Corpus overview


MeSH Disease

HGNC Genes

SARS-CoV-2 proteins

There are no SARS-CoV-2 protein terms in the subcorpus


SARS-CoV-2 Proteins
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    COVID-19 MESHD in Spain: age, Interleukin-6 HGNC, C Reactive Protein HGNC and lymphocytes as key clues from a multicentre retrospective study

    Authors: Aurora Jurado; M Carmen Martin; Cristina Abad-Molina; Antonio Orduna; Alba Martinez; Esther Ocana; Oscar Yarce; Ana M Navas; Antonio Trujillo; Luis Fernandez-Pereira; Esther Vergara; Beatriz Rodriguez; Bibiana Quirant; Eva Martinez-Caceres; Manuel Hernandez; Janire Perurena; Juana Gil; Sergi Cantenys; Gema Gonzalez-Martinez; Maria Teresa Martinez-Saavedra; Ricardo Rojo; Francisco M Marco; Sergio Mora; Jesus Ontanon; Marcos Lopez-Hoyos; Gonzalo Ocejo-Vinyals; Josefa Melero; Marta Aguilar; Delia Almeida; Silvia Medina; Maria Carmen Vegas; Yesenia Jimenez; Alvaro Prada; David Monzon; Francisco Boix; Vanesa Cunil; Juan Molina

    doi:10.1101/2020.05.13.20101345 Date: 2020-05-16 Source: medRxiv

    Background. SARS-CoV-2 infection MESHD has widely spread to the hugest public health challenge to date, COVID-19 MESHD COVID-19 MESHD pandemic. Different fatality rates among countries are probably due to non-standardized records being carried out by local health authorities. Spanish case-fatality rate is 11.94%, far higher to those reported in Asia or by other European countries. A multicenter retrospective study was performed of demographic, clinical, laboratory and immunological features of 574 Spanish COVID-19 MESHD hospitalized patients and their outcomes. The use of use of renin HGNC-angiotensin system blockers was also analyzed as a risk factor. Results. In this study, 27.7% of cases presented a mild curse, 42% a moderate one and for 30.3% of cases, the course was severe. Ages ranged from 18 to 98 (average 63.2). Fifty eight percent (58.9%) of patients were male. Interleukin 6 HGNC was higher as severity increased. On the other hand, CD8 HGNC lymphocyte count was significantly lower as severity grew and subpopulations CD4 HGNC, CD8 HGNC, CD19 HGNC and NK showed concordant lowering trends. Severity-related natural killer percent descents were evidenced just within aged cases. A significant severity-related decrease of CD4 HGNC lymphocytes was found in males. The use of renin HGNC-angiotensin system blockers was associated with moderate or mild disease courses. Conclusions. Age and age-related comorbidities, such as dyslipidaemia, hypertension MESHD or diabetes MESHD, determined more frequent severe forms of the disease in this study than in previous literature cohorts. Our cases are older than those so far reported and clinical course of the disease is found to be impaired by age. Immunosenescence might be therefore a suitable explanation for immune system effectors severity-related hampering. Adaptive immunity would go exhausted and a huge ineffective and almost deleterious innate response would account for COVID-19 MESHD severity. Renin HGNC-angiotensin system blockers treatment in hypertensive MESHD patients has a protective effect as regarding COVID-19 MESHD severity.

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MeSH Disease
HGNC Genes
SARS-CoV-2 Proteins

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