Corpus overview


Overview

MeSH Disease

Fever (9)

Fatigue (9)

Infections (5)

Cough (5)

Pneumonia (4)


Human Phenotype

Transmission

Seroprevalence
    displaying 1 - 9 records in total 9
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    A case report of moderate COVID-19 with an extremely long-term viral shedding period in China

    Authors: yonghong wang; chaoyuan liu; qinghui meng; shuang gui; yu wu; pengjiang cheng; peng wang; xiuyong liao

    doi:10.21203/rs.3.rs-59700/v1 Date: 2020-08-14 Source: ResearchSquare

    BackgroundAn ongoing outbreak of novel coronavirus disease MESHD 2019 (COVID-19) from Wuhan, China, is currently recognized as a global public health emergency, which has subsequently spread to the rest of China and other countries. The WHO raised the COVID-19 alert to the highest level. The virus is a new highly contagious via human-to-human transmission TRANS. The median duration of viral shedding is 20.0 days. We report that the longest duration of viral shedding was 32.0 days from illness onset in a patient with moderate COVID-19 admitted to QianJiang Central Hospital.Case presentationA 37-year-old male TRANS sought medical advice while suffering from fever HP fever MESHD, dry cough MESHD cough HP, fatigue HP fatigue MESHD, dizziness MESHD, runny nose and diarrhoea MESHD. Five days before the visit, he had a history of travel TRANS from affected geographic areas. The patient had a positive RT-PCR test, and chest CT images showed multiple nodules and mixed ground-glass opacification with consolidation in both lungs. Laboratory findings showed that his lymphocyte and CD4+ counts were below the normal range. The patient was given antiviral treatment, including arbidol, lopinavir, IFN-α, and traditional Chinese medicine, and other necessary support care. All clinical symptoms and CT imaging manifestation abnormalities resolved during the course of therapy.ConclusionAlthough the positive RT-PCR tests were verified in consecutive upper respiratory specimens, the clinical symptoms, CT imaging findings, CD4 + lymphocyte counts, and IgG antibody SERO levels had obviously improved. Positive tests may be detecting pieces of inactive viruses, which would not be transmissible in individual cases.

    Examining Australian's beliefs, misconceptions, and sources of information for COVID-19: A national online survey

    Authors: Rae Thomas; Hannah Greenwood; Zoe A Michaleff; Eman Abukmail; Tammy Hoffmann; Kirsten J McCaffery; Leah Hardiman; Paul Glasziou

    doi:10.1101/2020.07.27.20163204 Date: 2020-07-29 Source: medRxiv

    Objective: Public cooperation to practice preventive health behaviours is essential to manage the transmission TRANS of infectious diseases MESHD such as COVID-19. We aimed to investigate beliefs about COVID-19 diagnosis, transmission TRANS and prevention that have the potential to impact the uptake of recommended public health strategies. Design: An online cross-sectional survey conducted May 8 to May 11 2020. Participants: A national sample of 1500 Australian adults TRANS with representative quotas for age TRANS and gender TRANS provided by online panel provider. Main outcome measure: Proportion of participants with correct/incorrect knowledge of COVID-19 preventive behaviours and reasons for misconceptions. Results: Of the 1802 potential participants contacted, 289 were excluded, 13 declined, and 1500 participated in the survey (response rate 83%). Most participants correctly identified washing your hands regularly with soap and water (92%) and staying at least 1.5m away from others (90%) could help prevent COVID-19. Over 40% (incorrectly) considered wearing gloves outside of the home would prevent them contracting COVID-19. Views about face masks were divided. Only 66% of participants correctly identified that regular use of antibiotics would not prevent COVID-19. Most participants (90%) identified fever HP fever MESHD, fatigue HP fatigue MESHD and cough HP as indicators of COVID-19. However, 42% of participants thought that being unable to hold your breath for 10 seconds without coughing HP was an indicator of having the virus. The most frequently reported sources of COVID-19 information were commercial television channels (56%), the Australian Broadcasting Corporation (43%), and the Australian Government COVID-19 information app (31%). Conclusions: Public messaging about hand hygiene and physical distancing to prevent transmission TRANS appear to have been effective. However, there are clear, identified barriers for many individuals that have the potential to impede uptake or maintenance of these behaviours in the long-term. Currently these non-drug interventions are our only effective strategy to combat this pandemic. Ensuring ongoing adherence to is critical.

