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Overview

MeSH Disease

Disease (1)


Human Phenotype

There are no HP terms in the subcorpus


Transmission

There are no transmission terms in the subcorpus


Seroprevalence
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    Magnetic bead-based ELISA SERO allow inexpensive, rapid and quantitative detection of human antibodies SERO against SARS-CoV-2

    Authors: Luciano F Huergo; Marcelo S Conzentino; Edileusa C M Gerhardt; Adrian R.S. Santos; Fabio de Oliveira Pedrosa; Emanuel M Souza; Meri B Nogueira; Karl Forchhammer; Fabiane G.M Rego; Sonia M Raboni; Rodrigo A Reis

    doi:10.1101/2020.07.26.20162255 Date: 2020-07-29 Source: medRxiv

    Here we describe a novel immunogenic method to detect COVID-19. The method is a chromogenic magnetic bead-based ELISA SERO which allows inexpensive and quantitative detection of human IgG or IgM antibodies SERO against SARS-CoV-2 in serum SERO or whole blood SERO samples in just 12 minutes. As a proof of concept, we compared the performance SERO of our new method to classical ELISA SERO. Person correlation between optical densities obtained using the two methods was 0.98. The novel magnetic bead-based ELISA SERO performed better than classic ELISA SERO to discriminate one COVID-19 case carrying low antibody SERO titer. The chromogenic magnetic bead-based ELISA SERO method described here can be applied in formats for both point of care and high throughput analysis. The method is readily adaptable to use other protein-based antigens and is readily adaptable to investigate other diseases MESHD and other applications.

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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