Corpus overview


Overview

MeSH Disease

Human Phenotype

There are no HP terms in the subcorpus


Transmission

Seroprevalence
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    Relative COVID-19 viral persistence and antibody SERO kinetics

    Authors: Chung-Guei Huang; Ching-Tai Huang; Avijit Dutta; Pi-Yueh Chang; Mei-Jen Hsiao; Yu-Chia Hsieh; Shin-Ru Shih; Kuo-Chien Tsao; Cheng-Ta Yang

    doi:10.1101/2020.07.01.20143917 Date: 2020-07-02 Source: medRxiv

    Importance: The COVID-19 antibody SERO response is a critical indicator for evaluating immunity and also serves as the knowledge base for vaccine development. The picture is still not clear because of many limitations including testing tools, time of sampling, and the unclear impact of varying clinical status. In addition to these problems, antibody SERO levels may not be equivalent to protective capacity. Objective: To define the key factor for the different patterns of COVID-19 antibody SERO response. Design: We elucidated the antibody SERO response with time-series throat and serum samples SERO for viral loads and antibody SERO levels, then used a neutralization test to evaluate protectiveness. Setting: A medical center that typically cares for patients with moderate to severe diseases MESHD. Because of the low prevalence SERO of COVID-19 in Taiwan and local government policy, however, we also admit COVID-19 patients with mild disease MESHD or even those without symptoms for inpatient care. Participants: RT-PCR-confirmed COVID-19 patients. Results: We found that only patients with relative persistence of virus at pharynx displayed strong antibody SERO responses that were proportional to the pharyngeal viral load. They also had proportional neutralization titers per unit of serum SERO. Although antibody SERO levels decreased around 2 weeks after symptom onset TRANS, the neutralization efficacy per unit antibody SERO remained steady and even continued to increase over time. The antibody SERO response in patients with rapid virus clearance was weak, but the neutralization efficacy per unit antibody SERO in these patients was comparable to those with persistent presence of virus. The deceased were with higher viral load, higher level of antibody SERO, and higher neutralization titers in the serum SERO, but the neutralization capacity per unit antibody SERO is relatively low. Conclusions and Relevance: Strong antibody SERO response depends on the relative persistence of the virus, instead of the absolute virus amount. The antibody SERO response is still weak if large amount of virus is cleared quickly. The neutralization efficacy per unit antibody SERO is comparable between high and low antibody SERO patterns. Strong antibody SERO response contains more inefficient and maybe even harmful antibodies SERO. Low antibody SERO response is also equipped with a capable B cell pool of efficient antibodies SERO, which may expand with next virus encounter and confer protection.

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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