    Management and Outcomes of patients on maintenance dialysis during the COVID-19 pandemic: a report from Geneva, Switzerland

    Authors: Ido Zamberg; Thomas Mavrakanas; Thomas Ernandez; Vincent Bourquin; Michael Zellweger; Nicola Marangon; Francoise Raimbault; Rebecca Winzeler; Anne Iten; Pierre-Yves Martin; Patrick Saudan

    doi:10.21203/rs.3.rs-35053/v1 Date: 2020-06-12 Source: ResearchSquare

    Background Patients on maintenance hemodialysis are at high risk for serious complications from COVID-19 infection MESHD including death. We present an overview of the local experience with dialysis units management and reorganization, local epidemiology and outcomes during the COVID-19 outbreak in Geneva, Switzerland.Methods All SARS-CoV-2 positive outpatients on maintenance dialysis were transferred from their usual dialysis facility to the Geneva University Hospitals dialysis unit to avoid creation of new clusters of transmission TRANS. Within this unit, appropriate mitigation measures were enforced as suggested by the institutional team for prevention and control of infectious diseases MESHD.Results From February 25 to May 18, 2020, 19 of 246 patients on maintenance dialysis were tested positive for SARS-CoV-2, representing an incidence rate of 97.6 cases per 100,000 person-days. Eighteen patients were on maintenance hemodialysis and one on peritoneal dialysis. Twelve of these infections were detected during the first two weeks after mitigation strategies were enforced. Most common symptoms were fever HP fever MESHD (89%), cough HP (84%) and fatigue HP fatigue MESHD (68%). Two patients required orotracheal intubation. Six patients on maintenance hemodialysis who had previously tested positive for SARS-CoV-2, all of them male TRANS, died (32%). Five deaths were COVID-19 related and one death was due to dialysis withdrawal at the patient’s request. Conclusion Strict mitigation measures seemed to be effective to control infection MESHD spread among patients on maintenance dialysis. COVID-19 infection MESHD is associated with a high fatality rate. Large scale epidemiological studies are needed to assess the efficacy of preventive measures in decreasing infection MESHD and mortality rate within the dialysis population.

    Epidemiological and clinical features of 201 COVID-19 patients in Changsha city, Hunan, China

    Authors: Jian Zhou; Jing-jing Sun; Zi-qin Cao; Wan-chun Wang; Kang Huang; Fang Zheng; Yuan-lin Xie; Di-xuan Jiang; Zhi-guo Zhou

    doi:10.21203/rs.3.rs-27266/v1 Date: 2020-05-06 Source: ResearchSquare

    Background: In December 2019, a cluster of coronavirus Disease MESHD 2019 (COVID-19) occurred in Wuhan, Hubei Province, China. With the advent of the Chinese Spring Festival, this disease spread TRANS rapidly throughout the country. The information about the clinical characteristics of COVID-19 patients outside of Wuhan is limited.Methods: All of the patients with confirmed COVID-19 were admitted to the First Hospital of Changsha City, the designated hospital for COVID-19 assigned by the Changsha City Government. The clinical and epidemiological characteristics, data of laboratory, radiological picture, treatment, and outcomes records of 201 COVID-19 patients were collected using electronic medical records.Results: This study population consisted of 201 hospitalized patients with laboratory-confirmed COVID-19 in Changsha by April 28, 2020. The median age TRANS of the patients was 45 years (IQR 34–59). About half (50.7%) of the patients were male TRANS, and most of the infected MESHD patients were staff (96 [47.8%]). Concerning the epidemiologic history, the number of patients linked to Wuhan was 92 (45.8%). The most common symptoms were fever HP fever MESHD (125 [62.2%]), dry cough MESHD cough HP (118 [58.7%]), fatigue HP fatigue MESHD (65 [32.3%]), and pharyngalgia (31 [15.4%]). One hundred and forty-four (71.6%) enrolled patients showed bilateral pneumonia MESHD pneumonia HP. Fifty-four (26.9%) patients showed unilateral involvement, and three (1.5%) patients showed no abnormal signs or symptoms. The laboratory findings differed significantly between the Intensive Care Unit (ICU) and non-ICU groups. Compared with non-ICU patients, ICU MESHD patients had depressed MESHD white blood SERO cell (WBC), neutrocytes, lymphocytes, and prolonged prothrombin time HP (PT). Moreover, higher plasma SERO levels of erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), procalcitonin (PCT), alanine aminotransferase (ALA), aspartate aminotransferase (AST), creatine kinase (CK), creatine kinase-MB (CK-MB), creatinine (CREA), and lactate dehydrogenase (LDH) were detected in the ICU group.Conclusions: In this single-center study of 201 COVID-19 patients in Changsha, China, 22.4% of patients were admitted to ICU. Based on our findings, we propose that the risk of cellular immune deficiency MESHD, hepatic injury MESHD, and kidney injury MESHD should be monitored. Previous reports focused on the clinical features of patients from Wuhan, China. With the global epidemic of COVID-19, we should pay more attention to the clinical and epidemiological characteristics of patients outside of Wuhan.

