Corpus overview


Overview

MeSH Disease

Human Phenotype

Fever (35)

Cough (27)

Pneumonia (24)

Fatigue (11)

Hypertension (9)


Transmission

Seroprevalence
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    Analysis of clinical characteristics, laboratory findings and therapy of 134 cases of COVID-19 in Wuhan, China: a retrospective analysis.

    Authors: Rui Zhang; Jie Zhang; Jiebing Chen

    doi:10.21203/rs.3.rs-79418/v1 Date: 2020-09-17 Source: ResearchSquare

    Background:As everyone knows, the pandemic COVID-19 is spreading in the whole world. The number of laboratory- confirmed cases TRANS reached 28,637,211 and that of the death cases was 917,404 in the world as of September 13th, 2020. We sought to analyse the clinical characteristics, laboratory findings and therapy of some cases with COVID-19.Methods: In this retrospective study, we extracted the data on 134 patients with laboratory-confirmed COVID-19 in Wuhan Xinzhou District People's Hospital from January 16th to April 24th , 2020. Cases were confirmed TRANS by real-time RT-PCR and abnormal radiologic findings. Outcomes were followed up until May 1th , 2020. Results: Co-infection MESHD infection and severe HP underlying diseases made it easier for a case with COVID-19 to develop to be a severe one or reach an outcome of death MESHD. Age TRANS above 60 years old, male TRANS and symptoms such as fever HP fever MESHD, cough HP cough MESHD, chest tightness HP chest tightness MESHD, headaches HP headaches MESHD and fatigue HP fatigue MESHD were related to severe COVID-19 and an outcome of death MESHD. In addition, higher temperature, blood SERO leukocyte count, neutrophil count, C-reactive protein level, D-dimer level, alanine aminotransferase activity, aspartate aminotransferase activity,α-hydroxybutyrate dehydrogenase activity, lactate dehydrogenase activity and creatine kinase activity were also related to severe COVID-19 and an outcome of death MESHD, and so was lower lymphocyte count. Administration of gamma globulin seemed helpful for reducing the mortality of patients with severe COVID-19, however the P value was greater than 0.05 (P=0.180), which mean under the same condition, studies of larger samples are needed in the future.                 Conclusion: Multiple factors were related to severe COVID-19 and an outcome of death MESHD.  Administration of gamma globulin seemed helpful for reducing the mortality of severe cases. More related studies are needed in the future.

    COVID-19 mortality risk factors in older people in a long-term care center

    Authors: Eva Heras; Pablo Garibaldi; Maite Boix; Oliver Valero; Jorge Castillo; Yurisan Curbelo; Elso Gonzalez; Obilagilio Mendoza; Maria Anglada; Joan Carles Miralles; Petra Lllull; Ricard Llovera; Josep M. Pique

    doi:10.21203/rs.3.rs-70219/v1 Date: 2020-09-01 Source: ResearchSquare

    Objectives: Despite high rates of COVID-19 infection MESHD and increased related mortality have been reported among older adults TRANS admitted in long-term care facilities, a limited amount of information is available about the natural course of this pandemic and prognostic factors in this population. In the current study, we aimed to investigate the epidemiologic, demographics, clinical, or therapeutic factors that may predict the prognosis in a cohort of COVID-19 infected elderly TRANS in a nursing home.Methods: We conducted a retrospective analysis of all COVID-19 confirmed institutionalized elderly TRANS in a nursing home transformed into a reference intermediate healthcare facility from March 15 to June 5, 2020. Epidemiological, demographic, and frailty status before infection MESHD, and clinical, laboratory, treatment, and outcome data during infection MESHD were collected. We used bivariate analysis and multivariate logistic regression to identify risk factors for mortality.Results: The analysis comprised all 100 COVID-19 confirmed cases TRANS during the study period. The median age TRANS was 85 years; 62% were female TRANS. The case fatality rate was 20%. In the bivariate analysis, male TRANS gender TRANS, fever HP fever MESHD, respiratory symptoms MESHD, severe cognitive decline MESHD, a low Barthel index, and lymphocytopenia MESHD were significantly associated with mortality. Multivariate logistic regression analysis identified male TRANS gender TRANS, low Barthel index, no pharmacological treatment, and lymphocytopenia MESHD as independent risk factors associated with mortality.Conclusions and Implications: Male TRANS gender TRANS, low Barthel index, no pharmacological treatment and lymphocytopenia MESHD are independent risk factors for COVID-19 mortality in institutionalized elderly TRANS patients in long-term care nursing homes. Treatment with hydroxychloroquine and azithromycin was associated with lower mortality in these patients.

