 6-22.6 days while mean interval (SD) from contact to onset of symptoms TRANS was 5-19.5 days. People of age TRANS range 40-79 were more infected MESHD and deaths median age TRANS was 80. The main symptoms were fever HP fever MESHD, dry cough MESHD cough HP, fatigue HP fatigue MESHD and pneumonia HP pneumonia MESHD. The main infected cities were Tokyo (195/1192, 16.35%), Hokkaido (160/1192 13.42%), Aichi (150/1192, 12.58%) and Osaka (145/1192, 12.16%). Only 2.34% cases had travel TRANS history from Wuhan China and Osaka music concert was identify as main cluster for community transmission TRANS. While 556 (46.64%) cases were clinically diagnosed and 557 (46.72%) were confirmed by using RT-PCR. Conclusions: Other than, declare emergency Japan need to change their approach of diagnosing COVID-19, as asymptomatic TRANS cases prevalence SERO is high and maybe it is reason for current sudden increase of cases. Screening centre should be establish away from hospitals, which are treating positive cases.

    Epidemiological investigation and intergenerational clinical characteristics of 24 COVID-19 patients associated with supermarket cluster

    Authors: Suochen Tian; Min Wu; Zhenqin Chang; Yunxia Wang; Guijie Zhou; Wenming Zhang; Junmin Xing; Hui Tian; Xihong Zhang; Xiuli Zou; Lina Zhang; Mingxin Liu; Juan Chen; Jian Han; Kang Ning; Shuangfeng Chen; Tiejun Wu

    doi:10.1101/2020.04.11.20058891 Date: 2020-04-15 Source: medRxiv

    Objective: To analyze the epidemiological and intergenerational clinical characteristics of COVID-19 patients associated with cluster, so as to understand the rules of the patients associated with cluster of this outbreak and provide help for the prevention and control of COVID-19. Methods: All close contacts TRANS of the patient were screened since the first supermarket employee with COVID-19 was identified. A retrospective analysis was made on the epidemiological and clinical characteristics of the confirmed cases TRANS admitted to the designated hospitals for centralized treatment. The patients were divided into two groups according to the first generation (supermarket employees, group A) and the second or third generation ( family members TRANS or friends TRANS of supermarket employees, group B), and the similarities and differences between the two groups were compared. Results: A total of 24 COVID-19 patients were diagnosed, with an average age TRANS of 48{+/-}1.73 years. The mean duration from onset to release form quarantine was 21.04{+/-}6.77 days, and the onset time was concentrated in 5-11 days after the first patient was diagnosed. Among all the patients, 23 patients were moderate, among which 7 patients (29.17%) were asymptomatic TRANS. Symptoms of symptomatic patients were cough HP (75.00%), low fever MESHD fever HP (62.50%), shortness of breath MESHD (41.67%), sore throat (25.00%), gastrointestinal symptoms MESHD (25.00%), fatigue HP fatigue MESHD (20.83%), etc. Biochemical examination on admission showed that the white blood SERO cell count < 4.010x9/L (29.17%) and the lymphocyte count <1.1x109/L (58.33%). The lymphocyte count of 50.00% of the patients was [≤]0.6x109/L. On admission, chest CT showed pneumonia HP pneumonia MESHD (100%) with bilateral infiltration (75.00%). Treatment: antiviral drug (100%), Chinese medicine (100%), common oxygen therapy (45.83%). There were 11 cases in group A (first generation, 11 cases) and 13 cases in group B (second generation, 11 cases; third generation, 2 cases). In group B, there were more males TRANS, from onset to admission later, more patients had underlying diseases, and more patients were treated with albumin (P<0.05). However, there was no statistical difference between the two groups in other clinical indicators, including the duration from onset to release form quarantine(P>0.05). There was no improvement in granulocyte count in all patients, as well as in groups A and B, between admission and release from quarantine(P>0.05). Conclusion: The clinical characteristics of COVID-19 patients associated with cluster were similar to those of other COVID-19 patients, but there were some special features. The severity of the disease was similar and there was intergenerational spread. There was no difference in clinical characteristics between generations. Asymptomatic TRANS infections MESHD occurred in a proportion of patients and could cause spread.