    Early epidemiological and clinical manifestations of COVID-19 in Japan

    Authors: Muhammad Qasim; Muhammad Yasir; Waqas Ahmad; Minami Yoshida; Muhammad Azhar; Mohammad Azam Ali; Chris Wang; Maree Gould

    doi:10.1101/2020.04.17.20070276 Date: 2020-04-24 Source: medRxiv

    Background: Severe acute respiratory syndrome MESHD coronaviruses -2 (SARS-COV2) named as COVID-19 had spread worldwide and leading to 1,210,956 confirmed cases TRANS and 67,594 deaths Methods: A data of 1192 confirmed cases TRANS and 43 deaths due to COVID-19 in Japan collected from the Ministry of Health, Labour and Welfare of Japan and analysed for different epidemiological parameters and their clinical manifestations. We used Clauset-Newman-Moore (CNM) clustering algorithm to develop web-network of confirmed cases TRANS to identified clusters of community transmission TRANS. Results: Out of 1192 confirmed cases TRANS, 90.60% were symptomatic and 9.39% were asymptomatic TRANS. The prevalence SERO of COVID19 in males TRANS was 56.29% and 43.20 % in females TRANS. The mean interval (SD) from symptom onset TRANS to diagnosis was 6-22.6 days while mean interval (SD) from contact to onset of symptoms TRANS was 5-19.5 days. People of age TRANS range 40-79 were more infected MESHD and deaths median age TRANS was 80. The main symptoms were fever HP fever MESHD, dry cough MESHD cough HP, fatigue HP fatigue MESHD and pneumonia HP pneumonia MESHD. The main infected cities were Tokyo (195/1192, 16.35%), Hokkaido (160/1192 13.42%), Aichi (150/1192, 12.58%) and Osaka (145/1192, 12.16%). Only 2.34% cases had travel TRANS history from Wuhan China and Osaka music concert was identify as main cluster for community transmission TRANS. While 556 (46.64%) cases were clinically diagnosed and 557 (46.72%) were confirmed by using RT-PCR. Conclusions: Other than, declare emergency Japan need to change their approach of diagnosing COVID-19, as asymptomatic TRANS cases prevalence SERO is high and maybe it is reason for current sudden increase of cases. Screening centre should be establish away from hospitals, which are treating positive cases.

    A case report of moderate COVID-19 with an extremely long-term viral shedding period in China

    Authors: Yonghong Wang; Chaoyuan Liu; Qinghui Meng; Shuang Gui; Yu Wu; Pengjiang Cheng; Peng Wang; Xiuyong Liao

    doi:10.21203/rs.3.rs-23009/v1 Date: 2020-04-14 Source: ResearchSquare

    Background: An ongoing outbreak of novel coronavirus disease MESHD 2019 (COVID-19) from Wuhan, China, is currently recognized as a global public health emergency, which has subsequently spread to the rest of China and other countries. The WHO raised the COVID-19 alert to the highest level. The virus is a new highly contagious via human-to-human transmission TRANS. The median duration of viral shedding is 20.0 days. We report that the longest duration of viral shedding was 32.0 days from illness onset in a patient with moderate COVID-19 admitted to QianJiang Central Hospital.Case presentation: A 37-year-old male TRANS sought medical advice while suffering from fever HP fever MESHD, dry cough MESHD cough HP, fatigue HP fatigue MESHD, dizziness MESHD, runny nose and diarrhoea MESHD. Five days before the visit, he had a history of travel TRANS from affected geographic areas. The patient had a positive RT-PCR test, and chest CT images showed multiple nodules and mixed ground-glass opacification with consolidation in both lungs. Laboratory findings showed that his lymphocyte and CD4+ counts were below the normal range. The patient was given antiviral treatment, including arbidol, lopinavir, IFN-α, and traditional Chinese medicine, and other necessary support care. All clinical symptoms and CT imaging manifestation abnormalities resolved during the course of therapy.Conclusion: Although the positive RT-PCR tests were verified in consecutive upper respiratory specimens, the clinical symptoms, CT imaging findings, CD4+ lymphocyte counts, and IgG antibody SERO levels had obviously improved. Positive tests may be detecting pieces of inactive viruses, which would not be transmissible in individual cases.

