Corpus overview


Overview

MeSH Disease

Human Phenotype

Fever (14)

Cough (12)

Pneumonia (11)

Hypertension (7)

Fatigue (7)


Transmission

Seroprevalence
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    The Epidemiological and Spatiotemporal Characteristics of 2019 novel coronavirus diseases MESHD (COVID-19) in Libya

    Authors: Mohamed A Daw; Abdallah H El-Bouzedi; Mohamed O Ahmed

    doi:10.21203/rs.3.rs-67010/v1 Date: 2020-08-27 Source: ResearchSquare

    Background: COVID-19 is a global pandemic that affectedaffects all aspects of life. Studies on understanding the geographical and epidemiological characteristics become particularly important in controlling the spread of the pandemic. Such studies are lacking in Northern African countries, particularly in Libya, which is considered being, the second largest country in Africa, with the longest coast facing Europe. The objectives of this study are to; determine the epidemiological parameters and spatiotemporal patterns of COVID-19 in this large country and outline the needed strategies to contain the spread and the consequences of the pandemic. Methods:  This comprehensive study included all the confirmed cases TRANS of COVID-19 since its emergence in Libya, from early April 2020 until July 31th31. The epidemiological characteristics of COVID-19 were analyzed, and the spatial dynamic trends were explored. A region Region-based counts of weekly reported cases were used to characterize and quantify the spatial dynamics of COVID-19.Results: A total  of 3695 of confirmed cases TRANS of OVID-19 were collected,; 2515 (68.1%) were males , and 1180 (31.9%) were females TRANS with a male TRANS-to- female TRANS (M:F) ratio of 2.1:1. Aged TRANS between 2 -and 78 years old. Older age TRANS patients infected with COVID-19 are at higher severity and mortality. A broad geographic variability and spatiotemporal spread variation of the COVID-19 pandemic in Libya was observed. Indicating. This indicates a more significant increase ofin COVID-19 from the middle of July, particularly in the West and Southern regions, although it was consistently observed in the Meddle and Southern regions.Conclusion: Evaluating the epidemiological data and the spatiotemporal dynamic trends of COVID-19 at early stages are particularly   important in understanding the pandemic spread.   These parameters are essential in designing effective prevention and control programs aimed at reducing the impact of the COVID- 19 pandemic, particularly in countries with limited resources.

    The Epidemiological and Spatio-temporal Characteristics of 2019 Novel Coronavirus Diseases MESHD (COVID-19) in Libya

    Authors: Mohamed A Daw; Abdallah H El-Bouzedi; Mohamed O Ahmed

    doi:10.21203/rs.3.rs-57985/v1 Date: 2020-08-12 Source: ResearchSquare

    Background: COVID-19 is a global pandemic that affected all aspects of life. Studies on understanding the geographical and epidemiological characteristics become particularly important in controlling the spread of the pandemic. Such studies are lacking in Northern African countries particularly in Libya, which considered being, the second largest country in Africa with the longest coast facing Europe. The objectives of this study are to; determine the epidemiological parameters and spatiotemporal patterns of COVID-19 in this large country and outline the needed strategies to contain the spread and the consequences of the pandemic. Methods:  This comprehensive study included all the confirmed cases TRANS of COVID-19 since its emergence in Libya, from early April 2020 until August 31th. The epidemiological characteristics of COVID-19 were analyzed and the spatial dynamic trends were explored.  A region -based counts of weekly reported cases were used to characterize and quantify the spatial dynamics of COVID-19. Results: A total  3695  of confirmed cases TRANS of OVID-19 were collected, 2515(68.1%) were males and 1180(31.9%) female TRANS with a male TRANS-to- female TRANS(M:F) ratio 2.1:1. Aged TRANS between 2 -78 years old. Older age TRANS patients infected with COVID-19 are at higher severity and mortality. A broad geographic variability and Spatiotemporal spread variation of the COVID-19 pandemic in Libya was observed. Indicating a higher significant increase of COVID-19 from the middle of July particularly in the West and Southern regions although it was consistently observed in Meddle and Southern regions. Conclusion: Evaluating the epidemiological data and the spatiotemporal dynamic trends of COVID-19 at early stages are particularly  important in understanding the pandemic spread.  These parameters are essential in designing effective prevention and control programs aimed at reducing the impact of COVID- 19 pandemic particularly in countries with limited resources. 

