Corpus overview


Overview

MeSH Disease

Human Phenotype

Transmission

Seroprevalence
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    A Comprehensive Evaluation of Early Predictors of Disease MESHD Progression in Patients with COVID-19: A Case Control Study

    Authors: Qiang Tang; Yanwei Liu; Yingfeng Fu; Ziyang Di; Kailiang Xu; Bo Tang; Hui Wu; Maojun Di

    doi:10.21203/rs.3.rs-50527/v1 Date: 2020-07-29 Source: ResearchSquare

    Background: The 2019 coronavirus disease MESHD (COVID-19) has become an unprecedented public health crisis with nearly 16 million confirmed cases TRANS and 630,000 deaths worldwide. Methods: We retrospectively investigated the demographic, clinical, laboratory, radiological and treatment data of COVID-19 patients consecutively enrolled from January 18 to May 15, 2020, in Taihe and Jinzhou central hospital. Results: Of all 197 patients, the median age TRANS was 66.5 years (IQR 7-76), and 120 (60.9%) patients were males TRANS. We identified 88 (44.7%) of 197 COVID-19 patients as the disease progression (aggravation) cases. The aggravation cases tend to have more medical comorbidity: hypertension HP hypertension MESHD (34.1%), diabetes MESHD (30.7%), and presented with dyspnea HP dyspnea MESHD (34.1%), neutrophilia HP (60.2%), and lymphocytopenia MESHD (73.9%), compared with those without. And the patients with disease progression showed significantly higher level of Fibrinogen (Fbg), D-dimer, IL-6, C-reactive protein (CRP), procalcitonin (PCT), and serum SERO ferritin, and were more prone to develop organ damage in the liver, kidney, and heart (P<0.05). Multivariable regression showed that advanced age TRANS, comorbidities, lymphopenia HP lymphopenia MESHD, and elevated level of Fbg, lactate dehydrogenase (LDH), Cardiac troponin (CTnI), IL-6, serum SERO ferritin were the significant predictors of disease progression. Further, we investigated antibody SERO responses to SARS-CoV-2 and found that the levels of IgM and IgG were significantly higher in the disease progression cases compared to non-progression cases from 3 weeks after symptom onset TRANS. In addition, the disease progression group tended to peak later and has a more vigorous IgM/IgG response against SARS-CoV-2. Further, we performed Kaplan-Meier analysis and found that 61.6% of patients had not experienced ICU transfer or survival from hospital within 25 days from admission.Conclusions: Investigating the potential factors of advanced age TRANS, comorbidities and elevated level of IL-6, serum SERO ferritin and Kaplan-Meier analysis enables early identification and management of patients with poor prognosis. Detection of the dynamic antibody SERO may offer vital clinical information during the course of SARS-CoV-2 and provide prognostic value for patients infection MESHD.  

    Clinical characteristics of non-pneuminia COVID-19 infection MESHD adults TRANS in Shanghai, China

    Authors: Tao Li; Linjing Gong; Lijuan Hu; Haiying Ji; Zhilong Jiang; Lei Zhu

    doi:10.21203/rs.3.rs-23976/v1 Date: 2020-04-21 Source: ResearchSquare

    Background Adult TRANS patients diagnosed as COVID-19 in Shanghai were accepted in Shanghai Public Health Clinical Center. We found around 4.91% of cases showed non- pneumonia HP on CT imaging when they were confirmed. Understanding the characteristics of non- pneumonia HP pneumonia MESHD cases is of great significance to guide clinical treatment and improve prevention and control measures.Methods All dataset of demography, epidemiology, clinical manifestation, laboratory test, diagnosis, classification, condition change, treatment and outcome were obtained by retrospective investigation.Results 16 cases were confirmed TRANS COVID-19 with non-pneumonia MESHD pneumonia HP with clear epidemiological history. The median age TRANS of patients was 37 years old and 81.25% were female TRANS. The median incubation period TRANS was 15.25 days. 75% patients were familial clusters. These patients were presented with mild clinical manifestations, such as bronchitis HP bronchitis MESHD, common cold and asymptomatic TRANS infection MESHD with or without laboratory abnormalities MESHD. 4(25%)cases had underlying diseases MESHD. 3 of them had mild pneumonia HP pneumonia MESHD on chest CT imaging during hospitalization. All of the cases were cured and discharged after support treatment.Conclusions A few of adult TRANS patients after COVID-19 infection had non- pneumonia HP, with mild clinical manifestations and long incubation time. It usually occurred in young women and history of family aggregation. The mild clinical symptom may be caused by the decreasing pathogenicity after multiple generation of virus replication. However, we should be on alert that the virus is still contagious to human. Therefore, an intensive attention should be paid to these patients to avoid misdiagnosis and overlook, because these patients are potential viral source in infection of other people.

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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