Corpus overview


MeSH Disease

HGNC Genes

SARS-CoV-2 proteins

There are no SARS-CoV-2 protein terms in the subcorpus


SARS-CoV-2 Proteins
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    Analysis of the Clinical Characteristics of 77 COVID-19 MESHD Deaths

    Authors: Kaige Wang; Zhixin Qiu; Dan Liu; Jianfei Luo; Jiasheng Liu; Tao Fan; Chunrong Liu; Panwen Tian; Ye Wang; Zhong Ni; Shumin Zhang; Weimin Li

    doi:10.21203/ Date: 2020-04-20 Source: ResearchSquare

    Purpose: For the emerging pandemic Coronavirus Disease MESHD Coronavirus Disease 2019 MESHD ( COVID-19 MESHD), no clear description on its deaths’ clinical characteristics and causes of death MESHD is available. Hence, this study analyzed clinical characteristics of 77 COVID-19 MESHD deaths, providing data support to further understand this disease.Method: A retrospective analysis of 77 COVID-19 MESHD deaths in East Branch, Renmin Hospital of Wuhan University from February 1 to March 7, 2020 was performed in clinical characteristics, laboratory results, causes of death MESHD, and subgroup comparison. Results: Totally 72.7% of the deaths (male-female ratio: 51:26, average age at death: 71, mean survival time: 17.4 days) had hypertension MESHD, heart disease MESHD, diabetes MESHD, chronic lung disease MESHD, and other comorbidities. Acute respiratory distress syndrome MESHD ( ARDS MESHD) and sepsis MESHD were the main causes of death MESHD. Increases in C-reactive protein HGNC ( CRP HGNC), lactate dehydrogenase (LDH), D-dimer and lactic acid (LAC), and decreases in lymphocyte, cluster of differentiation (CD) 4+ and CD8+ cells were common in laboratory results. Subgroup analysis showed: 1) Most female deaths had cough MESHD and diabetes MESHD. 2) The male proportion in young and middle-aged deaths was higher; while elderly deaths were more prone to myocardial injury MESHD and elevated CRP. 3 HGNC) There was no statistical difference between short-term and non-short-term survival subgroups. 4) CRP HGNC and LDH increased and CD4+ and CD8+ cells decreased significantly in patients with hypertension MESHD.Conclusions: The majority of COVID-19 MESHD deaths are males, especially the elderly with underlying diseases. The main causes of death include ARDS MESHD and sepsis MESHD. Most female deaths have cough MESHD and diabetes MESHD. Myocardial injury MESHD is common in elderly deaths. Patients with hypertension MESHD are prone to increased inflammatory index, tissue hypoxia MESHD and cellular immune injury.Authors Kaige Wang and Zhixin Qiu contributed equally to this work.

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MeSH Disease
HGNC Genes
SARS-CoV-2 Proteins

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