Corpus overview


Overview

MeSH Disease

Human Phenotype

Fever (16)

Pneumonia (11)

Cough (10)

Hypertension (5)

Fatigue (4)


Transmission

Seroprevalence
    displaying 1 - 10 records in total 46
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    COVID-19 mortality risk factors in older people in a long-term care center

    Authors: Eva Heras; Pablo Garibaldi; Maite Boix; Oliver Valero; Jorge Castillo; Yurisan Curbelo; Elso Gonzalez; Obilagilio Mendoza; Maria Anglada; Joan Carles Miralles; Petra Lllull; Ricard Llovera; Josep M. Pique

    doi:10.21203/rs.3.rs-70219/v1 Date: 2020-09-01 Source: ResearchSquare

    Objectives: Despite high rates of COVID-19 infection MESHD and increased related mortality have been reported among older adults TRANS admitted in long-term care facilities, a limited amount of information is available about the natural course of this pandemic and prognostic factors in this population. In the current study, we aimed to investigate the epidemiologic, demographics, clinical, or therapeutic factors that may predict the prognosis in a cohort of COVID-19 infected elderly TRANS in a nursing home.Methods: We conducted a retrospective analysis of all COVID-19 confirmed institutionalized elderly TRANS in a nursing home transformed into a reference intermediate healthcare facility from March 15 to June 5, 2020. Epidemiological, demographic, and frailty status before infection MESHD, and clinical, laboratory, treatment, and outcome data during infection MESHD were collected. We used bivariate analysis and multivariate logistic regression to identify risk factors for mortality.Results: The analysis comprised all 100 COVID-19 confirmed cases TRANS during the study period. The median age TRANS was 85 years; 62% were female TRANS. The case fatality rate was 20%. In the bivariate analysis, male TRANS gender TRANS, fever HP fever MESHD, respiratory symptoms MESHD, severe cognitive decline MESHD, a low Barthel index, and lymphocytopenia MESHD were significantly associated with mortality. Multivariate logistic regression analysis identified male TRANS gender TRANS, low Barthel index, no pharmacological treatment, and lymphocytopenia MESHD as independent risk factors associated with mortality.Conclusions and Implications: Male TRANS gender TRANS, low Barthel index, no pharmacological treatment and lymphocytopenia MESHD are independent risk factors for COVID-19 mortality in institutionalized elderly TRANS patients in long-term care nursing homes. Treatment with hydroxychloroquine and azithromycin was associated with lower mortality in these patients.

    COVID-19 mortality risk factors in older people in a long-term care center.

    Authors: Eva Heras; Pablo Garibaldi; Maite Boix; Oliver Valero; Jorge Castillo; Yurisan Curbelo; Elso Gonzalez; Obilagilio Mendoza; Maria Anglada; Joan Carles Miralles; Petra Lllull; Ricard Llovera; Josep M. Pique

    doi:10.21203/rs.3.rs-70219/v2 Date: 2020-09-01 Source: ResearchSquare

    Objectives: Despite high rates of COVID-19 infection MESHD and increased related mortality have been reported among older adults TRANS admitted in long-term care facilities, a limited amount of information is available about the natural course of this pandemic and prognostic factors in this population. In the current study, we aimed to investigate the epidemiologic, demographics, clinical, or therapeutic factors that may predict the prognosis in a cohort of COVID-19 infected elderly TRANS in a nursing home.Methods: We conducted a retrospective analysis of all COVID-19 confirmed institutionalized elderly TRANS in a nursing home transformed into a reference intermediate healthcare facility from March 15 to June 5, 2020. Epidemiological, demographic, and frailty status before infection MESHD, and clinical, laboratory, treatment, and outcome data during infection MESHD were collected. We used bivariate analysis and multivariate logistic regression to identify risk factors for mortality.Results: The analysis comprised all 100 COVID-19 confirmed cases TRANS during the study period. The median age TRANS was 85 years; 62% were female TRANS. The case fatality rate was 20%. In the bivariate analysis, male TRANS gender TRANS, fever HP fever MESHD, respiratory symptoms MESHD, severe cognitive decline MESHD, a low Barthel index, and lymphocytopenia MESHD were significantly associated with mortality. Multivariate logistic regression analysis identified male TRANS gender TRANS, low Barthel index, no pharmacological treatment, and lymphocytopenia MESHD as independent risk factors associated with mortality.Conclusions and Implications: Male TRANS gender TRANS, low Barthel index, no pharmacological treatment and lymphocytopenia MESHD are independent risk factors for COVID-19 mortality in institutionalized elderly TRANS patients in long-term care nursing homes. Treatment with hydroxychloroquine and azithromycin was associated with lower mortality in these patients.