    Epidemiological and Clinical Features of 2019 Novel Coronavirus Diseases MESHD (COVID-19) in the South of Iran

    Authors: Reza Shahriarirad; Zohre Khodamoradi; Amirhossein Erfani; Hamid reza Hossein pour; Keivan Ranjbar; Yasaman Emami; Alireza Mirahmadizadeh; Mehrzad Lotfi; Babak Shirazi Yeganeh; Abolfazl Dorrani Nejad; Abdolrasool Hemmati; Mostafa Ebrahimi; Mohsen Moghadami

    doi:10.21203/ Date: 2020-04-10 Source: ResearchSquare

    Background: In March 2020, the WHO declared the novel coronavirus (COVID-19) outbreak a global pandemic. Although the number of infected MESHD cases is increasing, information about its clinical characteristics in the Middle East, especially in Iran, a country which is considered to be one of the most important focal points of the disease in the world, is lacking. To date, there is no available literature on the clinical data on COVID-19 patients in Iran. Methods: In this multicenter retrospective study, 113 hospitalized confirmed cases TRANS of COVID-19 admitted to university affiliated hospitals in Shiraz, Iran from February 20 to March 20 were entered in the study. Results: The mean age TRANS was 53.75 years and 71 (62.8%) were males TRANS. The most common symptoms at onset TRANS were fatigue HP fatigue MESHD (75: 66.4%), cough HP (73: 64.6%), and fever HP fever MESHD (67: 59.3%). Laboratory data revealed significant correlation between lymphocyte count (P value= 0.003), partial thromboplastin time (P value= 0.000), international normalized ratio (P value= 0.000) with the severity of the disease. The most common abnormality in chest CT scans was ground-glass opacity (77: 93.9%), followed by consolidation (48: 58.5%). Our results revealed an overall 8% (9 out of 113 cases) mortality rate among patients, in which the majority was among patients admitted to the ICU (5: 55.6%). Conclusion: Evaluating the clinical data of COVID-19 patients and finding the source of infection MESHD and studying the behavior of the disease is crucial for understanding the pandemic.

    Comorbid Diabetes Mellitus HP Diabetes Mellitus MESHD was Associated with Poorer Prognosis in Patients with COVID-19: A Retrospective Cohort Study

    Authors: Yan Zhang; Yanhui Cui; Minxue Shen; Jianchu Zhang; Ben Liu; Minhui Dai; Linli Chen; Duoduo Han; Yifei Fan; Yanjun Zeng; Wen Li; Fengyu Lin; Sha Li; Xiang Chen; Pinhua Pan

    doi:10.1101/2020.03.24.20042358 Date: 2020-03-26 Source: medRxiv

    Background The 2019 novel coronavirus disease MESHD (COVID-19) emerged in Wuhan, Hubei province, China, and was characterized as pandemic by the World Health Organization. Diabetes mellitus HP Diabetes mellitus MESHD is an established risk factor for poor clinical outcomes, but the association of diabetes MESHD with the prognosis of COVID-19 have not been reported yet. Methods In this cohort study, we retrospectively reviewed 258 consecutive hospitalized COVID-19 patients with or without diabetes MESHD at the West Court of Union Hospital of Huazhong University of Science and Technology in Wuhan, China, recruited from January 29 to February 12, 2020. The cases were confirmed TRANS by real-time PCR and the demographic, clinical, laboratory, radiological, and treatment data were collected and analyzed. Prognosis was defined as hospitalization, discharged survivor and death MESHD, which was followed up until March 12, 2020. Results Of the 258 hospitalized patients (63 with diabetes MESHD) with COVID-19, the median age TRANS was 64 years (range 23-91), and 138 (53.5%) were male TRANS. No significant differences in age TRANS and sex were identified between patients with and without diabetes MESHD. Common symptoms included fever HP fever MESHD (82.2%), dry cough MESHD cough HP (67.1%), polypnea (48.1%), and fatigue HP fatigue MESHD (38%). Patients with diabetes MESHD had significantly higher leucocyte and neutrophil counts, and higher levels of fasting blood SERO glucose, serum SERO creatinine, urea nitrogen and creatine kinase isoenzyme MB at admission compared with those without diabetes MESHD. COVID-19 patients with diabetes MESHD were more likely to develop severe or critical disease condition MESHD with more complications at presentation, and had higher incidence rates of antibiotic therapy, non-invasive and invasive mechanical ventilation, and death MESHD (11.1% vs. 4.1%). Cox proportional hazard model showed that diabetes MESHD (adjusted hazard ratio [aHR]=3.64; 95% confidence interval [CI]: 1.09, 12.21) and fasting blood SERO glucose (aHR=1.19; 95% CI: 1.08, 1.31) were associated with the fatality of COVID-19, adjusting for potential confounders. Conclusions Diabetes mellitus HP Diabetes mellitus MESHD is associated with greater disease severity and a higher risk of mortality in patients with COVID-19. Primary and secondary prevention strategies are needed for COVID-19 patients with diabetes MESHD.