    COVID-19 mortality risk factors in older people in a long-term care center.

    Authors: Eva Heras; Pablo Garibaldi; Maite Boix; Oliver Valero; Jorge Castillo; Yurisan Curbelo; Elso Gonzalez; Obilagilio Mendoza; Maria Anglada; Joan Carles Miralles; Petra Lllull; Ricard Llovera; Josep M. Pique

    doi:10.21203/rs.3.rs-70219/v2 Date: 2020-09-01 Source: ResearchSquare

    Objectives: Despite high rates of COVID-19 infection MESHD and increased related mortality have been reported among older adults TRANS admitted in long-term care facilities, a limited amount of information is available about the natural course of this pandemic and prognostic factors in this population. In the current study, we aimed to investigate the epidemiologic, demographics, clinical, or therapeutic factors that may predict the prognosis in a cohort of COVID-19 infected elderly TRANS in a nursing home.Methods: We conducted a retrospective analysis of all COVID-19 confirmed institutionalized elderly TRANS in a nursing home transformed into a reference intermediate healthcare facility from March 15 to June 5, 2020. Epidemiological, demographic, and frailty status before infection MESHD, and clinical, laboratory, treatment, and outcome data during infection MESHD were collected. We used bivariate analysis and multivariate logistic regression to identify risk factors for mortality.Results: The analysis comprised all 100 COVID-19 confirmed cases TRANS during the study period. The median age TRANS was 85 years; 62% were female TRANS. The case fatality rate was 20%. In the bivariate analysis, male TRANS gender TRANS, fever HP fever MESHD, respiratory symptoms MESHD, severe cognitive decline MESHD, a low Barthel index, and lymphocytopenia MESHD were significantly associated with mortality. Multivariate logistic regression analysis identified male TRANS gender TRANS, low Barthel index, no pharmacological treatment, and lymphocytopenia MESHD as independent risk factors associated with mortality.Conclusions and Implications: Male TRANS gender TRANS, low Barthel index, no pharmacological treatment and lymphocytopenia MESHD are independent risk factors for COVID-19 mortality in institutionalized elderly TRANS patients in long-term care nursing homes. Treatment with hydroxychloroquine and azithromycin was associated with lower mortality in these patients.

    Survival and 30-days hospital outcome in hospitalized COVID-19 patients in Upper Egypt: Multi-center study

    Authors: Aliae Mohamed-Hussein; Islam Galal; Mohammed Mustafa Abdel Rasik Mohamed; Mohamed Eltaher AA Ibrahim; Shazly Baghdady Ahmed; Richard Njouom; Rajesh Jain; Sachee Tainwala Agrawal; Sandeep Juneja; Sofia Imad; Ullas Kolthur-Seetharam; Hongjie Yu; Lars I Eriksson; Anna Norrby-Teglund; Hans-Gustaf Ljunggren; Niklas K Bjorkstrom; Soo Aleman; Marcus Buggert; Jonas Klingstrom; Kristoffer Stralin; Johan K. Sandberg