    Survival and 30-days hospital outcome in hospitalized COVID-19 patients in Upper Egypt: Multi-center study

    Authors: Aliae Mohamed-Hussein; Islam Galal; Mohammed Mustafa Abdel Rasik Mohamed; Mohamed Eltaher AA Ibrahim; Shazly Baghdady Ahmed; Richard Njouom; Rajesh Jain; Sachee Tainwala Agrawal; Sandeep Juneja; Sofia Imad; Ullas Kolthur-Seetharam; Hongjie Yu; Lars I Eriksson; Anna Norrby-Teglund; Hans-Gustaf Ljunggren; Niklas K Bjorkstrom; Soo Aleman; Marcus Buggert; Jonas Klingstrom; Kristoffer Stralin; Johan K. Sandberg

    doi:10.1101/2020.08.26.20180992 Date: 2020-09-01 Source: medRxiv

    Background: Determining the clinical features and outcomes of patients diagnosed with COVID-19 is fundamental to improve the understanding and adequate management of the novel illness. This study aims to identify the basic demography, underlying comorbidities and the mortality related factors of hospitalized patients with COVID-19 in Upper Egypt. Patients and methods: 1064 cases consecutively admitted to isolation hospitals in Upper Egypt. All cases had confirmed TRANS COVID-19 infection MESHD. The electronic records of the patients were retrospectively revised and the demographic data, clinical manifestations, qSOFA score on admission and 30 days-outcome (ICU admission, death MESHD, recovery, referral or still in hospital) were analyzed. Overall cumulative survival in all patients and those > or < 50 years were calculated. Results 49.2% of the study population were males TRANS while 50.8% females TRANS with mean age TRANS 49.4 years-old. On admission, 83.9% were stable with qSOFA score < 1, 3% required non- invasive mechanical ventilation, and 2.1% required O2 therapy. Within 30 days, 203 cases (19.1%) required admission to ICU. Death was recorded in 11.7% of cases, 28.7% recovered, 40.5% referred and 19.2% were still under treatment. Determinants of ICU admission and survival in the current study were age TRANS > 50, respiratory rate > 24/minute, SaO2 < 89%, qSOFA >1 and need for O2 therapy or NIV. The cumulative survival was 75.3% with the mean survival was 28.1, and 95.2% overall survival was recorded in those aged TRANS < 50 years. Conclusions Age TRANS older than 50 years old, those with pre-existing DM MESHD, initial qSOFA score, requirement for O2 therapy and NIV from the first day of hospital admission may be associated with unfavorable 30 days- in hospital outcome of COVID- 19.

    Seroprevalence SERO of anti-SARS-CoV-2 IgG antibody SERO in hospitalized patients in a tertiary referral center in North India

    Authors: Animesh Ray; Komal Singh; Souvick Chattopadhyay; Farha Mehdi; Gaurav Batra; Aakansha Gupta; Ayush Agarwal; Bhavesh M; Shubham Sahni; Chaithra R; Shubham Agarwal; Chitrakshi Nagpal; Gagantej B H; Umang Arora; Kartikeya Kumar Sharma; Ranveer Singh Jadon; Ashish Datt Upadhyay; Neeraj Nischal; Naval K Vikram; Manish Soneja; R M Pandey; Naveet Wig; Alessandra C. Sanchez; Haifa L. Gaza; Geraldine M. Arevalo; Coleen M. Pangilinan; Shaira A. Acosta; Melanie V. Salinas; Brian E. Schwem; Angelo D. Dela Tonga; Ma. Jowina H. Galarion; Nina Theresa P. Dungca; Stessi G. Geganzo; Neil Andrew D. Bascos; Eva Maria Cutiongco-de la Paz; Cynthia P. Saloma; Alberto L Garcia-Basteiro