    Epidemiological, Clinical Characteristics and Outcome of Medical Staff Infected with COVID-19 in Wuhan, China: A Retrospective Case Series Analysis

    Authors: Jie Liu; Liu Ouyang; Pi Guo; Hai sheng Wu; Peng Fu; Yu liang Chen; Dan Yang; Xiao yu Han; Yu kun Cao; Osamah Alwalid; Juan Tao; Shu yi Peng; He shui Shi; Fan Yang; Chuan sheng Zheng

    doi:10.1101/2020.03.09.20033118 Date: 2020-03-13 Source: medRxiv

    Backgrounds Since December 2019, a novel coronavirus epidemic has emerged in Wuhan city, China and then rapidly spread to other areas. As of 20 Feb 2020, a total of 2,055 medical staff confirmed with coronavirus disease MESHD 2019 (COVID-19) caused by SARS-Cov-2 in China had been reported. We sought to explore the epidemiological, clinical characteristics and prognosis of novel coronavirus-infected MESHD medical staff. Methods In this retrospective study, 64 confirmed cases TRANS of novel coronavirus-infected MESHD medical staff admitted to Union Hospital, Wuhan between 16 Jan, 2020 to 15 Feb, 2020 were included. Two groups concerned were extracted from the subjects based on duration of symptoms: group 1 (<= 10 days) and group 2 (>10 days). Epidemiological and clinical data were analyzed and compared across groups. The Kaplan-Meier plot was used to inspect the change in hospital discharge rate. The Cox regression model was utilized to identify factors associated with hospital discharge. Findings The median age TRANS of medical staff included was 35 years old. 64% were female TRANS and 67% were nurses. None had an exposure to Huanan seafood wholesale market or wildlife. A small proportion of the cohort had contact with specimens (5%) as well as patients in fever HP fever MESHD clinics (8%) and isolation wards (5%). Fever HP Fever MESHD (67%) was the most common symptom, followed by cough HP (47%) and fatigue HP fatigue MESHD (34%). The median time interval between symptoms onset TRANS and admission was 8.5 days. On admission, 80% of medical staff showed abnormal IL-6 levels and 34% had lymphocytopenia MESHD. Chest CT mainly manifested as bilateral (61%), subpleural (80%) and ground-glass (52%) opacities. During the study period, no patients was transferred to intensive care unit or died, and 34 (53%) had been discharged. Higher body mass index (BMI) (HR 0.14; 95% CI 0.03-0.73), fever HP fever MESHD (HR 0.24; 95% CI 0.09-0.60) and higher levels of IL-6 on admission (HR 0.31; 95% CI 0.11-0.87) were unfavorable factors for discharge. Interpretation In this study, medical staff infected with COVID-19 have relatively milder symptoms and favorable clinical course, which may be partly due to their medical expertise, younger age TRANS and less underlying diseases. Smaller BMI, absence of fever symptoms MESHD fever HP symptoms and normal IL-6 levels on admission are favorable for discharge for medical staff. Further studies should be devoted to identifying the exact patterns of SARS-CoV-2 infection MESHD among medical staff.