    A Comprehensive Evaluation of Early Predictors of Disease MESHD Progression in Patients with COVID-19: A Case Control Study

    Authors: Qiang Tang; Yanwei Liu; Yingfeng Fu; Ziyang Di; Kailiang Xu; Bo Tang; Hui Wu; Maojun Di

    doi:10.21203/rs.3.rs-50527/v1 Date: 2020-07-29 Source: ResearchSquare

    Background: The 2019 coronavirus disease MESHD (COVID-19) has become an unprecedented public health crisis with nearly 16 million confirmed cases TRANS and 630,000 deaths worldwide. Methods: We retrospectively investigated the demographic, clinical, laboratory, radiological and treatment data of COVID-19 patients consecutively enrolled from January 18 to May 15, 2020, in Taihe and Jinzhou central hospital. Results: Of all 197 patients, the median age TRANS was 66.5 years (IQR 7-76), and 120 (60.9%) patients were males TRANS. We identified 88 (44.7%) of 197 COVID-19 patients as the disease progression (aggravation) cases. The aggravation cases tend to have more medical comorbidity: hypertension HP hypertension MESHD (34.1%), diabetes MESHD (30.7%), and presented with dyspnea HP dyspnea MESHD (34.1%), neutrophilia HP (60.2%), and lymphocytopenia MESHD (73.9%), compared with those without. And the patients with disease progression showed significantly higher level of Fibrinogen (Fbg), D-dimer, IL-6, C-reactive protein (CRP), procalcitonin (PCT), and serum SERO ferritin, and were more prone to develop organ damage in the liver, kidney, and heart (P<0.05). Multivariable regression showed that advanced age TRANS, comorbidities, lymphopenia HP lymphopenia MESHD, and elevated level of Fbg, lactate dehydrogenase (LDH), Cardiac troponin (CTnI), IL-6, serum SERO ferritin were the significant predictors of disease progression. Further, we investigated antibody SERO responses to SARS-CoV-2 and found that the levels of IgM and IgG were significantly higher in the disease progression cases compared to non-progression cases from 3 weeks after symptom onset TRANS. In addition, the disease progression group tended to peak later and has a more vigorous IgM/IgG response against SARS-CoV-2. Further, we performed Kaplan-Meier analysis and found that 61.6% of patients had not experienced ICU transfer or survival from hospital within 25 days from admission.Conclusions: Investigating the potential factors of advanced age TRANS, comorbidities and elevated level of IL-6, serum SERO ferritin and Kaplan-Meier analysis enables early identification and management of patients with poor prognosis. Detection of the dynamic antibody SERO may offer vital clinical information during the course of SARS-CoV-2 and provide prognostic value for patients infection MESHD.  

    COVID-19: A Data-Driven Mean-Field-Type Game Perspective

    Authors: Hamidou Tembine

    doi:10.1101/2020.07.23.20160853 Date: 2020-07-24 Source: medRxiv

    In this article, a class of mean-field-type games with discrete-continuous state spaces is considered. We establish Bellman systems which provide sufficiency conditions for mean-field-type equilibria in state-and-mean-field-type feedback form. We then derive unnormalized master adjoint systems (MASS). The methodology is shown to be flexible enough to capture multi-class interaction in epidemic propagation in which multiple authorities are risk-aware atomic decision-makers and individuals are risk-aware non-atomic decision-makers. Based on MASS, we present a data-driven modelling and analytics for mitigating Coronavirus Disease MESHD 2019 (COVID-19). The model integrates untested cases, age TRANS-structure, decision-making, gender TRANS, pre-existing health conditions, location, testing capacity, hospital capacity, mobility map on local areas, in-city, inter-cities, and international. It shown that the data-driven model can capture most of the reported data on COVID-19 on confirmed cases TRANS, deaths MESHD, recovered, number of testing and number of active cases in 66+ countries. The model also reports non-Gaussianity and non-exponential properties in 15+ countries.

