Corpus overview


Overview

MeSH Disease

Human Phenotype

Viremia (3)

Fever (1)


Transmission

Seroprevalence
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    Seroprevalence SERO and Risk Factors of SARS CoV-2 in Health Care Workers of Tertiary-Care Hospitals in the Province of Khyber Pakhtunkhwa, Pakistan

    Authors: Mohsina Haq; Asif Rehman; Muhammad Noor; Jawad Ahmed; Junaid Ahmad; Muhammad irfan; Saeed Anwar; Sajjad Ahmad; Said Amin; Fawad Rahim; Najib Ul Haq

    doi:10.1101/2020.09.29.20203125 Date: 2020-09-30 Source: medRxiv

    Background: High number of SARS CoV2 infected MESHD patients has overburdened healthcare delivery system, particularly in low-income countries. In the recent past many studies from the developed countries have been published on the prevalence SERO of SARS CoV2 antibodies SERO and the risk factors of COVID 19 in healthcare-workers but little is known from developing countries. Methods: This cross-sectional study was conducted on prevalence SERO of SARS CoV2 antibody SERO and risk factors for seropositivity in HCWs in tertiary care hospitals of Peshawar city, Khyber Pakhtunkhwa province Pakistan. Findings: The overall seroprevalence SERO of SARS CoV2 antibodies SERO was 30.7% (CI, 27.8 to 33.6) in 1011 HCWs. Laboratory technicians had the highest seropositivity (50.0%, CI, 31.8 to 68.1). Risk analysis revealed that wearing face-mask and observing social-distancing within a family could reduce the risk (OR:0.67. p<0.05) and (OR:0.73. p<0.05) while the odds of seropositivity were higher among those attending funeral and visiting local-markets (OR:1.83. p<0.05) and (OR:1.66. p<0.01). In Univariable analysis, being a nursing staff and a paramedical staff led to higher risk of seropositivity (OR:1.58. p< 0.05), (OR:1.79. p< 0.05). Fever HP Fever MESHD (OR:2.36, CI, 1.52 to 3.68) and loss of smell (OR:2.95, CI: 1.46 to 5.98) were significantly associated with increased risk of seropositivity (p<0.01). Among the seropositive HCWs, 165 (53.2%) had no symptoms at all while 145 (46.8%) had one or more symptoms. Interpretation: The high prevalence SERO of SARS CoV2 antibodies SERO in HCWs warrants for better training and use of protective measure to reduce their risk. Early detection of asymptomatic TRANS HCWs may be of special importance because they are likely to be potential threat to others during the active phase of viremia HP viremia MESHD. Funding: Prime Foundation Pakistan.

    SARS-CoV-2 Viral Load is Associated with Increased Disease Severity and Mortality

    Authors: Jesse M Fajnzylber; James Regan; Kendyll Coxen; Heather Corry; Colline Wong; Alexandra Rosenthal; Daniel Worrall; Francoise Giguel; Alicja Piechocka-Trocha; Caroline Atyeo; Stephanie Fischinger; Andrew Chan; Keith T Flaherty; Kathryn Hall; Michael Dougan; Edward T Ryan; Elizabeth Gillespie; Rida Chishti; Yijia Li; Nikolaus Jilg; Dusan Hanidziar; Rebecca M Baron; Lindsey Baden; Athe M Tsibris; Katrina A Armstrong; Daniel R Kuritzkes; Galit Alter; Bruce D Walker; Xu Yu; Jonathan Li; - Massachusetts Consortium for Pathogen Readiness

    doi:10.1101/2020.07.15.20131789 Date: 2020-07-17 Source: medRxiv

    The relationship between SARS-CoV-2 viral load and risk of disease progression remains largely undefined in coronavirus disease 2019 (COVID-19). We quantified SARS-CoV-2 viral load from participants with a diverse range of COVID-19 severity, including those requiring hospitalization, outpatients with mild disease, and individuals with resolved infection. SARS-CoV-2 plasma SERO RNA was detected in 27% of hospitalized participants and 13% of outpatients diagnosed with COVID-19. Amongst the participants hospitalized with COVID-19, higher prevalence SERO of detectable SARS-CoV-2 plasma SERO viral load was associated with worse respiratory disease severity, lower absolute lymphocyte counts, and increased markers of inflammation, including C-reactive protein and IL-6. SARS-CoV-2 viral loads, especially plasma SERO viremia HP, were associated with increased risk of mortality. SARS-CoV-2 viral load may aid in the risk stratification of patients with COVID-19 and its role in disease pathogenesis should be further explored.

    SARS-CoV-2 Viral Load is Associated with Increased Disease Severity and Mortality

    Authors: Jesse Fajnzylber; James Regan; Kendyll Coxen; Heather Corry; Colline Wong; Alexandra Rosenthal; Daniel Worrall; Francoise Giguel; Alicja Piechocka-Trocha; Caroline Atyeo; Stephanie Fischinger; Andrew Chan; Keith Flaherty; Kathryn Hall; Michael Dougan; Edward Ryan; Elizabeth Gillespie; Rida Chishti; Yijia Li; Nikolaus Jilg; Dusan Hanidziar; Rebecca Baron; Lindsey Baden; Athe Tsibris; Katrina Armstrong; Galit Alter; Daniel Kuritzkes; Bruce Walker; Xu Yu; Jonathan Li

    doi:10.21203/rs.3.rs-43878/v1 Date: 2020-07-15 Source: ResearchSquare

    The relationship between SARS-CoV-2 viral load and risk of disease progression remains largely undefined in coronavirus disease MESHD 2019 (COVID-19). We quantified SARS-CoV-2 viral load from participants with a diverse range of COVID-19 severity, including those requiring hospitalization, outpatients with mild disease, and individuals with resolved infection MESHD. SARS-CoV-2 plasma SERO RNA was detected in 27% of hospitalized participants and 13% of outpatients diagnosed with COVID-19. Amongst the participants hospitalized with COVID-19, higher prevalence SERO of detectable SARS-CoV-2 plasma SERO viral load was associated with worse respiratory disease MESHD severity, lower absolute lymphocyte counts, and increased markers of inflammation MESHD, including C-reactive protein and IL-6. SARS-CoV-2 viral loads, especially plasma SERO viremia HP viremia MESHD, were associated with increased risk of mortality. SARS-CoV-2 viral load may aid in the risk stratification of patients with COVID-19 and its role in disease pathogenesis should be further explored.

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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