    doi:10.1101/2020.08.22.20179937 Date: 2020-08-25 Source: medRxiv

    Background: Seroprevalence SERO of IgG antibodies SERO against SARS-CoV-2 is an important tool to estimate the true extent of infection MESHD in a population. However, seroprevalence SERO studies have been scarce in South East Asia including India, which, as of now, carries the third largest burden of confirmed cases TRANS in the world. The present study aimed to estimate the seroprevalence SERO of the anti-SARS-CoV-2 IgG antibody SERO among hospitalized patients at one of the largest government hospital in India. Method: This cross-sectional study, conducted at a tertiary care hospital in North India, recruited consecutive patients who were negative for SARS-CoV-2 by RT-PCR or CB-NAAT. Anti-SARS-CoV-2 IgG antibody SERO levels targeting recombinant spike receptor-binding domain (RBD) protein of SARS CoV-2 were estimated in serum samples SERO by the ELISA SERO method. Results: A total of 212 hospitalized patients were recruited in the study with mean age TRANS (+/-SD) of 41.2 (+/-15.4) years and 55% male TRANS population. Positive serology against SARS CoV-2 was detected in 19.8% patients(95% CI 14.7-25.8). Residency in Delhi conferred a higher frequency of seropositivity 26.5% (95% CI 19.3-34.7) as compared to that of other states 8% (95% CI 3.0-16.4) with p-value 0.001. No particular age groups TRANS or socio-economic strata showed a higher proportion of seropositivity. Conclusion: Around, one-fifth of hospitalized patients, who were not diagnosed with COVID-19 before, demonstrated seropositivity against SARS-CoV-2. While there was no significant difference in the different age groups TRANS and socio-economic classes; residence in Delhi was associated with increased risk (relative risk of 3.62, 95% CI 1.59-8.21) Key Words: SARS-CoV-2 IgG Antibody SERO, Seroprevalence SERO, Hospitalized patient, COVID-19

    Clinical course, biomarkers, management and outcomes of patients hospitalised due to COVID-19 in Colombia

    Authors: Nancy Yomayusa; Kelly Rocío Chacón Acevedo; Adriana Janeth Avila Reina; Karen Lorena Rincón; Carlos Hernando Toloza; Olga Gomez Gomez; Eduardo Low Padilla; Juan Felipe Combariza Vallejo; Johana Vargas Rodriguez; Emilio Herrera Molina; Sandra Yadira Moreno Marin; Carlos Arturo Álvarez Moreno

    doi:10.21203/rs.3.rs-57978/v1 Date: 2020-08-12 Source: ResearchSquare

    Background: Coronavirus disease (COVID-19) represents an unprecedented challenge for both people and health systems. Latin America is the current epicentre of the pandemic; however, there is little published clinical information on the clinical characteristics and outcomes.Objective: To analyse the clinic characteristics, risk factors and evolution of the first cohort of hospitalised patients with confirmed infection TRANS by COVID-19 in 5 Colombian institutions.Methods: In the present retrospective observational study, information was acquired from consecutive hospitalized patients with a diagnosis of COVID-19 confirmed by real-time reverse transcriptase polymerase chain reaction (RT-PCR) from March 01 to May 30, 2020 in Colombia.Results: A total of 44 patients were included. The median age TRANS was 62 years, and 65.9% of the patients were male TRANS. A total of 69.8% of the patients were overweight HP or obese MESHD, and 13.6% of the patients had high blood SERO pressure and diabetes MESHD. The presence of systemic symptoms and cough HP cough MESHD were the most common. Ground-glass opacity was frequent finding upon chest imaging. The 30-day mortality rate was 47.7% with a median of 11 days. The composite outcome (critical care requirement, mechanical ventilation and death MESHD) occurred in 36.4% of the patients. The biomarkers associated with mortality risk included troponin higher than 14 ng/L (RR: 5.25; 95% CI 1.37-20.1, p = 0.004) and D-dimer higher than 1000 ng/ml (RR: 3.0; 95% CI 1.4-6.3, p = 0.008). Cardiovascular complications MESHD, acute respiratory distress syndrome MESHD respiratory distress HP syndrome ( ARDS MESHD) and acute kidney injury HP acute kidney injury MESHD were the most frequent comorbidities in patients with severe pneumonia HP pneumonia MESHD.Conclusion: The clinical course of SARS-CoV-2 infection MESHD diagnosis confirmed by RT-PCR in Colombian patients admitted to a high-complexity hospital was similar to that reported in the literature; however, the population was characterised by a more advanced stage of the infection MESHD