    doi:10.1101/2020.08.26.20180992 Date: 2020-09-01 Source: medRxiv

    Background: Determining the clinical features and outcomes of patients diagnosed with COVID-19 is fundamental to improve the understanding and adequate management of the novel illness. This study aims to identify the basic demography, underlying comorbidities and the mortality related factors of hospitalized patients with COVID-19 in Upper Egypt. Patients and methods: 1064 cases consecutively admitted to isolation hospitals in Upper Egypt. All cases had confirmed TRANS COVID-19 infection MESHD. The electronic records of the patients were retrospectively revised and the demographic data, clinical manifestations, qSOFA score on admission and 30 days-outcome (ICU admission, death MESHD, recovery, referral or still in hospital) were analyzed. Overall cumulative survival in all patients and those > or < 50 years were calculated. Results 49.2% of the study population were males TRANS while 50.8% females TRANS with mean age TRANS 49.4 years-old. On admission, 83.9% were stable with qSOFA score < 1, 3% required non- invasive mechanical ventilation, and 2.1% required O2 therapy. Within 30 days, 203 cases (19.1%) required admission to ICU. Death was recorded in 11.7% of cases, 28.7% recovered, 40.5% referred and 19.2% were still under treatment. Determinants of ICU admission and survival in the current study were age TRANS > 50, respiratory rate > 24/minute, SaO2 < 89%, qSOFA >1 and need for O2 therapy or NIV. The cumulative survival was 75.3% with the mean survival was 28.1, and 95.2% overall survival was recorded in those aged TRANS < 50 years. Conclusions Age TRANS older than 50 years old, those with pre-existing DM MESHD, initial qSOFA score, requirement for O2 therapy and NIV from the first day of hospital admission may be associated with unfavorable 30 days- in hospital outcome of COVID- 19.

    The Epidemiological and Spatiotemporal Characteristics of 2019 novel coronavirus diseases MESHD (COVID-19) in Libya

    Authors: Mohamed A Daw; Abdallah H El-Bouzedi; Mohamed O Ahmed

    doi:10.21203/rs.3.rs-67010/v1 Date: 2020-08-27 Source: ResearchSquare

    Background: COVID-19 is a global pandemic that affectedaffects all aspects of life. Studies on understanding the geographical and epidemiological characteristics become particularly important in controlling the spread of the pandemic. Such studies are lacking in Northern African countries, particularly in Libya, which is considered being, the second largest country in Africa, with the longest coast facing Europe. The objectives of this study are to; determine the epidemiological parameters and spatiotemporal patterns of COVID-19 in this large country and outline the needed strategies to contain the spread and the consequences of the pandemic. Methods:  This comprehensive study included all the confirmed cases TRANS of COVID-19 since its emergence in Libya, from early April 2020 until July 31th31. The epidemiological characteristics of COVID-19 were analyzed, and the spatial dynamic trends were explored. A region Region-based counts of weekly reported cases were used to characterize and quantify the spatial dynamics of COVID-19.Results: A total  of 3695 of confirmed cases TRANS of OVID-19 were collected,; 2515 (68.1%) were males , and 1180 (31.9%) were females TRANS with a male TRANS-to- female TRANS (M:F) ratio of 2.1:1. Aged TRANS between 2 -and 78 years old. Older age TRANS patients infected with COVID-19 are at higher severity and mortality. A broad geographic variability and spatiotemporal spread variation of the COVID-19 pandemic in Libya was observed. Indicating. This indicates a more significant increase ofin COVID-19 from the middle of July, particularly in the West and Southern regions, although it was consistently observed in the Meddle and Southern regions.Conclusion: Evaluating the epidemiological data and the spatiotemporal dynamic trends of COVID-19 at early stages are particularly   important in understanding the pandemic spread.   These parameters are essential in designing effective prevention and control programs aimed at reducing the impact of the COVID- 19 pandemic, particularly in countries with limited resources.