    Clinical Features of Hemodialysis (HD) patients confirmed with Coronavirus Disease MESHD 2019 (COVID-19): a Retrospective Case-Control Study

    Authors: Xiaohui Wang; Huan Zhou; Xiaofen Xiao; Xianhua Tan; Xin Zhang; Yong He; Jing Li; Guosheng Yang; Mingmei Li; Duan Liu; Shanshan Han; Haibo Kuang

    doi:10.1101/2020.07.06.20147827 Date: 2020-07-10 Source: medRxiv

    Background: Since December 2019, Coronavirus Disease MESHD 2019(COVID-19) occurred in wuhan, China, and outbreaked rapidly into a global pandemic. This current poses great challenges to hemodialysis (HD) patients. Objective: To make a comprehensive evaluation and comparison between HD patients confirmed with COVID-19 and the general HD patients. Methods: HD patients confirmed with COVID-19 in Wuhan No.5 Hospital were admitted as confirmed group from Jan 10 to Mar 15, 2020. And HD patients not infected in our dialysis center were chosen as control group. General characteristics, laboratory indicators were retrospectively collected, analyzed and compared. Results: A total of 142 cases were admitted, including 43 cases in confirmed TRANS group and 99 in control group. Body mass index (BMI) was slightly lower in confirmed group than that in control group (P=0.011). The proportion of one or less underlying disease in confirmed group(51.16%) was higher than that in control group(14.14%)(P< 0.001), and the proportion of three or more underlying diseases in confirmed group(11.63%) was lower than that in control group(52.53%)(P< 0.001). Patients in confirmed group exhibited significantly lower hemoglobin, lymphocyte count, and lymphocyte percentage, but higher neutrophil percentage, neutrophil-to-lymphocyte ratio (NLR), C-reactive protein, aspartate transaminase, and alkaline phosphatase. There was no significant difference in age TRANS, gender TRANS, dialysis age TRANS, primary disease MESHD, the using of ACEI/ARB, platelet-to-lymphocyte ratio (PLR) , and other indicators between the two groups. Conclusions: Faced with Severe Acute Respiratory Syndrome-CoV-2 MESHD (SARS-CoV-2), HD patients with lower BMI and hemoglobin were more susceptible to be infected MESHD, which might be related to malnutrition HP. Once confirmed with COVID-19, HD patients expressed obviously disregulated in inflammation MESHD and immune.

    Antibody Testing SERO Documents the Silent Spread of SARS-CoV-2in New York Prior to the First Reported Case

    Authors: Kathrine Meyers; Lihong Liu; Wen-Hsuan Lin; Yang Luo; Michael Yin; Yumeng Wu; Sandeep Wontakal; Alex Rai; Francesca La Carpia; Sebastian Fernando; Mitra Dowlatshahi; Elad Elkayam; Ankur Garg; Leemor Joshua-Tor; John Wolk; Barbara Alpert; Marie-Laure Romney; Brianna Costabile; Edoardo Gelardi; Francesca Vallese; Oliver Clarke; Filippo Mancia; Anne-Catrin Uhlemann; Magdalena Sobieszczyk; Alan Perelson; Yaoxing Huang; Eldad Hod; David Ho