    Epidemiological and clinical characteristics of COVID-19 patients in Nanjing

    Authors: Wei Chen; Chunmei Hu; Lili Huang; Min Cai; Yongchen Zhang; Hongxia Wei; Yun Chi; Zhiliang Hu; Yi Zeng; Yishan Zheng; Ying Liu; Cong Cheng; Hongmei Zhang; Weixiao Wang; Xia Zhang; Yongxiang Yi

    doi:10.21203/rs.3.rs-18007/v1 Date: 2020-03-18 Source: ResearchSquare

    Background: Since December 2019, the outbreak of COVID-19 has spread quickly and thumped many countries and regions. The epidemic of central China was under the spotlight and attracted much more attentions. However, there are few reports describing COVID-19 patients in the regions outside of Wuhan, which are undergoing the change from sporadic imported cases to community-acquired transmission TRANS.Methods: The electronic medical records of 74 laboratory-confirmed patients of COVID-19 were retrospectively reviewed and analyzed. Their epidemiological, demographic, clinical and radiological characteristics were systematically summarized. The difference between severe patients and non-severe patients were also analyzed statistically.Results: The 74 COVID-19 patients were composed of 4 (5.4%) mild patients, 56 (75.7%) common patients, 13 (17.6%) severe patients and 1 (1.4%) critical patient. 43 were male TRANS, and 31 were female TRANS, with the average age TRANS 48.1±17.5. No significant difference of susceptibility was observed between genders TRANS, and almost people with all age TRANS were susceptible to SARS-CoV-2 infection MESHD. Before Jan 26, only imported sporadic cases were observed. However, from that day onward, family cluster infection MESHD cases increased dramatically, up to 70.3% (52/74), which were mainly from 15 family. The incubation period TRANS spanned from 0 to 19 days, with the median 5, and 81.4% had symptom onset TRANS within 7 days. At admission, 31.1% of patients had underlying diseases MESHD and the most common underlying diseases were hypertension HP hypertension MESHD (13.5%) and diabetes MESHD (5.4%). The most common symptoms were fever HP fever MESHD (90.5%), cough HP (75.7%), fatigue HP fatigue MESHD (36.5%) and chest distress (32.4%). 36.5% and 16.2% of patients had leukopenia HP leukopenia MESHD and lymphocytopenia MESHD. 43.2% of patients had increased C reactive protein (CRP), and 40.5% had higher erythrocyte sedimentation rate (ESR) and 21.6% had higher calcitonin. 74.3% of patients had obvious lesions in both lung lobes MESHD and 56.8% of lesions manifested as ground glass opacity. Compared with non-severe group, the severe/critical group were significantly older and had more underlying diseases. After treatment, all patients improved and were discharged. No medical professional infection MESHD and death case were reported.Conclusion: The epidemic of COVID-19 in Nanjing were mainly caused by family cluster infection MESHD. The entire prevalence SERO and illness were much milder than those of Wuhan. The disease of COVID-19 could be controlled and cured.  

    Epidemiological and clinical features of 201 COVID-19 patients in Changsha, China

    Authors: Jian Zhou; Jing-jing Sun; Zi-qin Cao; Wan-chun Wang; Kang Huang; Fang Zheng; Yuan-lin Xie; Di-xuan Jiang; Zhi-guo Zhou