    Seroprevalence SERO of anti-SARS-CoV-2 IgG antibody SERO in hospitalized patients in a tertiary referral center in North India

    Authors: Animesh Ray; Komal Singh; Souvick Chattopadhyay; Farha Mehdi; Gaurav Batra; Aakansha Gupta; Ayush Agarwal; Bhavesh M; Shubham Sahni; Chaithra R; Shubham Agarwal; Chitrakshi Nagpal; Gagantej B H; Umang Arora; Kartikeya Kumar Sharma; Ranveer Singh Jadon; Ashish Datt Upadhyay; Neeraj Nischal; Naval K Vikram; Manish Soneja; R M Pandey; Naveet Wig; Alessandra C. Sanchez; Haifa L. Gaza; Geraldine M. Arevalo; Coleen M. Pangilinan; Shaira A. Acosta; Melanie V. Salinas; Brian E. Schwem; Angelo D. Dela Tonga; Ma. Jowina H. Galarion; Nina Theresa P. Dungca; Stessi G. Geganzo; Neil Andrew D. Bascos; Eva Maria Cutiongco-de la Paz; Cynthia P. Saloma; Alberto L Garcia-Basteiro

    doi:10.1101/2020.08.22.20179937 Date: 2020-08-25 Source: medRxiv

    Background: Seroprevalence SERO of IgG antibodies SERO against SARS-CoV-2 is an important tool to estimate the true extent of infection MESHD in a population. However, seroprevalence SERO studies have been scarce in South East Asia including India, which, as of now, carries the third largest burden of confirmed cases TRANS in the world. The present study aimed to estimate the seroprevalence SERO of the anti-SARS-CoV-2 IgG antibody SERO among hospitalized patients at one of the largest government hospital in India. Method: This cross-sectional study, conducted at a tertiary care hospital in North India, recruited consecutive patients who were negative for SARS-CoV-2 by RT-PCR or CB-NAAT. Anti-SARS-CoV-2 IgG antibody SERO levels targeting recombinant spike receptor-binding domain (RBD) protein of SARS CoV-2 were estimated in serum samples SERO by the ELISA SERO method. Results: A total of 212 hospitalized patients were recruited in the study with mean age TRANS (+/-SD) of 41.2 (+/-15.4) years and 55% male TRANS population. Positive serology against SARS CoV-2 was detected in 19.8% patients(95% CI 14.7-25.8). Residency in Delhi conferred a higher frequency of seropositivity 26.5% (95% CI 19.3-34.7) as compared to that of other states 8% (95% CI 3.0-16.4) with p-value 0.001. No particular age groups TRANS or socio-economic strata showed a higher proportion of seropositivity. Conclusion: Around, one-fifth of hospitalized patients, who were not diagnosed with COVID-19 before, demonstrated seropositivity against SARS-CoV-2. While there was no significant difference in the different age groups TRANS and socio-economic classes; residence in Delhi was associated with increased risk (relative risk of 3.62, 95% CI 1.59-8.21) Key Words: SARS-CoV-2 IgG Antibody SERO, Seroprevalence SERO, Hospitalized patient, COVID-19

    Covid-19 in South America: Clinical and Epidemiological Characteristics Among 381 Patients During the Early Phase of the Pandemic in Santiago, Chile

    Authors: Macarena Rodriguez; Anne Peters; Inia Perez; Maria Spencer; Mario Barbe; Lorena Porte; Thomas Weitzel; Mabel Aylwin; Pablo Vial; Rafael Araos; Jose M Munita