    doi:10.21203/rs.3.rs-39880/v1 Date: 2020-07-02 Source: ResearchSquare

    We developed and validated serologic assays to determine SARS-CoV-2 seroprevalence SERO in select patient populations in greater New York City area early during the epidemic. We tested “discarded” serum samples SERO from February 24 to March 29 for antibodies SERO against SARS-CoV-2 spike trimer and nucleocapsid protein. Using known durations for antibody SERO development, incubation period TRANS, serial interval TRANS, and reproductive ratio for this pandemic, we determined that introduction of SARS-CoV-2 into New York likely occurred between January 23 and February 4, 2020. SARS-CoV-2 spread silently for 4–5 weeks before the first community acquired infection MESHD was reported. A novel coronavirus emerged in December 2019 in Wuhan, China1,2 and devasted Hubei Province in early 2020 before spreading to every province within China and nearly every country in the world3. This pathogen, now termed severe acute respiratory syndrome coronavirus 2 MESHD (SARS-CoV-2), has caused a global pandemic, with ~ 10 million cases and over 500,000 deaths MESHD reported through June 30, 20203. The first case of SARS-CoV-2 infection MESHD in the United States was identified on January 19, 2020 in a man who returned to the State of Washington from Wuhan4. In the ensuing months, the U.S. has become a hotspot of the pandemic, presently accounting for almost one third of the total caseload and over one fourth of the deaths3. The first confirmed case TRANS in New York was reported on March 1 in a traveler recently returned from Iran. The first community-acquired SARS-CoV-2 infection MESHD was diagnosed on March 3 in a 50-year-old male TRANS who lived in New Rochelle and worked in New York City (https://www1.nyc.gov/site/doh/covid/covid-19-data-archive.page.) In the ensuing 18 weeks, New York City has suffered a peak daily infection number of ~ 4,500 (Fig. 1a) and a cumulative caseload of ~ 400,000 to date. The time period when SARS-CoV-2 gained entry into this epicenter of the pandemic remains unclear.

    Clinical characteristics of confirmed cases TRANS of COVID-19 admitted at Al-Nahdha hospital, Oman: a cross-sectional descriptive study

    Authors: Saud Al Harthi; Magdi AlOsali; Ruwaida Al Ismaili; Sultan Al Lawati; Bina Kamble; Mustafa Al Shaaibi; Nasser Al kindi; Salim Al Qasabi; Mohamed Al Hinai; Hamad Al Harthi; Thamra Al Ghafri

    doi:10.21203/rs.3.rs-39988/v1 Date: 2020-07-02 Source: ResearchSquare

    Background: With the coronavirus disease MESHD 19 (COVID-19) pervading the world, little has been published regarding the hospitalized cases of COVID-19 (confirmed) in the Arabian Gulf countries. This paper describes the socio-demographic, clinical, laboratory, and radiological characteristics, treatment and clinical outcomes of these cases in Al-Nahdha hospital, Oman. Additionally, factors associated with requiring critical care were identified.Methods: Data of all the positive cases in Al-Nahdha hospital were retrieved from the electronic health information system retrospectively from 3rd of March to 9th May 2020. Required information was recorded in a bespoke sheet and exported to SPSS for further analysis. The primary outcome was defined as requiring vs not requiring critical care.Results:Out of 102 total admissions, 19 cases required critical care (18.6%). Compared to the non-critical cases, majority of the severe cases requiring critical care were older [54.1(13.4) years vs 48.9(14.9) years], males TRANS [89.5% vs 74.7%] and non-nationals [63.2 vs 55.4%]. Significant factors associated with requiring critical care were symptoms of shortness of breath MESHD (89.5% vs 65.1%, P=0.03), diabetes MESHD (68.4% vs 32.5%, OR=1.5, P=0.004), chronic artery disease MESHD (15.8% vs 3.6%, OR=1.7, P=0.04), diagnosis of ARDS (63.2% vs 6.0%, P<0.001). Additionally, the mean ferritin levels was significantly higher in cases requiring critical care compared to their counter cases (2350.4(423.8) vs 795.7(554.3), P=0.005). Depending on disease severity, treatment included anti-bacterial, anti-viral, heparin and steroids. The utilization of steroids was significantly higher in the cases requiring critical care (63.2% vs 26.5%, P=0.001). Out of cases who required critical care (n=19), nine died (death rate= 47.4%). Conclusions:Results from this study provides fundamental information about the non-clinical and clinical characteristics of confirmed COVID-19 cases in Oman. The information obtained can be utilized to follow up the clinical progress of hospitalized patients with COVID-19 in the Arabic speaking countries where such reports are limited.