    Clinical characteristics of 36 non-survivors with COVID-19 in Wuhan, China

    Authors: Ying Huang; Rui Yang; Ying Xu; Ping Gong

    doi:10.1101/2020.02.27.20029009 Date: 2020-02-29 Source: medRxiv

    Background Although the outbreak of Coronavirus disease MESHD 2019 (COVID-19) has caused over 2200 deaths in China, there was no study about death yet. We aimed to describe the clinical characteristics of non-survivors with COVID-19. Methods For this retrospective, single-center study, we included 36 non-survivors with COVID-19 in the Fifth Hospital of Wuhan. Cases were confirmed TRANS by real-time RT-PCR between Jan 21 and Feb 10, 2020 according to the recommended protocol. The epidemiological, demographic, clinical, laboratory, radiological and treatment data were collected and analyzed. Outcomes were followed up until Feb 14, 2020. This study was approved by the ethics commissions of the Fifth Hospital of Wuhan, with a waiver of informed consent due to a public health outbreak investigation. Results We included 36 patients who died from COVID-19. The mean age TRANS of the patients was 69.22 years (SD 9.64, range 50-90). 25(69.44%) patients were males TRANS, and 11 (30.56%) female TRANS. 26 (72.22%) patients had chronic diseases MESHD, mainly including hypertension HP hypertension MESHD, cardiovascular disease MESHD and diabetes MESHD. Patients had common clinical symptoms of fever HP fever MESHD (34 [94.44%] patients), cough HP (28 [77.78%] patients), shortness of breath MESHD (21 [58.33%] patients), and fatigue HP fatigue MESHD (17 [47.22%] patient). Chest computed tomographic scans showed that 31 (96.88%) patients had bilateral pneumonia MESHD pneumonia HP. Lymphopenia HP Lymphopenia MESHD occurred in 24 patients (70.59%), decreased albumin (30.18, [SD, 4.76]) in 25 patients (80.65%), elevated D-dimer (8.64 [IQR, 2.39-20]) in 27 patients (100%), and elevated lactate dehydrogenase (502.5 U/L [IQR, 410-629]) in 26 patients (100%). Nearly all of the patients have elevated CRP (106.3 mg/L [IQR, 60.83-225.3]), PCT (0.61 ng/ml [IQR, 0.16-2.10]) and IL-6 (100.6 pg/ml [IQR, 51.51-919.5]). Most patients received antiviral therapy and antibiotic therapy, and more than half of patients received glucocorticoid therapy (25 [69.44%]). All the patients had acute respiratory distress syndrome MESHD respiratory distress HP syndrome ( ARDS MESHD). The median time from onset to ARDS MESHD was 11 days. One (2.78%) patient presented with acute renal injury MESHD. The median time from onset to death MESHD was 17 days. Interpretation Lots of patients died from COVID-19 till now. The median survival time of these non-survivors from onset to death was about 2 weeks. Most patients were older males TRANS with comorbidities. They finally progressed to ARDS MESHD. The median time from onset to ARDS MESHD was 11 days. Gradually decreased lymphocytes and increased inflammation MESHD biomarkers were common, and need to be monitored in the routine treatment.

    Epidemiologic and Clinical Characteristics of 91 Hospitalized Patients with COVID-19 in Zhejiang, China: A retrospective, multi-centre case series

    Authors: Guo-Qing Qian; Nai-Bin Yang; Feng Ding; Ada Hoi Yan Ma; Zong-Yi Wang; Yue-Fei Shen; Chun-Wei Shi; Xiang Lian; Jin-Guo Chu; Lei Chen; Zhi-Yu Wang; Da-Wei Ren; Guo-Xiang Li; Xue-Qin Chen; Hua-Jiang Shen; Xiao-Min Chen

    doi:10.1101/2020.02.23.20026856 Date: 2020-02-25 Source: medRxiv

    Background Recent studies have focused initial clinical and Epidemiologic characteristics on the COVID-19, mainly revealing situation in Wuhan, Hubei. Aim To reveal more data on the epidemiologic and clinical characteristics of COVID-19 patients outside of Wuhan, in Zhejiang, China. Design Retrospective case series. Methods 88 cases of laboratory-confirmed and 3 cases of clinical-confirmed COVID-19 were admitted to five hospitals in Zhejiang province, China. Data were collected from 20 January 2020 to 11 February 2020. Results Of all 91 patients, 88 (96.70%) were laboratory-confirmed COVID-19 with throat swab samples that tested positive for SARS-Cov-2 while 3 (3.30%) were clinical-diagnosed COVID-19 cases. The median age TRANS of the patients was 50 (36.5-57) years, and female TRANS accounted for 59.34%. In this sample 40 (43.96%) patients had contracted the diseases from local cases, 31 (34.07%) patients had been to Wuhan/Hubei, 8 (8.79%) cases had contacted with people from Wuhan, 11 (12.09%) cases were confirmed TRANS aircraft transmission TRANS. In particular within the city of Ningbo, 60.52% cases can be traced TRANS back to an event held in a temple. The most common symptoms were fever HP fever MESHD (71.43%), cough HP (60.44%) and fatigue HP fatigue MESHD (43.96%). The median of incubation period TRANS was 6 (IQR, 3-8) days and the median time from first visit to a doctor to confirmed diagnosis was 1 (1-2) days. According to the Chest computed tomography scans, 67.03% cases had bilateral pneumonia MESHD pneumonia HP. Conclusions Social activity cluster, family cluster and travel TRANS by airplane were how COVID-19 patients get transmitted and could be rapidly diagnosed COVID-19 in Zhejiang.

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MeSH Disease
Human Phenotype

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