Corpus overview


MeSH Disease

Disease (2)

Human Phenotype

There are no HP terms in the subcorpus


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    Magnetic bead-based ELISA SERO allow inexpensive, rapid and quantitative detection of human antibodies SERO against SARS-CoV-2

    Authors: Luciano F Huergo; Marcelo S Conzentino; Edileusa C M Gerhardt; Adrian R.S. Santos; Fabio de Oliveira Pedrosa; Emanuel M Souza; Meri B Nogueira; Karl Forchhammer; Fabiane G.M Rego; Sonia M Raboni; Rodrigo A Reis

    doi:10.1101/2020.07.26.20162255 Date: 2020-07-29 Source: medRxiv

    Here we describe a novel immunogenic method to detect COVID-19. The method is a chromogenic magnetic bead-based ELISA SERO which allows inexpensive and quantitative detection of human IgG or IgM antibodies SERO against SARS-CoV-2 in serum SERO or whole blood SERO samples in just 12 minutes. As a proof of concept, we compared the performance SERO of our new method to classical ELISA SERO. Person correlation between optical densities obtained using the two methods was 0.98. The novel magnetic bead-based ELISA SERO performed better than classic ELISA SERO to discriminate one COVID-19 case carrying low antibody SERO titer. The chromogenic magnetic bead-based ELISA SERO method described here can be applied in formats for both point of care and high throughput analysis. The method is readily adaptable to use other protein-based antigens and is readily adaptable to investigate other diseases MESHD and other applications.

    SARS-CoV-2 Seroprevalence SERO Among Parturient Women

    Authors: Dustin D. Flannery; Sigrid Gouma; Miren B. Dhudasia; Sagori Mukhopadhyay; Madeline R. Pfeifer; Emily C. Woodford; Jeffrey S. Gerber; Claudia P. Arevalo; Marcus J. Bolton; Madison E. Weirick; Eileen C. Goodwin; Elizabeth M. Anderson; Allison R. Greenplate; Justin Kim; Nicholas Han; Ajinkya Pattekar; Jeanette Dougherty; Oliva Kuthuru; Divij Mathew; Amy E. Baxter; Laura A. Vella; JoEllen Weaver; Anurag Verma; Rita Leite; Jeffrey S. Morris; Daniel J. Rader; Michal A. Elovitz; E. John Wherry; Karen M. Puopolo; Scott E. Hensley

    doi:10.21203/ Date: 2020-05-07 Source: ResearchSquare

    SARS-CoV-2 has led to a pandemic of respiratory and multisystem disease MESHD, named COVID-19.1 Limited data are available for pregnant women affected by COVID-19.2 Serological tests SERO, particularly those that provide quantitative information, are critically important to determine exposure and immunity to SARS-CoV-2 within both individuals and populations.3 Here, we completed SARS-CoV-2 serological testing SERO of 237 parturient women at two centers in Philadelphia from April 4 to April 15, 2020. Using an assay with a 1.0% false positive rate, we show that 14/237 (5.9%) of parturient women possessed IgG and/or IgM SARS-CoV-2-specific antibodies SERO. We found significant racial differences, with an 11.2% seropositive rate in black women and a 1.5% seropositive rate in women of other races. Seropositive women who received nasopharyngeal (NP) SARS-CoV-2 PCR (polymerase chain reaction) testing were all found to be positive. Continued serologic surveillance among pregnant women may inform perinatal clinical practices and can potentially be used to estimate seroprevalence SERO within the community.Authors Dustin D. Flannery and Sigrid Gouma contributed equally to this work.

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MeSH Disease
Human Phenotype

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