    Time Course of Psychological Impact for Male TRANS: Discovered in COVID-19 Cases

    Authors: Weizhi Liu; Nianqi Liu; Bin Yi; Xiao Pan; Zhilei Shang; Xiandong Tao; Yonghai Bai

    doi:10.21203/rs.3.rs-39067/v1 Date: 2020-06-29 Source: ResearchSquare

    The outbreak of Coronavirus Disease MESHD 2019 (COVID-19) pandemic is leading to widespread emotional distress such as post- traumatic stress disorder MESHD ( PTSD MESHD). Our objective was to investigate the gender TRANS differences in PTSD MESHD symptoms (PTSS) among COVID-19 symptomatic patients over time caused by delayed medical visit. We investigated 258 confirmed cases TRANS of COVID-19 from two designated hospitals in Wuhan from 26 February to 16 March. PTSS was measured by PTSD Checklist for DSM-5 (PCL-5). Demographics and time interval from symptom onset TRANS to the first medical visit were also collected. The results show that 48 of 258 participants (18.6 %) met the criteria of PTSD MESHD symptoms. Males TRANS had significantly higher PCL-5 scores when time interval was 7 days or more compared with less than 7 days (22.18 vs. 15.11, t=-2.280, P<0.05), whereas no such significant time effect was found in females TRANS, regardless of the severity of the disease. The present study emphasizes the significant effect of time course on PTSS only in male TRANS. It is suggested that policy makers and health services should pay more attention to PTSD MESHD in male TRANS, and call on male TRANS to seek medical treatment as soon as developing symptoms of coronavirus disease MESHD if local medical conditions permitted.

    Clinical course and potential predicting factors of pneumonia HP pneumonia MESHD of adult TRANS patients with coronavirus disease MESHD 2019 (COVID-19): A retrospective observational analysis of 193 confirmed cases TRANS in Thailand

    Authors: Wannarat A Pongpirul; Surasak Wiboonchutikul; Lantharita Charoenpong; Nayot Panitantum; Apichart Vachiraphan; Sumonmal Uttayamakul; Krit Pongpirul; Weerawat Manosuthi; Wisit Prasithsirikul

    doi:10.1101/2020.06.24.20139642 Date: 2020-06-26 Source: medRxiv

    Background: Clinical spectrum of COVID-19 has been unclear, especially with regard to the presence of pneumonia HP pneumonia MESHD. We aimed to present clinical course of all laboratory-confirmed adult TRANS COVID-19 patients and to identify potential predicting factors of pneumonia HP pneumonia MESHD. Methods: We conducted a retrospective study among adult TRANS patients with confirmed COVID-19 who were hospitalized at Bamrasnaradura Infectious Diseases Institute, Thailand, regardless of their disease severity, between January 8 and April 16, 2020. We described the full picture of COVID-19, defined definite outcomes and evaluated factors associated with pneumonia HP pneumonia MESHD. Results: One-hundred-and-ninety-three patients were included. The median (IQR) age TRANS was 37.0 (29.0-53.0) years, and 58.5% were male TRANS. Of whom, 189 (97.9%) recovered and 4 (2.1%) died. More than half (56%) of the patients were mild, 22% were moderate, 14% were severe, and 3% were critically ill. Asymptomatic TRANS infection MESHD was found in 5%. The overall incidence of pneumonia HP pneumonia MESHD was 39%. Bilateral was more prevalent than unilateral pneumonia MESHD pneumonia HP (65% vs. 35%). Increasing age TRANS (OR 2.60 for every 10-year increase from 30 years old; 95% CI, 1.68 to 3.97; p<0.001), obesity HP obesity MESHD (OR 9.17; 95% CI, 2.11 to 39.89; p=0.003), and higher temperature at presentation (OR 4.66 per one-degree Celsius increase from 37.2 degree Celsius; 95% CI, 2.32 to 9.34; p<0.001) were potential predicting factors of COVID-19 pneumonia HP pneumonia MESHD. Severe cases had a longer viral RNA shedding duration than the non-severe cases. The longest observed duration of viral RNA shedding was 45 days. Conclusion: Across different disease severities, most patients with COVID-19 in Thailand had a good prognosis. COVID-19 pneumonia HP pneumonia MESHD was found in one-third of the hospitalized patients. Potential predicting factors included old age TRANS, obesity HP obesity MESHD, fever HP fever MESHD at presentation.