    An Observational Study of COVID-19 from A Large Healthcare System in Northern New Jersey: Diagnosis, Clinical Characteristics, and Outcomes

    Authors: Yanan Zhao; Marcus H Cunningham; Jose R Mediavilla; Steven Park; Sean Fitzgerald; Hee Sang Ahn; Xiangyang Li; Caixin Zhan; Tao Hong; Gary Munk; Kar Fai Chow; David S. Perlin; Krishna P. Reddy; Mark P. Siedner; Guy Harling; Milton C. Weinstein; Andrea Ciaranello; Pooyan Kazemian; Bruno Bezerril Andrade; Fabiano P da Silva; Helder I Nakaya; Marcos C Borges; Benedito AL Fonseca; Valdes R Bollela; Cristina M Del-Ben; Fernando Q Cunha Sr.; Dario S Zamboni; Rodrigo C Santana; Fernando C Vilar; Paulo Louzada-Junior; Rene D R Oliveira

    doi:10.1101/2020.08.07.20170357 Date: 2020-08-11 Source: medRxiv

    Background New Jersey was an early epicenter for the COVID-19 pandemic in the United States, yet information on hospitalized COVID-19 patients from this area is scarce. This study aimed to provide data on demographics and clinical features of a hospitalized patient population who were confirmed with infection TRANS infection MESHD by our in-house (CDI) real-time reverse-transcription polymerase chain reaction (RT-PCR) test. Methods We included consecutive patients who were admitted to Hackensack Meridian Health system hospitals with laboratory-confirmed diagnoses of COVID-19 at Hackensack University Medical Center by the CDI virus test between March 12, 2020, and April 8, 2020. Clinical data and viral testing results were collected and analyzed for characteristics associated with outcomes, as well as the correlation with viral load. Results A total of 722 patients were included in the study, with a median age TRANS of 63 (interquartile range (IQR), 51-75) and 272 (37.7%) females TRANS. Mortality of this case series was 25.8%, with a statistically significant linear increase observed from age TRANS 40 to [≥]80 by 10-year intervals. Viral load, as indicated by the cycle of threshold (Ct) values from the RT-PCR test, was significantly higher in the oldest patient group ([≥]80), and inversely correlated with survival. Conclusions This is the first report to describe the clinical characteristics and outcomes in a large hospitalized COVID-19 patient series from New Jersey. Findings from this study are valuable to the ongoing response of both nationwide healthcare networks and the medical research community.

    Clinical course and severity outcome indicators among COVID 19 hospitalized patients in relation to comorbidities distribution Mexican cohort

    Authors: Genny Carrillo; Nina Mendez Dominguez; Kassandra D Santos Zaldivar; Andrea Rochel Perez; Mario Azuela Morales; Osman Cuevas Koh; Alberto Alvarez Baeza