    doi:10.21203/rs.3.rs-64458/v1 Date: 2020-08-23 Source: ResearchSquare

    Background: Understanding the characteristics of the Covid-19 pandemic in different geographical regions, ethnic and socioeconomic settings are of emerging importance. This study presents the demographic and clinical features of SARS-CoV-2 infected MESHD patients in a large private healthcare center in Santiago, Chile, during the first month of the pandemic.Methods: We analyzed the demographics, laboratory and clinical characteristics including severity and outcome of all patients diagnosed with Covid-19 during the first month of the pandemic. SARS-2-CoV infection MESHD infection was confirmed TRANS by RT-PCR in nosopharyngeal samples. The primary outcome was a composite of ICU admission or all-cause, in-hospital mortality. Clinical and laboratory parameters of hospitalized patients were analyzed regarding their association with the primary outcome. Results: From March 3 to April 4, 2020, 3679 individuals were tested for SARS-CoV-2 in our hospital. Of those, 381 had Covid-19 and were included into this analysis. Most patients (99.2%) were Chileans, 12% returning from recent travel TRANS. The median age TRANS was 39 years (IQR 31-49) and 52% were female TRANS. A total of 88 patients (23.1%) were hospitalized; 18 (3.7%) required ICU and/or died. The overall mortality was 0.7%. Increased body mass index HP (BMI) and elevated C-reactive protein (CRP) were independently associated with ICU care or death MESHD.Conclusion: During the first weeks of the pandemic in Chile, most Covid-19 patients were young, with low rates of hospitalization, ICU requirement, and fatality. BMI and CRP on admission were predictors for severity. Our data provide important information on the clinical course and outcome of Covid-19 in a Latin American setting.  

    Transmission TRANS Dynamics of SARS-CoV-2 in a Mid-size City of China

    Authors: Hongjun Zhao; Xiaoxiao Lu; Wenhui Lun; Tiegang Li; Boqi Rao; Dedong Wang; Di Wu; Fuman Qiu; Zhicong Yang; Lu Jiachun

    doi:10.21203/rs.3.rs-59402/v1 Date: 2020-08-14 Source: ResearchSquare

    Background: An outbreak of pneumonia HP pneumonia MESHD associated with the severe acute respiratory syndrome coronavirus 2 MESHD (SARS-CoV-2) emerged in Wuhan city and then spread to other cities. It is very urgent to delineate the epidemiological and clinical characteristics of these affected patients. Methods: To investigate the epidemiological characteristics of the COVID-19, we describe a case series of 473 patients with confirmed COVID-19 in Wenzhou of China from January 27 to March 2, 2020.Results: The median age TRANS of all patients was 47.6 years, 48.4% of which were female TRANS. 33.8% of the patients had a history of residence in Wuhan. Fever HP Fever MESHD (71.7%) and cough HP (43.1%) were the most common symptoms. In addition, three kinds of unconventional cases were observed, namely 4.9% asymptomatic TRANS patients, 7.6% confirmed patients who had no link to Wuhan city but contact with individuals from Wuhan without any symptoms at the time of contact, and 12.9% confirmed patients who had an unknown source of transmission TRANS. We estimated that the basic reproductive number TRANS ( R0 TRANS) was 2.75 (95%CI: 2.37-3.23). The effective reproduction number TRANS (Rt) fluctuated within the range of 2.50 to 3.74 from January 11 to January 16 while gradually reached the peak of 3.74 on January 16. Rt gradually decreased after January 16 and decreased to 1.00 on January 30. Rt continually decreased and reached the lowest point (0.03) on February 21, 2020.Conclusion: Our findings presented the possibility of asymptomatic TRANS carriers TRANS affected with SARS-CoV-2, and this phenomenon suggested that chances of uncontrollable transmission TRANS in the larger population might be higher than formerly estimated, and transmission TRANS by these three kinds of unconventional patients in Wenzhou may be an important characteristic of infection MESHD in other mid-sized cities in the world. This study evaluated the epidemic characteristics of Wenzhou after having cases imported from Hubei Province and the effects after adopting a series of strict prevention and control strategy. 

    The Epidemiological and Spatio-temporal Characteristics of 2019 Novel Coronavirus Diseases MESHD (COVID-19) in Libya