    The validation of the original and modified Caprini score in COVID-19 patients

    Authors: Sergey Tsaplin; Ilya Schastlivtsev; Kirill Lobastov; Sergey Zhuravlev; Victor Barinov; Joseph Caprini

    doi:10.1101/2020.06.22.20137075 Date: 2020-06-23 Source: medRxiv

    Objective. The study aimed to validate the original Caprini score and its modifications considering coronavirus disease MESHD (COVID-19) as a severe prothrombotic condition MESHD in patients admitted to the hospital with confirmed infection TRANS infection MESHD. Methods. The relevant data were extracted from the electronic medical records with the implemented Caprini score and were evaluated retrospectively. The score was calculated twice: by the physician at the admission and by the investigator at discharge or after death. The second calculation at discharge, considered additional risk factors that occurred during inpatient treatment. Besides the original Caprini score (a version of 2005), the modified version added the elevation of D-dimer and specific scores for COVID-19 as follows: 2 points for asymptomatic TRANS, 3 points for symptomatic and 5 points for symptomatic infection MESHD with positive D-dimer, were evaluated in a retrospective manner. The primary endpoint was symptomatic venous thromboembolism MESHD thromboembolism HP ( VTE MESHD) confirmed by appropriate imaging testing or dissection. The secondary endpoint included the unfavorable outcome as a combination of symptomatic VTE MESHD, admission to the intensive care unit, the requirement for invasive mechanical ventilation, and death MESHD. The association of eight different versions of the Caprini score with outcomes was evaluated. Results. Totally 168 patients (83 males TRANS and 85 females TRANS at the age TRANS of 58.3{+/-}12.7 years old) were admitted to the hospital between April 30 and May 29, 2020, and were discharged or died up to the time of data analysis. The original Caprini score varied between 2-12 (5.4{+/-}1.8) at the admission and between 2-15 (5.9{+/-}2.5) at discharge or death MESHD. The presence of the virus increased these scores and resulted in an increased score with the maximal value for those including COVID-19 points (10.0{+/-}3.0). Patients received prophylactic (2.4%), intermediate (76.8%), or therapeutic (20.8%) doses of enoxaparin. Despite this, the symptomatic VTE MESHD was detected in 11 (6.5%) and unfavorable outcomes in 31 (18.5%) patients. The Caprini score of all eight versions demonstrated a significant association with VTE MESHD with the highest predictability for the original scale when assessed at discharge. Supplementation of the original score by elevated D-dimer improved predictability only at the admission. Four versions of the Caprini score calculated at the admission had a significant correlation with the unfavorable outcome with the minor advantages of specific COVID-19 points. Conclusion. The study identified a significant correlation between the Caprini score and the risk of VTE MESHD or unfavorable outcomes in COVID-19 patients. All models, including specific COVID-19 scores, showed high predictability with minor differences.

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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