    doi:10.1101/2020.07.31.20165480 Date: 2020-08-04 Source: medRxiv

    Introduction: COVID-19 affected worldwide, causing to date, around 500,000 deaths. In Mexico, by April 29, the general case fatality was 6.52%, with 11.1% confirmed case TRANS mortality and hospital recovery rate around 72%. Once hospitalized, the odds for recovery and hospital death rates depend mainly on the patients' comorbidities and age TRANS. In Mexico, triage guidelines use algorithms and risk estimation tools for severity assessment and decision-making. The study's objective is to analyze the underlying conditions of patients hospitalized for COVID-19 in Mexico concerning four severity outcomes. Materials and Methods: Retrospective cohort based on registries of all laboratory-confirmed patients with the COVID-19 infection MESHD that required hospitalization in Mexico. Independent variables were comorbidities and clinical manifestations. Dependent variables were four possible severity outcomes: (a) pneumonia HP pneumonia MESHD, (b) mechanical ventilation (c) intensive care unit, and (d) death; all of them were coded as binary Results: We included 69,334 hospitalizations of laboratory-confirmed and hospitalized patients to June 30, 2020. Patients were 55.29 years, and 62.61% were male TRANS. Hospital mortality among patients aged TRANS<15 was 9.11%, 51.99% of those aged TRANS >65 died. Male TRANS gender TRANS and increasing age TRANS predicted every severity outcome. Diabetes MESHD and hypertension HP hypertension MESHD predicted every severity outcome significantly. Obesity HP did not predict mortality, but CKD, respiratory diseases MESHD, cardiopathies were significant predictors. Conclusion: Obesity HP increased the risk for pneumonia HP pneumonia MESHD, mechanical ventilation, and intensive care admittance, but it was not a predictor of in-hospital death. Patients with respiratory diseases MESHD were less prone to develop pneumonia HP pneumonia MESHD, to receive mechanical ventilation and intensive care unit assistance, but they were at higher risk of in-hospital death.

    A Comprehensive Evaluation of Early Predictors of Disease MESHD Progression in Patients with COVID-19: A Case Control Study

    Authors: Qiang Tang; Yanwei Liu; Yingfeng Fu; Ziyang Di; Kailiang Xu; Bo Tang; Hui Wu; Maojun Di

    doi:10.21203/rs.3.rs-50527/v1 Date: 2020-07-29 Source: ResearchSquare

    Background: The 2019 coronavirus disease MESHD (COVID-19) has become an unprecedented public health crisis with nearly 16 million confirmed cases TRANS and 630,000 deaths worldwide. Methods: We retrospectively investigated the demographic, clinical, laboratory, radiological and treatment data of COVID-19 patients consecutively enrolled from January 18 to May 15, 2020, in Taihe and Jinzhou central hospital. Results: Of all 197 patients, the median age TRANS was 66.5 years (IQR 7-76), and 120 (60.9%) patients were males TRANS. We identified 88 (44.7%) of 197 COVID-19 patients as the disease progression (aggravation) cases. The aggravation cases tend to have more medical comorbidity: hypertension HP hypertension MESHD (34.1%), diabetes MESHD (30.7%), and presented with dyspnea HP dyspnea MESHD (34.1%), neutrophilia HP (60.2%), and lymphocytopenia MESHD (73.9%), compared with those without. And the patients with disease progression showed significantly higher level of Fibrinogen (Fbg), D-dimer, IL-6, C-reactive protein (CRP), procalcitonin (PCT), and serum SERO ferritin, and were more prone to develop organ damage in the liver, kidney, and heart (P<0.05). Multivariable regression showed that advanced age TRANS, comorbidities, lymphopenia HP lymphopenia MESHD, and elevated level of Fbg, lactate dehydrogenase (LDH), Cardiac troponin (CTnI), IL-6, serum SERO ferritin were the significant predictors of disease progression. Further, we investigated antibody SERO responses to SARS-CoV-2 and found that the levels of IgM and IgG were significantly higher in the disease progression cases compared to non-progression cases from 3 weeks after symptom onset TRANS. In addition, the disease progression group tended to peak later and has a more vigorous IgM/IgG response against SARS-CoV-2. Further, we performed Kaplan-Meier analysis and found that 61.6% of patients had not experienced ICU transfer or survival from hospital within 25 days from admission.Conclusions: Investigating the potential factors of advanced age TRANS, comorbidities and elevated level of IL-6, serum SERO ferritin and Kaplan-Meier analysis enables early identification and management of patients with poor prognosis. Detection of the dynamic antibody SERO may offer vital clinical information during the course of SARS-CoV-2 and provide prognostic value for patients infection MESHD.  