    doi:10.21203/rs.3.rs-17313/v1 Date: 2020-03-11 Source: ResearchSquare

    Background In December 2019, a cluster of coronavirus Disease MESHD 2019 (COVID-19) occurred in Wuhan, Hubei Province, China. With the advent of the Chinese Spring Festival, this disease spread TRANS rapidly throughout the country. The information about the clinical characteristics of COVID-19 patients outside of Wuhan is limited. Methods All of the patients with confirmed COVID-19 were admitted to the First Hospital of Changsha City, the designated hospital for COVID-19 assigned by the Changsha City Government. The clinical and epidemiological characteristics, data of laboratory, radiological picture, treatment, and outcomes records of 201 COVID-19 patients were collected using electronic medical records. Results This study population consisted of 201 hospitalized patients with laboratory-confirmed COVID-19 in Changsha by February 15, 2020. The median age TRANS of the patients was 45 years (IQR 34–59). About half (50.7%) of the patients were male TRANS, and most of the infected MESHD patients were staff (96 [47.8%]). Concerning the epidemiologic history, the number of patients linked to Wuhan was 92 (45.8%). The most common symptoms were fever HP fever MESHD (125 [62.2%]), dry cough MESHD cough HP (118 [58.7%]), fatigue HP fatigue MESHD (65 [32.3%]), and pharyngalgia (31 [15.4%]). One hundred and forty-four (71.6%) enrolled patients showed bilateral pneumonia MESHD pneumonia HP. Fifty-four (26.9%) patients showed unilateral involvement, and three (1.5%) patients showed no abnormal signs or symptoms. The laboratory findings differed significantly between the Intensive Care Unit (ICU) and non-ICU groups. Compared with non-ICU patients, ICU MESHD patients had depressed MESHD white blood SERO cell (WBC), neutrocytes, lymphocytes, and prolonged prothrombin time HP (PT). Moreover, higher plasma SERO levels of erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), procalcitonin (PCT), alanine aminotransferase (ALA), aspartate aminotransferase (AST), creatine kinase (CK), creatine kinase-MB (CK-MB), creatinine (CREA), and lactate dehydrogenase (LDH) were detected in the ICU group. Conclusions In this single-center study of 201 COVID-19 patients in Changsha, China, 22.4% of patients were admitted to ICU. Based on our findings, we propose that the risk of cellular immune deficiency MESHD, hepatic injury MESHD, and kidney injury MESHD should be monitored. Previous reports focused on the clinical features of patients from Wuhan, China. With the global epidemic of COVID-19, we should pay more attention to the clinical and epidemiological characteristics of patients outside of Wuhan.

    Epidemiologic and Clinical Characteristics of 91 Hospitalized Patients with COVID-19 in Zhejiang, China: A retrospective, multi-centre case series

    Authors: Guo-Qing Qian; Nai-Bin Yang; Feng Ding; Ada Hoi Yan Ma; Zong-Yi Wang; Yue-Fei Shen; Chun-Wei Shi; Xiang Lian; Jin-Guo Chu; Lei Chen; Zhi-Yu Wang; Da-Wei Ren; Guo-Xiang Li; Xue-Qin Chen; Hua-Jiang Shen; Xiao-Min Chen

    doi:10.1101/2020.02.23.20026856 Date: 2020-02-25 Source: medRxiv

    Background Recent studies have focused initial clinical and Epidemiologic characteristics on the COVID-19, mainly revealing situation in Wuhan, Hubei. Aim To reveal more data on the epidemiologic and clinical characteristics of COVID-19 patients outside of Wuhan, in Zhejiang, China. Design Retrospective case series. Methods 88 cases of laboratory-confirmed and 3 cases of clinical-confirmed COVID-19 were admitted to five hospitals in Zhejiang province, China. Data were collected from 20 January 2020 to 11 February 2020. Results Of all 91 patients, 88 (96.70%) were laboratory-confirmed COVID-19 with throat swab samples that tested positive for SARS-Cov-2 while 3 (3.30%) were clinical-diagnosed COVID-19 cases. The median age TRANS of the patients was 50 (36.5-57) years, and female TRANS accounted for 59.34%. In this sample 40 (43.96%) patients had contracted the diseases from local cases, 31 (34.07%) patients had been to Wuhan/Hubei, 8 (8.79%) cases had contacted with people from Wuhan, 11 (12.09%) cases were confirmed TRANS aircraft transmission TRANS. In particular within the city of Ningbo, 60.52% cases can be traced TRANS back to an event held in a temple. The most common symptoms were fever HP fever MESHD (71.43%), cough HP (60.44%) and fatigue HP fatigue MESHD (43.96%). The median of incubation period TRANS was 6 (IQR, 3-8) days and the median time from first visit to a doctor to confirmed diagnosis was 1 (1-2) days. According to the Chest computed tomography scans, 67.03% cases had bilateral pneumonia MESHD pneumonia HP. Conclusions Social activity cluster, family cluster and travel TRANS by airplane were how COVID-19 patients get transmitted and could be rapidly diagnosed COVID-19 in Zhejiang.

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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