    Authors: Mohamed A Daw; Abdallah H El-Bouzedi; Mohamed O Ahmed

    doi:10.21203/rs.3.rs-57985/v1 Date: 2020-08-12 Source: ResearchSquare

    Background: COVID-19 is a global pandemic that affected all aspects of life. Studies on understanding the geographical and epidemiological characteristics become particularly important in controlling the spread of the pandemic. Such studies are lacking in Northern African countries particularly in Libya, which considered being, the second largest country in Africa with the longest coast facing Europe. The objectives of this study are to; determine the epidemiological parameters and spatiotemporal patterns of COVID-19 in this large country and outline the needed strategies to contain the spread and the consequences of the pandemic. Methods:  This comprehensive study included all the confirmed cases TRANS of COVID-19 since its emergence in Libya, from early April 2020 until August 31th. The epidemiological characteristics of COVID-19 were analyzed and the spatial dynamic trends were explored.  A region -based counts of weekly reported cases were used to characterize and quantify the spatial dynamics of COVID-19. Results: A total  3695  of confirmed cases TRANS of OVID-19 were collected, 2515(68.1%) were males and 1180(31.9%) female TRANS with a male TRANS-to- female TRANS(M:F) ratio 2.1:1. Aged TRANS between 2 -78 years old. Older age TRANS patients infected with COVID-19 are at higher severity and mortality. A broad geographic variability and Spatiotemporal spread variation of the COVID-19 pandemic in Libya was observed. Indicating a higher significant increase of COVID-19 from the middle of July particularly in the West and Southern regions although it was consistently observed in Meddle and Southern regions. Conclusion: Evaluating the epidemiological data and the spatiotemporal dynamic trends of COVID-19 at early stages are particularly  important in understanding the pandemic spread.  These parameters are essential in designing effective prevention and control programs aimed at reducing the impact of COVID- 19 pandemic particularly in countries with limited resources. 

    Clinical course, biomarkers, management and outcomes of patients hospitalised due to COVID-19 in Colombia

    Authors: Nancy Yomayusa; Kelly Rocío Chacón Acevedo; Adriana Janeth Avila Reina; Karen Lorena Rincón; Carlos Hernando Toloza; Olga Gomez Gomez; Eduardo Low Padilla; Juan Felipe Combariza Vallejo; Johana Vargas Rodriguez; Emilio Herrera Molina; Sandra Yadira Moreno Marin; Carlos Arturo Álvarez Moreno

    doi:10.21203/rs.3.rs-57978/v1 Date: 2020-08-12 Source: ResearchSquare

    Background: Coronavirus disease (COVID-19) represents an unprecedented challenge for both people and health systems. Latin America is the current epicentre of the pandemic; however, there is little published clinical information on the clinical characteristics and outcomes.Objective: To analyse the clinic characteristics, risk factors and evolution of the first cohort of hospitalised patients with confirmed infection TRANS by COVID-19 in 5 Colombian institutions.Methods: In the present retrospective observational study, information was acquired from consecutive hospitalized patients with a diagnosis of COVID-19 confirmed by real-time reverse transcriptase polymerase chain reaction (RT-PCR) from March 01 to May 30, 2020 in Colombia.Results: A total of 44 patients were included. The median age TRANS was 62 years, and 65.9% of the patients were male TRANS. A total of 69.8% of the patients were overweight HP or obese MESHD, and 13.6% of the patients had high blood SERO pressure and diabetes MESHD. The presence of systemic symptoms and cough HP cough MESHD were the most common. Ground-glass opacity was frequent finding upon chest imaging. The 30-day mortality rate was 47.7% with a median of 11 days. The composite outcome (critical care requirement, mechanical ventilation and death MESHD) occurred in 36.4% of the patients. The biomarkers associated with mortality risk included troponin higher than 14 ng/L (RR: 5.25; 95% CI 1.37-20.1, p = 0.004) and D-dimer higher than 1000 ng/ml (RR: 3.0; 95% CI 1.4-6.3, p = 0.008). Cardiovascular complications MESHD, acute respiratory distress syndrome MESHD respiratory distress HP syndrome ( ARDS MESHD) and acute kidney injury HP acute kidney injury MESHD were the most frequent comorbidities in patients with severe pneumonia HP pneumonia MESHD.Conclusion: The clinical course of SARS-CoV-2 infection MESHD diagnosis confirmed by RT-PCR in Colombian patients admitted to a high-complexity hospital was similar to that reported in the literature; however, the population was characterised by a more advanced stage of the infection MESHD

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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