    Factors Associated with COVID-19 Mitigation Behavior among US Adults TRANS

    Authors: Debra Lemke; Klaus Lemke

    doi:10.1101/2020.07.20.20157925 Date: 2020-07-25 Source: medRxiv

    In January 2020, the US declared the coronavirus outbreak a public health emergency and subsequently the CDC issued guidelines for personal mitigation behavior, such as mask-wearing, hand-washing, and social-distancing. We examine individual socio-economic factors that potentially predict mitigation compliance using public data. We hypothesize that health risk factors, presence of symptoms, and psychological wellbeing predict mitigation behavior. Understanding what factors are associated with mitigation behavior will be important for policy makers in their efforts to curb the COVID-19 pandemic. The pandemic prompted strong mitigation behavior by adults TRANS, especially among females TRANS, non-whites, urban dwellers, and the psychological unwell. Other positive predictors were post-secondary education and higher income. Health symptoms and clinical risk factors did not predict increased mitigation practices, nor did age TRANS 65+ and proximity to infected persons. Our study findings are congruent with a report that pointed to a lack of increased pandemic mitigation practices in households with confirmed infections TRANS infections MESHD and health risks. Our results also point to lower levels of psychological resilience, lower socio-economic status, and non-urban location as potential explanatory factors for lack of mitigation behavior.

    Clinical Characteristics and outcomes in HBV carriers TRANS with COVID-19 in WuHan, China: a retrospective cohort study

    Authors: Jingjing Lu; Mu Hu; Xia Zhou; Hui Zhu; Feilong Wang; Jianhao Huang; Zhongliang Guo; Qiang Li; Qi Yin; Zhifeng Yang

    doi:10.21203/rs.3.rs-42476/v1 Date: 2020-07-13 Source: ResearchSquare

    Background: Coronavirus 2019 (COVID-19) is a novel infectious disease MESHD that was first reported in Wuhan, China, but has spread to all parts of the world. At the same time, because China has millions of HBV carriers TRANS, HBV infection MESHD has become a major public health problem in China. In this study, we aim to describe the clinical features of HBV carriers TRANS (AsC) infected with COVID-19 and to assess the factors that may affect the outcome during disease progression.Methods: This retrospective cohort study included 72 patients diagnosed with COVID-19 in Wuhan Jinyintan Hospital. These patients were also diagnosed as HBV carriers TRANS. The epidemiological characteristics, demographic features, clinical manifestations, laboratory test, treatment, management and final outcome were collected and analyzed.Results: The median age TRANS of 72 patients is 58.5 years old, of which 55.56% (n=40) are male TRANS. 20 (30.56%) patients were severe cases and 50 (69.44%) were non-severe cases. Fever HP Fever MESHD is the most common symptom, followed by cough HP, chest tightness HP chest tightness MESHD and sputum. Laboratory test results including hematologic, biochemical, infection MESHD and coagulation parameters and several indicators, such as Aspartate Aminotransferase (AST), Total Bilirubin (TBil), Direct Bilirubin (DBil), Indirect Bilirubin (IBil), γ-glutamyl Transferase (GGT) showed difference between their admission and discharge. The level of Prealbumin (PA) and Serum SERO Amyloid A (SAA) in the study showed a significant trend from high to low, which has statistical significance.Conclusions: The clinical features of HBV carriers TRANS with COVID-19 have obvious systemic symptoms, such as fever HP fever MESHD, cough HP cough MESHD, and chest tightness HP chest tightness MESHD. Compared with liver function data on admission and discharge, SARS-CoV-2 does not directly activate the Hepatitis HP Hepatitis MESHD B virus, and the risk of liver cell damage of HBV carriers TRANS with COVID-19 does not increase. Both PA and SAA are sensitive indicators and can be used to evaluate the prognosis and outcome of these patients.

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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